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PubMed code 15771457

Compile data set for download or QSAR
Found 77 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163592
PNG
((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3OCCCc3cc2c1
Show InChI InChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3/t13-,17+
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n/an/a 0.550n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163613
PNG
((2,3-Dihydro-1H-cyclopenta[b]quinolin-7-yl)-(4-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3CCCc3cc2c1
Show InChI InChI=1S/C20H23NO2/c1-23-17-8-5-13(6-9-17)20(22)15-7-10-19-16(12-15)11-14-3-2-4-18(14)21-19/h7,10-13,17H,2-6,8-9H2,1H3/t13-,17+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163596
PNG
((2-Amino-3-ethyl-quinolin-6-yl)-(4-methoxy-cyclohe...)
Show SMILES CCc1cc2cc(ccc2nc1N)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C19H24N2O2/c1-3-12-10-15-11-14(6-9-17(15)21-19(12)20)18(22)13-4-7-16(23-2)8-5-13/h6,9-11,13,16H,3-5,7-8H2,1-2H3,(H2,20,21)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163617
PNG
((2,3-Dihydro-thieno[2,3-b]quinolin-6-yl)-(4-methox...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3SCCc3cc2c1
Show InChI InChI=1S/C19H21NO2S/c1-22-16-5-2-12(3-6-16)18(21)13-4-7-17-15(10-13)11-14-8-9-23-19(14)20-17/h4,7,10-12,16H,2-3,5-6,8-9H2,1H3/t12-,16+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163617
PNG
((2,3-Dihydro-thieno[2,3-b]quinolin-6-yl)-(4-methox...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3SCCc3cc2c1
Show InChI InChI=1S/C19H21NO2S/c1-22-16-5-2-12(3-6-16)18(21)13-4-7-17-15(10-13)11-14-8-9-23-19(14)20-17/h4,7,10-12,16H,2-3,5-6,8-9H2,1H3/t12-,16+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163590
PNG
((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Show SMILES CCc1cc2cc(ccc2nc1CC)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C21H27NO2/c1-4-14-12-17-13-16(8-11-20(17)22-19(14)5-2)21(23)15-6-9-18(24-3)10-7-15/h8,11-13,15,18H,4-7,9-10H2,1-3H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163592
PNG
((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3OCCCc3cc2c1
Show InChI InChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3/t13-,17+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163589
PNG
((4-Methoxy-cyclohexyl)-(2-propyl-quinolin-6-yl)-me...)
Show SMILES CCCc1ccc2cc(ccc2n1)C(=O)[C@@H]1CC[C@@H](CC1)OC
Show InChI InChI=1S/C20H25NO2/c1-3-4-17-9-5-15-13-16(8-12-19(15)21-17)20(22)14-6-10-18(23-2)11-7-14/h5,8-9,12-14,18H,3-4,6-7,10-11H2,1-2H3/t14-,18+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163616
PNG
((2-Chloro-3-ethyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Show SMILES CCc1cc2cc(ccc2nc1Cl)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C19H22ClNO2/c1-3-12-10-15-11-14(6-9-17(15)21-19(12)20)18(22)13-4-7-16(23-2)8-5-13/h6,9-11,13,16H,3-5,7-8H2,1-2H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163613
PNG
((2,3-Dihydro-1H-cyclopenta[b]quinolin-7-yl)-(4-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3CCCc3cc2c1
Show InChI InChI=1S/C20H23NO2/c1-23-17-8-5-13(6-9-17)20(22)15-7-10-19-16(12-15)11-14-3-2-4-18(14)21-19/h7,10-13,17H,2-6,8-9H2,1H3/t13-,17+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163607
PNG
(3-ethyl-6-[(4-methoxycyclohexyl)carbonyl]quinoline...)
Show SMILES CCc1cnc2ccc(cc2c1)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C19H23NO2/c1-3-13-10-16-11-15(6-9-18(16)20-12-13)19(21)14-4-7-17(22-2)8-5-14/h6,9-12,14,17H,3-5,7-8H2,1-2H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163616
PNG
((2-Chloro-3-ethyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Show SMILES CCc1cc2cc(ccc2nc1Cl)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C19H22ClNO2/c1-3-12-10-15-11-14(6-9-17(15)21-19(12)20)18(22)13-4-7-16(23-2)8-5-13/h6,9-11,13,16H,3-5,7-8H2,1-2H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163589
PNG
((4-Methoxy-cyclohexyl)-(2-propyl-quinolin-6-yl)-me...)
Show SMILES CCCc1ccc2cc(ccc2n1)C(=O)[C@@H]1CC[C@@H](CC1)OC
Show InChI InChI=1S/C20H25NO2/c1-3-4-17-9-5-15-13-16(8-12-19(15)21-17)20(22)14-6-10-18(23-2)11-7-14/h5,8-9,12-14,18H,3-4,6-7,10-11H2,1-2H3/t14-,18+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163609
PNG
((4-Methoxy-cyclohexyl)-(2-methyl-3-propyl-quinolin...)
Show SMILES CCCc1cc2cc(ccc2nc1C)C(=O)[C@@H]1CC[C@@H](CC1)OC
Show InChI InChI=1S/C21H27NO2/c1-4-5-16-12-18-13-17(8-11-20(18)22-14(16)2)21(23)15-6-9-19(24-3)10-7-15/h8,11-13,15,19H,4-7,9-10H2,1-3H3/t15-,19+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163606
PNG
(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-ph...)
Show SMILES O=C(Cc1ccccc1)c1ccc2nc3OCCCc3cc2c1
Show InChI InChI=1S/C20H17NO2/c22-19(11-14-5-2-1-3-6-14)15-8-9-18-17(12-15)13-16-7-4-10-23-20(16)21-18/h1-3,5-6,8-9,12-13H,4,7,10-11H2
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163611
PNG
(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-th...)
Show SMILES O=C(Cc1ccsc1)c1ccc2nc3OCCCc3cc2c1
Show InChI InChI=1S/C18H15NO2S/c20-17(8-12-5-7-22-11-12)13-3-4-16-15(9-13)10-14-2-1-6-21-18(14)19-16/h3-5,7,9-11H,1-2,6,8H2
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163609
PNG
((4-Methoxy-cyclohexyl)-(2-methyl-3-propyl-quinolin...)
Show SMILES CCCc1cc2cc(ccc2nc1C)C(=O)[C@@H]1CC[C@@H](CC1)OC
Show InChI InChI=1S/C21H27NO2/c1-4-5-16-12-18-13-17(8-11-20(18)22-14(16)2)21(23)15-6-9-19(24-3)10-7-15/h8,11-13,15,19H,4-7,9-10H2,1-3H3/t15-,19+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163601
PNG
((2,3-Dihydro-benzo[1,4]dioxin-2-yl)-(3-ethyl-2-met...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1COc2ccccc2O1
Show InChI InChI=1S/C21H19NO3/c1-3-14-10-16-11-15(8-9-17(16)22-13(14)2)21(23)20-12-24-18-6-4-5-7-19(18)25-20/h4-11,20H,3,12H2,1-2H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163590
PNG
((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Show SMILES CCc1cc2cc(ccc2nc1CC)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C21H27NO2/c1-4-14-12-17-13-16(8-11-20(17)22-19(14)5-2)21(23)15-6-9-18(24-3)10-7-15/h8,11-13,15,18H,4-7,9-10H2,1-3H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163615
PNG
((4-Methoxy-cyclohexyl)-(1-methyl-1,2,3,4-tetrahydr...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3N(C)CCCc3cc2c1
Show InChI InChI=1S/C21H26N2O2/c1-23-11-3-4-16-13-17-12-15(7-10-19(17)22-21(16)23)20(24)14-5-8-18(25-2)9-6-14/h7,10,12-14,18H,3-6,8-9,11H2,1-2H3/t14-,18+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163623
PNG
((3-Ethyl-2-fluoro-quinolin-6-yl)-(4-methoxy-cycloh...)
Show SMILES CCc1cc2cc(ccc2nc1F)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C19H22FNO2/c1-3-12-10-15-11-14(6-9-17(15)21-19(12)20)18(22)13-4-7-16(23-2)8-5-13/h6,9-11,13,16H,3-5,7-8H2,1-2H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163604
PNG
(1-(3-Ethyl-2-methyl-quinolin-6-yl)-2-phenyl-ethano...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)Cc1ccccc1
Show InChI InChI=1S/C20H19NO/c1-3-16-12-18-13-17(9-10-19(18)21-14(16)2)20(22)11-15-7-5-4-6-8-15/h4-10,12-13H,3,11H2,1-2H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163599
PNG
(Bicyclo[2.2.1]hept-2-yl-(3-ethyl-2-methyl-quinolin...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1CC2CCC1C2
Show InChI InChI=1S/C20H23NO/c1-3-14-10-17-11-16(6-7-19(17)21-12(14)2)20(22)18-9-13-4-5-15(18)8-13/h6-7,10-11,13,15,18H,3-5,8-9H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163584
PNG
((3-Ethyl-2-iodo-quinolin-6-yl)-(4-methoxy-cyclohex...)
Show SMILES CCc1cc2cc(ccc2nc1I)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C19H22INO2/c1-3-12-10-15-11-14(6-9-17(15)21-19(12)20)18(22)13-4-7-16(23-2)8-5-13/h6,9-11,13,16H,3-5,7-8H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163606
PNG
(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-ph...)
Show SMILES O=C(Cc1ccccc1)c1ccc2nc3OCCCc3cc2c1
Show InChI InChI=1S/C20H17NO2/c22-19(11-14-5-2-1-3-6-14)15-8-9-18-17(12-15)13-16-7-4-10-23-20(16)21-18/h1-3,5-6,8-9,12-13H,4,7,10-11H2
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n/an/a 14n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163620
PNG
((3-Ethyl-2-hydroxy-quinolin-6-yl)-(4-methoxy-cyclo...)
Show SMILES CCc1cc2cc(ccc2[nH]c1=O)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C19H23NO3/c1-3-12-10-15-11-14(6-9-17(15)20-19(12)22)18(21)13-4-7-16(23-2)8-5-13/h6,9-11,13,16H,3-5,7-8H2,1-2H3,(H,20,22)
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n/an/a 15n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163598
PNG
(1-(3-Ethyl-2-methyl-quinolin-6-yl)-2-(4-methoxy-cy...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C[C@H]1CC[C@H](CC1)OC
Show InChI InChI=1S/C21H27NO2/c1-4-16-12-18-13-17(7-10-20(18)22-14(16)2)21(23)11-15-5-8-19(24-3)9-6-15/h7,10,12-13,15,19H,4-6,8-9,11H2,1-3H3/t15-,19+
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n/an/a 16n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50410312
PNG
(CHEMBL2112048)
Show SMILES C[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3CCCCCc3cc2c1
Show InChI InChI=1S/C22H27NO/c1-15-7-9-16(10-8-15)22(24)18-11-12-21-19(14-18)13-17-5-3-2-4-6-20(17)23-21/h11-16H,2-10H2,1H3/t15-,16+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163614
PNG
((4-Methoxy-cyclohexyl)-(7,8,9,10-tetrahydro-6H-cyc...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3CCCCCc3cc2c1
Show InChI InChI=1S/C22H27NO2/c1-25-19-10-7-15(8-11-19)22(24)17-9-12-21-18(14-17)13-16-5-3-2-4-6-20(16)23-21/h9,12-15,19H,2-8,10-11H2,1H3/t15-,19+
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n/an/a 18n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163586
PNG
((3-Ethyl-2-methoxy-quinolin-6-yl)-(4-methoxy-cyclo...)
Show SMILES CCc1cc2cc(ccc2nc1OC)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C20H25NO3/c1-4-13-11-16-12-15(7-10-18(16)21-20(13)24-3)19(22)14-5-8-17(23-2)9-6-14/h7,10-12,14,17H,4-6,8-9H2,1-3H3
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n/an/a 19n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163586
PNG
((3-Ethyl-2-methoxy-quinolin-6-yl)-(4-methoxy-cyclo...)
Show SMILES CCc1cc2cc(ccc2nc1OC)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C20H25NO3/c1-4-13-11-16-12-15(7-10-18(16)21-20(13)24-3)19(22)14-5-8-17(23-2)9-6-14/h7,10-12,14,17H,4-6,8-9H2,1-3H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor 1 transmembrane domain


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163615
PNG
((4-Methoxy-cyclohexyl)-(1-methyl-1,2,3,4-tetrahydr...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3N(C)CCCc3cc2c1
Show InChI InChI=1S/C21H26N2O2/c1-23-11-3-4-16-13-17-12-15(7-10-19(17)22-21(16)23)20(24)14-5-8-18(25-2)9-6-14/h7,10,12-14,18H,3-6,8-9,11H2,1-2H3/t14-,18+
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n/an/a 29n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163610
PNG
((4-Ethyl-1,2,3,9b-tetraaza-cyclopenta[a]naphthalen...)
Show SMILES CCc1cc2cc(ccc2n2nnnc12)C(=O)[C@@H]1CC[C@@H](CC1)OC
Show InChI InChI=1S/C19H22N4O2/c1-3-12-10-15-11-14(6-9-17(15)23-19(12)20-21-22-23)18(24)13-4-7-16(25-2)8-5-13/h6,9-11,13,16H,3-5,7-8H2,1-2H3/t13-,16+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163592
PNG
((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3OCCCc3cc2c1
Show InChI InChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3/t13-,17+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163600
PNG
((3-Ethyl-2-methyl-quinolin-6-yl)-(4-hydroxy-cycloh...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1CCC(O)CC1
Show InChI InChI=1S/C19H23NO2/c1-3-13-10-16-11-15(6-9-18(16)20-12(13)2)19(22)14-4-7-17(21)8-5-14/h6,9-11,14,17,21H,3-5,7-8H2,1-2H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163604
PNG
(1-(3-Ethyl-2-methyl-quinolin-6-yl)-2-phenyl-ethano...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)Cc1ccccc1
Show InChI InChI=1S/C20H19NO/c1-3-16-12-18-13-17(9-10-19(18)21-14(16)2)20(22)11-15-7-5-4-6-8-15/h4-10,12-13H,3,11H2,1-2H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163587
PNG
((3-Ethyl-2-methyl-quinolin-6-yl)-indan-2-yl-methan...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1Cc2ccccc2C1
Show InChI InChI=1S/C22H21NO/c1-3-15-10-19-13-18(8-9-21(19)23-14(15)2)22(24)20-11-16-6-4-5-7-17(16)12-20/h4-10,13,20H,3,11-12H2,1-2H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163584
PNG
((3-Ethyl-2-iodo-quinolin-6-yl)-(4-methoxy-cyclohex...)
Show SMILES CCc1cc2cc(ccc2nc1I)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C19H22INO2/c1-3-12-10-15-11-14(6-9-17(15)21-19(12)20)18(22)13-4-7-16(23-2)8-5-13/h6,9-11,13,16H,3-5,7-8H2,1-2H3
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n/an/a 62n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163590
PNG
((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Show SMILES CCc1cc2cc(ccc2nc1CC)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C21H27NO2/c1-4-14-12-17-13-16(8-11-20(17)22-19(14)5-2)21(23)15-6-9-18(24-3)10-7-15/h8,11-13,15,18H,4-7,9-10H2,1-3H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163611
PNG
(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-th...)
Show SMILES O=C(Cc1ccsc1)c1ccc2nc3OCCCc3cc2c1
Show InChI InChI=1S/C18H15NO2S/c20-17(8-12-5-7-22-11-12)13-3-4-16-15(9-13)10-14-2-1-6-21-18(14)19-16/h3-5,7,9-11H,1-2,6,8H2
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n/an/a 74n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163597
PNG
(CHEMBL367227 | [3-Ethyl-2-(2-methoxy-ethylamino)-q...)
Show SMILES CCc1cc2cc(ccc2nc1NCCOC)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C22H30N2O3/c1-4-15-13-18-14-17(21(25)16-5-8-19(27-3)9-6-16)7-10-20(18)24-22(15)23-11-12-26-2/h7,10,13-14,16,19H,4-6,8-9,11-12H2,1-3H3,(H,23,24)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163614
PNG
((4-Methoxy-cyclohexyl)-(7,8,9,10-tetrahydro-6H-cyc...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3CCCCCc3cc2c1
Show InChI InChI=1S/C22H27NO2/c1-25-19-10-7-15(8-11-19)22(24)17-9-12-21-18(14-17)13-16-5-3-2-4-6-20(16)23-21/h9,12-15,19H,2-8,10-11H2,1H3/t15-,19+
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163600
PNG
((3-Ethyl-2-methyl-quinolin-6-yl)-(4-hydroxy-cycloh...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1CCC(O)CC1
Show InChI InChI=1S/C19H23NO2/c1-3-13-10-16-11-15(6-9-18(16)20-12(13)2)19(22)14-4-7-17(21)8-5-14/h6,9-11,14,17,21H,3-5,7-8H2,1-2H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163601
PNG
((2,3-Dihydro-benzo[1,4]dioxin-2-yl)-(3-ethyl-2-met...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1COc2ccccc2O1
Show InChI InChI=1S/C21H19NO3/c1-3-14-10-16-11-15(8-9-17(16)22-13(14)2)21(23)20-12-24-18-6-4-5-7-19(18)25-20/h4-11,20H,3,12H2,1-2H3
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163605
PNG
(3-Cyclohexa-1,5-dienyl-1-(3,4-dihydro-2H-1-oxa-9-a...)
Show SMILES O=C(CCc1ccccc1)c1ccc2nc3OCCCc3cc2c1
Show InChI InChI=1S/C21H19NO2/c23-20(11-8-15-5-2-1-3-6-15)16-9-10-19-18(13-16)14-17-7-4-12-24-21(17)22-19/h1-3,5-6,9-10,13-14H,4,7-8,11-12H2
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n/an/a 85n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163620
PNG
((3-Ethyl-2-hydroxy-quinolin-6-yl)-(4-methoxy-cyclo...)
Show SMILES CCc1cc2cc(ccc2[nH]c1=O)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C19H23NO3/c1-3-12-10-15-11-14(6-9-17(15)20-19(12)22)18(21)13-4-7-16(23-2)8-5-13/h6,9-11,13,16H,3-5,7-8H2,1-2H3,(H,20,22)
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n/an/a 85n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163598
PNG
(1-(3-Ethyl-2-methyl-quinolin-6-yl)-2-(4-methoxy-cy...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C[C@H]1CC[C@H](CC1)OC
Show InChI InChI=1S/C21H27NO2/c1-4-16-12-18-13-17(7-10-20(18)22-14(16)2)21(23)11-15-5-8-19(24-3)9-6-15/h7,10,12-13,15,19H,4-6,8-9,11H2,1-3H3/t15-,19+
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n/an/a 85n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163586
PNG
((3-Ethyl-2-methoxy-quinolin-6-yl)-(4-methoxy-cyclo...)
Show SMILES CCc1cc2cc(ccc2nc1OC)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C20H25NO3/c1-4-13-11-16-12-15(7-10-18(16)21-20(13)24-3)19(22)14-5-8-17(23-2)9-6-14/h7,10-12,14,17H,4-6,8-9H2,1-3H3
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n/an/a 94n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163597
PNG
(CHEMBL367227 | [3-Ethyl-2-(2-methoxy-ethylamino)-q...)
Show SMILES CCc1cc2cc(ccc2nc1NCCOC)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C22H30N2O3/c1-4-15-13-18-14-17(21(25)16-5-8-19(27-3)9-6-16)7-10-20(18)24-22(15)23-11-12-26-2/h7,10,13-14,16,19H,4-6,8-9,11-12H2,1-3H3,(H,23,24)
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n/an/a 105n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163592
PNG
((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3OCCCc3cc2c1
Show InChI InChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3/t13-,17+
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n/an/a 106n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163626
PNG
(CHEMBL177866 | Chroman-3-yl-(3-ethyl-2-methyl-quin...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1COc2ccccc2C1
Show InChI InChI=1S/C22H21NO2/c1-3-15-10-18-12-17(8-9-20(18)23-14(15)2)22(24)19-11-16-6-4-5-7-21(16)25-13-19/h4-10,12,19H,3,11,13H2,1-2H3
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n/an/a 115n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163621
PNG
(Adamantan-1-yl-(3-ethyl-2-methyl-quinolin-6-yl)-me...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C23H27NO/c1-3-18-9-20-10-19(4-5-21(20)24-14(18)2)22(25)23-11-15-6-16(12-23)8-17(7-15)13-23/h4-5,9-10,15-17H,3,6-8,11-13H2,1-2H3
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n/an/a 126n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163616
PNG
((2-Chloro-3-ethyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Show SMILES CCc1cc2cc(ccc2nc1Cl)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C19H22ClNO2/c1-3-12-10-15-11-14(6-9-17(15)21-19(12)20)18(22)13-4-7-16(23-2)8-5-13/h6,9-11,13,16H,3-5,7-8H2,1-2H3
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n/an/a 145n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163605
PNG
(3-Cyclohexa-1,5-dienyl-1-(3,4-dihydro-2H-1-oxa-9-a...)
Show SMILES O=C(CCc1ccccc1)c1ccc2nc3OCCCc3cc2c1
Show InChI InChI=1S/C21H19NO2/c23-20(11-8-15-5-2-1-3-6-15)16-9-10-19-18(13-16)14-17-7-4-12-24-21(17)22-19/h1-3,5-6,9-10,13-14H,4,7-8,11-12H2
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n/an/a 160n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163625
PNG
(1-(3-Ethyl-2-methyl-quinolin-6-yl)-3-methyl-butan-...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)CC(C)C
Show InChI InChI=1S/C17H21NO/c1-5-13-9-15-10-14(17(19)8-11(2)3)6-7-16(15)18-12(13)4/h6-7,9-11H,5,8H2,1-4H3
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n/an/a 162n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163603
PNG
(3-Ethyl-6-(4-methoxy-cyclohexanecarbonyl)-quinolin...)
Show SMILES CCc1cc2cc(ccc2nc1C#N)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C20H22N2O2/c1-3-13-10-16-11-15(6-9-18(16)22-19(13)12-21)20(23)14-4-7-17(24-2)8-5-14/h6,9-11,14,17H,3-5,7-8H2,1-2H3
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n/an/a 174n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163618
PNG
((3-Ethyl-2-thiophen-3-yl-quinolin-6-yl)-(4-methoxy...)
Show SMILES CCc1cc2cc(ccc2nc1-c1ccsc1)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C23H25NO2S/c1-3-15-12-19-13-17(23(25)16-4-7-20(26-2)8-5-16)6-9-21(19)24-22(15)18-10-11-27-14-18/h6,9-14,16,20H,3-5,7-8H2,1-2H3
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n/an/a 191n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163585
PNG
(1-(3-Ethyl-2-methyl-quinolin-6-yl)-3-phenyl-propan...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)CCc1ccccc1
Show InChI InChI=1S/C21H21NO/c1-3-17-13-19-14-18(10-11-20(19)22-15(17)2)21(23)12-9-16-7-5-4-6-8-16/h4-8,10-11,13-14H,3,9,12H2,1-2H3
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n/an/a 230n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163594
PNG
(CHEMBL177736 | [1-(3-Ethyl-2-methoxy-quinolin-6-yl...)
Show SMILES CCc1cc2cc(ccc2nc1OC)C(N=N)[C@@H]1CC[C@@H](CC1)OC
Show InChI InChI=1S/C20H27N3O2/c1-4-13-11-16-12-15(7-10-18(16)22-20(13)25-3)19(23-21)14-5-8-17(24-2)9-6-14/h7,10-12,14,17,19,21H,4-6,8-9H2,1-3H3/t14-,17+,19?
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n/an/a 320n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163627
PNG
(1-(3-Ethyl-2-methyl-quinolin-6-yl)-2-(3-methoxy-ph...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)Cc1cccc(OC)c1
Show InChI InChI=1S/C21H21NO2/c1-4-16-12-18-13-17(8-9-20(18)22-14(16)2)21(23)11-15-6-5-7-19(10-15)24-3/h5-10,12-13H,4,11H2,1-3H3
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n/an/a 435n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163610
PNG
((4-Ethyl-1,2,3,9b-tetraaza-cyclopenta[a]naphthalen...)
Show SMILES CCc1cc2cc(ccc2n2nnnc12)C(=O)[C@@H]1CC[C@@H](CC1)OC
Show InChI InChI=1S/C19H22N4O2/c1-3-12-10-15-11-14(6-9-17(15)23-19(12)20-21-22-23)18(24)13-4-7-16(25-2)8-5-13/h6,9-11,13,16H,3-5,7-8H2,1-2H3/t13-,16+
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n/an/a 450n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163622
PNG
(2-(4-Dimethylamino-phenyl)-1-(3-ethyl-2-methyl-qui...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)Cc1ccc(cc1)N(C)C
Show InChI InChI=1S/C22H24N2O/c1-5-17-13-19-14-18(8-11-21(19)23-15(17)2)22(25)12-16-6-9-20(10-7-16)24(3)4/h6-11,13-14H,5,12H2,1-4H3
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n/an/a 645n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163587
PNG
((3-Ethyl-2-methyl-quinolin-6-yl)-indan-2-yl-methan...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1Cc2ccccc2C1
Show InChI InChI=1S/C22H21NO/c1-3-15-10-19-13-18(8-9-21(19)23-14(15)2)22(24)20-11-16-6-4-5-7-17(16)12-20/h4-10,13,20H,3,11-12H2,1-2H3
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n/an/a 1.18E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163586
PNG
((3-Ethyl-2-methoxy-quinolin-6-yl)-(4-methoxy-cyclo...)
Show SMILES CCc1cc2cc(ccc2nc1OC)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C20H25NO3/c1-4-13-11-16-12-15(7-10-18(16)21-20(13)24-3)19(22)14-5-8-17(23-2)9-6-14/h7,10-12,14,17H,4-6,8-9H2,1-3H3
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n/an/a 2.37E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163628
PNG
(3-Ethyl-2-methoxy-6-[1-(4-methoxy-cyclohexyl)-viny...)
Show SMILES CCc1cc2cc(ccc2nc1OC)C(=C)[C@@H]1CC[C@@H](CC1)OC
Show InChI InChI=1S/C21H27NO2/c1-5-15-12-18-13-17(8-11-20(18)22-21(15)24-4)14(2)16-6-9-19(23-3)10-7-16/h8,11-13,16,19H,2,5-7,9-10H2,1,3-4H3/t16-,19+
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n/an/a 2.63E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163593
PNG
((3-Ethyl-2-thiophen-2-yl-quinolin-6-yl)-(4-methoxy...)
Show SMILES CCc1cc2cc(ccc2nc1-c1cccs1)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C23H25NO2S/c1-3-15-13-18-14-17(23(25)16-6-9-19(26-2)10-7-16)8-11-20(18)24-22(15)21-5-4-12-27-21/h4-5,8,11-14,16,19H,3,6-7,9-10H2,1-2H3
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n/an/a 3.31E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163594
PNG
(CHEMBL177736 | [1-(3-Ethyl-2-methoxy-quinolin-6-yl...)
Show SMILES CCc1cc2cc(ccc2nc1OC)C(N=N)[C@@H]1CC[C@@H](CC1)OC
Show InChI InChI=1S/C20H27N3O2/c1-4-13-11-16-12-15(7-10-18(16)22-20(13)25-3)19(23-21)14-5-8-17(24-2)9-6-14/h7,10-12,14,17,19,21H,4-6,8-9H2,1-3H3/t14-,17+,19?
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n/an/a 4.36E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163608
PNG
((3-Ethyl-2-methoxy-quinolin-6-yl)-(4-methoxy-cyclo...)
Show SMILES Cc1cc2cc(ccc2[nH]c1=O)C(C)(C#N)c1ccccc1
Show InChI InChI=1S/C19H16N2O/c1-13-10-14-11-16(8-9-17(14)21-18(13)22)19(2,12-20)15-6-4-3-5-7-15/h3-11H,1-2H3,(H,21,22)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor 1 transmembrane domain


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163595
PNG
(1-[3-Ethyl-6-(4-methoxy-cyclohexanecarbonyl)-quino...)
Show SMILES CCc1cc2cc(ccc2nc1C(=O)OC(C)C)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C23H29NO4/c1-5-15-12-18-13-17(22(25)16-6-9-19(27-4)10-7-16)8-11-20(18)24-21(15)23(26)28-14(2)3/h8,11-14,16,19H,5-7,9-10H2,1-4H3
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n/an/a 6.31E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163612
PNG
(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-7-yl)-2-ph...)
Show SMILES O=C(Cc1ccccc1)c1ccc2cc3CCCOc3nc2c1
Show InChI InChI=1S/C20H17NO2/c22-19(11-14-5-2-1-3-6-14)16-9-8-15-12-17-7-4-10-23-20(17)21-18(15)13-16/h1-3,5-6,8-9,12-13H,4,7,10-11H2
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n/an/a 8.30E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163599
PNG
(Bicyclo[2.2.1]hept-2-yl-(3-ethyl-2-methyl-quinolin...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1CC2CCC1C2
Show InChI InChI=1S/C20H23NO/c1-3-14-10-17-11-16(6-7-19(17)21-12(14)2)20(22)18-9-13-4-5-15(18)8-13/h6-7,10-11,13,15,18H,3-5,8-9H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163591
PNG
(2-(3,4-Dimethoxy-phenyl)-1-(3-ethyl-2-methyl-quino...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)Cc1ccc(OC)c(OC)c1
Show InChI InChI=1S/C22H23NO3/c1-5-16-12-18-13-17(7-8-19(18)23-14(16)2)20(24)10-15-6-9-21(25-3)22(11-15)26-4/h6-9,11-13H,5,10H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163602
PNG
((3-Ethyl-2-methoxy-quinolin-6-yl)-(4-methoxy-cyclo...)
Show SMILES CCc1cc2cc(ccc2nc1OC)C(N=O)[C@@H]1CC[C@@H](CC1)OC
Show InChI InChI=1S/C20H26N2O3/c1-4-13-11-16-12-15(7-10-18(16)21-20(13)25-3)19(22-23)14-5-8-17(24-2)9-6-14/h7,10-12,14,17,19H,4-6,8-9H2,1-3H3/t14-,17+,19?
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50163585
PNG
(1-(3-Ethyl-2-methyl-quinolin-6-yl)-3-phenyl-propan...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)CCc1ccccc1
Show InChI InChI=1S/C21H21NO/c1-3-17-13-19-14-18(10-11-20(19)22-15(17)2)21(23)12-9-16-7-5-4-6-8-16/h4-8,10-11,13-14H,3,9,12H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against human metabotropic glutamate receptor


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163619
PNG
(CHEMBL558629 | [3-Ethyl-2-(3H-1lambda*4*-thiazol-2...)
Show SMILES CCc1cc2cc(ccc2nc1-c1[nH+]ccs1)C(=O)C1CCC(CC1)OC
Show InChI InChI=1S/C22H24N2O2S/c1-3-14-12-17-13-16(21(25)15-4-7-18(26-2)8-5-15)6-9-19(17)24-20(14)22-23-10-11-27-22/h6,9-13,15,18H,3-5,7-8H2,1-2H3/p+1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163624
PNG
(4-(3-Ethyl-2-methyl-quinoline-6-carbonyl)-piperidi...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C23H30N2O3/c1-6-16-13-19-14-18(7-8-20(19)24-15(16)2)21(26)17-9-11-25(12-10-17)22(27)28-23(3,4)5/h7-8,13-14,17H,6,9-12H2,1-5H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50163588
PNG
((3-Ethyl-2-methyl-quinolin-6-yl)-piperidin-4-yl-me...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1CCNCC1
Show InChI InChI=1S/C18H22N2O/c1-3-13-10-16-11-15(4-5-17(16)20-12(13)2)18(21)14-6-8-19-9-7-14/h4-5,10-11,14,19H,3,6-9H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


J Med Chem 48: 2134-53 (2005)


Article DOI: 10.1021/jm049499o
BindingDB Entry DOI: 10.7270/Q2RR2017
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%