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PubMed code 16338239

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50178975
PNG
(4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-i...)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc3[nH]c(cc3c2Cl)C(O)=O)ccc1O
Show InChI InChI=1S/C18H15Cl2NO4/c1-8(2)10-5-9(3-4-15(10)22)25-17-12(19)7-13-11(16(17)20)6-14(21-13)18(23)24/h3-8,21-22H,1-2H3,(H,23,24)
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n/an/a 0.0600n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRbeta1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50178971
PNG
((R)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-di...)
Show SMILES N[C@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
Show InChI InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m1/s1
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n/an/a 0.240n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRalpha1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50178971
PNG
((R)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-di...)
Show SMILES N[C@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
Show InChI InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m1/s1
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n/an/a 0.260n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRbeta1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50178974
PNG
(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-in...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc3[nH]c(cc3c2Br)C(O)=O)ccc1O
Show InChI InChI=1S/C18H15Br2NO4/c1-8(2)10-5-9(3-4-15(10)22)25-17-12(19)7-13-11(16(17)20)6-14(21-13)18(23)24/h3-8,21-22H,1-2H3,(H,23,24)
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n/an/a 0.280n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRbeta1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50178975
PNG
(4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-i...)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc3[nH]c(cc3c2Cl)C(O)=O)ccc1O
Show InChI InChI=1S/C18H15Cl2NO4/c1-8(2)10-5-9(3-4-15(10)22)25-17-12(19)7-13-11(16(17)20)6-14(21-13)18(23)24/h3-8,21-22H,1-2H3,(H,23,24)
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n/an/a 1.40n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRalpha1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50178974
PNG
(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-in...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc3[nH]c(cc3c2Br)C(O)=O)ccc1O
Show InChI InChI=1S/C18H15Br2NO4/c1-8(2)10-5-9(3-4-15(10)22)25-17-12(19)7-13-11(16(17)20)6-14(21-13)18(23)24/h3-8,21-22H,1-2H3,(H,23,24)
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n/an/a 2.5n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRalpha1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50178972
PNG
(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-2,3-d...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc3CC(Cc3c2Br)C(O)=O)ccc1O
Show InChI InChI=1S/C19H18Br2O4/c1-9(2)13-8-12(3-4-16(13)22)25-18-15(20)7-10-5-11(19(23)24)6-14(10)17(18)21/h3-4,7-9,11,22H,5-6H2,1-2H3,(H,23,24)
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n/an/a 8.5n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRbeta1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50178970
PNG
(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethylquino...)
Show SMILES CC(C)c1cc(Oc2c(C)cc3nc(ccc3c2C)C(O)=O)ccc1O
Show InChI InChI=1S/C21H21NO4/c1-11(2)16-10-14(5-8-19(16)23)26-20-12(3)9-18-15(13(20)4)6-7-17(22-18)21(24)25/h5-11,23H,1-4H3,(H,24,25)
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n/an/a 15n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRbeta1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50178972
PNG
(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-2,3-d...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc3CC(Cc3c2Br)C(O)=O)ccc1O
Show InChI InChI=1S/C19H18Br2O4/c1-9(2)13-8-12(3-4-16(13)22)25-18-15(20)7-10-5-11(19(23)24)6-14(10)17(18)21/h3-4,7-9,11,22H,5-6H2,1-2H3,(H,23,24)
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n/an/a 38n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRalpha1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50178976
PNG
(5,7-dibromo-6-(4-hydroxy-3-isopropylphenoxy)-4-oxo...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc3nc(cc(O)c3c2Br)C(O)=O)ccc1O
Show InChI InChI=1S/C19H15Br2NO5/c1-8(2)10-5-9(3-4-14(10)23)27-18-11(20)6-12-16(17(18)21)15(24)7-13(22-12)19(25)26/h3-8,23H,1-2H3,(H,22,24)(H,25,26)
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n/an/a 51n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRbeta1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50178970
PNG
(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethylquino...)
Show SMILES CC(C)c1cc(Oc2c(C)cc3nc(ccc3c2C)C(O)=O)ccc1O
Show InChI InChI=1S/C21H21NO4/c1-11(2)16-10-14(5-8-19(16)23)26-20-12(3)9-18-15(13(20)4)6-7-17(22-18)21(24)25/h5-11,23H,1-4H3,(H,24,25)
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n/an/a 200n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRalpha1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50241363
PNG
(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethyl-4-ox...)
Show SMILES CC(C)c1cc(Oc2c(C)cc3nc(cc(O)c3c2C)C(O)=O)ccc1O
Show InChI InChI=1S/C21H21NO5/c1-10(2)14-8-13(5-6-17(14)23)27-20-11(3)7-15-19(12(20)4)18(24)9-16(22-15)21(25)26/h5-10,23H,1-4H3,(H,22,24)(H,25,26)
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n/an/a 240n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRbeta1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50178976
PNG
(5,7-dibromo-6-(4-hydroxy-3-isopropylphenoxy)-4-oxo...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc3nc(cc(O)c3c2Br)C(O)=O)ccc1O
Show InChI InChI=1S/C19H15Br2NO5/c1-8(2)10-5-9(3-4-14(10)23)27-18-11(20)6-12-16(17(18)21)15(24)7-13(22-12)19(25)26/h3-8,23H,1-2H3,(H,22,24)(H,25,26)
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n/an/a 250n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRalpha1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50241363
PNG
(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethyl-4-ox...)
Show SMILES CC(C)c1cc(Oc2c(C)cc3nc(cc(O)c3c2C)C(O)=O)ccc1O
Show InChI InChI=1S/C21H21NO5/c1-10(2)14-8-13(5-6-17(14)23)27-20-11(3)7-15-19(12(20)4)18(24)9-16(22-15)21(25)26/h5-10,23H,1-4H3,(H,22,24)(H,25,26)
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n/an/a 620n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRalpha1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50241362
PNG
(5,7-dichloro-6-(4-hydroxy-3-isopropylphenoxy)-4-ox...)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc3nc(cc(O)c3c2Cl)C(O)=O)ccc1O
Show InChI InChI=1S/C19H15Cl2NO5/c1-8(2)10-5-9(3-4-14(10)23)27-18-11(20)6-12-16(17(18)21)15(24)7-13(22-12)19(25)26/h3-8,23H,1-2H3,(H,22,24)(H,25,26)
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n/an/a 870n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRbeta1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50241362
PNG
(5,7-dichloro-6-(4-hydroxy-3-isopropylphenoxy)-4-ox...)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc3nc(cc(O)c3c2Cl)C(O)=O)ccc1O
Show InChI InChI=1S/C19H15Cl2NO5/c1-8(2)10-5-9(3-4-14(10)23)27-18-11(20)6-12-16(17(18)21)15(24)7-13(22-12)19(25)26/h3-8,23H,1-2H3,(H,22,24)(H,25,26)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Inhibition of human TRalpha1 by radioligand binding assay


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50178972
PNG
(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-2,3-d...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc3CC(Cc3c2Br)C(O)=O)ccc1O
Show InChI InChI=1S/C19H18Br2O4/c1-9(2)13-8-12(3-4-16(13)22)25-18-15(20)7-10-5-11(19(23)24)6-14(10)17(18)21/h3-4,7-9,11,22H,5-6H2,1-2H3,(H,23,24)
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n/an/an/an/a 4.10n/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Efficacy against TRAF-alpha-1 reporter cells


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50178972
PNG
(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-2,3-d...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc3CC(Cc3c2Br)C(O)=O)ccc1O
Show InChI InChI=1S/C19H18Br2O4/c1-9(2)13-8-12(3-4-16(13)22)25-18-15(20)7-10-5-11(19(23)24)6-14(10)17(18)21/h3-4,7-9,11,22H,5-6H2,1-2H3,(H,23,24)
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n/an/an/an/a 4.30n/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Efficacy against TRAF-beta-1 reporter cells


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50178974
PNG
(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-in...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc3[nH]c(cc3c2Br)C(O)=O)ccc1O
Show InChI InChI=1S/C18H15Br2NO4/c1-8(2)10-5-9(3-4-15(10)22)25-17-12(19)7-13-11(16(17)20)6-14(21-13)18(23)24/h3-8,21-22H,1-2H3,(H,23,24)
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n/an/an/an/a 4.20n/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Efficacy against TRAF-beta-1 reporter cells


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50178971
PNG
((R)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-di...)
Show SMILES N[C@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
Show InChI InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m1/s1
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n/an/an/an/a 1.30n/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Efficacy against TRAF-alpha-1 reporter cells


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50178974
PNG
(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-in...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc3[nH]c(cc3c2Br)C(O)=O)ccc1O
Show InChI InChI=1S/C18H15Br2NO4/c1-8(2)10-5-9(3-4-15(10)22)25-17-12(19)7-13-11(16(17)20)6-14(21-13)18(23)24/h3-8,21-22H,1-2H3,(H,23,24)
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n/an/an/an/a 10n/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Efficacy against TRAF-alpha-1 reporter cells


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50178975
PNG
(4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-i...)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc3[nH]c(cc3c2Cl)C(O)=O)ccc1O
Show InChI InChI=1S/C18H15Cl2NO4/c1-8(2)10-5-9(3-4-15(10)22)25-17-12(19)7-13-11(16(17)20)6-14(21-13)18(23)24/h3-8,21-22H,1-2H3,(H,23,24)
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n/an/an/an/a 4.70n/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Efficacy against TRAF-beta-1 reporter cells


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50178971
PNG
((R)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-di...)
Show SMILES N[C@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
Show InChI InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m1/s1
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n/an/an/an/a 3.5n/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Efficacy against TRAF-beta-1 reporter cells


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Thyroid Hormone Receptor (TR-beta)


(Homo sapiens (human))
BDBM50178970
PNG
(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethylquino...)
Show SMILES CC(C)c1cc(Oc2c(C)cc3nc(ccc3c2C)C(O)=O)ccc1O
Show InChI InChI=1S/C21H21NO4/c1-11(2)16-10-14(5-8-19(16)23)26-20-12(3)9-18-15(13(20)4)6-7-17(22-18)21(24)25/h5-11,23H,1-4H3,(H,24,25)
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n/an/an/an/a 49n/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Efficacy against TRAF-beta-1 reporter cells


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50178975
PNG
(4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-i...)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc3[nH]c(cc3c2Cl)C(O)=O)ccc1O
Show InChI InChI=1S/C18H15Cl2NO4/c1-8(2)10-5-9(3-4-15(10)22)25-17-12(19)7-13-11(16(17)20)6-14(21-13)18(23)24/h3-8,21-22H,1-2H3,(H,23,24)
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n/an/an/an/a 10n/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Efficacy against TRAF-alpha-1 reporter cells


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
Thyroid hormone receptor


(Homo sapiens (human))
BDBM50178970
PNG
(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethylquino...)
Show SMILES CC(C)c1cc(Oc2c(C)cc3nc(ccc3c2C)C(O)=O)ccc1O
Show InChI InChI=1S/C21H21NO4/c1-11(2)16-10-14(5-8-19(16)23)26-20-12(3)9-18-15(13(20)4)6-7-17(22-18)21(24)25/h5-11,23H,1-4H3,(H,24,25)
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n/an/an/an/a 83n/an/an/an/a



Karo Bio AB

Curated by ChEMBL


Assay Description
Efficacy against TRAF-alpha-1 reporter cells


Bioorg Med Chem Lett 16: 1240-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.077
BindingDB Entry DOI: 10.7270/Q2T72H1W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%