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PubMed code 16302817

Compile data set for download or QSAR
Found 83 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dynamin-1


(Homo sapiens)
BDBM50177937
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4,5-trihydroxyphenyl)ac...)
Show SMILES Oc1cc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C23H20N4O8/c24-10-14(4-12-6-16(28)20(32)17(29)7-12)22(34)26-2-1-3-27-23(35)15(11-25)5-13-8-18(30)21(33)19(31)9-13/h4-9,28-33H,1-3H2,(H,26,34)(H,27,35)/b14-4+,15-5+
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n/an/a 1.70E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177941
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4,5-trihydroxyphenyl)ac...)
Show SMILES Oc1cc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C22H18N4O8/c23-9-13(3-11-5-15(27)19(31)16(28)6-11)21(33)25-1-2-26-22(34)14(10-24)4-12-7-17(29)20(32)18(30)8-12/h3-8,27-32H,1-2H2,(H,25,33)(H,26,34)/b13-3+,14-4+
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n/an/a 1.70E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177923
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4,5-trihydroxyphenyl)ac...)
Show SMILES Oc1cc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C25H24N4O8/c26-12-16(6-14-8-18(30)22(34)19(31)9-14)24(36)28-4-2-1-3-5-29-25(37)17(13-27)7-15-10-20(32)23(35)21(33)11-15/h6-11,30-35H,1-5H2,(H,28,36)(H,29,37)/b16-6+,17-7+
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n/an/a 1.70E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM5149
PNG
((2E)-2-cyano-N-{3-[(2E)-2-cyano-3-(3,4-dihydroxyph...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C23H20N4O6/c24-12-16(8-14-2-4-18(28)20(30)10-14)22(32)26-6-1-7-27-23(33)17(13-25)9-15-3-5-19(29)21(31)11-15/h2-5,8-11,28-31H,1,6-7H2,(H,26,32)(H,27,33)/b16-8+,17-9+
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n/an/a 1.70E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM5152
PNG
((2E)-2-cyano-N-{4-[(2E)-2-cyano-3-(3,4,5-trihydrox...)
Show SMILES Oc1cc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C24H22N4O8/c25-11-15(5-13-7-17(29)21(33)18(30)8-13)23(35)27-3-1-2-4-28-24(36)16(12-26)6-14-9-19(31)22(34)20(32)10-14/h5-10,29-34H,1-4H2,(H,27,35)(H,28,36)/b15-5+,16-6+
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n/an/a 2.10E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM5151
PNG
((2E)-2-cyano-N-{4-[(2E)-2-cyano-3-(3,4-dihydroxyph...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C24H22N4O6/c25-13-17(9-15-3-5-19(29)21(31)11-15)23(33)27-7-1-2-8-28-24(34)18(14-26)10-16-4-6-20(30)22(32)12-16/h3-6,9-12,29-32H,1-2,7-8H2,(H,27,33)(H,28,34)/b17-9+,18-10+
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n/an/a 3.20E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177943
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxy-5-methoxyph...)
Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C25H24N4O8/c1-36-20-10-14(8-18(30)22(20)32)6-16(12-26)24(34)28-4-3-5-29-25(35)17(13-27)7-15-9-19(31)23(33)21(11-15)37-2/h6-11,30-33H,3-5H2,1-2H3,(H,28,34)(H,29,35)/b16-6+,17-7+
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n/an/a 5.00E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM5153
PNG
((2E)-2-cyano-N-{5-[(2E)-2-cyano-3-(3,4-dihydroxyph...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C25H24N4O6/c26-14-18(10-16-4-6-20(30)22(32)12-16)24(34)28-8-2-1-3-9-29-25(35)19(15-27)11-17-5-7-21(31)23(33)13-17/h4-7,10-13,30-33H,1-3,8-9H2,(H,28,34)(H,29,35)/b18-10+,19-11+
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n/an/a 5.00E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177940
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxyphenyl)acryl...)
Show SMILES OC(CNC(=O)C(=C\c1ccc(O)c(O)c1)\C#N)CNC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C23H20N4O7/c24-9-15(5-13-1-3-18(29)20(31)7-13)22(33)26-11-17(28)12-27-23(34)16(10-25)6-14-2-4-19(30)21(32)8-14/h1-8,17,28-32H,11-12H2,(H,26,33)(H,27,34)/b15-5+,16-6+
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n/an/a 5.10E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM5150
PNG
((2E)-2-cyano-N-{2-[(2E)-2-cyano-3-(3,4-dihydroxyph...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C22H18N4O6/c23-11-15(7-13-1-3-17(27)19(29)9-13)21(31)25-5-6-26-22(32)16(12-24)8-14-2-4-18(28)20(30)10-14/h1-4,7-10,27-30H,5-6H2,(H,25,31)(H,26,32)/b15-7+,16-8+
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n/an/a 5.10E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177965
PNG
(2-cyano-N-{3-[-2-cyano-3-(3,4,5-trihydroxyphenyl)a...)
Show SMILES Oc1cc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C26H26N4O8/c27-13-17(7-15-9-19(31)23(35)20(32)10-15)25(37)29-5-3-1-2-4-6-30-26(38)18(14-28)8-16-11-21(33)24(36)22(34)12-16/h7-12,31-36H,1-6H2,(H,29,37)(H,30,38)/b17-7+,18-8+
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n/an/a 6.00E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177944
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxy-5-methoxyph...)
Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C27H28N4O8/c1-38-22-12-16(10-20(32)24(22)34)8-18(14-28)26(36)30-6-4-3-5-7-31-27(37)19(15-29)9-17-11-21(33)25(35)23(13-17)39-2/h8-13,32-35H,3-7H2,1-2H3,(H,30,36)(H,31,37)/b18-8+,19-9+
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n/an/a 8.00E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177973
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxy-5-methoxyph...)
Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C26H26N4O8/c1-37-21-11-15(9-19(31)23(21)33)7-17(13-27)25(35)29-5-3-4-6-30-26(36)18(14-28)8-16-10-20(32)24(34)22(12-16)38-2/h7-12,31-34H,3-6H2,1-2H3,(H,29,35)(H,30,36)/b17-7+,18-8+
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n/an/a 8.00E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177955
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxy-5-methoxyph...)
Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C24H22N4O8/c1-35-19-9-13(7-17(29)21(19)31)5-15(11-25)23(33)27-3-4-28-24(34)16(12-26)6-14-8-18(30)22(32)20(10-14)36-2/h5-10,29-32H,3-4H2,1-2H3,(H,27,33)(H,28,34)/b15-5+,16-6+
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n/an/a 9.00E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM5154
PNG
((2E)-2-cyano-N-{6-[(2E)-2-cyano-3-(3,4-dihydroxyph...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C26H26N4O6/c27-15-19(11-17-5-7-21(31)23(33)13-17)25(35)29-9-3-1-2-4-10-30-26(36)20(16-28)12-18-6-8-22(32)24(34)14-18/h5-8,11-14,31-34H,1-4,9-10H2,(H,29,35)(H,30,36)/b19-11+,20-12+
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n/an/a 2.60E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177950
PNG
(2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-c...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCCOC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C23H18N2O8/c24-12-16(8-14-2-4-18(26)20(28)10-14)22(30)32-6-1-7-33-23(31)17(13-25)9-15-3-5-19(27)21(29)11-15/h2-5,8-11,26-29H,1,6-7H2/b16-8+,17-9+
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n/an/a 3.80E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177970
PNG
(2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-c...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCOC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C22H16N2O8/c23-11-15(7-13-1-3-17(25)19(27)9-13)21(29)31-5-6-32-22(30)16(12-24)8-14-2-4-18(26)20(28)10-14/h1-4,7-10,25-28H,5-6H2/b15-7+,16-8+
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n/an/a 4.20E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177915
PNG
(2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-c...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCCCOC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C24H20N2O8/c25-13-17(9-15-3-5-19(27)21(29)11-15)23(31)33-7-1-2-8-34-24(32)18(14-26)10-16-4-6-20(28)22(30)12-16/h3-6,9-12,27-30H,1-2,7-8H2/b17-9+,18-10+
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n/an/a 6.10E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM4363
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)
Show SMILES NC(=S)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
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n/an/a 7.00E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177930
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxy-5-methoxyph...)
Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C28H30N4O8/c1-39-23-13-17(11-21(33)25(23)35)9-19(15-29)27(37)31-7-5-3-4-6-8-32-28(38)20(16-30)10-18-12-22(34)26(36)24(14-18)40-2/h9-14,33-36H,3-8H2,1-2H3,(H,31,37)(H,32,38)/b19-9+,20-10+
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n/an/a 8.00E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM5156
PNG
((2E)-2-cyano-N-[(3-{[(2E)-2-cyano-3-(3,4-dihydroxy...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCc2cccc(CNC(=O)C(=C\c3ccc(O)c(O)c3)\C#N)c2)cc1O
Show InChI InChI=1S/C28H22N4O6/c29-13-21(9-17-4-6-23(33)25(35)11-17)27(37)31-15-19-2-1-3-20(8-19)16-32-28(38)22(14-30)10-18-5-7-24(34)26(36)12-18/h1-12,33-36H,15-16H2,(H,31,37)(H,32,38)/b21-9+,22-10+
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n/an/a 8.40E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177951
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxyphenyl)acryl...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)N[C@H]2CCCC[C@@H]2NC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C26H24N4O6/c27-13-17(9-15-5-7-21(31)23(33)11-15)25(35)29-19-3-1-2-4-20(19)30-26(36)18(14-28)10-16-6-8-22(32)24(34)12-16/h5-12,19-20,31-34H,1-4H2,(H,29,35)(H,30,36)/b17-9+,18-10+/t19-,20-/m0/s1
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n/an/a 9.50E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177910
PNG
(2-cyano-N-{3-[2-cyano-3-(3-hydroxy-4-methoxyphenyl...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(OC)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C25H24N4O6/c1-34-22-6-4-16(12-20(22)30)10-18(14-26)24(32)28-8-3-9-29-25(33)19(15-27)11-17-5-7-23(35-2)21(31)13-17/h4-7,10-13,30-31H,3,8-9H2,1-2H3,(H,28,32)(H,29,33)/b18-10+,19-11+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177927
PNG
(2-cyano-N-{4-[2-cyano-3-(4-hydroxyphenyl)acryloyla...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2ccc(O)cc2)\C#N)cc1
Show InChI InChI=1S/C24H22N4O4/c25-15-19(13-17-3-7-21(29)8-4-17)23(31)27-11-1-2-12-28-24(32)20(16-26)14-18-5-9-22(30)10-6-18/h3-10,13-14,29-30H,1-2,11-12H2,(H,27,31)(H,28,32)/b19-13+,20-14+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177928
PNG
(2-cyano-N-{2-[2-cyano-3-(4-hydroxyphenyl)acryloyla...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2ccc(O)cc2)\C#N)cc1
Show InChI InChI=1S/C22H18N4O4/c23-13-17(11-15-1-5-19(27)6-2-15)21(29)25-9-10-26-22(30)18(14-24)12-16-3-7-20(28)8-4-16/h1-8,11-12,27-28H,9-10H2,(H,25,29)(H,26,30)/b17-11+,18-12+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177935
PNG
(2-cyano-N-{5-[2-cyano-3-(4-carboxyphenyl)acryloyla...)
Show SMILES OC(=O)c1ccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2ccc(cc2)C(O)=O)\C#N)cc1
Show InChI InChI=1S/C27H24N4O6/c28-16-22(14-18-4-8-20(9-5-18)26(34)35)24(32)30-12-2-1-3-13-31-25(33)23(17-29)15-19-6-10-21(11-7-19)27(36)37/h4-11,14-15H,1-3,12-13H2,(H,30,32)(H,31,33)(H,34,35)(H,36,37)/b22-14+,23-15+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177932
PNG
(2-cyano-N-{14-[2-cyano-3-(3,4-dihydroxy-5-methoxyp...)
Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCCCCCCCCCCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C34H42N4O8/c1-45-29-19-23(17-27(39)31(29)41)15-25(21-35)33(43)37-13-11-9-7-5-3-4-6-8-10-12-14-38-34(44)26(22-36)16-24-18-28(40)32(42)30(20-24)46-2/h15-20,39-42H,3-14H2,1-2H3,(H,37,43)(H,38,44)/b25-15+,26-16+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177933
PNG
(2-cyano-N-{5-[2-cyano-3-(3-hydroxyphenyl)acryloyla...)
Show SMILES Oc1cccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2cccc(O)c2)\C#N)c1
Show InChI InChI=1S/C25H24N4O4/c26-16-20(12-18-6-4-8-22(30)14-18)24(32)28-10-2-1-3-11-29-25(33)21(17-27)13-19-7-5-9-23(31)15-19/h4-9,12-15,30-31H,1-3,10-11H2,(H,28,32)(H,29,33)/b20-12+,21-13+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177938
PNG
(2-cyano-N-{4-[2-cyano-3-(3-hydroxy-4-methoxyphenyl...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2ccc(OC)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C26H26N4O6/c1-35-23-7-5-17(13-21(23)31)11-19(15-27)25(33)29-9-3-4-10-30-26(34)20(16-28)12-18-6-8-24(36-2)22(32)14-18/h5-8,11-14,31-32H,3-4,9-10H2,1-2H3,(H,29,33)(H,30,34)/b19-11+,20-12+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177946
PNG
(2-cyano-N-[2-(2-cyano-3-phenylacryloylamino)ethyl]...)
Show SMILES O=C(NCCNC(=O)C(=C\c1ccccc1)\C#N)C(=C\c1ccccc1)\C#N
Show InChI InChI=1S/C22H18N4O2/c23-15-19(13-17-7-3-1-4-8-17)21(27)25-11-12-26-22(28)20(16-24)14-18-9-5-2-6-10-18/h1-10,13-14H,11-12H2,(H,25,27)(H,26,28)/b19-13+,20-14+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177953
PNG
(2-cyano-N-{2-[2-cyano-3-(3,4-dimethoxyphenyl)acryl...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2ccc(OC)c(OC)c2)\C#N)cc1OC
Show InChI InChI=1S/C26H26N4O6/c1-33-21-7-5-17(13-23(21)35-3)11-19(15-27)25(31)29-9-10-30-26(32)20(16-28)12-18-6-8-22(34-2)24(14-18)36-4/h5-8,11-14H,9-10H2,1-4H3,(H,29,31)(H,30,32)/b19-11+,20-12+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177954
PNG
(3-(4-chlorophenyl)-N-{2-[3-(4-chlorophenyl)-2-cyan...)
Show SMILES Clc1cccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2cccc(Cl)c2)\C#N)c1
Show InChI InChI=1S/C22H16Cl2N4O2/c23-19-5-1-3-15(11-19)9-17(13-25)21(29)27-7-8-28-22(30)18(14-26)10-16-4-2-6-20(24)12-16/h1-6,9-12H,7-8H2,(H,27,29)(H,28,30)/b17-9+,18-10+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177960
PNG
(CHEMBL436325 | N-{2-propoxy-3-[2-cyano-3-(3,4-dihy...)
Show SMILES CCCOC(CNC(=O)C(=C\c1ccc(O)c(O)c1)\C#N)CNC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C26H26N4O7/c1-2-7-37-20(14-29-25(35)18(12-27)8-16-3-5-21(31)23(33)10-16)15-30-26(36)19(13-28)9-17-4-6-22(32)24(34)11-17/h3-6,8-11,20,31-34H,2,7,14-15H2,1H3,(H,29,35)(H,30,36)/b18-8+,19-9+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177971
PNG
(2-cyano-N-{2-[2-cyano-3-(3-hydroxy-4-methoxyphenyl...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2ccc(OC)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C24H22N4O6/c1-33-21-5-3-15(11-19(21)29)9-17(13-25)23(31)27-7-8-28-24(32)18(14-26)10-16-4-6-22(34-2)20(30)12-16/h3-6,9-12,29-30H,7-8H2,1-2H3,(H,27,31)(H,28,32)/b17-9+,18-10+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177980
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4-dimethoxyphenyl)acryl...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(OC)c(OC)c2)\C#N)cc1OC
Show InChI InChI=1S/C27H28N4O6/c1-34-22-8-6-18(14-24(22)36-3)12-20(16-28)26(32)30-10-5-11-31-27(33)21(17-29)13-19-7-9-23(35-2)25(15-19)37-4/h6-9,12-15H,5,10-11H2,1-4H3,(H,30,32)(H,31,33)/b20-12+,21-13+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177976
PNG
(2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxyphenyl)acryl...)
Show SMILES CN(CCCNC(=O)C(=C\c1ccc(O)c(O)c1)\C#N)C(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C24H22N4O6/c1-28(24(34)18(14-26)10-16-4-6-20(30)22(32)12-16)8-2-7-27-23(33)17(13-25)9-15-3-5-19(29)21(31)11-15/h3-6,9-12,29-32H,2,7-8H2,1H3,(H,27,33)/b17-9+,18-10+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177979
PNG
(3-(2-chlorophenyl)-N-{4-[3-(2-chlorophenyl)-2-cyan...)
Show SMILES Clc1ccccc1\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c1ccccc1Cl)\C#N
Show InChI InChI=1S/C24H20Cl2N4O2/c25-21-9-3-1-7-17(21)13-19(15-27)23(31)29-11-5-6-12-30-24(32)20(16-28)14-18-8-2-4-10-22(18)26/h1-4,7-10,13-14H,5-6,11-12H2,(H,29,31)(H,30,32)/b19-13+,20-14+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177982
PNG
(2-cyano-N-{4-[2-cyano-3-(4-carboxyphenyl)acryloyla...)
Show SMILES OC(=O)c1ccc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2ccc(cc2)C(O)=O)\C#N)cc1
Show InChI InChI=1S/C26H22N4O6/c27-15-21(13-17-3-7-19(8-4-17)25(33)34)23(31)29-11-1-2-12-30-24(32)22(16-28)14-18-5-9-20(10-6-18)26(35)36/h3-10,13-14H,1-2,11-12H2,(H,29,31)(H,30,32)(H,33,34)(H,35,36)/b21-13+,22-14+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177974
PNG
(2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-c...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCCCCCOC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C26H24N2O8/c27-15-19(11-17-5-7-21(29)23(31)13-17)25(33)35-9-3-1-2-4-10-36-26(34)20(16-28)12-18-6-8-22(30)24(32)14-18/h5-8,11-14,29-32H,1-4,9-10H2/b19-11+,20-12+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177916
PNG
(2-cyano-N-{6-[2-cyano-3-(4-hydroxyphenyl)acryloyla...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2ccc(O)cc2)\C#N)cc1
Show InChI InChI=1S/C26H26N4O4/c27-17-21(15-19-5-9-23(31)10-6-19)25(33)29-13-3-1-2-4-14-30-26(34)22(18-28)16-20-7-11-24(32)12-8-20/h5-12,15-16,31-32H,1-4,13-14H2,(H,29,33)(H,30,34)/b21-15+,22-16+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177917
PNG
(3-(2-chlorophenyl)-N-{3-[3-(2-chlorophenyl)-2-cyan...)
Show SMILES Clc1ccccc1\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c1ccccc1Cl)\C#N
Show InChI InChI=1S/C23H18Cl2N4O2/c24-20-8-3-1-6-16(20)12-18(14-26)22(30)28-10-5-11-29-23(31)19(15-27)13-17-7-2-4-9-21(17)25/h1-4,6-9,12-13H,5,10-11H2,(H,28,30)(H,29,31)/b18-12+,19-13+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177920
PNG
(2-cyano-N-{5-[2-cyano-3-(4-methoxyphenyl)acryloyla...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1
Show InChI InChI=1S/C27H28N4O4/c1-34-24-10-6-20(7-11-24)16-22(18-28)26(32)30-14-4-3-5-15-31-27(33)23(19-29)17-21-8-12-25(35-2)13-9-21/h6-13,16-17H,3-5,14-15H2,1-2H3,(H,30,32)(H,31,33)/b22-16+,23-17+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177922
PNG
(2-cyano-N-{6-[2-cyano-3-(3-hydroxy-4-methoxyphenyl...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2ccc(OC)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C28H30N4O6/c1-37-25-9-7-19(15-23(25)33)13-21(17-29)27(35)31-11-5-3-4-6-12-32-28(36)22(18-30)14-20-8-10-26(38-2)24(34)16-20/h7-10,13-16,33-34H,3-6,11-12H2,1-2H3,(H,31,35)(H,32,36)/b21-13+,22-14+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177949
PNG
(3-(4-chlorophenyl)-N-{5-[3-(4-chlorophenyl)-2-cyan...)
Show SMILES Clc1cccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2cccc(Cl)c2)\C#N)c1
Show InChI InChI=1S/C25H22Cl2N4O2/c26-22-8-4-6-18(14-22)12-20(16-28)24(32)30-10-2-1-3-11-31-25(33)21(17-29)13-19-7-5-9-23(27)15-19/h4-9,12-15H,1-3,10-11H2,(H,30,32)(H,31,33)/b20-12+,21-13+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177957
PNG
(2-cyano-N-{6-[2-cyano-3-(3,4-dimethoxyphenyl)acryl...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2ccc(OC)c(OC)c2)\C#N)cc1OC
Show InChI InChI=1S/C30H34N4O6/c1-37-25-11-9-21(17-27(25)39-3)15-23(19-31)29(35)33-13-7-5-6-8-14-34-30(36)24(20-32)16-22-10-12-26(38-2)28(18-22)40-4/h9-12,15-18H,5-8,13-14H2,1-4H3,(H,33,35)(H,34,36)/b23-15+,24-16+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177964
PNG
(2-cyano-N-{4-[2-cyano-3-(4-methoxyphenyl)acryloyla...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1
Show InChI InChI=1S/C26H26N4O4/c1-33-23-9-5-19(6-10-23)15-21(17-27)25(31)29-13-3-4-14-30-26(32)22(18-28)16-20-7-11-24(34-2)12-8-20/h5-12,15-16H,3-4,13-14H2,1-2H3,(H,29,31)(H,30,32)/b21-15+,22-16+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177975
PNG
(3-(4-chlorophenyl)-N-{4-[3-(4-chlorophenyl)-2-cyan...)
Show SMILES Clc1cccc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2cccc(Cl)c2)\C#N)c1
Show InChI InChI=1S/C24H20Cl2N4O2/c25-21-7-3-5-17(13-21)11-19(15-27)23(31)29-9-1-2-10-30-24(32)20(16-28)12-18-6-4-8-22(26)14-18/h3-8,11-14H,1-2,9-10H2,(H,29,31)(H,30,32)/b19-11+,20-12+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177924
PNG
(2-cyano-N-{5-[2-cyano-3-(3,4-dimethoxyphenyl)acryl...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2ccc(OC)c(OC)c2)\C#N)cc1OC
Show InChI InChI=1S/C29H32N4O6/c1-36-24-10-8-20(16-26(24)38-3)14-22(18-30)28(34)32-12-6-5-7-13-33-29(35)23(19-31)15-21-9-11-25(37-2)27(17-21)39-4/h8-11,14-17H,5-7,12-13H2,1-4H3,(H,32,34)(H,33,35)/b22-14+,23-15+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177956
PNG
(3-(2-chloro-phenyl)-N-{2-[3-(2-chlorophenyl)-2-cya...)
Show SMILES Clc1ccccc1\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c1ccccc1Cl)\C#N
Show InChI InChI=1S/C22H16Cl2N4O2/c23-19-7-3-1-5-15(19)11-17(13-25)21(29)27-9-10-28-22(30)18(14-26)12-16-6-2-4-8-20(16)24/h1-8,11-12H,9-10H2,(H,27,29)(H,28,30)/b17-11+,18-12+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177958
PNG
(2-cyano-N-[4-(2-cyano-3-phenylacryloylamino)butyl]...)
Show SMILES O=C(NCCCCNC(=O)C(=C\c1ccccc1)\C#N)C(=C\c1ccccc1)\C#N
Show InChI InChI=1S/C24H22N4O2/c25-17-21(15-19-9-3-1-4-10-19)23(29)27-13-7-8-14-28-24(30)22(18-26)16-20-11-5-2-6-12-20/h1-6,9-12,15-16H,7-8,13-14H2,(H,27,29)(H,28,30)/b21-15+,22-16+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177969
PNG
(2-cyano-N-{2-[2-cyano-3-(4-methoxyphenyl)acryloyla...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1
Show InChI InChI=1S/C24H22N4O4/c1-31-21-7-3-17(4-8-21)13-19(15-25)23(29)27-11-12-28-24(30)20(16-26)14-18-5-9-22(32-2)10-6-18/h3-10,13-14H,11-12H2,1-2H3,(H,27,29)(H,28,30)/b19-13+,20-14+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177972
PNG
(3-(2-chlorophenyl)-N-{5-[3-(2-chlorophenyl)-2-cyan...)
Show SMILES Clc1ccccc1\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c1ccccc1Cl)\C#N
Show InChI InChI=1S/C25H22Cl2N4O2/c26-22-10-4-2-8-18(22)14-20(16-28)24(32)30-12-6-1-7-13-31-25(33)21(17-29)15-19-9-3-5-11-23(19)27/h2-5,8-11,14-15H,1,6-7,12-13H2,(H,30,32)(H,31,33)/b20-14+,21-15+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177947
PNG
(2-cyano-N-(3-{[2-cyano-3-(3,4-dihydroxyphenyl)acry...)
Show SMILES CN(CCCN(C)C(=O)C(=C\c1ccc(O)c(O)c1)\C#N)C(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C25H24N4O6/c1-28(24(34)18(14-26)10-16-4-6-20(30)22(32)12-16)8-3-9-29(2)25(35)19(15-27)11-17-5-7-21(31)23(33)13-17/h4-7,10-13,30-33H,3,8-9H2,1-2H3/b18-10+,19-11+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177966
PNG
(2-cyano-N-{14-[2-cyano-3-(3,4,5-trihydroxyphenyl)a...)
Show SMILES Oc1cc(\C=C(/C#N)C(=O)NCCCCCCCCCCCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C32H38N4O8/c33-19-23(13-21-15-25(37)29(41)26(38)16-21)31(43)35-11-9-7-5-3-1-2-4-6-8-10-12-36-32(44)24(20-34)14-22-17-27(39)30(42)28(40)18-22/h13-18,37-42H,1-12H2,(H,35,43)(H,36,44)/b23-13+,24-14+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177967
PNG
(2-cyano-N-{5-[2-cyano-3-(3-methoxyphenyl)acryloyla...)
Show SMILES COc1cccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2cccc(OC)c2)\C#N)c1
Show InChI InChI=1S/C27H28N4O4/c1-34-24-10-6-8-20(16-24)14-22(18-28)26(32)30-12-4-3-5-13-31-27(33)23(19-29)15-21-9-7-11-25(17-21)35-2/h6-11,14-17H,3-5,12-13H2,1-2H3,(H,30,32)(H,31,33)/b22-14+,23-15+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177913
PNG
(2-cyano-N-{5-[2-cyano-3-(4-hydroxyphenyl)acryloyla...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2ccc(O)cc2)\C#N)cc1
Show InChI InChI=1S/C25H24N4O4/c26-16-20(14-18-4-8-22(30)9-5-18)24(32)28-12-2-1-3-13-29-25(33)21(17-27)15-19-6-10-23(31)11-7-19/h4-11,14-15,30-31H,1-3,12-13H2,(H,28,32)(H,29,33)/b20-14+,21-15+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177929
PNG
(2-cyano-N-{6-[2-cyano-3-(3-methoxyphenyl)acryloyla...)
Show SMILES COc1cccc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2cccc(OC)c2)\C#N)c1
Show InChI InChI=1S/C28H30N4O4/c1-35-25-11-7-9-21(17-25)15-23(19-29)27(33)31-13-5-3-4-6-14-32-28(34)24(20-30)16-22-10-8-12-26(18-22)36-2/h7-12,15-18H,3-6,13-14H2,1-2H3,(H,31,33)(H,32,34)/b23-15+,24-16+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177942
PNG
(2-cyano-N-{2-[2-cyano-3-(3-methoxyphenyl)acryloyla...)
Show SMILES COc1cccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2cccc(OC)c2)\C#N)c1
Show InChI InChI=1S/C24H22N4O4/c1-31-21-7-3-5-17(13-21)11-19(15-25)23(29)27-9-10-28-24(30)20(16-26)12-18-6-4-8-22(14-18)32-2/h3-8,11-14H,9-10H2,1-2H3,(H,27,29)(H,28,30)/b19-11+,20-12+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177945
PNG
(2-cyano-N-{3-[2-cyano-3-(4-hydroxyphenyl)acryloyla...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(O)cc2)\C#N)cc1
Show InChI InChI=1S/C23H20N4O4/c24-14-18(12-16-2-6-20(28)7-3-16)22(30)26-10-1-11-27-23(31)19(15-25)13-17-4-8-21(29)9-5-17/h2-9,12-13,28-29H,1,10-11H2,(H,26,30)(H,27,31)/b18-12+,19-13+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177968
PNG
(2-cyano-N-[5-(2-cyano-3-phenylacryloylamino)pentyl...)
Show SMILES O=C(NCCCCCNC(=O)C(=C\c1ccccc1)\C#N)C(=C\c1ccccc1)\C#N
Show InChI InChI=1S/C25H24N4O2/c26-18-22(16-20-10-4-1-5-11-20)24(30)28-14-8-3-9-15-29-25(31)23(19-27)17-21-12-6-2-7-13-21/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2,(H,28,30)(H,29,31)/b22-16+,23-17+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177939
PNG
(2-cyano-N-{3-[2-cyano-3-(3-hydroxyphenyl)acryloyla...)
Show SMILES Oc1cccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2cccc(O)c2)\C#N)c1
Show InChI InChI=1S/C23H20N4O4/c24-14-18(10-16-4-1-6-20(28)12-16)22(30)26-8-3-9-27-23(31)19(15-25)11-17-5-2-7-21(29)13-17/h1-2,4-7,10-13,28-29H,3,8-9H2,(H,26,30)(H,27,31)/b18-10+,19-11+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177961
PNG
(2-cyano-N-{3-[2-cyano-3-(4-carboxyphenyl)acryloyla...)
Show SMILES OC(=O)c1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(cc2)C(O)=O)\C#N)cc1
Show InChI InChI=1S/C25H20N4O6/c26-14-20(12-16-2-6-18(7-3-16)24(32)33)22(30)28-10-1-11-29-23(31)21(15-27)13-17-4-8-19(9-5-17)25(34)35/h2-9,12-13H,1,10-11H2,(H,28,30)(H,29,31)(H,32,33)(H,34,35)/b20-12+,21-13+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177962
PNG
(3-(4-chlorophenyl)-N-{6-[3-(4-chlorophenyl)-2-cyan...)
Show SMILES Clc1cccc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2cccc(Cl)c2)\C#N)c1
Show InChI InChI=1S/C26H24Cl2N4O2/c27-23-9-5-7-19(15-23)13-21(17-29)25(33)31-11-3-1-2-4-12-32-26(34)22(18-30)14-20-8-6-10-24(28)16-20/h5-10,13-16H,1-4,11-12H2,(H,31,33)(H,32,34)/b21-13+,22-14+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177959
PNG
(2-cyano-N-{3-[2-cyano-3-(4-methoxyphenyl)acryloyla...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1
Show InChI InChI=1S/C25H24N4O4/c1-32-22-8-4-18(5-9-22)14-20(16-26)24(30)28-12-3-13-29-25(31)21(17-27)15-19-6-10-23(33-2)11-7-19/h4-11,14-15H,3,12-13H2,1-2H3,(H,28,30)(H,29,31)/b20-14+,21-15+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177963
PNG
(2-cyano-N-{14-[2-cyano-3-(3,4-dihydroxyphenyl)acry...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCCCCCCCCCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C32H38N4O6/c33-21-25(17-23-11-13-27(37)29(39)19-23)31(41)35-15-9-7-5-3-1-2-4-6-8-10-16-36-32(42)26(22-34)18-24-12-14-28(38)30(40)20-24/h11-14,17-20,37-40H,1-10,15-16H2,(H,35,41)(H,36,42)/b25-17+,26-18+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177977
PNG
(CHEMBL371021 | N-{2-benzyloxy-3-[2-cyano-3-(3,4-di...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCC(CNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)OCc2ccccc2)cc1O
Show InChI InChI=1S/C30H26N4O7/c31-14-22(10-20-6-8-25(35)27(37)12-20)29(39)33-16-24(41-18-19-4-2-1-3-5-19)17-34-30(40)23(15-32)11-21-7-9-26(36)28(38)13-21/h1-13,24,35-38H,16-18H2,(H,33,39)(H,34,40)/b22-10+,23-11+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177914
PNG
(2-cyano-N-{4-[2-cyano-3-(3-hydroxyphenyl)acryloyla...)
Show SMILES Oc1cccc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2cccc(O)c2)\C#N)c1
Show InChI InChI=1S/C24H22N4O4/c25-15-19(11-17-5-3-7-21(29)13-17)23(31)27-9-1-2-10-28-24(32)20(16-26)12-18-6-4-8-22(30)14-18/h3-8,11-14,29-30H,1-2,9-10H2,(H,27,31)(H,28,32)/b19-11+,20-12+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177918
PNG
(2-cyano-N-{2-[2-cyano-3-(3-hydroxyphenyl)acryloyla...)
Show SMILES Oc1cccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2cccc(O)c2)\C#N)c1
Show InChI InChI=1S/C22H18N4O4/c23-13-17(9-15-3-1-5-19(27)11-15)21(29)25-7-8-26-22(30)18(14-24)10-16-4-2-6-20(28)12-16/h1-6,9-12,27-28H,7-8H2,(H,25,29)(H,26,30)/b17-9+,18-10+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177919
PNG
(2-cyano-N-{6-[2-cyano-3-(3-hydroxyphenyl)acryloyla...)
Show SMILES Oc1cccc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2cccc(O)c2)\C#N)c1
Show InChI InChI=1S/C26H26N4O4/c27-17-21(13-19-7-5-9-23(31)15-19)25(33)29-11-3-1-2-4-12-30-26(34)22(18-28)14-20-8-6-10-24(32)16-20/h5-10,13-16,31-32H,1-4,11-12H2,(H,29,33)(H,30,34)/b21-13+,22-14+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177921
PNG
(2-cyano-N-{4-[2-cyano-3-(3-methoxyphenyl)acryloyla...)
Show SMILES COc1cccc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2cccc(OC)c2)\C#N)c1
Show InChI InChI=1S/C26H26N4O4/c1-33-23-9-5-7-19(15-23)13-21(17-27)25(31)29-11-3-4-12-30-26(32)22(18-28)14-20-8-6-10-24(16-20)34-2/h5-10,13-16H,3-4,11-12H2,1-2H3,(H,29,31)(H,30,32)/b21-13+,22-14+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177931
PNG
(2-cyano-N-{6-[2-cyano-3-(4-methoxyphenyl)acryloyla...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1
Show InChI InChI=1S/C28H30N4O4/c1-35-25-11-7-21(8-12-25)17-23(19-29)27(33)31-15-5-3-4-6-16-32-28(34)24(20-30)18-22-9-13-26(36-2)14-10-22/h7-14,17-18H,3-6,15-16H2,1-2H3,(H,31,33)(H,32,34)/b23-17+,24-18+
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177936
PNG
(2-cyano-N-{2-[2-cyano-3-(4-carboxyphenyl)acryloyla...)
Show SMILES OC(=O)c1ccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2ccc(cc2)C(O)=O)\C#N)cc1
Show InChI InChI=1S/C24H18N4O6/c25-13-19(11-15-1-5-17(6-2-15)23(31)32)21(29)27-9-10-28-22(30)20(14-26)12-16-3-7-18(8-4-16)24(33)34/h1-8,11-12H,9-10H2,(H,27,29)(H,28,30)(H,31,32)(H,33,34)/b19-11+,20-12+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177934
PNG
(2-cyano-N-{3-[2-cyano-3-(3-methoxyphenyl)acryloyla...)
Show SMILES COc1cccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2cccc(OC)c2)\C#N)c1
Show InChI InChI=1S/C25H24N4O4/c1-32-22-8-3-6-18(14-22)12-20(16-26)24(30)28-10-5-11-29-25(31)21(17-27)13-19-7-4-9-23(15-19)33-2/h3-4,6-9,12-15H,5,10-11H2,1-2H3,(H,28,30)(H,29,31)/b20-12+,21-13+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177952
PNG
(3-(4-chlorophenyl)-N-{3-[3-(4-chlorophenyl)-2-cyan...)
Show SMILES Clc1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(Cl)cc2)\C#N)cc1
Show InChI InChI=1S/C23H18Cl2N4O2/c24-20-6-2-16(3-7-20)12-18(14-26)22(30)28-10-1-11-29-23(31)19(15-27)13-17-4-8-21(25)9-5-17/h2-9,12-13H,1,10-11H2,(H,28,30)(H,29,31)/b18-12+,19-13+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177911
PNG
(2-cyano-N-{6-[2-cyano-3-(4-carboxyphenyl)acryloyla...)
Show SMILES OC(=O)c1ccc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2ccc(cc2)C(O)=O)\C#N)cc1
Show InChI InChI=1S/C28H26N4O6/c29-17-23(15-19-5-9-21(10-6-19)27(35)36)25(33)31-13-3-1-2-4-14-32-26(34)24(18-30)16-20-7-11-22(12-8-20)28(37)38/h5-12,15-16H,1-4,13-14H2,(H,31,33)(H,32,34)(H,35,36)(H,37,38)/b23-15+,24-16+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177912
PNG
(CHEMBL372539 | N-(2-[2-cyano-3-(3,4-dihydroxypheny...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCC(CNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)NC(=O)c2ccccc2)cc1O
Show InChI InChI=1S/C30H25N5O7/c31-14-21(10-18-6-8-24(36)26(38)12-18)28(40)33-16-23(35-30(42)20-4-2-1-3-5-20)17-34-29(41)22(15-32)11-19-7-9-25(37)27(39)13-19/h1-13,23,36-39H,16-17H2,(H,33,40)(H,34,41)(H,35,42)/b21-10+,22-11+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM5162
PNG
((2E)-2-({4-[(2E)-2-cyano-2-[(3,4-dihydroxyphenyl)m...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)N2CCN(CC2)C(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C24H20N4O6/c25-13-17(9-15-1-3-19(29)21(31)11-15)23(33)27-5-7-28(8-6-27)24(34)18(14-26)10-16-2-4-20(30)22(32)12-16/h1-4,9-12,29-32H,5-8H2/b17-9+,18-10+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177925
PNG
(2-cyano-N-{4-[2-cyano-3-(3,4-dimethoxyphenyl)acryl...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2ccc(OC)c(OC)c2)\C#N)cc1OC
Show InChI InChI=1S/C28H30N4O6/c1-35-23-9-7-19(15-25(23)37-3)13-21(17-29)27(33)31-11-5-6-12-32-28(34)22(18-30)14-20-8-10-24(36-2)26(16-20)38-4/h7-10,13-16H,5-6,11-12H2,1-4H3,(H,31,33)(H,32,34)/b21-13+,22-14+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177926
PNG
(2-cyano-N-[3-(2-cyano-3-phenylacryloylamino)propyl...)
Show SMILES O=C(NCCCNC(=O)C(=C\c1ccccc1)\C#N)C(=C\c1ccccc1)\C#N
Show InChI InChI=1S/C23H20N4O2/c24-16-20(14-18-8-3-1-4-9-18)22(28)26-12-7-13-27-23(29)21(17-25)15-19-10-5-2-6-11-19/h1-6,8-11,14-15H,7,12-13H2,(H,26,28)(H,27,29)/b20-14+,21-15+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177948
PNG
(2-cyano-N-[6-(2-cyano-3-phenylacryloylamino)hexyl]...)
Show SMILES O=C(NCCCCCCNC(=O)C(=C\c1ccccc1)\C#N)C(=C\c1ccccc1)\C#N
Show InChI InChI=1S/C26H26N4O2/c27-19-23(17-21-11-5-3-6-12-21)25(31)29-15-9-1-2-10-16-30-26(32)24(20-28)18-22-13-7-4-8-14-22/h3-8,11-14,17-18H,1-2,9-10,15-16H2,(H,29,31)(H,30,32)/b23-17+,24-18+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177978
PNG
(3-(2-chlorophenyl)-N-{6-[3-(2-chlorophenyl)-2-cyan...)
Show SMILES Clc1ccccc1\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c1ccccc1Cl)\C#N
Show InChI InChI=1S/C26H24Cl2N4O2/c27-23-11-5-3-9-19(23)15-21(17-29)25(33)31-13-7-1-2-8-14-32-26(34)22(18-30)16-20-10-4-6-12-24(20)28/h3-6,9-12,15-16H,1-2,7-8,13-14H2,(H,31,33)(H,32,34)/b21-15+,22-16+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50177981
PNG
(2-cyano-N-{5-[2-cyano-3-(3-hydroxy-4-methoxyphenyl...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2ccc(OC)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C27H28N4O6/c1-36-24-8-6-18(14-22(24)32)12-20(16-28)26(34)30-10-4-3-5-11-31-27(35)21(17-29)13-19-7-9-25(37-2)23(33)15-19/h6-9,12-15,32-33H,3-5,10-11H2,1-2H3,(H,30,34)(H,31,35)/b20-12+,21-13+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM4301
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Show SMILES NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
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n/an/a>3.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%