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PubMed code 16162008

Compile data set for download or QSAR
Found 146 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aromatase (CYP19)


(Homo sapiens (human))
BDBM8826
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1
Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8870
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)
Show SMILES Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Show InChI InChI=1S/C19H14ClN5OS/c20-12-2-1-3-14(8-12)25-19(26)24-13-6-4-11(5-7-13)15-9-27-18-16(15)17(21)22-10-23-18/h1-10H,(H2,21,22,23)(H2,24,25,26)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8826
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1
Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8826
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1
Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8813
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C21H19N5OS/c1-12-4-3-5-16(10-12)26-21(27)25-15-8-6-14(7-9-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8813
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C21H19N5OS/c1-12-4-3-5-16(10-12)26-21(27)25-15-8-6-14(7-9-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM8862
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-3-fluoro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)c(F)c2)c1
Show InChI InChI=1S/C20H16FN5OS/c1-11-3-2-4-12(7-11)25-20(27)26-13-5-6-14(16(21)8-13)15-9-28-19-17(15)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8862
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-3-fluoro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)c(F)c2)c1
Show InChI InChI=1S/C20H16FN5OS/c1-11-3-2-4-12(7-11)25-20(27)26-13-5-6-14(16(21)8-13)15-9-28-19-17(15)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8844
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(C)cc(C)c2)cc1
Show InChI InChI=1S/C22H21N5OS/c1-12-8-13(2)10-17(9-12)27-22(28)26-16-6-4-15(5-7-16)18-14(3)29-21-19(18)20(23)24-11-25-21/h4-11H,1-3H3,(H2,23,24,25)(H2,26,27,28)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8867
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-2-methox...)
Show SMILES COc1cc(ccc1NC(=O)Nc1cccc(C)c1)-c1csc2ncnc(N)c12
Show InChI InChI=1S/C21H19N5O2S/c1-12-4-3-5-14(8-12)25-21(27)26-16-7-6-13(9-17(16)28-2)15-10-29-20-18(15)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8860
PNG
(3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyri...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CCCO)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C23H23N5O2S/c1-14-4-2-5-17(12-14)28-23(30)27-16-9-7-15(8-10-16)19-18(6-3-11-29)31-22-20(19)21(24)25-13-26-22/h2,4-5,7-10,12-13,29H,3,6,11H2,1H3,(H2,24,25,26)(H2,27,28,30)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8833
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2c(C)sc3ncnc(N)c23)cc1
Show InChI InChI=1S/C21H19N5O2S/c1-12-17(18-19(22)23-11-24-20(18)29-12)13-3-5-14(6-4-13)25-21(27)26-15-7-9-16(28-2)10-8-15/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8846
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H15F4N5OS/c1-10-16(17-18(26)27-9-28-19(17)32-10)11-2-5-13(6-3-11)29-20(31)30-15-8-12(21(23,24)25)4-7-14(15)22/h2-9H,1H3,(H2,26,27,28)(H2,29,30,31)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8847
PNG
(3-[4-amino-5-(4-{[(3-methylphenyl)carbamoyl]amino}...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CCC(N)=O)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C23H22N6O2S/c1-13-3-2-4-16(11-13)29-23(31)28-15-7-5-14(6-8-15)19-17(9-10-18(24)30)32-22-20(19)21(25)26-12-27-22/h2-8,11-12H,9-10H2,1H3,(H2,24,30)(H2,25,26,27)(H2,28,29,31)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4814
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8858
PNG
(3-{4-[4-amino-6-(2-hydroxyethyl)thieno[2,3-d]pyrim...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CCO)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C22H21N5O2S/c1-13-3-2-4-16(11-13)27-22(29)26-15-7-5-14(6-8-15)18-17(9-10-28)30-21-19(18)20(23)24-12-25-21/h2-8,11-12,28H,9-10H2,1H3,(H2,23,24,25)(H2,26,27,29)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8832
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES COc1cccc(NC(=O)Nc2ccc(cc2)-c2c(C)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C21H19N5O2S/c1-12-17(18-19(22)23-11-24-20(18)29-12)13-6-8-14(9-7-13)25-21(27)26-15-4-3-5-16(10-15)28-2/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8865
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-2-fluoro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2F)-c2csc3ncnc(N)c23)c1
Show InChI InChI=1S/C20H16FN5OS/c1-11-3-2-4-13(7-11)25-20(27)26-16-6-5-12(8-15(16)21)14-9-28-19-17(14)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8844
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(C)cc(C)c2)cc1
Show InChI InChI=1S/C22H21N5OS/c1-12-8-13(2)10-17(9-12)27-22(28)26-16-6-4-15(5-7-16)18-14(3)29-21-19(18)20(23)24-11-25-21/h4-11H,1-3H3,(H2,23,24,25)(H2,26,27,28)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8838
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-5-7-14(8-6-12)25-20(27)26-15-4-2-3-13(21)9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8824
PNG
(3-(4-{4-amino-6-ethylthieno[2,3-d]pyrimidin-5-yl}p...)
Show SMILES CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C22H21N5OS/c1-3-17-18(19-20(23)24-12-25-21(19)29-17)14-7-9-15(10-8-14)26-22(28)27-16-6-4-5-13(2)11-16/h4-12H,3H2,1-2H3,(H2,23,24,25)(H2,26,27,28)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8860
PNG
(3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyri...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CCCO)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C23H23N5O2S/c1-14-4-2-5-17(12-14)28-23(30)27-16-9-7-15(8-10-16)19-18(6-3-11-29)31-22-20(19)21(24)25-13-26-22/h2,4-5,7-10,12-13,29H,3,6,11H2,1H3,(H2,24,25,26)(H2,27,28,30)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8853
PNG
(3-(4-{4-amino-6-propylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES CCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H23N5OS/c1-3-5-18-19(20-21(24)25-13-26-22(20)30-18)15-8-10-16(11-9-15)27-23(29)28-17-7-4-6-14(2)12-17/h4,6-13H,3,5H2,1-2H3,(H2,24,25,26)(H2,27,28,29)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8862
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-3-fluoro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)c(F)c2)c1
Show InChI InChI=1S/C20H16FN5OS/c1-11-3-2-4-12(7-11)25-20(27)26-13-5-6-14(16(21)8-13)15-9-28-19-17(15)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8835
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(F)c2)cc1
Show InChI InChI=1S/C20H16FN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-5-7-14(8-6-12)25-20(27)26-15-4-2-3-13(21)9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8824
PNG
(3-(4-{4-amino-6-ethylthieno[2,3-d]pyrimidin-5-yl}p...)
Show SMILES CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C22H21N5OS/c1-3-17-18(19-20(23)24-12-25-21(19)29-17)14-7-9-15(10-8-14)26-22(28)27-16-6-4-5-13(2)11-16/h4-12H,3H2,1-2H3,(H2,23,24,25)(H2,26,27,28)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8867
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-2-methox...)
Show SMILES COc1cc(ccc1NC(=O)Nc1cccc(C)c1)-c1csc2ncnc(N)c12
Show InChI InChI=1S/C21H19N5O2S/c1-12-4-3-5-14(8-12)25-21(27)26-16-7-6-13(9-17(16)28-2)15-10-29-20-18(15)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8839
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-2-6-14(7-3-12)25-20(27)26-15-8-4-13(21)5-9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8812
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C20H17N5OS/c1-12-16(17-18(21)22-11-23-19(17)27-12)13-7-9-15(10-8-13)25-20(26)24-14-5-3-2-4-6-14/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8836
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H16FN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-2-6-14(7-3-12)25-20(27)26-15-8-4-13(21)5-9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8856
PNG
(3-{4-[4-amino-6-(pyridin-3-ylmethyl)thieno[2,3-d]p...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(Cc3cccnc3)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C26H22N6OS/c1-16-4-2-6-20(12-16)32-26(33)31-19-9-7-18(8-10-19)22-21(13-17-5-3-11-28-14-17)34-25-23(22)24(27)29-15-30-25/h2-12,14-15H,13H2,1H3,(H2,27,29,30)(H2,31,32,33)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8832
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES COc1cccc(NC(=O)Nc2ccc(cc2)-c2c(C)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C21H19N5O2S/c1-12-17(18-19(22)23-11-24-20(18)29-12)13-6-8-14(9-7-13)25-21(27)26-15-4-3-5-16(10-15)28-2/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8838
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-5-7-14(8-6-12)25-20(27)26-15-4-2-3-13(21)9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM8868
PNG
(3-{16-amino-11-thia-13,15-diazatetracyclo[8.7.0.0^...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3-c4c(CCc3c2)sc2ncnc(N)c42)c1
Show InChI InChI=1S/C22H19N5OS/c1-12-3-2-4-14(9-12)26-22(28)27-15-6-7-16-13(10-15)5-8-17-18(16)19-20(23)24-11-25-21(19)29-17/h2-4,6-7,9-11H,5,8H2,1H3,(H2,23,24,25)(H2,26,27,28)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8812
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C20H17N5OS/c1-12-16(17-18(21)22-11-23-19(17)27-12)13-7-9-15(10-8-13)25-20(26)24-14-5-3-2-4-6-14/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8858
PNG
(3-{4-[4-amino-6-(2-hydroxyethyl)thieno[2,3-d]pyrim...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CCO)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C22H21N5O2S/c1-13-3-2-4-16(11-13)27-22(29)26-15-7-5-14(6-8-15)18-17(9-10-28)30-21-19(18)20(23)24-12-25-21/h2-8,11-12,28H,9-10H2,1H3,(H2,23,24,25)(H2,26,27,29)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8865
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-2-fluoro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2F)-c2csc3ncnc(N)c23)c1
Show InChI InChI=1S/C20H16FN5OS/c1-11-3-2-4-13(7-11)25-20(27)26-16-6-5-12(8-15(16)21)14-9-28-19-17(14)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8843
PNG
(Methyl 3-[({[4-(4-Amino-6-methylthieno[2,3-d]pyrim...)
Show SMILES COC(=O)c1cccc(NC(=O)Nc2ccc(cc2)-c2c(C)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C22H19N5O3S/c1-12-17(18-19(23)24-11-25-20(18)31-12)13-6-8-15(9-7-13)26-22(29)27-16-5-3-4-14(10-16)21(28)30-2/h3-11H,1-2H3,(H2,23,24,25)(H2,26,27,29)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8846
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H15F4N5OS/c1-10-16(17-18(26)27-9-28-19(17)32-10)11-2-5-13(6-3-11)29-20(31)30-15-8-12(21(23,24)25)4-7-14(15)22/h2-9H,1H3,(H2,26,27,28)(H2,29,30,31)
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n/an/a 45n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8840
PNG
(-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)-...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(Br)c2)cc1
Show InChI InChI=1S/C20H16BrN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-5-7-14(8-6-12)25-20(27)26-15-4-2-3-13(21)9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 46n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8841
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(Br)cc2)cc1
Show InChI InChI=1S/C20H16BrN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-2-6-14(7-3-12)25-20(27)26-15-8-4-13(21)5-9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 48n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8869
PNG
(3-(4-{4-amino-6-ethylthieno[2,3-d]pyrimidin-5-yl}p...)
Show SMILES CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H18F3N5OS/c1-2-16-17(18-19(26)27-11-28-20(18)32-16)12-6-8-14(9-7-12)29-21(31)30-15-5-3-4-13(10-15)22(23,24)25/h3-11H,2H2,1H3,(H2,26,27,28)(H2,29,30,31)
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n/an/a 50n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8831
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES COc1ccccc1NC(=O)Nc1ccc(cc1)-c1c(C)sc2ncnc(N)c12
Show InChI InChI=1S/C21H19N5O2S/c1-12-17(18-19(22)23-11-24-20(18)29-12)13-7-9-14(10-8-13)25-21(27)26-15-5-3-4-6-16(15)28-2/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 50n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8840
PNG
(-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)-...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(Br)c2)cc1
Show InChI InChI=1S/C20H16BrN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-5-7-14(8-6-12)25-20(27)26-15-4-2-3-13(21)9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 50n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8836
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H16FN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-2-6-14(7-3-12)25-20(27)26-15-8-4-13(21)5-9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 52n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8842
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F3N5OS/c1-11-16(17-18(25)26-10-27-19(17)31-11)12-5-7-14(8-6-12)28-20(30)29-15-4-2-3-13(9-15)21(22,23)24/h2-10H,1H3,(H2,25,26,27)(H2,28,29,30)
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n/an/a 52n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8830
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(C)cc2)cc1
Show InChI InChI=1S/C21H19N5OS/c1-12-3-7-15(8-4-12)25-21(27)26-16-9-5-14(6-10-16)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 53n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8857
PNG
(3-{4-[4-amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]p...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(Cc3ccncc3)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C26H22N6OS/c1-16-3-2-4-20(13-16)32-26(33)31-19-7-5-18(6-8-19)22-21(14-17-9-11-28-12-10-17)34-25-23(22)24(27)29-15-30-25/h2-13,15H,14H2,1H3,(H2,27,29,30)(H2,31,32,33)
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n/an/a 53n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8866
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-2-chloro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2Cl)-c2csc3ncnc(N)c23)c1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-3-2-4-13(7-11)25-20(27)26-16-6-5-12(8-15(16)21)14-9-28-19-17(14)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 54n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8835
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(F)c2)cc1
Show InChI InChI=1S/C20H16FN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-5-7-14(8-6-12)25-20(27)26-15-4-2-3-13(21)9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 54n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8820
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES CN(C(=O)Nc1cccc(C)c1)c1ccc(cc1)-c1c(C)sc2ncnc(N)c12
Show InChI InChI=1S/C22H21N5OS/c1-13-5-4-6-16(11-13)26-22(28)27(3)17-9-7-15(8-10-17)18-14(2)29-21-19(18)20(23)24-12-25-21/h4-12H,1-3H3,(H,26,28)(H2,23,24,25)
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n/an/a 55n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM8863
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-3-chloro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)c(Cl)c2)c1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-3-2-4-12(7-11)25-20(27)26-13-5-6-14(16(21)8-13)15-9-28-19-17(15)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 59n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8859
PNG
(3-{4-[4-amino-6-(2-methoxyethyl)thieno[2,3-d]pyrim...)
Show SMILES COCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H23N5O2S/c1-14-4-3-5-17(12-14)28-23(29)27-16-8-6-15(7-9-16)19-18(10-11-30-2)31-22-20(19)21(24)25-13-26-22/h3-9,12-13H,10-11H2,1-2H3,(H2,24,25,26)(H2,27,28,29)
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n/an/a 64n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM8865
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-2-fluoro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2F)-c2csc3ncnc(N)c23)c1
Show InChI InChI=1S/C20H16FN5OS/c1-11-3-2-4-13(7-11)25-20(27)26-16-6-5-12(8-15(16)21)14-9-28-19-17(14)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 67n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8829
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2C)cc1
Show InChI InChI=1S/C21H19N5OS/c1-12-5-3-4-6-16(12)26-21(27)25-15-9-7-14(8-10-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8833
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2c(C)sc3ncnc(N)c23)cc1
Show InChI InChI=1S/C21H19N5O2S/c1-12-17(18-19(22)23-11-24-20(18)29-12)13-3-5-14(6-4-13)25-21(27)26-15-7-9-16(28-2)10-8-15/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8853
PNG
(3-(4-{4-amino-6-propylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES CCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H23N5OS/c1-3-5-18-19(20-21(24)25-13-26-22(20)30-18)15-8-10-16(11-9-15)27-23(29)28-17-7-4-6-14(2)12-17/h4,6-13H,3,5H2,1-2H3,(H2,24,25,26)(H2,27,28,29)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8866
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-2-chloro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2Cl)-c2csc3ncnc(N)c23)c1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-3-2-4-13(7-11)25-20(27)26-16-6-5-12(8-15(16)21)14-9-28-19-17(14)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8830
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(C)cc2)cc1
Show InChI InChI=1S/C21H19N5OS/c1-12-3-7-15(8-4-12)25-21(27)26-16-9-5-14(6-10-16)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8839
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-2-6-14(7-3-12)25-20(27)26-15-8-4-13(21)5-9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8864
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-3-methox...)
Show SMILES COc1cc(NC(=O)Nc2cccc(C)c2)ccc1-c1csc2ncnc(N)c12
Show InChI InChI=1S/C21H19N5O2S/c1-12-4-3-5-13(8-12)25-21(27)26-14-6-7-15(17(9-14)28-2)16-10-29-20-18(16)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8842
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F3N5OS/c1-11-16(17-18(25)26-10-27-19(17)31-11)12-5-7-14(8-6-12)28-20(30)29-15-4-2-3-13(9-15)21(22,23)24/h2-10H,1H3,(H2,25,26,27)(H2,28,29,30)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8863
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-3-chloro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)c(Cl)c2)c1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-3-2-4-12(7-11)25-20(27)26-13-5-6-14(16(21)8-13)15-9-28-19-17(15)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8831
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES COc1ccccc1NC(=O)Nc1ccc(cc1)-c1c(C)sc2ncnc(N)c12
Show InChI InChI=1S/C21H19N5O2S/c1-12-17(18-19(22)23-11-24-20(18)29-12)13-7-9-14(10-8-13)25-21(27)26-15-5-3-4-6-16(15)28-2/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8834
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2F)cc1
Show InChI InChI=1S/C20H16FN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-6-8-13(9-7-12)25-20(27)26-15-5-3-2-4-14(15)21/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8813
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C21H19N5OS/c1-12-4-3-5-16(10-12)26-21(27)25-15-8-6-14(7-9-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8860
PNG
(3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyri...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CCCO)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C23H23N5O2S/c1-14-4-2-5-17(12-14)28-23(30)27-16-9-7-15(8-10-16)19-18(6-3-11-29)31-22-20(19)21(24)25-13-26-22/h2,4-5,7-10,12-13,29H,3,6,11H2,1H3,(H2,24,25,26)(H2,27,28,30)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8837
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2Cl)cc1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-6-8-13(9-7-12)25-20(27)26-15-5-3-2-4-14(15)21/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8847
PNG
(3-[4-amino-5-(4-{[(3-methylphenyl)carbamoyl]amino}...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CCC(N)=O)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C23H22N6O2S/c1-13-3-2-4-16(11-13)29-23(31)28-15-7-5-14(6-8-15)19-17(9-10-18(24)30)32-22-20(19)21(25)26-12-27-22/h2-8,11-12H,9-10H2,1H3,(H2,24,30)(H2,25,26,27)(H2,28,29,31)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8841
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(Br)cc2)cc1
Show InChI InChI=1S/C20H16BrN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-2-6-14(7-3-12)25-20(27)26-15-8-4-13(21)5-9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8854
PNG
(3-{4-[4-amino-6-(propan-2-yl)thieno[2,3-d]pyrimidi...)
Show SMILES CC(C)c1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H23N5OS/c1-13(2)20-18(19-21(24)25-12-26-22(19)30-20)15-7-9-16(10-8-15)27-23(29)28-17-6-4-5-14(3)11-17/h4-13H,1-3H3,(H2,24,25,26)(H2,27,28,29)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM8867
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-2-methox...)
Show SMILES COc1cc(ccc1NC(=O)Nc1cccc(C)c1)-c1csc2ncnc(N)c12
Show InChI InChI=1S/C21H19N5O2S/c1-12-4-3-5-14(8-12)25-21(27)26-16-7-6-13(9-17(16)28-2)15-10-29-20-18(15)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8840
PNG
(-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)-...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(Br)c2)cc1
Show InChI InChI=1S/C20H16BrN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-5-7-14(8-6-12)25-20(27)26-15-4-2-3-13(21)9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8849
PNG
(3-[4-amino-5-(4-{[(3-methylphenyl)carbamoyl]amino}...)
Show SMILES CN(C)C(=O)CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C25H26N6O2S/c1-15-5-4-6-18(13-15)30-25(33)29-17-9-7-16(8-10-17)21-19(11-12-20(32)31(2)3)34-24-22(21)23(26)27-14-28-24/h4-10,13-14H,11-12H2,1-3H3,(H2,26,27,28)(H2,29,30,33)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM8864
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-3-methox...)
Show SMILES COc1cc(NC(=O)Nc2cccc(C)c2)ccc1-c1csc2ncnc(N)c12
Show InChI InChI=1S/C21H19N5O2S/c1-12-4-3-5-13(8-12)25-21(27)26-14-6-7-15(17(9-14)28-2)16-10-29-20-18(16)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8842
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F3N5OS/c1-11-16(17-18(25)26-10-27-19(17)31-11)12-5-7-14(8-6-12)28-20(30)29-15-4-2-3-13(9-15)21(22,23)24/h2-10H,1H3,(H2,25,26,27)(H2,28,29,30)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8868
PNG
(3-{16-amino-11-thia-13,15-diazatetracyclo[8.7.0.0^...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3-c4c(CCc3c2)sc2ncnc(N)c42)c1
Show InChI InChI=1S/C22H19N5OS/c1-12-3-2-4-14(9-12)26-22(28)27-15-6-7-16-13(10-15)5-8-17-18(16)19-20(23)24-11-25-21(19)29-17/h2-4,6-7,9-11H,5,8H2,1H3,(H2,23,24,25)(H2,26,27,28)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8847
PNG
(3-[4-amino-5-(4-{[(3-methylphenyl)carbamoyl]amino}...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CCC(N)=O)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C23H22N6O2S/c1-13-3-2-4-16(11-13)29-23(31)28-15-7-5-14(6-8-15)19-17(9-10-18(24)30)32-22-20(19)21(25)26-12-27-22/h2-8,11-12H,9-10H2,1H3,(H2,24,30)(H2,25,26,27)(H2,28,29,31)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8845
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(Cl)cc(Cl)c2)cc1
Show InChI InChI=1S/C20H15Cl2N5OS/c1-10-16(17-18(23)24-9-25-19(17)29-10)11-2-4-14(5-3-11)26-20(28)27-15-7-12(21)6-13(22)8-15/h2-9H,1H3,(H2,23,24,25)(H2,26,27,28)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8825
PNG
(3-(4-{4-amino-6-ethylthieno[2,3-d]pyrimidin-5-yl}p...)
Show SMILES CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)NC2CCCCC2)cc1
Show InChI InChI=1S/C21H25N5OS/c1-2-16-17(18-19(22)23-12-24-20(18)28-16)13-8-10-15(11-9-13)26-21(27)25-14-6-4-3-5-7-14/h8-12,14H,2-7H2,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8818
PNG
(5-[4-(1,3-Benzoxazol-2-ylamino)phenyl]-6-methylthi...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(Nc2nc3ccccc3o2)cc1
Show InChI InChI=1S/C20H15N5OS/c1-11-16(17-18(21)22-10-23-19(17)27-11)12-6-8-13(9-7-12)24-20-25-14-4-2-3-5-15(14)26-20/h2-10H,1H3,(H,24,25)(H2,21,22,23)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8844
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(C)cc(C)c2)cc1
Show InChI InChI=1S/C22H21N5OS/c1-12-8-13(2)10-17(9-12)27-22(28)26-16-6-4-15(5-7-16)18-14(3)29-21-19(18)20(23)24-11-25-21/h4-11H,1-3H3,(H2,23,24,25)(H2,26,27,28)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8845
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(Cl)cc(Cl)c2)cc1
Show InChI InChI=1S/C20H15Cl2N5OS/c1-10-16(17-18(23)24-9-25-19(17)29-10)11-2-4-14(5-3-11)26-20(28)27-15-7-12(21)6-13(22)8-15/h2-9H,1H3,(H2,23,24,25)(H2,26,27,28)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8827
PNG
(1-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-3...)
Show SMILES CCCCNC(=O)Nc1ccc(cc1)-c1csc2ncnc(N)c12
Show InChI InChI=1S/C17H19N5OS/c1-2-3-8-19-17(23)22-12-6-4-11(5-7-12)13-9-24-16-14(13)15(18)20-10-21-16/h4-7,9-10H,2-3,8H2,1H3,(H2,18,20,21)(H2,19,22,23)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8852
PNG
(3-(4-{4-amino-6-[(dimethylamino)methyl]thieno[2,3-...)
Show SMILES CN(C)Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H24N6OS/c1-14-5-4-6-17(11-14)28-23(30)27-16-9-7-15(8-10-16)19-18(12-29(2)3)31-22-20(19)21(24)25-13-26-22/h4-11,13H,12H2,1-3H3,(H2,24,25,26)(H2,27,28,30)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8864
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-3-methox...)
Show SMILES COc1cc(NC(=O)Nc2cccc(C)c2)ccc1-c1csc2ncnc(N)c12
Show InChI InChI=1S/C21H19N5O2S/c1-12-4-3-5-13(8-12)25-21(27)26-14-6-7-15(17(9-14)28-2)16-10-29-20-18(16)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8846
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H15F4N5OS/c1-10-16(17-18(26)27-9-28-19(17)32-10)11-2-5-13(6-3-11)29-20(31)30-15-8-12(21(23,24)25)4-7-14(15)22/h2-9H,1H3,(H2,26,27,28)(H2,29,30,31)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8861
PNG
(3-(4-{4-amino-6-[2-(dimethylamino)ethyl]thieno[2,3...)
Show SMILES CN(C)CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C24H26N6OS/c1-15-5-4-6-18(13-15)29-24(31)28-17-9-7-16(8-10-17)20-19(11-12-30(2)3)32-23-21(20)22(25)26-14-27-23/h4-10,13-14H,11-12H2,1-3H3,(H2,25,26,27)(H2,28,29,31)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8863
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-3-chloro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)c(Cl)c2)c1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-3-2-4-12(7-11)25-20(27)26-13-5-6-14(16(21)8-13)15-9-28-19-17(15)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8849
PNG
(3-[4-amino-5-(4-{[(3-methylphenyl)carbamoyl]amino}...)
Show SMILES CN(C)C(=O)CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C25H26N6O2S/c1-15-5-4-6-18(13-15)30-25(33)29-17-9-7-16(8-10-17)21-19(11-12-20(32)31(2)3)34-24-22(21)23(26)27-14-28-24/h4-10,13-14H,11-12H2,1-3H3,(H2,26,27,28)(H2,29,30,33)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8838
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-5-7-14(8-6-12)25-20(27)26-15-4-2-3-13(21)9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8850
PNG
(3-{4-[4-amino-6-(morpholin-4-ylmethyl)thieno[2,3-d...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CN3CCOCC3)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C25H26N6O2S/c1-16-3-2-4-19(13-16)30-25(32)29-18-7-5-17(6-8-18)21-20(14-31-9-11-33-12-10-31)34-24-22(21)23(26)27-15-28-24/h2-8,13,15H,9-12,14H2,1H3,(H2,26,27,28)(H2,29,30,32)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8859
PNG
(3-{4-[4-amino-6-(2-methoxyethyl)thieno[2,3-d]pyrim...)
Show SMILES COCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H23N5O2S/c1-14-4-3-5-17(12-14)28-23(29)27-16-8-6-15(7-9-16)19-18(10-11-30-2)31-22-20(19)21(24)25-13-26-22/h3-9,12-13H,10-11H2,1-2H3,(H2,24,25,26)(H2,27,28,29)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8861
PNG
(3-(4-{4-amino-6-[2-(dimethylamino)ethyl]thieno[2,3...)
Show SMILES CN(C)CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C24H26N6OS/c1-15-5-4-6-18(13-15)29-24(31)28-17-9-7-16(8-10-17)20-19(11-12-30(2)3)32-23-21(20)22(25)26-14-27-23/h4-10,13-14H,11-12H2,1-3H3,(H2,25,26,27)(H2,28,29,31)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8856
PNG
(3-{4-[4-amino-6-(pyridin-3-ylmethyl)thieno[2,3-d]p...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(Cc3cccnc3)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C26H22N6OS/c1-16-4-2-6-20(12-16)32-26(33)31-19-9-7-18(8-10-19)22-21(13-17-5-3-11-28-14-17)34-25-23(22)24(27)29-15-30-25/h2-12,14-15H,13H2,1H3,(H2,27,29,30)(H2,31,32,33)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8829
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2C)cc1
Show InChI InChI=1S/C21H19N5OS/c1-12-5-3-4-6-16(12)26-21(27)25-15-9-7-14(8-10-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8858
PNG
(3-{4-[4-amino-6-(2-hydroxyethyl)thieno[2,3-d]pyrim...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CCO)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C22H21N5O2S/c1-13-3-2-4-16(11-13)27-22(29)26-15-7-5-14(6-8-15)18-17(9-10-28)30-21-19(18)20(23)24-12-25-21/h2-8,11-12,28H,9-10H2,1H3,(H2,23,24,25)(H2,26,27,29)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8857
PNG
(3-{4-[4-amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]p...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(Cc3ccncc3)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C26H22N6OS/c1-16-3-2-4-20(13-16)32-26(33)31-19-7-5-18(6-8-19)22-21(14-17-9-11-28-12-10-17)34-25-23(22)24(27)29-15-30-25/h2-13,15H,14H2,1H3,(H2,27,29,30)(H2,31,32,33)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8855
PNG
(3-(4-{4-amino-6-benzylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(Cc3ccccc3)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C27H23N5OS/c1-17-6-5-9-21(14-17)32-27(33)31-20-12-10-19(11-13-20)23-22(15-18-7-3-2-4-8-18)34-26-24(23)25(28)29-16-30-26/h2-14,16H,15H2,1H3,(H2,28,29,30)(H2,31,32,33)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8843
PNG
(Methyl 3-[({[4-(4-Amino-6-methylthieno[2,3-d]pyrim...)
Show SMILES COC(=O)c1cccc(NC(=O)Nc2ccc(cc2)-c2c(C)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C22H19N5O3S/c1-12-17(18-19(23)24-11-25-20(18)31-12)13-6-8-15(9-7-13)26-22(29)27-16-5-3-4-14(10-16)21(28)30-2/h3-11H,1-2H3,(H2,23,24,25)(H2,26,27,29)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8853
PNG
(3-(4-{4-amino-6-propylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES CCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H23N5OS/c1-3-5-18-19(20-21(24)25-13-26-22(20)30-18)15-8-10-16(11-9-15)27-23(29)28-17-7-4-6-14(2)12-17/h4,6-13H,3,5H2,1-2H3,(H2,24,25,26)(H2,27,28,29)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8848
PNG
(3-[4-amino-5-(4-{[(3-methylphenyl)carbamoyl]amino}...)
Show SMILES CNC(=O)CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C24H24N6O2S/c1-14-4-3-5-17(12-14)30-24(32)29-16-8-6-15(7-9-16)20-18(10-11-19(31)26-2)33-23-21(20)22(25)27-13-28-23/h3-9,12-13H,10-11H2,1-2H3,(H,26,31)(H2,25,27,28)(H2,29,30,32)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8822
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)NCc2ccccc2)cc1
Show InChI InChI=1S/C21H19N5OS/c1-13-17(18-19(22)24-12-25-20(18)28-13)15-7-9-16(10-8-15)26-21(27)23-11-14-5-3-2-4-6-14/h2-10,12H,11H2,1H3,(H2,22,24,25)(H2,23,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8837
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2Cl)cc1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-6-8-13(9-7-12)25-20(27)26-15-5-3-2-4-14(15)21/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8824
PNG
(3-(4-{4-amino-6-ethylthieno[2,3-d]pyrimidin-5-yl}p...)
Show SMILES CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C22H21N5OS/c1-3-17-18(19-20(23)24-12-25-21(19)29-17)14-7-9-15(10-8-14)26-22(28)27-16-6-4-5-13(2)11-16/h4-12H,3H2,1-2H3,(H2,23,24,25)(H2,26,27,28)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8859
PNG
(3-{4-[4-amino-6-(2-methoxyethyl)thieno[2,3-d]pyrim...)
Show SMILES COCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H23N5O2S/c1-14-4-3-5-17(12-14)28-23(29)27-16-8-6-15(7-9-16)19-18(10-11-30-2)31-22-20(19)21(24)25-13-26-22/h3-9,12-13H,10-11H2,1-2H3,(H2,24,25,26)(H2,27,28,29)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8832
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES COc1cccc(NC(=O)Nc2ccc(cc2)-c2c(C)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C21H19N5O2S/c1-12-17(18-19(22)23-11-24-20(18)29-12)13-6-8-14(9-7-13)25-21(27)26-15-4-3-5-16(10-15)28-2/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8845
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(Cl)cc(Cl)c2)cc1
Show InChI InChI=1S/C20H15Cl2N5OS/c1-10-16(17-18(23)24-9-25-19(17)29-10)11-2-4-14(5-3-11)26-20(28)27-15-7-12(21)6-13(22)8-15/h2-9H,1H3,(H2,23,24,25)(H2,26,27,28)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8848
PNG
(3-[4-amino-5-(4-{[(3-methylphenyl)carbamoyl]amino}...)
Show SMILES CNC(=O)CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C24H24N6O2S/c1-14-4-3-5-17(12-14)30-24(32)29-16-8-6-15(7-9-16)20-18(10-11-19(31)26-2)33-23-21(20)22(25)27-13-28-23/h3-9,12-13H,10-11H2,1-2H3,(H,26,31)(H2,25,27,28)(H2,29,30,32)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8835
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(F)c2)cc1
Show InChI InChI=1S/C20H16FN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-5-7-14(8-6-12)25-20(27)26-15-4-2-3-13(21)9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8850
PNG
(3-{4-[4-amino-6-(morpholin-4-ylmethyl)thieno[2,3-d...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CN3CCOCC3)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C25H26N6O2S/c1-16-3-2-4-19(13-16)30-25(32)29-18-7-5-17(6-8-18)21-20(14-31-9-11-33-12-10-31)34-24-22(21)23(26)27-15-28-24/h2-8,13,15H,9-12,14H2,1H3,(H2,26,27,28)(H2,29,30,32)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8848
PNG
(3-[4-amino-5-(4-{[(3-methylphenyl)carbamoyl]amino}...)
Show SMILES CNC(=O)CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C24H24N6O2S/c1-14-4-3-5-17(12-14)30-24(32)29-16-8-6-15(7-9-16)20-18(10-11-19(31)26-2)33-23-21(20)22(25)27-13-28-23/h3-9,12-13H,10-11H2,1-2H3,(H,26,31)(H2,25,27,28)(H2,29,30,32)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8843
PNG
(Methyl 3-[({[4-(4-Amino-6-methylthieno[2,3-d]pyrim...)
Show SMILES COC(=O)c1cccc(NC(=O)Nc2ccc(cc2)-c2c(C)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C22H19N5O3S/c1-12-17(18-19(23)24-11-25-20(18)31-12)13-6-8-15(9-7-13)26-22(29)27-16-5-3-4-14(10-16)21(28)30-2/h3-11H,1-2H3,(H2,23,24,25)(H2,26,27,29)
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n/an/a 510n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8850
PNG
(3-{4-[4-amino-6-(morpholin-4-ylmethyl)thieno[2,3-d...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CN3CCOCC3)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C25H26N6O2S/c1-16-3-2-4-19(13-16)30-25(32)29-18-7-5-17(6-8-18)21-20(14-31-9-11-33-12-10-31)34-24-22(21)23(26)27-15-28-24/h2-8,13,15H,9-12,14H2,1H3,(H2,26,27,28)(H2,29,30,32)
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n/an/a 580n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8854
PNG
(3-{4-[4-amino-6-(propan-2-yl)thieno[2,3-d]pyrimidi...)
Show SMILES CC(C)c1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H23N5OS/c1-13(2)20-18(19-21(24)25-12-26-22(19)30-20)15-7-9-16(10-8-15)27-23(29)28-17-6-4-5-14(3)11-17/h4-13H,1-3H3,(H2,24,25,26)(H2,27,28,29)
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n/an/a 580n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8851
PNG
(3-(4-{4-amino-6-[(4-methylpiperazin-1-yl)methyl]th...)
Show SMILES CN1CCN(Cc2sc3ncnc(N)c3c2-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)CC1
Show InChI InChI=1S/C26H29N7OS/c1-17-4-3-5-20(14-17)31-26(34)30-19-8-6-18(7-9-19)22-21(15-33-12-10-32(2)11-13-33)35-25-23(22)24(27)28-16-29-25/h3-9,14,16H,10-13,15H2,1-2H3,(H2,27,28,29)(H2,30,31,34)
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n/an/a 590n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8851
PNG
(3-(4-{4-amino-6-[(4-methylpiperazin-1-yl)methyl]th...)
Show SMILES CN1CCN(Cc2sc3ncnc(N)c3c2-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)CC1
Show InChI InChI=1S/C26H29N7OS/c1-17-4-3-5-20(14-17)31-26(34)30-19-8-6-18(7-9-19)22-21(15-33-12-10-32(2)11-13-33)35-25-23(22)24(27)28-16-29-25/h3-9,14,16H,10-13,15H2,1-2H3,(H2,27,28,29)(H2,30,31,34)
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n/an/a 630n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM8866
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}-2-chloro...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2Cl)-c2csc3ncnc(N)c23)c1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-3-2-4-13(7-11)25-20(27)26-16-6-5-12(8-15(16)21)14-9-28-19-17(14)18(22)23-10-24-19/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 700n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8826
PNG
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1
Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)
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n/an/a 720n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8819
PNG
(N-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Cc2cccc(C)c2)cc1
Show InChI InChI=1S/C22H20N4OS/c1-13-4-3-5-15(10-13)11-18(27)26-17-8-6-16(7-9-17)19-14(2)28-22-20(19)21(23)24-12-25-22/h3-10,12H,11H2,1-2H3,(H,26,27)(H2,23,24,25)
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n/an/a 760n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8856
PNG
(3-{4-[4-amino-6-(pyridin-3-ylmethyl)thieno[2,3-d]p...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(Cc3cccnc3)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C26H22N6OS/c1-16-4-2-6-20(12-16)32-26(33)31-19-9-7-18(8-10-19)22-21(13-17-5-3-11-28-14-17)34-25-23(22)24(27)29-15-30-25/h2-12,14-15H,13H2,1H3,(H2,27,29,30)(H2,31,32,33)
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n/an/a 790n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8823
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)NCC2CCCCC2)cc1
Show InChI InChI=1S/C21H25N5OS/c1-13-17(18-19(22)24-12-25-20(18)28-13)15-7-9-16(10-8-15)26-21(27)23-11-14-5-3-2-4-6-14/h7-10,12,14H,2-6,11H2,1H3,(H2,22,24,25)(H2,23,26,27)
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n/an/a 790n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8851
PNG
(3-(4-{4-amino-6-[(4-methylpiperazin-1-yl)methyl]th...)
Show SMILES CN1CCN(Cc2sc3ncnc(N)c3c2-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)CC1
Show InChI InChI=1S/C26H29N7OS/c1-17-4-3-5-20(14-17)31-26(34)30-19-8-6-18(7-9-19)22-21(15-33-12-10-32(2)11-13-33)35-25-23(22)24(27)28-16-29-25/h3-9,14,16H,10-13,15H2,1-2H3,(H2,27,28,29)(H2,30,31,34)
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n/an/a 800n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8861
PNG
(3-(4-{4-amino-6-[2-(dimethylamino)ethyl]thieno[2,3...)
Show SMILES CN(C)CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C24H26N6OS/c1-15-5-4-6-18(13-15)29-24(31)28-17-9-7-16(8-10-17)20-19(11-12-30(2)3)32-23-21(20)22(25)26-14-27-23/h4-10,13-14H,11-12H2,1-3H3,(H2,25,26,27)(H2,28,29,31)
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n/an/a 810n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8836
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H16FN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-2-6-14(7-3-12)25-20(27)26-15-8-4-13(21)5-9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 850n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8855
PNG
(3-(4-{4-amino-6-benzylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(Cc3ccccc3)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C27H23N5OS/c1-17-6-5-9-21(14-17)32-27(33)31-20-12-10-19(11-13-20)23-22(15-18-7-3-2-4-8-18)34-26-24(23)25(28)29-16-30-26/h2-14,16H,15H2,1H3,(H2,28,29,30)(H2,31,32,33)
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n/an/a 880n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8830
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(C)cc2)cc1
Show InChI InChI=1S/C21H19N5OS/c1-12-3-7-15(8-4-12)25-21(27)26-16-9-5-14(6-10-16)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 890n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8837
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2Cl)cc1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-6-8-13(9-7-12)25-20(27)26-15-5-3-2-4-14(15)21/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 900n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8831
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES COc1ccccc1NC(=O)Nc1ccc(cc1)-c1c(C)sc2ncnc(N)c12
Show InChI InChI=1S/C21H19N5O2S/c1-12-17(18-19(22)23-11-24-20(18)29-12)13-7-9-14(10-8-13)25-21(27)26-15-5-3-4-6-16(15)28-2/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 920n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8849
PNG
(3-[4-amino-5-(4-{[(3-methylphenyl)carbamoyl]amino}...)
Show SMILES CN(C)C(=O)CCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C25H26N6O2S/c1-15-5-4-6-18(13-15)30-25(33)29-17-9-7-16(8-10-17)21-19(11-12-20(32)31(2)3)34-24-22(21)23(26)27-14-28-24/h4-10,13-14H,11-12H2,1-3H3,(H2,26,27,28)(H2,29,30,33)
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n/an/a 930n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM8857
PNG
(3-{4-[4-amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]p...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(Cc3ccncc3)sc3ncnc(N)c23)c1
Show InChI InChI=1S/C26H22N6OS/c1-16-3-2-4-20(13-16)32-26(33)31-19-7-5-18(6-8-19)22-21(14-17-9-11-28-12-10-17)34-25-23(22)24(27)29-15-30-25/h2-13,15H,14H2,1H3,(H2,27,29,30)(H2,31,32,33)
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n/an/a 960n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8834
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2F)cc1
Show InChI InChI=1S/C20H16FN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-6-8-13(9-7-12)25-20(27)26-15-5-3-2-4-14(15)21/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8816
PNG
(1-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(cc1)N=C(NC#N)Nc1cccc(C)c1
Show InChI InChI=1S/C22H19N7S/c1-13-4-3-5-17(10-13)29-22(25-11-23)28-16-8-6-15(7-9-16)18-14(2)30-21-19(18)20(24)26-12-27-21/h3-10,12H,1-2H3,(H2,24,26,27)(H2,25,28,29)
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n/an/a 1.10E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8841
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(Br)cc2)cc1
Show InChI InChI=1S/C20H16BrN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-2-6-14(7-3-12)25-20(27)26-15-8-4-13(21)5-9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8812
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C20H17N5OS/c1-12-16(17-18(21)22-11-23-19(17)27-12)13-7-9-15(10-8-13)25-20(26)24-14-5-3-2-4-6-14/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)
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n/an/a 1.20E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8839
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-16(17-18(22)23-10-24-19(17)28-11)12-2-6-14(7-3-12)25-20(27)26-15-8-4-13(21)5-9-15/h2-10H,1H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8829
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2C)cc1
Show InChI InChI=1S/C21H19N5OS/c1-12-5-3-4-6-16(12)26-21(27)25-15-9-7-14(8-10-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM8833
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2c(C)sc3ncnc(N)c23)cc1
Show InChI InChI=1S/C21H19N5O2S/c1-12-17(18-19(22)23-11-24-20(18)29-12)13-3-5-14(6-4-13)25-21(27)26-15-7-9-16(28-2)10-8-15/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8828
PNG
(1-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-3...)
Show SMILES CC(C)CNC(=O)Nc1ccc(cc1)-c1csc2ncnc(N)c12
Show InChI InChI=1S/C17H19N5OS/c1-10(2)7-19-17(23)22-12-5-3-11(4-6-12)13-8-24-16-14(13)15(18)20-9-21-16/h3-6,8-10H,7H2,1-2H3,(H2,18,20,21)(H2,19,22,23)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8821
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES CN(C(=O)Nc1ccc(cc1)-c1c(C)sc2ncnc(N)c12)c1cccc(C)c1
Show InChI InChI=1S/C22H21N5OS/c1-13-5-4-6-17(11-13)27(3)22(28)26-16-9-7-15(8-10-16)18-14(2)29-21-19(18)20(23)24-12-25-21/h4-12H,1-3H3,(H,26,28)(H2,23,24,25)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8815
PNG
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=S)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C21H19N5S2/c1-12-4-3-5-16(10-12)26-21(27)25-15-8-6-14(7-9-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)
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n/an/a 2.80E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8810
PNG
(N-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)c2cccc(C)c2)cc1
Show InChI InChI=1S/C21H18N4OS/c1-12-4-3-5-15(10-12)20(26)25-16-8-6-14(7-9-16)17-13(2)27-21-18(17)19(22)23-11-24-21/h3-11H,1-2H3,(H,25,26)(H2,22,23,24)
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n/an/a 4.60E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8809
PNG
(5-(4-Aminophenyl)-6-methylthieno[2,3-d]pyrimidin-4...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(N)cc1
Show InChI InChI=1S/C13H12N4S/c1-7-10(8-2-4-9(14)5-3-8)11-12(15)16-6-17-13(11)18-7/h2-6H,14H2,1H3,(H2,15,16,17)
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n/an/a 4.60E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8817
PNG
(N-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)c2cc3ccccc3[nH]2)cc1
Show InChI InChI=1S/C22H17N5OS/c1-12-18(19-20(23)24-11-25-22(19)29-12)13-6-8-15(9-7-13)26-21(28)17-10-14-4-2-3-5-16(14)27-17/h2-11,27H,1H3,(H,26,28)(H2,23,24,25)
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n/an/a>5.00E+4n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8814
PNG
(4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)-N-...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(cc1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C21H18N4OS/c1-12-4-3-5-16(10-12)25-20(26)15-8-6-14(7-9-15)17-13(2)27-21-18(17)19(22)23-11-24-21/h3-11H,1-2H3,(H,25,26)(H2,22,23,24)
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n/an/a>5.00E+4n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM8811
PNG
(N-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C19H16N4O2S2/c1-12-16(17-18(20)21-11-22-19(17)26-12)13-7-9-14(10-8-13)23-27(24,25)15-5-3-2-4-6-15/h2-11,23H,1H3,(H2,20,21,22)
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n/an/a>5.00E+4n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 48: 6066-83 (2005)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2WD3XSF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%