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PubMed code 16621538

Compile data set for download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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PubMed
1.60n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D2 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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PubMed
3.60n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D4.4 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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3.60n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D4.4 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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5.10n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D3 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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5.30n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D4.4 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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28n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5HT1A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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31n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5HT2A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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34n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-1A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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34n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-1A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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39n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-1A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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42n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-1B receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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42n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-1B receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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43n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-1B receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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51n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D2 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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51n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D2 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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76n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5HT2A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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76n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5HT2A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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94n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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94n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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143n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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516n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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722n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5HT1A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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722n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5HT1A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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872n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5HT2C receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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1.07E+3n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D3 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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1.07E+3n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D3 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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1.47E+3n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned histamine H1 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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1.47E+3n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned histamine H1 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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1.54E+3n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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2.24E+3n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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2.24E+3n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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2.84E+3n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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3.60E+3n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5HT2C receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
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3.60E+3n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5HT2C receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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8.78E+3n/an/an/an/an/an/an/an/a



Florida A& M University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned histamine H1 receptor by radioligand binding assay


Bioorg Med Chem Lett 16: 3219-23 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.057
BindingDB Entry DOI: 10.7270/Q2571BM5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%