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Found 23 Enz. Inhib. hit(s) with all data for entry = 3320
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31285(BMCL163310 Compound 1 | CHEMBL361103 | benzodiazep...)
Affinity DataIC50:  420nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31328(1,4-benzodiazepine-2,5-dione antagonist, 13 | Race...)
Affinity DataIC50:  510nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31318(1,4-benzodiazepine-2,5-dione antagonist, 2 | Racem...)
Affinity DataIC50:  540nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31305(1,4-benzodiazepine-2,5-dione, 12b | BMCL163310 Com...)
Affinity DataIC50:  700nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31338(1,4-benzodiazepine-2,5-dione antagonist, 23)
Affinity DataIC50:  710nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31320(1,4-benzodiazepine-2,5-dione antagonist, 4 | Racem...)
Affinity DataIC50:  850nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31321(1,4-benzodiazepine-2,5-dione antagonist, 5 | Racem...)
Affinity DataIC50:  870nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31336(1,4-benzodiazepine-2,5-dione antagonist, 21)
Affinity DataIC50:  980nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31337(1,4-benzodiazepine-2,5-dione antagonist, 22)
Affinity DataIC50:  1.04E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31327(1,4-benzodiazepine-2,5-dione antagonist, 12 | Race...)
Affinity DataIC50:  1.09E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31339(1,4-benzodiazepine-2,5-dione antagonist, 24)
Affinity DataIC50:  1.11E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31319(1,4-benzodiazepine-2,5-dione antagonist, 3 | Racem...)
Affinity DataIC50:  2.12E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31331(1,4-benzodiazepine-2,5-dione antagonist, 16 | Race...)
Affinity DataIC50:  2.13E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31335(1,4-benzodiazepine-2,5-dione antagonist, 20 | Race...)
Affinity DataIC50:  2.15E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31323(1,4-benzodiazepine-2,5-dione antagonist, 8 | Racem...)
Affinity DataIC50:  2.18E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31330(1,4-benzodiazepine-2,5-dione antagonist, 15 | Race...)
Affinity DataIC50:  2.82E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31324(1,4-benzodiazepine-2,5-dione antagonist, 9 | Racem...)
Affinity DataIC50:  3.33E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31325(1,4-benzodiazepine-2,5-dione antagonist, 10 | Race...)
Affinity DataIC50:  4.35E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31332(1,4-benzodiazepine-2,5-dione antagonist, 17 | Race...)
Affinity DataIC50:  8.22E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31326(1,4-benzodiazepine-2,5-dione antagonist, 11 | Race...)
Affinity DataIC50:  1.02E+4nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31333(1,4-benzodiazepine-2,5-dione antagonist, 18)
Affinity DataIC50:  1.33E+4nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31322(1,4-benzodiazepine-2,5-dione antagonist, 6 | Racem...)
Affinity DataIC50:  2.70E+4nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31329(1,4-benzodiazepine-2,5-dione antagonist, 14 | Race...)
Affinity DataIC50:  3.60E+4nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed