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PubMed code 1662725

Compile data set for download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma


(HUMAN)
BDBM50007400
PNG
(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
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0.800n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Sigma opioid receptor in guinea pig brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007396
PNG
(4-Phenyl-1-(5-phenyl-pentyl)-piperidine | CHEMBL11...)
Show SMILES C(CCN1CCC(CC1)c1ccccc1)CCc1ccccc1
Show InChI InChI=1S/C22H29N/c1-4-10-20(11-5-1)12-6-3-9-17-23-18-15-22(16-19-23)21-13-7-2-8-14-21/h1-2,4-5,7-8,10-11,13-14,22H,3,6,9,12,15-19H2
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0.900n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards sigma receptor in guinea pig brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007393
PNG
(4-Phenyl-1-(3-phenyl-propyl)-piperidine | CHEMBL11...)
Show SMILES C(CN1CCC(CC1)c1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C20H25N/c1-3-8-18(9-4-1)10-7-15-21-16-13-20(14-17-21)19-11-5-2-6-12-19/h1-6,8-9,11-12,20H,7,10,13-17H2
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1.10n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Sigma opioid receptor in guinea pig brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007401
PNG
(1-Phenyl-4-(4-phenyl-butyl)-piperazine | CHEMBL858...)
Show SMILES C(CCc1ccccc1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H26N2/c1-3-9-19(10-4-1)11-7-8-14-21-15-17-22(18-16-21)20-12-5-2-6-13-20/h1-6,9-10,12-13H,7-8,11,14-18H2
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2.60n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007409
PNG
(1-Naphthalen-2-yl-4-(3-phenyl-propyl)-piperazine |...)
Show SMILES C(CN1CCN(CC1)c1ccc2ccccc2c1)Cc1ccccc1
Show InChI InChI=1S/C23H26N2/c1-2-7-20(8-3-1)9-6-14-24-15-17-25(18-16-24)23-13-12-21-10-4-5-11-22(21)19-23/h1-5,7-8,10-13,19H,6,9,14-18H2
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2.80n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007410
PNG
(1-(4-Chloro-phenyl)-4-(3-phenyl-propyl)-piperazine...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCc2ccccc2)CC1
Show InChI InChI=1S/C19H23ClN2/c20-18-8-10-19(11-9-18)22-15-13-21(14-16-22)12-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-11H,4,7,12-16H2
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2.90n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007398
PNG
(4-Phenyl-1-(3-phenyl-propyl)-piperidin-4-ol | 4-ph...)
Show SMILES OC1(CCN(CCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C20H25NO/c22-20(19-11-5-2-6-12-19)13-16-21(17-14-20)15-7-10-18-8-3-1-4-9-18/h1-6,8-9,11-12,22H,7,10,13-17H2
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3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Sigma opioid receptor in guinea pig brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007397
PNG
(1-(3-Naphthalen-2-yl-propyl)-4-phenyl-piperazine |...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C23H26N2/c1-2-10-23(11-3-1)25-17-15-24(16-18-25)14-6-7-20-12-13-21-8-4-5-9-22(21)19-20/h1-5,8-13,19H,6-7,14-18H2
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4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007395
PNG
(4-(4-Chloro-phenyl)-1-(4-phenyl-butyl)-1,2,3,6-tet...)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCc2ccccc2)CC1
Show InChI InChI=1S/C21H24ClN/c22-21-11-9-19(10-12-21)20-13-16-23(17-14-20)15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-13H,4-5,8,14-17H2
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4.10n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards sigma receptor in guinea pig brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007399
PNG
(1-(4-Phenyl-butyl)-4-(3-trifluoromethyl-phenyl)-pi...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCc2ccccc2)CC1
Show InChI InChI=1S/C21H25F3N2/c22-21(23,24)19-10-6-11-20(17-19)26-15-13-25(14-16-26)12-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-11,17H,4-5,9,12-16H2
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5.40n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007392
PNG
(1-Phenyl-4-(3-phenyl-propyl)-piperazine | CHEMBL11...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C19H24N2/c1-3-8-18(9-4-1)10-7-13-20-14-16-21(17-15-20)19-11-5-2-6-12-19/h1-6,8-9,11-12H,7,10,13-17H2
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6.70n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007405
PNG
(1-Phenethyl-4-(3-trifluoromethyl-phenyl)-piperazin...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C19H21F3N2/c20-19(21,22)17-7-4-8-18(15-17)24-13-11-23(12-14-24)10-9-16-5-2-1-3-6-16/h1-8,15H,9-14H2
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7.5n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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10n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Sigma opioid receptor in guinea pig brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007404
PNG
(1-(3-Chloro-phenyl)-4-phenethyl-piperazine | CHEMB...)
Show SMILES Clc1cccc(c1)N1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C18H21ClN2/c19-17-7-4-8-18(15-17)21-13-11-20(12-14-21)10-9-16-5-2-1-3-6-16/h1-8,15H,9-14H2
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11n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007412
PNG
(1-(3-Chloro-phenyl)-4-(3-phenyl-propyl)-piperazine...)
Show SMILES Clc1cccc(c1)N1CCN(CCCc2ccccc2)CC1
Show InChI InChI=1S/C19H23ClN2/c20-18-9-4-10-19(16-18)22-14-12-21(13-15-22)11-5-8-17-6-2-1-3-7-17/h1-4,6-7,9-10,16H,5,8,11-15H2
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19n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007402
PNG
(1-Phenyl-4-propyl-piperazine | 1-Phenyl-4-propylpi...)
Show SMILES CCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C13H20N2/c1-2-8-14-9-11-15(12-10-14)13-6-4-3-5-7-13/h3-7H,2,8-12H2,1H3
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74n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007413
PNG
(CHEMBL19351 | Phenyl-[4-(4-phenyl-butyl)-piperazin...)
Show SMILES O=C(N1CCN(CCCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C21H26N2O/c24-21(20-12-5-2-6-13-20)23-17-15-22(16-18-23)14-8-7-11-19-9-3-1-4-10-19/h1-6,9-10,12-13H,7-8,11,14-18H2
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125n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007411
PNG
(1-Naphthalen-2-yl-piperazine | CHEMBL278509)
Show SMILES C1CN(CCN1)c1ccc2ccccc2c1
Show InChI InChI=1S/C14H16N2/c1-2-4-13-11-14(6-5-12(13)3-1)16-9-7-15-8-10-16/h1-6,11,15H,7-10H2
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550n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50001897
PNG
(1-(4-Chloro-phenyl)-piperazine | CHEMBL114478 | pC...)
Show SMILES Clc1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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1.15E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007406
PNG
(1-(3-(trifluoromethyl)phenyl)piperazine | 1-(3-Tri...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCNCC1
Show InChI InChI=1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2
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1.34E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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1.98E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards sigma receptor in guinea pig brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007407
PNG
(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Show SMILES C1CN(CCN1)c1cccc2ccccc12
Show InChI InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
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2.72E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50001913
PNG
(1-(4-Methoxy-phenyl)-piperazine | 4-METHOXYPHENYLP...)
Show SMILES COc1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C11H16N2O/c1-14-11-4-2-10(3-5-11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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5.85E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50001915
PNG
(1-(3-chlorophenyl)piperazine | CHEMBL478 | m-Chlor...)
Show SMILES Clc1cccc(c1)N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2
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6.15E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007403
PNG
(1-(2-pyrimidyl)piperazine | 1-PP | 2-Piperazin-1-Y...)
Show SMILES C1CN(CCN1)c1ncccn1
Show InChI InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50004308
PNG
(1-Benzoylpiperazine | 1-Benzyl-piperazine | 1-Benz...)
Show SMILES C(N1CCNCC1)c1ccccc1
Show InChI InChI=1S/C11H16N2/c1-2-4-11(5-3-1)10-13-8-6-12-7-9-13/h1-5,12H,6-10H2
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1.05E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50001862
PNG
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Show SMILES COc1ccccc1N1CCNCC1
Show InChI InChI=1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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1.12E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50004323
PNG
(CHEMBL113624 | Phenyl-piperazin-1-yl-methanone)
Show SMILES O=C(N1CCNCC1)c1ccccc1
Show InChI InChI=1S/C11H14N2O/c14-11(10-4-2-1-3-5-10)13-8-6-12-7-9-13/h1-5,12H,6-9H2
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1.14E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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1.14E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007394
PNG
(4-(2-Methoxy-phenyl)-piperidin-4-ol | CHEMBL334036)
Show SMILES COc1ccccc1C1(O)CCNCC1
Show InChI InChI=1S/C12H17NO2/c1-15-11-5-3-2-4-10(11)12(14)6-8-13-9-7-12/h2-5,13-14H,6-9H2,1H3
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1.43E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 5.5n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 by using [3H]-domperidone as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007401
PNG
(1-Phenyl-4-(4-phenyl-butyl)-piperazine | CHEMBL858...)
Show SMILES C(CCc1ccccc1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H26N2/c1-3-9-19(10-4-1)11-7-8-14-21-15-17-22(18-16-21)20-12-5-2-6-13-20/h1-6,9-10,12-13H,7-8,11,14-18H2
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n/an/a 45n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards dopamine receptor D2 by using [3H]-domperidone as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007397
PNG
(1-(3-Naphthalen-2-yl-propyl)-4-phenyl-piperazine |...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C23H26N2/c1-2-10-23(11-3-1)25-17-15-24(16-18-25)14-6-7-20-12-13-21-8-4-5-9-22(21)19-20/h1-5,8-13,19H,6-7,14-18H2
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n/an/a 160n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards dopamine receptor D2 by using [3H]-domperidone as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007400
PNG
(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
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n/an/a 165n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 by using [3H]-domperidone as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007396
PNG
(4-Phenyl-1-(5-phenyl-pentyl)-piperidine | CHEMBL11...)
Show SMILES C(CCN1CCC(CC1)c1ccccc1)CCc1ccccc1
Show InChI InChI=1S/C22H29N/c1-4-10-20(11-5-1)12-6-3-9-17-23-18-15-22(16-19-23)21-13-7-2-8-14-21/h1-2,4-5,7-8,10-11,13-14,22H,3,6,9,12,15-19H2
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n/an/a 210n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards dopamine receptor D2 by using [3H]-domperidone as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007393
PNG
(4-Phenyl-1-(3-phenyl-propyl)-piperidine | CHEMBL11...)
Show SMILES C(CN1CCC(CC1)c1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C20H25N/c1-3-8-18(9-4-1)10-7-15-21-16-13-20(14-17-21)19-11-5-2-6-12-19/h1-6,8-9,11-12,20H,7,10,13-17H2
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n/an/a 335n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 by using [3H]-domperidone as radioligand


Citation and Details
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 337n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards Dopamine receptor D1 in rat membranes using [3H]-SCH-23,390 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007398
PNG
(4-Phenyl-1-(3-phenyl-propyl)-piperidin-4-ol | 4-ph...)
Show SMILES OC1(CCN(CCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C20H25NO/c22-20(19-11-5-2-6-12-19)13-16-21(17-14-20)15-7-10-18-8-3-1-4-9-18/h1-6,8-9,11-12,22H,7,10,13-17H2
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n/an/a 1.25E+3n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 by using [3H]-domperidone as radioligand


Citation and Details
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007401
PNG
(1-Phenyl-4-(4-phenyl-butyl)-piperazine | CHEMBL858...)
Show SMILES C(CCc1ccccc1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H26N2/c1-3-9-19(10-4-1)11-7-8-14-21-15-17-22(18-16-21)20-12-5-2-6-13-20/h1-6,9-10,12-13H,7-8,11,14-18H2
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n/an/a 2.82E+3n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards Dopamine receptor D1 in rat membranes using [3H]-SCH-23,390 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007397
PNG
(1-(3-Naphthalen-2-yl-propyl)-4-phenyl-piperazine |...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C23H26N2/c1-2-10-23(11-3-1)25-17-15-24(16-18-25)14-6-7-20-12-13-21-8-4-5-9-22(21)19-20/h1-5,8-13,19H,6-7,14-18H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards Dopamine receptor D1 in rat membranes using [3H]-SCH-23,390 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007393
PNG
(4-Phenyl-1-(3-phenyl-propyl)-piperidine | CHEMBL11...)
Show SMILES C(CN1CCC(CC1)c1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C20H25N/c1-3-8-18(9-4-1)10-7-15-21-16-13-20(14-17-21)19-11-5-2-6-12-19/h1-6,8-9,11-12,20H,7,10,13-17H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards Dopamine receptor D1 in rat membranes using [3H]-SCH-23,390 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50007397
PNG
(1-(3-Naphthalen-2-yl-propyl)-4-phenyl-piperazine |...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C23H26N2/c1-2-10-23(11-3-1)25-17-15-24(16-18-25)14-6-7-20-12-13-21-8-4-5-9-22(21)19-20/h1-5,8-13,19H,6-7,14-18H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards PCP receptor in rat brain membrane [3H]-MK-801 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007398
PNG
(4-Phenyl-1-(3-phenyl-propyl)-piperidin-4-ol | 4-ph...)
Show SMILES OC1(CCN(CCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C20H25NO/c22-20(19-11-5-2-6-12-19)13-16-21(17-14-20)15-7-10-18-8-3-1-4-9-18/h1-6,8-9,11-12,22H,7,10,13-17H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards Dopamine receptor D1 in rat membranes using [3H]-SCH-23,390 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50007401
PNG
(1-Phenyl-4-(4-phenyl-butyl)-piperazine | CHEMBL858...)
Show SMILES C(CCc1ccccc1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H26N2/c1-3-9-19(10-4-1)11-7-8-14-21-15-17-22(18-16-21)20-12-5-2-6-13-20/h1-6,9-10,12-13H,7-8,11,14-18H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards PCP receptor in rat brain membrane [3H]-MK-801 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50007396
PNG
(4-Phenyl-1-(5-phenyl-pentyl)-piperidine | CHEMBL11...)
Show SMILES C(CCN1CCC(CC1)c1ccccc1)CCc1ccccc1
Show InChI InChI=1S/C22H29N/c1-4-10-20(11-5-1)12-6-3-9-17-23-18-15-22(16-19-23)21-13-7-2-8-14-21/h1-2,4-5,7-8,10-11,13-14,22H,3,6,9,12,15-19H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards PCP receptor in rat brain membrane [3H]-MK-801 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007400
PNG
(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards Dopamine receptor D1 in rat membranes using [3H]-SCH-23,390 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50007393
PNG
(4-Phenyl-1-(3-phenyl-propyl)-piperidine | CHEMBL11...)
Show SMILES C(CN1CCC(CC1)c1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C20H25N/c1-3-8-18(9-4-1)10-7-15-21-16-13-20(14-17-21)19-11-5-2-6-12-19/h1-6,8-9,11-12,20H,7,10,13-17H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards PCP receptor in rat brain membrane [3H]-MK-801 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007396
PNG
(4-Phenyl-1-(5-phenyl-pentyl)-piperidine | CHEMBL11...)
Show SMILES C(CCN1CCC(CC1)c1ccccc1)CCc1ccccc1
Show InChI InChI=1S/C22H29N/c1-4-10-20(11-5-1)12-6-3-9-17-23-18-15-22(16-19-23)21-13-7-2-8-14-21/h1-2,4-5,7-8,10-11,13-14,22H,3,6,9,12,15-19H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity determined in radioreceptor binding assay by using [3H]-SCH-23,390 radioligand against dopamine receptor D1


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%