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PubMed code 16190758

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(RAT)
BDBM50174516
PNG
(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Show SMILES NC1(CC2ON=C(C2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)
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PubMed
2.70E+4n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50174519
PNG
((3aR,5R,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m0/s1
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3.30E+4n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50174516
PNG
(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Show SMILES NC1(CC2ON=C(C2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)
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9.40E+4n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
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9.50E+4n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50174515
PNG
((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174516
PNG
(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Show SMILES NC1(CC2ON=C(C2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174517
PNG
(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Show SMILES NC(CC1CC(=NO1)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H10N2O5/c8-4(6(10)11)1-3-2-5(7(12)13)9-14-3/h3-4H,1-2,8H2,(H,10,11)(H,12,13)
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50174517
PNG
(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Show SMILES NC(CC1CC(=NO1)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H10N2O5/c8-4(6(10)11)1-3-2-5(7(12)13)9-14-3/h3-4H,1-2,8H2,(H,10,11)(H,12,13)
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50130515
PNG
((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50130515
PNG
((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50130515
PNG
((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR2 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174519
PNG
((3aR,5R,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50174517
PNG
(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Show SMILES NC(CC1CC(=NO1)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H10N2O5/c8-4(6(10)11)1-3-2-5(7(12)13)9-14-3/h3-4H,1-2,8H2,(H,10,11)(H,12,13)
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR2 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174515
PNG
((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50174515
PNG
((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR2 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50174515
PNG
((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50174517
PNG
(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Show SMILES NC(CC1CC(=NO1)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H10N2O5/c8-4(6(10)11)1-3-2-5(7(12)13)9-14-3/h3-4H,1-2,8H2,(H,10,11)(H,12,13)
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n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50130515
PNG
((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m1/s1
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Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR2 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50174515
PNG
((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR2 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174516
PNG
(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Show SMILES NC1(CC2ON=C(C2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)
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n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174517
PNG
(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Show SMILES NC(CC1CC(=NO1)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H10N2O5/c8-4(6(10)11)1-3-2-5(7(12)13)9-14-3/h3-4H,1-2,8H2,(H,10,11)(H,12,13)
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n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50174517
PNG
(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Show SMILES NC(CC1CC(=NO1)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H10N2O5/c8-4(6(10)11)1-3-2-5(7(12)13)9-14-3/h3-4H,1-2,8H2,(H,10,11)(H,12,13)
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n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR2 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50174516
PNG
(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Show SMILES NC1(CC2ON=C(C2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)
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n/an/an/an/a 3.60E+4n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR2 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174519
PNG
((3aR,5R,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174515
PNG
((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50130515
PNG
((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50130515
PNG
((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50174516
PNG
(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Show SMILES NC1(CC2ON=C(C2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)
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n/an/an/an/a 1.60E+4n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR2 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%