Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM894![]() (2-{4-[(2R)-2-[(2S,3S)-3-{[(tert-butoxy)carbonyl]am...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM891![]() (L-685,434 deriv. 39 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM892![]() (L-685,434 deriv. 40 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM895![]() (L-685,434 deriv. 44 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM880![]() (L-685,434 deriv. 24 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM1046![]() (CHEMBL298316 | L-685,927 | tert-butyl N-[(2S,3S,5R...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM877![]() (L-685,434 deriv. 19 | N-(2(R)-Hydroxy-1(S)-indany1...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM888![]() (L-685,434 deriv. 36 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM896![]() (L-685,434 deriv. 45 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM893![]() (4-(2-{4-[(2R)-2-[(2S,3S)-3-{[(tert-butoxy)carbonyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM879![]() (L-685,434 deriv. 23 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM1030![]() (CHEMBL296115 | L-685,434 | Urethane deriv. 1 | ter...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM881![]() (L-685,434 derivative | L-689,502 | N-(2(R)-Hydroxy...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM890![]() (L-685,434 deriv. 38 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM882![]() (L-685,434 deriv. 30 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM889![]() (L-685,434 deriv. 37 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM886![]() (L-685,434 deriv. 34 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM887![]() (L-685,434 deriv. 35 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM883![]() (L-685,434 deriv. 31 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM884![]() (L-685,434 deriv. 32 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM885![]() (L-685,434 deriv. 33 | N-(2(R)-Hydroxy-1(S)-indanyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | 5.5 | 30 |
Merck Research Laboratories | Assay Description Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o... | J Med Chem 35: 1685-701 (1992) Article DOI: 10.1021/jm00088a003 BindingDB Entry DOI: 10.7270/Q2JH3JCF | |||||||||||
More data for this Ligand-Target Pair |