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PubMed code 15837304

Compile data set for download or QSAR
Found 132 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11974
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CN(CCc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-13-28(9-8-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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n/an/a 1.40n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11973
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(trifl...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)-c1ccc(cc1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H20F5N3OS/c24-16-5-6-18(25)14(9-16)10-17(29)11-21(32)31-8-7-20-19(12-31)30-22(33-20)13-1-3-15(4-2-13)23(26,27)28/h1-6,9,17H,7-8,10-12,29H2/t17-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11972
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H20F3N3OS/c23-15-3-1-13(2-4-15)22-27-19-12-28(8-7-20(19)30-22)21(29)11-17(26)10-14-9-16(24)5-6-18(14)25/h1-6,9,17H,7-8,10-12,26H2/t17-/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11958
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)[nH]nc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(27)26-4-3-12-14(8-26)24-25-16(12)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2,(H,24,25)/t11-/m1/s1
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n/an/a 39n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11971
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3OS/c18-10-1-2-12(19)9(5-10)6-11(23)7-15(26)25-4-3-14-13(8-25)24-16(27-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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n/an/a 57n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11959
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1S/C18H19F5N4O/c1-26-15-9-27(5-4-13(15)17(25-26)18(21,22)23)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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n/an/a 72n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11962
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)noc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3O2/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(26)25-4-3-12-14(8-25)24-27-16(12)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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n/an/a 85n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11944
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2n[nH]c(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(27)26-4-3-14-12(8-26)16(25-24-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2,(H,24,25)/t11-/m1/s1
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n/an/a 110n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11961
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CN(CCc2c1C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H19F5N4O/c1-26-17(18(21,22)23)13-4-5-27(9-15(13)25-26)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11957
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2noc(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3O2/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(26)25-4-3-14-12(8-25)16(27-24-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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n/an/a 130n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11969
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11945
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1S/C18H19F5N4O/c1-26-15-4-5-27(9-13(15)17(25-26)18(21,22)23)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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n/an/a 130n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11948
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCc2nn(CC(F)(F)F)c(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H18F8N4O/c20-11-1-2-14(21)10(5-11)6-12(28)7-16(32)30-4-3-15-13(8-30)17(19(25,26)27)31(29-15)9-18(22,23)24/h1-2,5,12H,3-4,6-9,28H2/t12-/m1/s1
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n/an/a 150n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11956
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES Cn1nc2CCN(Cc2c1-c1ccc(F)cc1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F3N4O/c1-29-23(14-2-4-16(24)5-3-14)19-13-30(9-8-21(19)28-29)22(31)12-18(27)11-15-10-17(25)6-7-20(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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n/an/a 150n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11946
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CCN(Cc2c1C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H19F5N4O/c1-26-17(18(21,22)23)13-9-27(5-4-15(13)25-26)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11951
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,...)
Show SMILES N[C@@H](CC(=O)N1CCc2n[nH]c(c2C1)C(F)(F)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H17F7N4O/c19-10-1-2-13(20)9(5-10)6-11(26)7-15(30)29-4-3-14-12(8-29)16(28-27-14)17(21,22)18(23,24)25/h1-2,5,11H,3-4,6-8,26H2,(H,27,28)/t11-/m1/s1
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n/an/a 160n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11960
PNG
((3R)-3-amino-1-{3-cyclopropyl-1H,4H,5H,6H,7H-pyraz...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)n[nH]c2C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H22F2N4O/c20-13-3-4-16(21)12(7-13)8-14(22)9-18(26)25-6-5-15-17(10-25)23-24-19(15)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2,(H,23,24)/t14-/m1/s1
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n/an/a 160n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11950
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES Cc1c2CN(CCc2nn1-c1ccc(F)cc1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)28-30(14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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n/an/a 160n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11947
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)c(nn2CC(F)(F)F)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H18F8N4O/c20-11-1-2-14(21)10(5-11)6-12(28)7-16(32)30-4-3-15-13(8-30)17(19(25,26)27)29-31(15)9-18(22,23)24/h1-2,5,12H,3-4,6-9,28H2/t12-/m1/s1
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n/an/a 180n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11975
PNG
((3R)-3-amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[3...)
Show SMILES N[C@@H](CC(=O)N1CCc2oc(nc2C1)C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H21F2N3O2/c20-13-3-4-15(21)12(7-13)8-14(22)9-18(25)24-6-5-17-16(10-24)23-19(26-17)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2/t14-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11952
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C19H19F7N4O/c1-29-15-4-5-30(9-13(15)17(28-29)18(22,23)19(24,25)26)16(31)8-12(27)7-10-6-11(20)2-3-14(10)21/h2-3,6,12H,4-5,7-9,27H2,1H3/t12-/m1/s1
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n/an/a 220n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11943
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{3-methyl-1H...)
Show SMILES Cc1[nH]nc2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H20F2N4O/c1-10-14-9-23(5-4-16(14)22-21-10)17(24)8-13(20)7-11-6-12(18)2-3-15(11)19/h2-3,6,13H,4-5,7-9,20H2,1H3,(H,21,22)/t13-/m1/s1
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n/an/a 250n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11967
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(trifl...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(cc1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H20F5N3OS/c24-16-5-6-18(25)14(9-16)10-17(29)11-21(32)31-8-7-19-20(12-31)33-22(30-19)13-1-3-15(4-2-13)23(26,27)28/h1-6,9,17H,7-8,10-12,29H2/t17-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11954
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2[nH]nc(c2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H21F3N4O/c23-15-3-1-13(2-4-15)22-18-12-29(8-7-20(18)27-28-22)21(30)11-17(26)10-14-9-16(24)5-6-19(14)25/h1-6,9,17H,7-8,10-12,26H2,(H,27,28)/t17-/m1/s1
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n/an/a 270n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11970
PNG
((3R)-3-amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[4...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(oc2C1)C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H21F2N3O2/c20-13-3-4-15(21)12(7-13)8-14(22)9-18(25)24-6-5-16-17(10-24)26-19(23-16)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2/t14-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11953
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CCN(Cc2c1C(F)(F)C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H19F7N4O/c1-29-17(18(22,23)19(24,25)26)13-9-30(5-4-15(13)28-29)16(31)8-12(27)7-10-6-11(20)2-3-14(10)21/h2-3,6,12H,4-5,7-9,27H2,1H3/t12-/m1/s1
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n/an/a 300n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11965
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3OS/c18-10-1-2-12(19)9(5-10)6-11(23)7-15(26)25-4-3-13-14(8-25)27-16(24-13)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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n/an/a 310n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11949
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluoro...)
Show SMILES Cc1nn(c2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)30(28-14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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n/an/a 350n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11966
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H20F3N3OS/c23-15-3-1-13(2-4-15)22-27-19-7-8-28(12-20(19)30-22)21(29)11-17(26)10-14-9-16(24)5-6-18(14)25/h1-6,9,17H,7-8,10-12,26H2/t17-/m1/s1
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n/an/a 360n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11968
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(methy...)
Show SMILES CSc1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3OS2/c1-30-18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)31-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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n/an/a 380n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11964
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-methyl-4H...)
Show SMILES Cc1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H19F2N3OS/c1-10-21-15-4-5-22(9-16(15)24-10)17(23)8-13(20)7-11-6-12(18)2-3-14(11)19/h2-3,6,13H,4-5,7-9,20H2,1H3/t13-/m1/s1
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n/an/a 480n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11963
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCCc2n[nH]c(c12)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-3-4-12(19)9(6-10)7-11(23)8-14(27)26-5-1-2-13-15(26)16(25-24-13)17(20,21)22/h3-4,6,11H,1-2,5,7-8,23H2,(H,24,25)/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11955
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23F3N4O/c1-29-21-8-9-30(13-19(21)23(28-29)14-2-4-16(24)5-3-14)22(31)12-18(27)11-15-10-17(25)6-7-20(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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n/an/a 780n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11968
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(methy...)
Show SMILES CSc1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3OS2/c1-30-18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)31-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11967
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(trifl...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(cc1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H20F5N3OS/c24-16-5-6-18(25)14(9-16)10-17(29)11-21(32)31-8-7-19-20(12-31)33-22(30-19)13-1-3-15(4-2-13)23(26,27)28/h1-6,9,17H,7-8,10-12,29H2/t17-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11969
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11968
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(methy...)
Show SMILES CSc1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3OS2/c1-30-18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)31-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11956
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES Cn1nc2CCN(Cc2c1-c1ccc(F)cc1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F3N4O/c1-29-23(14-2-4-16(24)5-3-14)19-13-30(9-8-21(19)28-29)22(31)12-18(27)11-15-10-17(25)6-7-20(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11966
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H20F3N3OS/c23-15-3-1-13(2-4-15)22-27-19-7-8-28(12-20(19)30-22)21(29)11-17(26)10-14-9-16(24)5-6-18(14)25/h1-6,9,17H,7-8,10-12,26H2/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11968
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(methy...)
Show SMILES CSc1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3OS2/c1-30-18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)31-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11950
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES Cc1c2CN(CCc2nn1-c1ccc(F)cc1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)28-30(14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11962
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)noc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3O2/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(26)25-4-3-12-14(8-25)24-27-16(12)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11969
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11964
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-methyl-4H...)
Show SMILES Cc1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H19F2N3OS/c1-10-21-15-4-5-22(9-16(15)24-10)17(23)8-13(20)7-11-6-12(18)2-3-14(11)19/h2-3,6,13H,4-5,7-9,20H2,1H3/t13-/m1/s1
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n/an/a 7.10E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11966
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H20F3N3OS/c23-15-3-1-13(2-4-15)22-27-19-7-8-28(12-20(19)30-22)21(29)11-17(26)10-14-9-16(24)5-6-18(14)25/h1-6,9,17H,7-8,10-12,26H2/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11973
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(trifl...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)-c1ccc(cc1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H20F5N3OS/c24-16-5-6-18(25)14(9-16)10-17(29)11-21(32)31-8-7-20-19(12-31)30-22(33-20)13-1-3-15(4-2-13)23(26,27)28/h1-6,9,17H,7-8,10-12,29H2/t17-/m1/s1
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n/an/a 7.90E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11974
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CN(CCc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-13-28(9-8-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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n/an/a 8.60E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11950
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES Cc1c2CN(CCc2nn1-c1ccc(F)cc1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)28-30(14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11967
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(trifl...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(cc1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H20F5N3OS/c24-16-5-6-18(25)14(9-16)10-17(29)11-21(32)31-8-7-19-20(12-31)33-22(30-19)13-1-3-15(4-2-13)23(26,27)28/h1-6,9,17H,7-8,10-12,29H2/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11958
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)[nH]nc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(27)26-4-3-12-14(8-26)24-25-16(12)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2,(H,24,25)/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11967
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(trifl...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(cc1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H20F5N3OS/c24-16-5-6-18(25)14(9-16)10-17(29)11-21(32)31-8-7-19-20(12-31)33-22(30-19)13-1-3-15(4-2-13)23(26,27)28/h1-6,9,17H,7-8,10-12,29H2/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11972
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H20F3N3OS/c23-15-3-1-13(2-4-15)22-27-19-12-28(8-7-20(19)30-22)21(29)11-17(26)10-14-9-16(24)5-6-18(14)25/h1-6,9,17H,7-8,10-12,26H2/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11960
PNG
((3R)-3-amino-1-{3-cyclopropyl-1H,4H,5H,6H,7H-pyraz...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)n[nH]c2C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H22F2N4O/c20-13-3-4-16(21)12(7-13)8-14(22)9-18(26)25-6-5-15-17(10-25)23-24-19(15)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2,(H,23,24)/t14-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11958
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)[nH]nc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(27)26-4-3-12-14(8-26)24-25-16(12)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2,(H,24,25)/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11966
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H20F3N3OS/c23-15-3-1-13(2-4-15)22-27-19-7-8-28(12-20(19)30-22)21(29)11-17(26)10-14-9-16(24)5-6-18(14)25/h1-6,9,17H,7-8,10-12,26H2/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11973
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(trifl...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)-c1ccc(cc1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H20F5N3OS/c24-16-5-6-18(25)14(9-16)10-17(29)11-21(32)31-8-7-20-19(12-31)30-22(33-20)13-1-3-15(4-2-13)23(26,27)28/h1-6,9,17H,7-8,10-12,29H2/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11947
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)c(nn2CC(F)(F)F)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H18F8N4O/c20-11-1-2-14(21)10(5-11)6-12(28)7-16(32)30-4-3-15-13(8-30)17(19(25,26)27)29-31(15)9-18(22,23)24/h1-2,5,12H,3-4,6-9,28H2/t12-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11972
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H20F3N3OS/c23-15-3-1-13(2-4-15)22-27-19-12-28(8-7-20(19)30-22)21(29)11-17(26)10-14-9-16(24)5-6-18(14)25/h1-6,9,17H,7-8,10-12,26H2/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11949
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluoro...)
Show SMILES Cc1nn(c2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)30(28-14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11949
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluoro...)
Show SMILES Cc1nn(c2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)30(28-14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11948
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCc2nn(CC(F)(F)F)c(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H18F8N4O/c20-11-1-2-14(21)10(5-11)6-12(28)7-16(32)30-4-3-15-13(8-30)17(19(25,26)27)31(29-15)9-18(22,23)24/h1-2,5,12H,3-4,6-9,28H2/t12-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11964
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-methyl-4H...)
Show SMILES Cc1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H19F2N3OS/c1-10-21-15-4-5-22(9-16(15)24-10)17(23)8-13(20)7-11-6-12(18)2-3-14(11)19/h2-3,6,13H,4-5,7-9,20H2,1H3/t13-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11944
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2n[nH]c(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(27)26-4-3-14-12(8-26)16(25-24-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2,(H,24,25)/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11954
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2[nH]nc(c2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H21F3N4O/c23-15-3-1-13(2-4-15)22-18-12-29(8-7-20(18)27-28-22)21(30)11-17(26)10-14-9-16(24)5-6-19(14)25/h1-6,9,17H,7-8,10-12,26H2,(H,27,28)/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11943
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{3-methyl-1H...)
Show SMILES Cc1[nH]nc2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H20F2N4O/c1-10-14-9-23(5-4-16(14)22-21-10)17(24)8-13(20)7-11-6-12(18)2-3-15(11)19/h2-3,6,13H,4-5,7-9,20H2,1H3,(H,21,22)/t13-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11949
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluoro...)
Show SMILES Cc1nn(c2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)30(28-14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11974
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CN(CCc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-13-28(9-8-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11959
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1S/C18H19F5N4O/c1-26-15-9-27(5-4-13(15)17(25-26)18(21,22)23)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11955
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23F3N4O/c1-29-21-8-9-30(13-19(21)23(28-29)14-2-4-16(24)5-3-14)22(31)12-18(27)11-15-10-17(25)6-7-20(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11950
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES Cc1c2CN(CCc2nn1-c1ccc(F)cc1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)28-30(14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11970
PNG
((3R)-3-amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[4...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(oc2C1)C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H21F2N3O2/c20-13-3-4-15(21)12(7-13)8-14(22)9-18(25)24-6-5-16-17(10-24)26-19(23-16)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2/t14-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11973
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(trifl...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)-c1ccc(cc1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H20F5N3OS/c24-16-5-6-18(25)14(9-16)10-17(29)11-21(32)31-8-7-20-19(12-31)30-22(33-20)13-1-3-15(4-2-13)23(26,27)28/h1-6,9,17H,7-8,10-12,29H2/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11965
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3OS/c18-10-1-2-12(19)9(5-10)6-11(23)7-15(26)25-4-3-13-14(8-25)27-16(24-13)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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n/an/a 2.90E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11970
PNG
((3R)-3-amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[4...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(oc2C1)C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H21F2N3O2/c20-13-3-4-15(21)12(7-13)8-14(22)9-18(25)24-6-5-16-17(10-24)26-19(23-16)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2/t14-/m1/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11958
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)[nH]nc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(27)26-4-3-12-14(8-26)24-25-16(12)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2,(H,24,25)/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11963
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCCc2n[nH]c(c12)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-3-4-12(19)9(6-10)7-11(23)8-14(27)26-5-1-2-13-15(26)16(25-24-13)17(20,21)22/h3-4,6,11H,1-2,5,7-8,23H2,(H,24,25)/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11959
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1S/C18H19F5N4O/c1-26-15-9-27(5-4-13(15)17(25-26)18(21,22)23)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11960
PNG
((3R)-3-amino-1-{3-cyclopropyl-1H,4H,5H,6H,7H-pyraz...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)n[nH]c2C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H22F2N4O/c20-13-3-4-16(21)12(7-13)8-14(22)9-18(26)25-6-5-15-17(10-25)23-24-19(15)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2,(H,23,24)/t14-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11969
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11962
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)noc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3O2/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(26)25-4-3-12-14(8-25)24-27-16(12)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11945
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1S/C18H19F5N4O/c1-26-15-4-5-27(9-13(15)17(25-26)18(21,22)23)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11952
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C19H19F7N4O/c1-29-15-4-5-30(9-13(15)17(28-29)18(22,23)19(24,25)26)16(31)8-12(27)7-10-6-11(20)2-3-14(10)21/h2-3,6,12H,4-5,7-9,27H2,1H3/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11965
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3OS/c18-10-1-2-12(19)9(5-10)6-11(23)7-15(26)25-4-3-13-14(8-25)27-16(24-13)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11954
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2[nH]nc(c2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H21F3N4O/c23-15-3-1-13(2-4-15)22-18-12-29(8-7-20(18)27-28-22)21(30)11-17(26)10-14-9-16(24)5-6-19(14)25/h1-6,9,17H,7-8,10-12,26H2,(H,27,28)/t17-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11960
PNG
((3R)-3-amino-1-{3-cyclopropyl-1H,4H,5H,6H,7H-pyraz...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)n[nH]c2C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H22F2N4O/c20-13-3-4-16(21)12(7-13)8-14(22)9-18(26)25-6-5-15-17(10-25)23-24-19(15)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2,(H,23,24)/t14-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11972
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H20F3N3OS/c23-15-3-1-13(2-4-15)22-27-19-12-28(8-7-20(19)30-22)21(29)11-17(26)10-14-9-16(24)5-6-18(14)25/h1-6,9,17H,7-8,10-12,26H2/t17-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11954
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2[nH]nc(c2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H21F3N4O/c23-15-3-1-13(2-4-15)22-18-12-29(8-7-20(18)27-28-22)21(30)11-17(26)10-14-9-16(24)5-6-19(14)25/h1-6,9,17H,7-8,10-12,26H2,(H,27,28)/t17-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11974
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CN(CCc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-13-28(9-8-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11946
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CCN(Cc2c1C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H19F5N4O/c1-26-17(18(21,22)23)13-9-27(5-4-15(13)25-26)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11975
PNG
((3R)-3-amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[3...)
Show SMILES N[C@@H](CC(=O)N1CCc2oc(nc2C1)C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H21F2N3O2/c20-13-3-4-15(21)12(7-13)8-14(22)9-18(25)24-6-5-17-16(10-24)23-19(26-17)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2/t14-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11957
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2noc(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3O2/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(26)25-4-3-14-12(8-25)16(27-24-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11952
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C19H19F7N4O/c1-29-15-4-5-30(9-13(15)17(28-29)18(22,23)19(24,25)26)16(31)8-12(27)7-10-6-11(20)2-3-14(10)21/h2-3,6,12H,4-5,7-9,27H2,1H3/t12-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11970
PNG
((3R)-3-amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[4...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(oc2C1)C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H21F2N3O2/c20-13-3-4-15(21)12(7-13)8-14(22)9-18(25)24-6-5-16-17(10-24)26-19(23-16)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2/t14-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11956
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES Cn1nc2CCN(Cc2c1-c1ccc(F)cc1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F3N4O/c1-29-23(14-2-4-16(24)5-3-14)19-13-30(9-8-21(19)28-29)22(31)12-18(27)11-15-10-17(25)6-7-20(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11955
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23F3N4O/c1-29-21-8-9-30(13-19(21)23(28-29)14-2-4-16(24)5-3-14)22(31)12-18(27)11-15-10-17(25)6-7-20(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11965
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3OS/c18-10-1-2-12(19)9(5-10)6-11(23)7-15(26)25-4-3-13-14(8-25)27-16(24-13)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11971
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3OS/c18-10-1-2-12(19)9(5-10)6-11(23)7-15(26)25-4-3-14-13(8-25)24-16(27-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11943
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{3-methyl-1H...)
Show SMILES Cc1[nH]nc2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H20F2N4O/c1-10-14-9-23(5-4-16(14)22-21-10)17(24)8-13(20)7-11-6-12(18)2-3-15(11)19/h2-3,6,13H,4-5,7-9,20H2,1H3,(H,21,22)/t13-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11961
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CN(CCc2c1C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H19F5N4O/c1-26-17(18(21,22)23)13-4-5-27(9-15(13)25-26)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11944
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2n[nH]c(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(27)26-4-3-14-12(8-26)16(25-24-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2,(H,24,25)/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11951
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,...)
Show SMILES N[C@@H](CC(=O)N1CCc2n[nH]c(c2C1)C(F)(F)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H17F7N4O/c19-10-1-2-13(20)9(5-10)6-11(26)7-15(30)29-4-3-14-12(8-29)16(28-27-14)17(21,22)18(23,24)25/h1-2,5,11H,3-4,6-8,26H2,(H,27,28)/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11959
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1S/C18H19F5N4O/c1-26-15-9-27(5-4-13(15)17(25-26)18(21,22)23)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11945
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1S/C18H19F5N4O/c1-26-15-4-5-27(9-13(15)17(25-26)18(21,22)23)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11947
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)c(nn2CC(F)(F)F)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H18F8N4O/c20-11-1-2-14(21)10(5-11)6-12(28)7-16(32)30-4-3-15-13(8-30)17(19(25,26)27)29-31(15)9-18(22,23)24/h1-2,5,12H,3-4,6-9,28H2/t12-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11943
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{3-methyl-1H...)
Show SMILES Cc1[nH]nc2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H20F2N4O/c1-10-14-9-23(5-4-16(14)22-21-10)17(24)8-13(20)7-11-6-12(18)2-3-15(11)19/h2-3,6,13H,4-5,7-9,20H2,1H3,(H,21,22)/t13-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11944
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2n[nH]c(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(27)26-4-3-14-12(8-26)16(25-24-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2,(H,24,25)/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11951
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,...)
Show SMILES N[C@@H](CC(=O)N1CCc2n[nH]c(c2C1)C(F)(F)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H17F7N4O/c19-10-1-2-13(20)9(5-10)6-11(26)7-15(30)29-4-3-14-12(8-29)16(28-27-14)17(21,22)18(23,24)25/h1-2,5,11H,3-4,6-8,26H2,(H,27,28)/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11964
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-methyl-4H...)
Show SMILES Cc1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H19F2N3OS/c1-10-21-15-4-5-22(9-16(15)24-10)17(23)8-13(20)7-11-6-12(18)2-3-14(11)19/h2-3,6,13H,4-5,7-9,20H2,1H3/t13-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11961
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CN(CCc2c1C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H19F5N4O/c1-26-17(18(21,22)23)13-4-5-27(9-15(13)25-26)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11953
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CCN(Cc2c1C(F)(F)C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H19F7N4O/c1-29-17(18(22,23)19(24,25)26)13-9-30(5-4-15(13)28-29)16(31)8-12(27)7-10-6-11(20)2-3-14(10)21/h2-3,6,12H,4-5,7-9,27H2,1H3/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11971
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3OS/c18-10-1-2-12(19)9(5-10)6-11(23)7-15(26)25-4-3-14-13(8-25)24-16(27-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11971
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3OS/c18-10-1-2-12(19)9(5-10)6-11(23)7-15(26)25-4-3-14-13(8-25)24-16(27-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11975
PNG
((3R)-3-amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[3...)
Show SMILES N[C@@H](CC(=O)N1CCc2oc(nc2C1)C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H21F2N3O2/c20-13-3-4-15(21)12(7-13)8-14(22)9-18(25)24-6-5-17-16(10-24)23-19(26-17)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2/t14-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11953
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CCN(Cc2c1C(F)(F)C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H19F7N4O/c1-29-17(18(22,23)19(24,25)26)13-9-30(5-4-15(13)28-29)16(31)8-12(27)7-10-6-11(20)2-3-14(10)21/h2-3,6,12H,4-5,7-9,27H2,1H3/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11945
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1S/C18H19F5N4O/c1-26-15-4-5-27(9-13(15)17(25-26)18(21,22)23)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11955
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23F3N4O/c1-29-21-8-9-30(13-19(21)23(28-29)14-2-4-16(24)5-3-14)22(31)12-18(27)11-15-10-17(25)6-7-20(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11962
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)noc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3O2/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(26)25-4-3-12-14(8-25)24-27-16(12)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11946
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CCN(Cc2c1C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H19F5N4O/c1-26-17(18(21,22)23)13-9-27(5-4-15(13)25-26)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11948
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCc2nn(CC(F)(F)F)c(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H18F8N4O/c20-11-1-2-14(21)10(5-11)6-12(28)7-16(32)30-4-3-15-13(8-30)17(19(25,26)27)31(29-15)9-18(22,23)24/h1-2,5,12H,3-4,6-9,28H2/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11957
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2noc(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3O2/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(26)25-4-3-14-12(8-25)16(27-24-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11948
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCc2nn(CC(F)(F)F)c(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H18F8N4O/c20-11-1-2-14(21)10(5-11)6-12(28)7-16(32)30-4-3-15-13(8-30)17(19(25,26)27)31(29-15)9-18(22,23)24/h1-2,5,12H,3-4,6-9,28H2/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11951
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,...)
Show SMILES N[C@@H](CC(=O)N1CCc2n[nH]c(c2C1)C(F)(F)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H17F7N4O/c19-10-1-2-13(20)9(5-10)6-11(26)7-15(30)29-4-3-14-12(8-29)16(28-27-14)17(21,22)18(23,24)25/h1-2,5,11H,3-4,6-8,26H2,(H,27,28)/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11956
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES Cn1nc2CCN(Cc2c1-c1ccc(F)cc1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F3N4O/c1-29-23(14-2-4-16(24)5-3-14)19-13-30(9-8-21(19)28-29)22(31)12-18(27)11-15-10-17(25)6-7-20(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11961
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CN(CCc2c1C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H19F5N4O/c1-26-17(18(21,22)23)13-4-5-27(9-15(13)25-26)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11947
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)c(nn2CC(F)(F)F)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H18F8N4O/c20-11-1-2-14(21)10(5-11)6-12(28)7-16(32)30-4-3-15-13(8-30)17(19(25,26)27)29-31(15)9-18(22,23)24/h1-2,5,12H,3-4,6-9,28H2/t12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11952
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CN(CCc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C19H19F7N4O/c1-29-15-4-5-30(9-13(15)17(28-29)18(22,23)19(24,25)26)16(31)8-12(27)7-10-6-11(20)2-3-14(10)21/h2-3,6,12H,4-5,7-9,27H2,1H3/t12-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11953
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CCN(Cc2c1C(F)(F)C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H19F7N4O/c1-29-17(18(22,23)19(24,25)26)13-9-30(5-4-15(13)28-29)16(31)8-12(27)7-10-6-11(20)2-3-14(10)21/h2-3,6,12H,4-5,7-9,27H2,1H3/t12-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11963
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCCc2n[nH]c(c12)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-3-4-12(19)9(6-10)7-11(23)8-14(27)26-5-1-2-13-15(26)16(25-24-13)17(20,21)22/h3-4,6,11H,1-2,5,7-8,23H2,(H,24,25)/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11957
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2noc(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3O2/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(26)25-4-3-14-12(8-25)16(27-24-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11975
PNG
((3R)-3-amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[3...)
Show SMILES N[C@@H](CC(=O)N1CCc2oc(nc2C1)C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H21F2N3O2/c20-13-3-4-15(21)12(7-13)8-14(22)9-18(25)24-6-5-17-16(10-24)23-19(26-17)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2/t14-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11946
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Show SMILES Cn1nc2CCN(Cc2c1C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H19F5N4O/c1-26-17(18(21,22)23)13-9-27(5-4-15(13)25-26)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
PDB

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UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11963
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCCc2n[nH]c(c12)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-3-4-12(19)9(6-10)7-11(23)8-14(27)26-5-1-2-13-15(26)16(25-24-13)17(20,21)22/h3-4,6,11H,1-2,5,7-8,23H2,(H,24,25)/t11-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%