Compile Data Set for Download or QSAR
maximum 50k data
Found 43 Enz. Inhib. hit(s) with all data for entry = 1926
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataIC50:  73nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15218(Isoquinoline-5-sulfonic acid (2S,4S)-(4-(4-chlorob...)
Affinity DataIC50:  170nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM16222(CCT077373 | N-[2-({2-[(4-chlorobenzyl)oxy]ethyl}am...)
Affinity DataIC50:  170nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15198(Isoquinoline-5-sulfonic acid (2-(2-(3,4-dichlorobe...)
Affinity DataIC50:  210nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM16222(CCT077373 | N-[2-({2-[(4-chlorobenzyl)oxy]ethyl}am...)
Affinity DataIC50:  260nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15220(4-Methylisoquinoline-5-sulfonic acid (2S,4S)-(2-(4...)
Affinity DataIC50:  320nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15196(Isoquinoline-5-sulfonic acid (2-(2-(3-chlorobenzyl...)
Affinity DataIC50:  370nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15216(Isoquinoline-5-sulfonic acid (2S,4R)-(4-(4-chlorob...)
Affinity DataIC50:  400nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15196(Isoquinoline-5-sulfonic acid (2-(2-(3-chlorobenzyl...)
Affinity DataIC50:  410nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15215(Isoquinoline-5-sulfonic acid (2S,4S)-(2-(4-chlorob...)
Affinity DataIC50:  420nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15218(Isoquinoline-5-sulfonic acid (2S,4S)-(4-(4-chlorob...)
Affinity DataIC50:  480nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15221(1-Hydroxyisoquinoline-5-sulfonic acid (2S,4S)-(2-(...)
Affinity DataIC50:  520nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15192(Isoquinoline-5-sulfonic acid (2-(2-(2-methylbenzyl...)
Affinity DataIC50:  570nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataIC50:  590nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15215(Isoquinoline-5-sulfonic acid (2S,4S)-(2-(4-chlorob...)
Affinity DataIC50:  780nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15195(Isoquinoline-5-sulfonic acid (2-(2-(2-chlorobenzyl...)
Affinity DataIC50:  960nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15195(Isoquinoline-5-sulfonic acid (2-(2-(2-chlorobenzyl...)
Affinity DataIC50:  1.00E+3nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15193(Isoquinoline-5-sulfonic acid (2-(2-(3-methylbenzyl...)
Affinity DataIC50:  1.10E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15191(Isoquinoline-5-sulfonic acid (2-(2-benzyloxyethyla...)
Affinity DataIC50:  1.17E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15221(1-Hydroxyisoquinoline-5-sulfonic acid (2S,4S)-(2-(...)
Affinity DataIC50:  1.30E+3nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15194(Isoquinoline-5-sulfonic acid (2-(2-(4-methylbenzyl...)
Affinity DataIC50:  1.53E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15216(Isoquinoline-5-sulfonic acid (2S,4R)-(4-(4-chlorob...)
Affinity DataIC50:  1.70E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15219(Isoquinoline-5-sulfonic acid (2R*,5S*)-(5-(4-chlor...)
Affinity DataIC50:  1.70E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15200(Isoquinoline-5-sulfonic acid (2-(2-(3-methoxybenzy...)
Affinity DataIC50:  2.20E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15220(4-Methylisoquinoline-5-sulfonic acid (2S,4S)-(2-(4...)
Affinity DataIC50:  2.60E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15201(N-[2-({2-[(4-methoxyphenyl)methoxy]ethyl}amino)eth...)
Affinity DataIC50:  2.90E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15217(Isoquinoline-5-sulfonic acid (2S,4S)-(4-(benzyloxy...)
Affinity DataIC50:  3.40E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15204(Isoquinoline-5-sulfonic acid piperidin-4-ylamide |...)
Affinity DataIC50:  3.90E+3nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15208(Isoquinoline-5-sulfonic acid pyrrolidin-3-ylamide ...)
Affinity DataIC50:  3.90E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15202(N-(3-aminopropyl)isoquinoline-5-sulfonamide | isoq...)
Affinity DataIC50:  4.80E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15214(Isoquinoline-5-sulfonic acid (2S,4R)-[2-(4-chlorob...)
Affinity DataIC50:  5.20E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15210(CHEMBL148333 | H-8 | Lopac-M-9656 | N-(2-methylami...)
Affinity DataIC50:  5.30E+3nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15207(Isoquinoline-5-sulfonic acid trans-(4-aminocyclohe...)
Affinity DataIC50:  5.70E+3nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15199(Isoquinoline-5-sulfonic acid (2-(2-(2-methoxybenzy...)
Affinity DataIC50:  6.60E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15212(Isoquinoline-5-sulfonic acid trans-(4-benzylaminoc...)
Affinity DataIC50:  6.60E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15210(CHEMBL148333 | H-8 | Lopac-M-9656 | N-(2-methylami...)
Affinity DataIC50:  7.60E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15207(Isoquinoline-5-sulfonic acid trans-(4-aminocyclohe...)
Affinity DataIC50:  8.10E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15204(Isoquinoline-5-sulfonic acid piperidin-4-ylamide |...)
Affinity DataIC50:  8.70E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15213(5-[(3-{[(4-chlorophenyl)methoxy]methyl}piperazine-...)
Affinity DataIC50:  1.20E+4nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15203(5-(piperazine-1-sulfonyl)isoquinoline | CHEMBL7577...)
Affinity DataIC50:  2.30E+4nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15205(1-(isoquinoline-5-sulfonyl)piperidin-4-amine | Iso...)
Affinity DataIC50: >3.00E+4nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15209(Isoquinoline-5-sulfonic acid ((2S)-pyrrolidin-2-yl...)
Affinity DataIC50:  3.90E+4nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15206(Isoquinoline-5-sulfonic acid (piperidin-4-ylmethyl...)
Affinity DataIC50:  5.70E+4nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed