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PubMed code 16413780

Compile data set for download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15067
PNG
((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM15067
PNG
((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 6.5n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15067
PNG
((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15068
PNG
(13b (R-) | 6-{5-[(2R)-2-amino-3-(1H-indol-3-yl)pro...)
Show SMILES N[C@@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m1/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15067
PNG
((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15066
PNG
(5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-(pyrid...)
Show SMILES N[C@H](COc1cncc2nc(ccc12)-c1ccncc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C24H21N5O/c25-18(11-17-12-28-22-4-2-1-3-19(17)22)15-30-24-14-27-13-23-20(24)5-6-21(29-23)16-7-9-26-10-8-16/h1-10,12-14,18,28H,11,15,25H2/t18-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15064
PNG
(N-[(2S)-2-amino-3-(1H-indol-3-yl)propyl]-5-(isoqui...)
Show SMILES N[C@H](CNc1cncc(Oc2cccc3cnccc23)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H23N5O/c26-19(10-18-13-30-24-6-2-1-5-22(18)24)14-29-20-11-21(16-28-15-20)31-25-7-3-4-17-12-27-9-8-23(17)25/h1-9,11-13,15-16,19,29-30H,10,14,26H2/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15023
PNG
(3-[(2S)-2-amino-3-({5-[2-(pyridin-4-yl)ethynyl]pyr...)
Show SMILES N[C@H](COc1cncc(c1)C#Cc1ccncc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H20N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-4,7-11,13-15,20,27H,12,16,24H2/t20-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15050
PNG
(N-(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES CC(=O)Nc1ccc(cc1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C24H24N4O2/c1-16(29)28-21-8-6-17(7-9-21)18-11-22(14-26-12-18)30-15-20(25)10-19-13-27-24-5-3-2-4-23(19)24/h2-9,11-14,20,27H,10,15,25H2,1H3,(H,28,29)/t20-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15037
PNG
(3-[(2S)-2-amino-3-{[5-(pyridin-4-yl)pyridin-3-yl]o...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccncc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C21H20N4O/c22-18(9-17-12-25-21-4-2-1-3-20(17)21)14-26-19-10-16(11-24-13-19)15-5-7-23-8-6-15/h1-8,10-13,18,25H,9,14,22H2/t18-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (human))
BDBM15067
PNG
((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1
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n/an/a 270n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15065
PNG
(3-N-[(2S)-2-amino-3-(1H-indol-3-yl)propyl]-5-N-(is...)
Show SMILES N[C@H](CNc1cncc(Nc2cccc3cnccc23)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H24N6/c26-19(10-18-13-30-24-6-2-1-5-22(18)24)14-29-20-11-21(16-28-15-20)31-25-7-3-4-17-12-27-9-8-23(17)25/h1-9,11-13,15-16,19,29-31H,10,14,26H2/t19-/m0/s1
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n/an/a 270n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15062
PNG
(3-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-6-(pyrid...)
Show SMILES N[C@H](COc1cnc2ccc(cc2c1)-c1ccncc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H22N4O/c26-21(12-20-14-28-25-4-2-1-3-23(20)25)16-30-22-13-19-11-18(5-6-24(19)29-15-22)17-7-9-27-10-8-17/h1-11,13-15,21,28H,12,16,26H2/t21-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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n/an/a 354n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 570n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15021
PNG
(3-[(2S)-2-amino-3-phenylpropoxy]-5-[(E)-2-(pyridin...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1ccccc1
Show InChI InChI=1S/C21H21N3O/c22-20(12-18-4-2-1-3-5-18)16-25-21-13-19(14-24-15-21)7-6-17-8-10-23-11-9-17/h1-11,13-15,20H,12,16,22H2/b7-6+/t20-/m0/s1
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n/an/a 690n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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n/an/a 930n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15055
PNG
(3-(5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(NC(=O)Nc2ccccc2)nc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C28H26N6O2/c29-22(12-21-16-31-26-9-5-4-8-25(21)26)18-36-24-13-20(14-30-17-24)19-10-11-27(32-15-19)34-28(35)33-23-6-2-1-3-7-23/h1-11,13-17,22,31H,12,18,29H2,(H2,32,33,34,35)/t22-/m0/s1
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n/an/a 1.12E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (human))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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n/an/a 1.20E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15038
PNG
(5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES Cc1c(cc(C#N)c(=O)n1C)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C24H23N5O2/c1-15-22(9-16(10-25)24(30)29(15)2)18-8-20(13-27-11-18)31-14-19(26)7-17-12-28-23-6-4-3-5-21(17)23/h3-6,8-9,11-13,19,28H,7,14,26H2,1-2H3/t19-/m0/s1
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n/an/a 1.34E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15049
PNG
(2-(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES N[C@H](COc1cncc(c1)-c1cccc(CC(N)=O)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C24H24N4O2/c25-20(10-19-13-28-23-7-2-1-6-22(19)23)15-30-21-11-18(12-27-14-21)17-5-3-4-16(8-17)9-24(26)29/h1-8,11-14,20,28H,9-10,15,25H2,(H2,26,29)/t20-/m0/s1
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n/an/a 1.39E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15060
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(N)c(c1)C(=O)c1cccc(Cl)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C29H25ClN4O2/c30-22-5-3-4-19(10-22)29(35)26-13-18(8-9-27(26)32)20-12-24(16-33-14-20)36-17-23(31)11-21-15-34-28-7-2-1-6-25(21)28/h1-10,12-16,23,34H,11,17,31-32H2/t23-/m0/s1
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n/an/a 1.45E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15040
PNG
(3-[(2S)-2-amino-3-{[5-(4-fluorophenyl)pyridin-3-yl...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(F)cc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H20FN3O/c23-18-7-5-15(6-8-18)16-10-20(13-25-11-16)27-14-19(24)9-17-12-26-22-4-2-1-3-21(17)22/h1-8,10-13,19,26H,9,14,24H2/t19-/m0/s1
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n/an/a 1.56E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15039
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C#N)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H20N4O/c24-11-16-5-7-17(8-6-16)18-10-21(14-26-12-18)28-15-20(25)9-19-13-27-23-4-2-1-3-22(19)23/h1-8,10,12-14,20,27H,9,15,25H2/t20-/m0/s1
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n/an/a 1.83E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15025
PNG
(5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-N-(pyrid...)
Show SMILES N[C@H](COc1cncc(c1)C(=O)Nc1ccncc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H21N5O2/c23-17(9-15-12-26-21-4-2-1-3-20(15)21)14-29-19-10-16(11-25-13-19)22(28)27-18-5-7-24-8-6-18/h1-8,10-13,17,26H,9,14,23H2,(H,24,27,28)/t17-/m0/s1
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n/an/a 2.02E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15033
PNG
(5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-N-(pyrid...)
Show SMILES N[C@H](COc1cncc(Nc2cccnc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C21H21N5O/c22-16(8-15-10-25-21-6-2-1-5-20(15)21)14-27-19-9-18(12-24-13-19)26-17-4-3-7-23-11-17/h1-7,9-13,16,25-26H,8,14,22H2/t16-/m0/s1
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n/an/a 2.16E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15061
PNG
(5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1cccc2c(cccc12)C(N)=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C27H24N4O2/c28-19(11-17-14-31-26-10-2-1-5-22(17)26)16-33-20-12-18(13-30-15-20)21-6-3-8-24-23(21)7-4-9-25(24)27(29)32/h1-10,12-15,19,31H,11,16,28H2,(H2,29,32)/t19-/m0/s1
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n/an/a 2.17E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15056
PNG
(4-N-(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]p...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(Nc2ccnc(N)n2)cc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C26H25N7O/c27-20(11-19-14-31-24-4-2-1-3-23(19)24)16-34-22-12-18(13-29-15-22)17-5-7-21(8-6-17)32-25-9-10-30-26(28)33-25/h1-10,12-15,20,31H,11,16,27H2,(H3,28,30,32,33)/t20-/m0/s1
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n/an/a 2.71E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15032
PNG
(5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-N-(pyrid...)
Show SMILES N[C@H](COc1cncc(Nc2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C21H21N5O/c22-16(9-15-11-25-21-4-2-1-3-20(15)21)14-27-19-10-18(12-24-13-19)26-17-5-7-23-8-6-17/h1-8,10-13,16,25H,9,14,22H2,(H,23,26)/t16-/m0/s1
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n/an/a 2.86E+3n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15058
PNG
(N-(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES N[C@H](COc1cncc(c1)-c1cccc(Nc2ncccn2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C26H24N6O/c27-21(11-20-15-31-25-8-2-1-7-24(20)25)17-33-23-13-19(14-28-16-23)18-5-3-6-22(12-18)32-26-29-9-4-10-30-26/h1-10,12-16,21,31H,11,17,27H2,(H,29,30,32)/t21-/m0/s1
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n/an/a 3.67E+3n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human))
BDBM15067
PNG
((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1
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n/an/a 6.10E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15059
PNG
(N-(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES N[C@H](COc1cncc(c1)-c1cccc(Nc2nccs2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H23N5OS/c26-20(10-19-14-29-24-7-2-1-6-23(19)24)16-31-22-12-18(13-27-15-22)17-4-3-5-21(11-17)30-25-28-8-9-32-25/h1-9,11-15,20,29H,10,16,26H2,(H,28,30)/t20-/m0/s1
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n/an/a 6.23E+3n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15042
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(N)cc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H22N4O/c23-18-7-5-15(6-8-18)16-10-20(13-25-11-16)27-14-19(24)9-17-12-26-22-4-2-1-3-21(17)22/h1-8,10-13,19,26H,9,14,23-24H2/t19-/m0/s1
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n/an/a 6.94E+3n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15035
PNG
(5-[(2S)-2-amino-3-phenylpropoxy]-N-(pyridin-3-yl)p...)
Show SMILES N[C@H](COc1cncc(Nc2cccnc2)c1)Cc1ccccc1
Show InChI InChI=1S/C19H20N4O/c20-16(9-15-5-2-1-3-6-15)14-24-19-10-18(12-22-13-19)23-17-7-4-8-21-11-17/h1-8,10-13,16,23H,9,14,20H2/t16-/m0/s1
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n/an/a 6.97E+3n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15063
PNG
(3-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-6-(pyrid...)
Show SMILES N[C@H](COc1cnc2ccc(cc2c1)-c1cccnc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H22N4O/c26-21(11-20-14-28-25-6-2-1-5-23(20)25)16-30-22-12-19-10-17(7-8-24(19)29-15-22)18-4-3-9-27-13-18/h1-10,12-15,21,28H,11,16,26H2/t21-/m0/s1
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n/an/a 7.09E+3n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15044
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C(N)=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O2/c24-19(9-18-12-27-22-4-2-1-3-21(18)22)14-29-20-10-17(11-26-13-20)15-5-7-16(8-6-15)23(25)28/h1-8,10-13,19,27H,9,14,24H2,(H2,25,28)/t19-/m0/s1
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n/an/a 9.31E+3n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15031
PNG
(2-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-4...)
Show SMILES N[C@H](COc1cncc(c1)-c1nc(cs1)-c1cccnc1)Cc1ccccc1
Show InChI InChI=1S/C22H20N4OS/c23-19(9-16-5-2-1-3-6-16)14-27-20-10-18(12-25-13-20)22-26-21(15-28-22)17-7-4-8-24-11-17/h1-8,10-13,15,19H,9,14,23H2/t19-/m0/s1
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n/an/a 9.35E+3n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15030
PNG
(2-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-4...)
Show SMILES N[C@H](COc1cncc(c1)-c1nc(cs1)-c1ccncc1)Cc1ccccc1
Show InChI InChI=1S/C22H20N4OS/c23-19(10-16-4-2-1-3-5-16)14-27-20-11-18(12-25-13-20)22-26-21(15-28-22)17-6-8-24-9-7-17/h1-9,11-13,15,19H,10,14,23H2/t19-/m0/s1
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n/an/a 9.87E+3n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15051
PNG
(N-(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES CC(=O)Nc1cccc(c1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C24H24N4O2/c1-16(29)28-21-6-4-5-17(10-21)18-11-22(14-26-12-18)30-15-20(25)9-19-13-27-24-8-3-2-7-23(19)24/h2-8,10-14,20,27H,9,15,25H2,1H3,(H,28,29)/t20-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15057
PNG
(N-(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(Nc2ncccn2)cc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C26H24N6O/c27-21(12-20-15-31-25-5-2-1-4-24(20)25)17-33-23-13-19(14-28-16-23)18-6-8-22(9-7-18)32-26-29-10-3-11-30-26/h1-11,13-16,21,31H,12,17,27H2,(H,29,30,32)/t21-/m0/s1
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n/an/a 1.43E+4n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15034
PNG
(5-[(2S)-2-amino-3-phenylpropoxy]-N-(pyridin-4-yl)p...)
Show SMILES N[C@H](COc1cncc(Nc2ccncc2)c1)Cc1ccccc1
Show InChI InChI=1S/C19H20N4O/c20-16(10-15-4-2-1-3-5-15)14-24-19-11-18(12-22-13-19)23-17-6-8-21-9-7-17/h1-9,11-13,16H,10,14,20H2,(H,21,23)/t16-/m0/s1
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n/an/a 1.88E+4n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15024
PNG
(3-[(2S)-2-amino-3-({5-[2-(pyridin-3-yl)ethynyl]pyr...)
Show SMILES N[C@H](COc1cncc(c1)C#Cc1cccnc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H20N4O/c24-20(11-19-14-27-23-6-2-1-5-22(19)23)16-28-21-10-18(13-26-15-21)8-7-17-4-3-9-25-12-17/h1-6,9-10,12-15,20,27H,11,16,24H2/t20-/m0/s1
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n/an/a 2.52E+4n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15043
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C(O)=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H21N3O3/c24-19(9-18-12-26-22-4-2-1-3-21(18)22)14-29-20-10-17(11-25-13-20)15-5-7-16(8-6-15)23(27)28/h1-8,10-13,19,26H,9,14,24H2,(H,27,28)/t19-/m0/s1
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n/an/a 3.13E+4n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15036
PNG
(N-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}py...)
Show SMILES N[C@H](COc1cncc(NC(=O)c2ccncc2)c1)Cc1ccccc1
Show InChI InChI=1S/C20H20N4O2/c21-17(10-15-4-2-1-3-5-15)14-26-19-11-18(12-23-13-19)24-20(25)16-6-8-22-9-7-16/h1-9,11-13,17H,10,14,21H2,(H,24,25)/t17-/m0/s1
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n/an/a 3.20E+4n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15053
PNG
(N-(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C23H24N4O3S/c1-31(28,29)27-20-8-6-16(7-9-20)17-11-21(14-25-12-17)30-15-19(24)10-18-13-26-23-5-3-2-4-22(18)23/h2-9,11-14,19,26-27H,10,15,24H2,1H3/t19-/m0/s1
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n/an/a 3.30E+4n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15054
PNG
(3-[(2S)-2-amino-3-({5-[4-(2H-1,2,3,4-tetrazol-5-yl...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)-c1nnn[nH]1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H21N7O/c24-19(9-18-12-26-22-4-2-1-3-21(18)22)14-31-20-10-17(11-25-13-20)15-5-7-16(8-6-15)23-27-29-30-28-23/h1-8,10-13,19,26H,9,14,24H2,(H,27,28,29,30)/t19-/m0/s1
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n/an/a 3.32E+4n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15047
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)S(N)(=O)=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H22N4O3S/c23-18(9-17-12-26-22-4-2-1-3-21(17)22)14-29-19-10-16(11-25-13-19)15-5-7-20(8-6-15)30(24,27)28/h1-8,10-13,18,26H,9,14,23H2,(H2,24,27,28)/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15041
PNG
(3-[(2S)-2-amino-3-{[5-(4-nitrophenyl)pyridin-3-yl]...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)N(=O)=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H20N4O3/c23-18(9-17-12-25-22-4-2-1-3-21(17)22)14-29-20-10-16(11-24-13-20)15-5-7-19(8-6-15)26(27)28/h1-8,10-13,18,25H,9,14,23H2/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15052
PNG
(N-[(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]py...)
Show SMILES CC(=O)NCc1ccc(cc1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C25H26N4O2/c1-17(30)28-12-18-6-8-19(9-7-18)20-11-23(15-27-13-20)31-16-22(26)10-21-14-29-25-5-3-2-4-24(21)25/h2-9,11,13-15,22,29H,10,12,16,26H2,1H3,(H,28,30)/t22-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15029
PNG
(3-[(2S)-2-amino-3-({5-[2-(pyridin-4-yl)phenyl]pyri...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccccc1-c1ccncc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C27H24N4O/c28-22(13-20-16-31-27-8-4-3-7-26(20)27)18-32-23-14-21(15-30-17-23)25-6-2-1-5-24(25)19-9-11-29-12-10-19/h1-12,14-17,22,31H,13,18,28H2/t22-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15026
PNG
(N-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}py...)
Show SMILES N[C@H](COc1cncc(NC(=O)c2cccnc2)c1)Cc1ccccc1
Show InChI InChI=1S/C20H20N4O2/c21-17(9-15-5-2-1-3-6-15)14-26-19-10-18(12-23-13-19)24-20(25)16-7-4-8-22-11-16/h1-8,10-13,17H,9,14,21H2,(H,24,25)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15028
PNG
(5-[(2S)-2-amino-3-phenylpropoxy]-N-(pyridin-3-ylme...)
Show SMILES N[C@H](COc1cncc(NCc2cccnc2)c1)Cc1ccccc1
Show InChI InChI=1S/C20H22N4O/c21-18(9-16-5-2-1-3-6-16)15-25-20-10-19(13-23-14-20)24-12-17-7-4-8-22-11-17/h1-8,10-11,13-14,18,24H,9,12,15,21H2/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15046
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C(=N)NO)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H23N5O2/c24-19(9-18-12-27-22-4-2-1-3-21(18)22)14-30-20-10-17(11-26-13-20)15-5-7-16(8-6-15)23(25)28-29/h1-8,10-13,19,27,29H,9,14,24H2,(H2,25,28)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15027
PNG
(5-[(2S)-2-amino-3-phenylpropoxy]-N-(pyridin-4-ylme...)
Show SMILES N[C@H](COc1cncc(NCc2ccncc2)c1)Cc1ccccc1
Show InChI InChI=1S/C20H22N4O/c21-18(10-16-4-2-1-3-5-16)15-25-20-11-19(13-23-14-20)24-12-17-6-8-22-9-7-17/h1-9,11,13-14,18,24H,10,12,15,21H2/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15045
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C(N)=N)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H23N5O/c24-19(9-18-12-28-22-4-2-1-3-21(18)22)14-29-20-10-17(11-27-13-20)15-5-7-16(8-6-15)23(25)26/h1-8,10-13,19,28H,9,14,24H2,(H3,25,26)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15048
PNG
(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1cccc(c1)S(N)(=O)=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H22N4O3S/c23-18(8-17-12-26-22-7-2-1-6-21(17)22)14-29-19-9-16(11-25-13-19)15-4-3-5-20(10-15)30(24,27)28/h1-7,9-13,18,26H,8,14,23H2,(H2,24,27,28)/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%