BindingDB logo
myBDB logout

PubMed code 16198559

Compile data set for download or QSAR
Found 17 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50174677
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(CCc4ccc5OCCc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C24H27NO7/c26-12-19-21(27)22(28)23(29)24(32-19)31-18-3-1-2-16-20(18)15(11-25-16)6-4-13-5-7-17-14(10-13)8-9-30-17/h1-3,5,7,10-11,19,21-29H,4,6,8-9,12H2/t19-,21-,22+,23-,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50174680
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3ncn(CCc4ccc5OCCc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C23H26N2O7/c26-11-18-20(27)21(28)22(29)23(32-18)31-17-3-1-2-15-19(17)25(12-24-15)8-6-13-4-5-16-14(10-13)7-9-30-16/h1-5,10,12,18,20-23,26-29H,6-9,11H2/t18-,20-,21+,22-,23-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 39n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50174679
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES Cn1cc(CCc2ccc3OCCc3c2)c2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cccc12
Show InChI InChI=1S/C25H29NO7/c1-26-12-16(7-5-14-6-8-18-15(11-14)9-10-31-18)21-17(26)3-2-4-19(21)32-25-24(30)23(29)22(28)20(13-27)33-25/h2-4,6,8,11-12,20,22-25,27-30H,5,7,9-10,13H2,1H3/t20-,22-,23+,24-,25-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 67n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 139n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT1 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50174677
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(CCc4ccc5OCCc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C24H27NO7/c26-12-19-21(27)22(28)23(29)24(32-19)31-18-3-1-2-16-20(18)15(11-25-16)6-4-13-5-7-17-14(10-13)8-9-30-17/h1-3,5,7,10-11,19,21-29H,4,6,8-9,12H2/t19-,21-,22+,23-,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 145n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT1 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50174682
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-methoxyphenethyl)-1H-indo...)
Show SMILES COc1ccc(CCc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C23H27NO7/c1-29-15-9-6-13(7-10-15)5-8-14-11-24-16-3-2-4-17(19(14)16)30-23-22(28)21(27)20(26)18(12-25)31-23/h2-4,6-7,9-11,18,20-28H,5,8,12H2,1H3/t18-,20-,21+,22-,23-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 163n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50174679
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES Cn1cc(CCc2ccc3OCCc3c2)c2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cccc12
Show InChI InChI=1S/C25H29NO7/c1-26-12-16(7-5-14-6-8-18-15(11-14)9-10-31-18)21-17(26)3-2-4-19(21)32-25-24(30)23(29)22(28)20(13-27)33-25/h2-4,6,8,11-12,20,22-25,27-30H,5,7,9-10,13H2,1H3/t20-,22-,23+,24-,25-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 198n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT1 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50174684
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-methoxyphenethyl)-3H-benz...)
Show SMILES COc1ccc(CCn2nnc3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C21H25N3O7/c1-29-13-7-5-12(6-8-13)9-10-24-17-14(22-23-24)3-2-4-15(17)30-21-20(28)19(27)18(26)16(11-25)31-21/h2-8,16,18-21,25-28H,9-11H2,1H3/t16-,18-,19+,20-,21-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 380n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50174678
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-methoxyphenethyl)-6-methy...)
Show SMILES COc1ccc(CCc2c[nH]c3cc(C)cc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C24H29NO7/c1-13-9-17-20(15(11-25-17)6-3-14-4-7-16(30-2)8-5-14)18(10-13)31-24-23(29)22(28)21(27)19(12-26)32-24/h4-5,7-11,19,21-29H,3,6,12H2,1-2H3/t19-,21-,22+,23-,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 394n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50174681
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES Cc1cc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2c(CCc3ccc4OCCc4c3)n[nH]c2c1
Show InChI InChI=1S/C24H28N2O7/c1-12-8-16-20(18(9-12)32-24-23(30)22(29)21(28)19(11-27)33-24)15(25-26-16)4-2-13-3-5-17-14(10-13)6-7-31-17/h3,5,8-10,19,21-24,27-30H,2,4,6-7,11H2,1H3,(H,25,26)/t19-,21-,22+,23-,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 458n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50174675
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(benzofuran-5-yl)ethyl)-6...)
Show SMILES Cc1cc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2c(CCc3ccc4occc4c3)n[nH]c2c1
Show InChI InChI=1S/C24H26N2O7/c1-12-8-16-20(18(9-12)32-24-23(30)22(29)21(28)19(11-27)33-24)15(25-26-16)4-2-13-3-5-17-14(10-13)6-7-31-17/h3,5-10,19,21-24,27-30H,2,4,11H2,1H3,(H,25,26)/t19-,21-,22+,23-,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 491n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50174676
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES CCc1cc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2c(CCc3ccc4OCCc4c3)n[nH]c2c1
Show InChI InChI=1S/C25H30N2O7/c1-2-13-10-17-21(19(11-13)33-25-24(31)23(30)22(29)20(12-28)34-25)16(26-27-17)5-3-14-4-6-18-15(9-14)7-8-32-18/h4,6,9-11,20,22-25,28-31H,2-3,5,7-8,12H2,1H3,(H,26,27)/t20-,22-,23+,24-,25-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 532n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50174682
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-methoxyphenethyl)-1H-indo...)
Show SMILES COc1ccc(CCc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C23H27NO7/c1-29-15-9-6-13(7-10-15)5-8-14-11-24-16-3-2-4-17(19(14)16)30-23-22(28)21(27)20(26)18(12-25)31-23/h2-4,6-7,9-11,18,20-28H,5,8,12H2,1H3/t18-,20-,21+,22-,23-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 611n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT1 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50174680
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3ncn(CCc4ccc5OCCc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C23H26N2O7/c26-11-18-20(27)21(28)22(29)23(32-18)31-17-3-1-2-15-19(17)25(12-24-15)8-6-13-4-5-16-14(10-13)7-9-30-16/h1-5,10,12,18,20-23,26-29H,6-9,11H2/t18-,20-,21+,22-,23-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 718n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT1 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50174683
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES Cc1cc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2c(CCc3ccc4OCCc4c3)nn(C)c2c1
Show InChI InChI=1S/C25H30N2O7/c1-13-9-17-21(19(10-13)33-25-24(31)23(30)22(29)20(12-28)34-25)16(26-27(17)2)5-3-14-4-6-18-15(11-14)7-8-32-18/h4,6,9-11,20,22-25,28-31H,3,5,7-8,12H2,1-2H3/t20-,22-,23+,24-,25-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 754n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50174678
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-methoxyphenethyl)-6-methy...)
Show SMILES COc1ccc(CCc2c[nH]c3cc(C)cc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C24H29NO7/c1-13-9-17-20(15(11-25-17)6-3-14-4-7-16(30-2)8-5-14)18(10-13)31-24-23(29)22(28)21(27)19(12-26)32-24/h4-5,7-11,19,21-29H,3,6,12H2,1-2H3/t19-,21-,22+,23-,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.05E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity towards human SGLT1 expressed in CHO-K1 cells


Bioorg Med Chem Lett 15: 5202-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.067
BindingDB Entry DOI: 10.7270/Q2WW7H66
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%