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PubMed code 1619616

Compile data set for download or QSAR
Found 94 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor


(RAT)
BDBM50229676
PNG
(CHEMBL78697)
Show SMILES Nc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C7H12N6/c8-7-9-11-13(10-7)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2,(H2,8,10)/t5-,6-/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229669
PNG
(CHEMBL309432)
Show SMILES OC(c1nnn(n1)C1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H23N5O/c27-21(17-7-3-1-4-8-17,18-9-5-2-6-10-18)20-22-24-26(23-20)19-15-25-13-11-16(19)12-14-25/h1-10,16,19,27H,11-15H2
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n/an/a 2.80n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229684
PNG
(CHEMBL78615)
Show SMILES Clc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C8H12ClN5/c9-7-10-12-14(11-7)8-2-1-4-13(6-8)5-3-8/h1-6H2
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n/an/a 3.5n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229669
PNG
(CHEMBL309432)
Show SMILES OC(c1nnn(n1)C1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H23N5O/c27-21(17-7-3-1-4-8-17,18-9-5-2-6-10-18)20-22-24-26(23-20)19-15-25-13-11-16(19)12-14-25/h1-10,16,19,27H,11-15H2
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n/an/a 3.60n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229617
PNG
(CHEMBL311799)
Show SMILES Cc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H13N5/c1-6-9-11-13(10-6)8-5-12-3-2-7(8)4-12/h7-8H,2-5H2,1H3/t7-,8-/m0/s1
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n/an/a 4.20n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229681
PNG
(CHEMBL79040)
Show SMILES Cn1ncc(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C9H14N4/c1-12-10-4-9(11-12)8-6-13-3-2-7(8)5-13/h4,7-8H,2-3,5-6H2,1H3/t7-,8-/m0/s1
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n/an/a 5.40n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229685
PNG
(CHEMBL311212)
Show SMILES Brc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C8H12BrN5/c9-7-10-12-14(11-7)8-2-1-4-13(6-8)5-3-8/h1-6H2
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n/an/a 5.5n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229678
PNG
(CHEMBL80723)
Show SMILES Nc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C8H14N6/c9-7-10-12-14(11-7)8-2-1-4-13(6-8)5-3-8/h1-6H2,(H2,9,11)
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n/an/a 5.90n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229696
PNG
(CHEMBL419659)
Show SMILES Brc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C7H10BrN5/c8-7-9-11-13(10-7)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2/t5-,6-/m0/s1
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n/an/a 7.40n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229694
PNG
(CHEMBL81481)
Show SMILES Clc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C7H10ClN5/c8-7-9-11-13(10-7)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2/t5-,6-/m0/s1
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n/an/a 7.60n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229623
PNG
(CHEMBL81281)
Show SMILES Cn1nnc(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H13N5/c1-12-10-8(9-11-12)7-5-13-3-2-6(7)4-13/h6-7H,2-5H2,1H3/t6-,7-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229692
PNG
(CHEMBL311562)
Show SMILES Cc1ncn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C10H16N4/c1-9-11-8-14(12-9)10-3-2-5-13(7-10)6-4-10/h8H,2-7H2,1H3
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n/an/a 12n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM10759
PNG
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Show SMILES CC(=O)OCC[N+](C)(C)C
Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
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n/an/a 12n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229675
PNG
(CHEMBL309638)
Show SMILES C1CC2(CN1CCC2)n1cncn1
Show InChI InChI=1S/C9H14N4/c1-2-9(13-8-10-7-11-13)3-5-12(4-1)6-9/h7-8H,1-6H2
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n/an/a 12n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50005677
PNG
(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Show SMILES C[N+](C)(C)CC#CCN1CCCC1=O
Show InChI InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
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n/an/a 13n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229672
PNG
(CHEMBL309729)
Show SMILES Nc1ncn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C9H15N5/c10-8-11-7-14(12-8)9-2-1-4-13(6-9)5-3-9/h7H,1-6H2,(H2,10,12)
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n/an/a 13n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229621
PNG
(CHEMBL311036)
Show SMILES Cn1ncc(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C10H16N4/c1-13-11-7-9(12-13)10-3-2-5-14(8-10)6-4-10/h7H,2-6,8H2,1H3
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n/an/a 14n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229693
PNG
(CHEMBL312434)
Show SMILES Clc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H11ClN4/c9-8-10-5-13(11-8)7-4-12-2-1-6(7)3-12/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229673
PNG
(CHEMBL311703)
Show SMILES Cc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C9H15N5/c1-8-10-12-14(11-8)9-3-2-5-13(7-9)6-4-9/h2-7H2,1H3
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n/an/a 14n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229683
PNG
(CHEMBL79020)
Show SMILES Cn1ncc(n1)[C@@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C9H14N4/c1-12-10-4-9(11-12)8-6-13-3-2-7(8)5-13/h4,7-8H,2-3,5-6H2,1H3/t7-,8+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50004665
PNG
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Show SMILES O=C1CCCN1CC#CCN1CCCC1
Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
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n/an/a 17n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229698
PNG
(CHEMBL81492)
Show SMILES Cc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C9H14N4/c1-7-10-6-13(11-7)9-5-12-3-2-8(9)4-12/h6,8-9H,2-5H2,1H3/t8-,9-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229686
PNG
(CHEMBL311989)
Show SMILES Nc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H13N5/c9-8-10-5-13(11-8)7-4-12-2-1-6(7)3-12/h5-7H,1-4H2,(H2,9,11)/t6-,7-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229619
PNG
(CHEMBL442975)
Show SMILES C1CC2(CN1CCC2)n1ncnn1
Show InChI InChI=1S/C8H13N5/c1-2-8(13-10-7-9-11-13)3-5-12(4-1)6-8/h7H,1-6H2
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n/an/a 19n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229680
PNG
(CHEMBL312656)
Show SMILES Brc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C8H12BrN5/c9-8-10-12-14(11-8)7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2
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n/an/a 20n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229614
PNG
(CHEMBL78964)
Show SMILES Clc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C8H12ClN5/c9-8-10-12-14(11-8)7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2
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n/an/a 27n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229615
PNG
(CHEMBL81314)
Show SMILES C1C[N@@]2C[C@H]1[C@H](C2)n1ncnn1
Show InChI InChI=1S/C7H11N5/c1-2-11-3-6(1)7(4-11)12-9-5-8-10-12/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229691
PNG
(CHEMBL23118)
Show SMILES Cc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C9H15N5/c1-7-10-12-14(11-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 31n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229687
PNG
(CHEMBL308343)
Show SMILES Brc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H11BrN4/c9-8-10-5-13(11-8)7-4-12-2-1-6(7)3-12/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229682
PNG
(CHEMBL79374)
Show SMILES Cn1ncc(n1)[C@@]12CC[N@@](CC1)C2
Show InChI InChI=1S/C9H14N4/c1-12-10-6-8(11-12)9-2-4-13(7-9)5-3-9/h6H,2-5,7H2,1H3
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n/an/a 35n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229690
PNG
(CHEMBL311297)
Show SMILES Nc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C8H14N6/c9-8-10-12-14(11-8)7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2,(H2,9,11)
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n/an/a 38n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229674
PNG
(CHEMBL81968)
Show SMILES Ic1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C8H12IN5/c9-8-10-12-14(11-8)7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2
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n/an/a 43n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229697
PNG
(CHEMBL23721)
Show SMILES Cn1ncc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-13-11-6-10(12-13)9-7-14-4-2-8(9)3-5-14/h6,8-9H,2-5,7H2,1H3
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n/an/a 48n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229620
PNG
(CHEMBL421332)
Show SMILES Ic1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C7H10IN5/c8-7-9-11-13(10-7)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2/t5-,6-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229618
PNG
(CHEMBL23335)
Show SMILES Cc1ncn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-8-11-7-14(12-8)10-6-13-4-2-9(10)3-5-13/h7,9-10H,2-6H2,1H3
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n/an/a 75n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229689
PNG
(CHEMBL309498)
Show SMILES C1C[N@@]2C[C@H]1[C@H](C2)n1cncn1
Show InChI InChI=1S/C8H12N4/c1-2-11-3-7(1)8(4-11)12-6-9-5-10-12/h5-8H,1-4H2/t7-,8-/m0/s1
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n/an/a 79n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229671
PNG
(CHEMBL311008)
Show SMILES C1C[C@@]2(CC[N@]1C2)n1cncn1
Show InChI InChI=1S/C8H12N4/c1-3-11-4-2-8(1,5-11)12-7-9-6-10-12/h6-7H,1-5H2
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n/an/a 79n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229679
PNG
(CHEMBL280219)
Show SMILES Cc1ncn(n1)[C@@]12CC[N@@](CC1)C2
Show InChI InChI=1S/C9H14N4/c1-8-10-7-13(11-8)9-2-4-12(6-9)5-3-9/h7H,2-6H2,1H3
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n/an/a 86n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229695
PNG
(CHEMBL309281)
Show SMILES Cn1nnc(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C9H15N5/c1-13-11-8(10-12-13)9-3-2-5-14(7-9)6-4-9/h2-7H2,1H3
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n/an/a 100n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM46858
PNG
(1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid...)
Show SMILES COC(=O)C1=CCCN(C)C1
Show InChI InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
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n/an/a 115n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229688
PNG
(CHEMBL276975)
Show SMILES Cn1nnc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C9H15N5/c1-13-11-9(10-12-13)8-6-14-4-2-7(8)3-5-14/h7-8H,2-6H2,1H3
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n/an/a 143n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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n/an/a 213n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229674
PNG
(CHEMBL81968)
Show SMILES Ic1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C8H12IN5/c9-8-10-12-14(11-8)7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2
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n/an/a 216n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229667
PNG
(CHEMBL23563)
Show SMILES C1CN2CCC1C(C2)n1ncnn1
Show InChI InChI=1S/C8H13N5/c1-3-12-4-2-7(1)8(5-12)13-10-6-9-11-13/h6-8H,1-5H2
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n/an/a 242n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229622
PNG
(CHEMBL311246)
Show SMILES Cn1nnc(n1)[C@@]12CC[N@@](CC1)C2
Show InChI InChI=1S/C8H13N5/c1-12-10-7(9-11-12)8-2-4-13(6-8)5-3-8/h2-6H2,1H3
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n/an/a 250n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229685
PNG
(CHEMBL311212)
Show SMILES Brc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C8H12BrN5/c9-7-10-12-14(11-7)8-2-1-4-13(6-8)5-3-8/h1-6H2
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n/an/a 279n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229677
PNG
(CHEMBL79265)
Show SMILES Cn1nnc(n1)[C@@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H13N5/c1-12-10-8(9-11-12)7-5-13-3-2-6(7)4-13/h6-7H,2-5H2,1H3/t6-,7+/m0/s1
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n/an/a 325n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229684
PNG
(CHEMBL78615)
Show SMILES Clc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C8H12ClN5/c9-7-10-12-14(11-7)8-2-1-4-13(6-8)5-3-8/h1-6H2
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n/an/a 332n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229620
PNG
(CHEMBL421332)
Show SMILES Ic1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C7H10IN5/c8-7-9-11-13(10-7)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2/t5-,6-/m0/s1
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n/an/a 372n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229680
PNG
(CHEMBL312656)
Show SMILES Brc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C8H12BrN5/c9-8-10-12-14(11-8)7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2
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n/an/a 488n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229614
PNG
(CHEMBL78964)
Show SMILES Clc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C8H12ClN5/c9-8-10-12-14(11-8)7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2
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n/an/a 578n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229694
PNG
(CHEMBL81481)
Show SMILES Clc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C7H10ClN5/c8-7-9-11-13(10-7)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2/t5-,6-/m0/s1
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n/an/a 630n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229696
PNG
(CHEMBL419659)
Show SMILES Brc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C7H10BrN5/c8-7-9-11-13(10-7)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2/t5-,6-/m0/s1
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n/an/a 822n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229616
PNG
(CHEMBL82188)
Show SMILES [N-]=[N+]=Nc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H11N7/c9-13-11-8-10-5-15(12-8)7-4-14-2-1-6(7)3-14/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 1.02E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229693
PNG
(CHEMBL312434)
Show SMILES Clc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H11ClN4/c9-8-10-5-13(11-8)7-4-12-2-1-6(7)3-12/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 1.29E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortexMuscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229668
PNG
(CHEMBL80917)
Show SMILES N#Cc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C9H12N6/c10-5-9-11-13-15(12-9)8-6-14-3-1-7(8)2-4-14/h7-8H,1-4,6H2
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n/an/a 1.40E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229617
PNG
(CHEMBL311799)
Show SMILES Cc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H13N5/c1-6-9-11-13(10-6)8-5-12-3-2-7(8)4-12/h7-8H,2-5H2,1H3/t7-,8-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229673
PNG
(CHEMBL311703)
Show SMILES Cc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C9H15N5/c1-8-10-12-14(11-8)9-3-2-5-13(7-9)6-4-9/h2-7H2,1H3
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n/an/a 1.93E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229692
PNG
(CHEMBL311562)
Show SMILES Cc1ncn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C10H16N4/c1-9-11-8-14(12-9)10-3-2-5-13(7-10)6-4-10/h8H,2-7H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229678
PNG
(CHEMBL80723)
Show SMILES Nc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C8H14N6/c9-7-10-12-14(11-7)8-2-1-4-13(6-8)5-3-8/h1-6H2,(H2,9,11)
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n/an/a 2.67E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229681
PNG
(CHEMBL79040)
Show SMILES Cn1ncc(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C9H14N4/c1-12-10-4-9(11-12)8-6-13-3-2-7(8)5-13/h4,7-8H,2-3,5-6H2,1H3/t7-,8-/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229691
PNG
(CHEMBL23118)
Show SMILES Cc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C9H15N5/c1-7-10-12-14(11-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229623
PNG
(CHEMBL81281)
Show SMILES Cn1nnc(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H13N5/c1-12-10-8(9-11-12)7-5-13-3-2-6(7)4-13/h6-7H,2-5H2,1H3/t6-,7-/m0/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229687
PNG
(CHEMBL308343)
Show SMILES Brc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H11BrN4/c9-8-10-5-13(11-8)7-4-12-2-1-6(7)3-12/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 3.04E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229621
PNG
(CHEMBL311036)
Show SMILES Cn1ncc(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C10H16N4/c1-13-11-7-9(12-13)10-3-2-5-14(8-10)6-4-10/h7H,2-6,8H2,1H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50004665
PNG
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Show SMILES O=C1CCCN1CC#CCN1CCCC1
Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
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n/an/a 3.30E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229686
PNG
(CHEMBL311989)
Show SMILES Nc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H13N5/c9-8-10-5-13(11-8)7-4-12-2-1-6(7)3-12/h5-7H,1-4H2,(H2,9,11)/t6-,7-/m0/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229675
PNG
(CHEMBL309638)
Show SMILES C1CC2(CN1CCC2)n1cncn1
Show InChI InChI=1S/C9H14N4/c1-2-9(13-8-10-7-11-13)3-5-12(4-1)6-9/h7-8H,1-6H2
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n/an/a 3.60E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229672
PNG
(CHEMBL309729)
Show SMILES Nc1ncn(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C9H15N5/c10-8-11-7-14(12-8)9-2-1-4-13(6-9)5-3-9/h7H,1-6H2,(H2,10,12)
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n/an/a 3.90E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229670
PNG
(CHEMBL78820)
Show SMILES [O-][N+](=O)c1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H11N5O2/c14-13(15)8-9-5-12(10-8)7-4-11-2-1-6(7)3-11/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 4.10E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229698
PNG
(CHEMBL81492)
Show SMILES Cc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C9H14N4/c1-7-10-6-13(11-7)9-5-12-3-2-8(9)4-12/h6,8-9H,2-5H2,1H3/t8-,9-/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229676
PNG
(CHEMBL78697)
Show SMILES Nc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C7H12N6/c8-7-9-11-13(10-7)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2,(H2,8,10)/t5-,6-/m0/s1
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n/an/a 4.36E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229690
PNG
(CHEMBL311297)
Show SMILES Nc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C8H14N6/c9-8-10-12-14(11-8)7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2,(H2,9,11)
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n/an/a 4.40E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229618
PNG
(CHEMBL23335)
Show SMILES Cc1ncn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-8-11-7-14(12-8)10-6-13-4-2-9(10)3-5-13/h7,9-10H,2-6H2,1H3
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n/an/a 4.50E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229697
PNG
(CHEMBL23721)
Show SMILES Cn1ncc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-13-11-6-10(12-13)9-7-14-4-2-8(9)3-5-14/h6,8-9H,2-5,7H2,1H3
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n/an/a 4.52E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229688
PNG
(CHEMBL276975)
Show SMILES Cn1nnc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C9H15N5/c1-13-11-9(10-12-13)8-6-14-4-2-7(8)3-5-14/h7-8H,2-6H2,1H3
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n/an/a 5.10E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229668
PNG
(CHEMBL80917)
Show SMILES N#Cc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C9H12N6/c10-5-9-11-13-15(12-9)8-6-14-3-1-7(8)2-4-14/h7-8H,1-4,6H2
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n/an/a 5.20E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229695
PNG
(CHEMBL309281)
Show SMILES Cn1nnc(n1)C12CCN(C1)CCC2
Show InChI InChI=1S/C9H15N5/c1-13-11-8(10-12-13)9-3-2-5-14(7-9)6-4-9/h2-7H2,1H3
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n/an/a 5.70E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229619
PNG
(CHEMBL442975)
Show SMILES C1CC2(CN1CCC2)n1ncnn1
Show InChI InChI=1S/C8H13N5/c1-2-8(13-10-7-9-11-13)3-5-12(4-1)6-8/h7H,1-6H2
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n/an/a 7.20E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229683
PNG
(CHEMBL79020)
Show SMILES Cn1ncc(n1)[C@@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C9H14N4/c1-12-10-4-9(11-12)8-6-13-3-2-7(8)5-13/h4,7-8H,2-3,5-6H2,1H3/t7-,8+/m0/s1
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n/an/a 1.35E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229615
PNG
(CHEMBL81314)
Show SMILES C1C[N@@]2C[C@H]1[C@H](C2)n1ncnn1
Show InChI InChI=1S/C7H11N5/c1-2-11-3-6(1)7(4-11)12-9-5-8-10-12/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 1.43E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229682
PNG
(CHEMBL79374)
Show SMILES Cn1ncc(n1)[C@@]12CC[N@@](CC1)C2
Show InChI InChI=1S/C9H14N4/c1-12-10-6-8(11-12)9-2-4-13(7-9)5-3-9/h6H,2-5,7H2,1H3
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n/an/a 1.44E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229679
PNG
(CHEMBL280219)
Show SMILES Cc1ncn(n1)[C@@]12CC[N@@](CC1)C2
Show InChI InChI=1S/C9H14N4/c1-8-10-7-13(11-8)9-2-4-12(6-9)5-3-9/h7H,2-6H2,1H3
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n/an/a 1.49E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229667
PNG
(CHEMBL23563)
Show SMILES C1CN2CCC1C(C2)n1ncnn1
Show InChI InChI=1S/C8H13N5/c1-3-12-4-2-7(1)8(5-12)13-10-6-9-11-13/h6-8H,1-5H2
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n/an/a 1.59E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50005677
PNG
(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Show SMILES C[N+](C)(C)CC#CCN1CCCC1=O
Show InChI InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
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n/an/a 2.30E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM10759
PNG
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Show SMILES CC(=O)OCC[N+](C)(C)C
Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
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n/an/a 2.40E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM46858
PNG
(1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid...)
Show SMILES COC(=O)C1=CCCN(C)C1
Show InChI InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
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n/an/a 2.54E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229616
PNG
(CHEMBL82188)
Show SMILES [N-]=[N+]=Nc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H11N7/c9-13-11-8-10-5-15(12-8)7-4-14-2-1-6(7)3-14/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 2.62E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229677
PNG
(CHEMBL79265)
Show SMILES Cn1nnc(n1)[C@@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H13N5/c1-12-10-8(9-11-12)7-5-13-3-2-6(7)4-13/h6-7H,2-5H2,1H3/t6-,7+/m0/s1
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n/an/a 3.06E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229670
PNG
(CHEMBL78820)
Show SMILES [O-][N+](=O)c1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H11N5O2/c14-13(15)8-9-5-12(10-8)7-4-11-2-1-6(7)3-11/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 3.56E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229689
PNG
(CHEMBL309498)
Show SMILES C1C[N@@]2C[C@H]1[C@H](C2)n1cncn1
Show InChI InChI=1S/C8H12N4/c1-2-11-3-7(1)8(4-11)12-6-9-5-10-12/h5-8H,1-4H2/t7-,8-/m0/s1
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n/an/a 3.82E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229671
PNG
(CHEMBL311008)
Show SMILES C1C[C@@]2(CC[N@]1C2)n1cncn1
Show InChI InChI=1S/C8H12N4/c1-3-11-4-2-8(1,5-11)12-7-9-6-10-12/h6-7H,1-5H2
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n/an/a 3.99E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229622
PNG
(CHEMBL311246)
Show SMILES Cn1nnc(n1)[C@@]12CC[N@@](CC1)C2
Show InChI InChI=1S/C8H13N5/c1-12-10-7(9-11-12)8-2-4-13(6-8)5-3-8/h2-6H2,1H3
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n/an/a 4.67E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%