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PubMed code 1654430

Compile data set for download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000925
PNG
(7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1C
Show InChI InChI=1S/C12H11N3O/c1-6-3-4-9-8(7(6)2)5-10-11(13-9)15-12(16)14-10/h3-5H,1-2H3,(H2,13,14,15,16)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007250
PNG
(7-Methoxy-1-methyl-1,3-dihydro-imidazo[4,5-b]quino...)
Show SMILES COc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C12H11N3O2/c1-15-10-6-7-5-8(17-2)3-4-9(7)13-11(10)14-12(15)16/h3-6H,1-2H3,(H,13,14,16)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/a 3.40E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007229
PNG
(7-Fluoro-1,3,9,9a-tetrahydro-imidazo[4,5-b]quinoli...)
Show SMILES Fc1ccc2Nc3[nH]c(=O)[nH]c3Cc2c1
Show InChI InChI=1S/C10H8FN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-3,12H,4H2,(H2,13,14,15)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007227
PNG
(1-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Cn1c2cc3ccccc3nc2[nH]c1=O
Show InChI InChI=1S/C11H9N3O/c1-14-9-6-7-4-2-3-5-8(7)12-10(9)13-11(14)15/h2-6H,1H3,(H,12,13,15)
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n/an/a 6.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007248
PNG
(1,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1cccc2nc3[nH]c(=O)n(C)c3cc12
Show InChI InChI=1S/C12H11N3O/c1-7-4-3-5-9-8(7)6-10-11(13-9)14-12(16)15(10)2/h3-6H,1-2H3,(H,13,14,16)
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n/an/a 6.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007235
PNG
(1,7-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C12H11N3O/c1-7-3-4-9-8(5-7)6-10-11(13-9)14-12(16)15(10)2/h3-6H,1-2H3,(H,13,14,16)
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n/an/a 7.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007220
PNG
(1,3-Dihydro-imidazo[4,5-b]quinolin-2-one | CHEMBL9...)
Show SMILES O=c1[nH]c2cc3ccccc3nc2[nH]1
Show InChI InChI=1S/C10H7N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-5H,(H2,11,12,13,14)
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n/an/a 8.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007217
PNG
(7-Chloro-1,3,9,9a-tetrahydro-imidazo[4,5-b]quinoli...)
Show SMILES Clc1ccc2Nc3[nH]c(=O)[nH]c3Cc2c1
Show InChI InChI=1S/C10H8ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-3,12H,4H2,(H2,13,14,15)
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n/an/a 8.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007222
PNG
(1,3,9,9a-Tetrahydro-imidazo[4,5-b]quinolin-2-one |...)
Show SMILES O=c1[nH]c2Cc3ccccc3Nc2[nH]1
Show InChI InChI=1S/C10H9N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-4,11H,5H2,(H2,12,13,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007221
PNG
(7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Clc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C10H6ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007234
PNG
(7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Fc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C10H6FN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007236
PNG
(1,3-Dihydro-naphtho[2,3-d]imidazol-2-one | CHEMBL3...)
Show SMILES O=c1[nH]c2cc3ccccc3cc2[nH]1
Show InChI InChI=1S/C11H8N2O/c14-11-12-9-5-7-3-1-2-4-8(7)6-10(9)13-11/h1-6H,(H2,12,13,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007247
PNG
(1,7,8-Trimethyl-1,3-dihydro-imidazo[4,5-b]quinolin...)
Show SMILES Cc1ccc2nc3[nH]c(=O)n(C)c3cc2c1C
Show InChI InChI=1S/C13H13N3O/c1-7-4-5-10-9(8(7)2)6-11-12(14-10)15-13(17)16(11)3/h4-6H,1-3H3,(H,14,15,17)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007216
PNG
(7-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C11H9N3O/c1-6-2-3-8-7(4-6)5-9-10(12-8)14-11(15)13-9/h2-5H,1H3,(H2,12,13,14,15)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%