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PubMed code 1672156

Compile data set for download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007692
PNG
(8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-bu...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C24H32N4O2S/c29-21-17-24(9-3-4-10-24)18-22(30)28(21)12-6-5-11-26-13-15-27(16-14-26)23-19-7-1-2-8-20(19)31-25-23/h1-2,7-8H,3-6,9-18H2
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n/an/a 18n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 20n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007692
PNG
(8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-bu...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C24H32N4O2S/c29-21-17-24(9-3-4-10-24)18-22(30)28(21)12-6-5-11-26-13-15-27(16-14-26)23-19-7-1-2-8-20(19)31-25-23/h1-2,7-8H,3-6,9-18H2
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n/an/a 22n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007498
PNG
(8-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=C1CC2(CCCC2)CCN1OCCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C23H32N4O2S/c28-21-18-23(8-3-4-9-23)10-12-27(21)29-17-5-11-25-13-15-26(16-14-25)22-19-6-1-2-7-20(19)30-24-22/h1-2,6-7H,3-5,8-18H2
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007505
PNG
(8-{3-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H30F3N3O3/c24-23(25,26)18-5-3-6-19(15-18)28-12-10-27(11-13-28)9-4-14-32-29-20(30)16-22(17-21(29)31)7-1-2-8-22/h3,5-6,15H,1-2,4,7-14,16-17H2
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001885
PNG
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007494
PNG
(8-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propoxy}...)
Show SMILES Clc1cccc(c1)N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H30ClN3O3/c23-18-5-3-6-19(15-18)25-12-10-24(11-13-25)9-4-14-29-26-20(27)16-22(17-21(26)28)7-1-2-8-22/h3,5-6,15H,1-2,4,7-14,16-17H2
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007496
PNG
(8-{3-[4-(3-Methylsulfanyl-phenyl)-piperazin-1-yl]-...)
Show SMILES CSc1cccc(c1)N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H33N3O3S/c1-30-20-7-4-6-19(16-20)25-13-11-24(12-14-25)10-5-15-29-26-21(27)17-23(18-22(26)28)8-2-3-9-23/h4,6-7,16H,2-3,5,8-15,17-18H2,1H3
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007495
PNG
(9-Hydroxy-8-{3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CCCON2C(O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H35N3O4/c1-29-20-8-3-2-7-19(20)25-14-12-24(13-15-25)11-6-16-30-26-21(27)17-23(18-22(26)28)9-4-5-10-23/h2-3,7-8,21,27H,4-6,9-18H2,1H3
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007492
PNG
(8-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propoxy...)
Show SMILES COc1ccccc1N1CCN(CCCON2CCC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H35N3O3/c1-28-21-8-3-2-7-20(21)25-16-14-24(15-17-25)12-6-18-29-26-13-11-23(19-22(26)27)9-4-5-10-23/h2-3,7-8H,4-6,9-19H2,1H3
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007483
PNG
(8-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES OC1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C23H32N4O3S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)30-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)31-24-22/h1-2,6-7,20,28H,3-5,8-17H2
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007484
PNG
(8-[3-(4-m-Tolyl-piperazin-1-yl)-propoxy]-8-aza-spi...)
Show SMILES Cc1cccc(c1)N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H33N3O3/c1-19-6-4-7-20(16-19)25-13-11-24(12-14-25)10-5-15-29-26-21(27)17-23(18-22(26)28)8-2-3-9-23/h4,6-7,16H,2-3,5,8-15,17-18H2,1H3
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007481
PNG
(8-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C23H30N4O3S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)30-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)31-24-22/h1-2,6-7H,3-5,8-17H2
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007480
PNG
(8-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propoxy...)
Show SMILES COc1ccccc1N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H33N3O4/c1-29-20-8-3-2-7-19(20)25-14-12-24(13-15-25)11-6-16-30-26-21(27)17-23(18-22(26)28)9-4-5-10-23/h2-3,7-8H,4-6,9-18H2,1H3
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007481
PNG
(8-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C23H30N4O3S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)30-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)31-24-22/h1-2,6-7H,3-5,8-17H2
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007498
PNG
(8-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=C1CC2(CCCC2)CCN1OCCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C23H32N4O2S/c28-21-18-23(8-3-4-9-23)10-12-27(21)29-17-5-11-25-13-15-26(16-14-25)22-19-6-1-2-7-20(19)30-24-22/h1-2,6-7H,3-5,8-18H2
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007506
PNG
(8-{3-[4-(2,3-Dimethyl-phenyl)-piperazin-1-yl]-prop...)
Show SMILES Cc1cccc(N2CCN(CCCON3C(=O)CC4(CCCC4)CC3=O)CC2)c1C
Show InChI InChI=1S/C24H35N3O3/c1-19-7-5-8-21(20(19)2)26-14-12-25(13-15-26)11-6-16-30-27-22(28)17-24(18-23(27)29)9-3-4-10-24/h5,7-8H,3-4,6,9-18H2,1-2H3
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007485
PNG
(8-{3-[4-(2-Chloro-phenyl)-piperazin-1-yl]-propoxy}...)
Show SMILES Clc1ccccc1N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H30ClN3O3/c23-18-6-1-2-7-19(18)25-13-11-24(12-14-25)10-5-15-29-26-20(27)16-22(17-21(26)28)8-3-4-9-22/h1-2,6-7H,3-5,8-17H2
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007483
PNG
(8-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES OC1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C23H32N4O3S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)30-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)31-24-22/h1-2,6-7,20,28H,3-5,8-17H2
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007486
PNG
(8-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethoxy}...)
Show SMILES COc1ccccc1N1CCN(CCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H31N3O4/c1-28-19-7-3-2-6-18(19)24-12-10-23(11-13-24)14-15-29-25-20(26)16-22(17-21(25)27)8-4-5-9-22/h2-3,6-7H,4-5,8-17H2,1H3
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007493
PNG
(8-[3-(4-Pyrimidin-2-yl-piperazin-1-yl)-propoxy]-8-...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C20H29N5O3/c26-17-15-20(5-1-2-6-20)16-18(27)25(17)28-14-4-9-23-10-12-24(13-11-23)19-21-7-3-8-22-19/h3,7-8H,1-2,4-6,9-16H2
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Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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n/an/a 580n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007485
PNG
(8-{3-[4-(2-Chloro-phenyl)-piperazin-1-yl]-propoxy}...)
Show SMILES Clc1ccccc1N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H30ClN3O3/c23-18-6-1-2-7-19(18)25-13-11-24(12-14-25)10-5-15-29-26-20(27)16-22(17-21(26)28)8-3-4-9-22/h1-2,6-7H,3-5,8-17H2
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n/an/a 680n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007492
PNG
(8-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propoxy...)
Show SMILES COc1ccccc1N1CCN(CCCON2CCC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H35N3O3/c1-28-21-8-3-2-7-20(21)25-16-14-24(15-17-25)12-6-18-29-26-13-11-23(19-22(26)27)9-4-5-10-23/h2-3,7-8H,4-6,9-19H2,1H3
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n/an/a 720n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007486
PNG
(8-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethoxy}...)
Show SMILES COc1ccccc1N1CCN(CCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H31N3O4/c1-28-19-7-3-2-6-18(19)24-12-10-23(11-13-24)14-15-29-25-20(26)16-22(17-21(25)27)8-4-5-9-22/h2-3,6-7H,4-5,8-17H2,1H3
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n/an/a 740n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001885
PNG
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
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n/an/a 820n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007480
PNG
(8-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propoxy...)
Show SMILES COc1ccccc1N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H33N3O4/c1-29-20-8-3-2-7-19(20)25-14-12-24(13-15-25)11-6-16-30-26-21(27)17-23(18-22(26)28)9-4-5-10-23/h2-3,7-8H,4-6,9-18H2,1H3
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n/an/a 930n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007497
PNG
(8-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C22H28N4O3S/c27-19-15-22(7-3-4-8-22)16-20(28)26(19)29-14-13-24-9-11-25(12-10-24)21-17-5-1-2-6-18(17)30-23-21/h1-2,5-6H,3-4,7-16H2
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n/an/a 970n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007495
PNG
(9-Hydroxy-8-{3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CCCON2C(O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H35N3O4/c1-29-20-8-3-2-7-19(20)25-14-12-24(13-15-25)11-6-16-30-26-21(27)17-23(18-22(26)28)9-4-5-10-23/h2-3,7-8,21,27H,4-6,9-18H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
OPIATE Sigma


(RAT)
BDBM50007481
PNG
(8-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C23H30N4O3S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)30-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)31-24-22/h1-2,6-7H,3-5,8-17H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
compound was measured as affinity for sigma receptor labeled with [3H]-SKF- 10,0477 radioligand in slide-mounted slices


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007493
PNG
(8-[3-(4-Pyrimidin-2-yl-piperazin-1-yl)-propoxy]-8-...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C20H29N5O3/c26-17-15-20(5-1-2-6-20)16-18(27)25(17)28-14-4-9-23-10-12-24(13-11-23)19-21-7-3-8-22-19/h3,7-8H,1-2,4-6,9-16H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007506
PNG
(8-{3-[4-(2,3-Dimethyl-phenyl)-piperazin-1-yl]-prop...)
Show SMILES Cc1cccc(N2CCN(CCCON3C(=O)CC4(CCCC4)CC3=O)CC2)c1C
Show InChI InChI=1S/C24H35N3O3/c1-19-7-5-8-21(20(19)2)26-14-12-25(13-15-26)11-6-16-30-27-22(28)17-24(18-23(27)29)9-3-4-10-24/h5,7-8H,3-4,6,9-18H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007490
PNG
(8-[3-(4-Benzothiazol-2-yl-piperazin-1-yl)-propoxy]...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1nc2ccccc2s1
Show InChI InChI=1S/C23H30N4O3S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)30-15-5-10-25-11-13-26(14-12-25)22-24-18-6-1-2-7-19(18)31-22/h1-2,6-7H,3-5,8-17H2
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n/an/a 2.20E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007497
PNG
(8-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C22H28N4O3S/c27-19-15-22(7-3-4-8-22)16-20(28)26(19)29-14-13-24-9-11-25(12-10-24)21-17-5-1-2-6-18(17)30-23-21/h1-2,5-6H,3-4,7-16H2
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n/an/a 2.70E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007489
PNG
(8-[2-(4-Pyrimidin-2-yl-piperazin-1-yl)-ethoxy]-8-a...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C19H27N5O3/c25-16-14-19(4-1-2-5-19)15-17(26)24(16)27-13-12-22-8-10-23(11-9-22)18-20-6-3-7-21-18/h3,6-7H,1-2,4-5,8-15H2
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n/an/a 2.76E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007494
PNG
(8-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propoxy}...)
Show SMILES Clc1cccc(c1)N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H30ClN3O3/c23-18-5-3-6-19(15-18)25-12-10-24(11-13-25)9-4-14-29-26-20(27)16-22(17-21(26)28)7-1-2-8-22/h3,5-6,15H,1-2,4,7-14,16-17H2
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n/an/a 2.80E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007505
PNG
(8-{3-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H30F3N3O3/c24-23(25,26)18-5-3-6-19(15-18)28-12-10-27(11-13-28)9-4-14-32-29-20(30)16-22(17-21(29)31)7-1-2-8-22/h3,5-6,15H,1-2,4,7-14,16-17H2
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n/an/a 2.90E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007484
PNG
(8-[3-(4-m-Tolyl-piperazin-1-yl)-propoxy]-8-aza-spi...)
Show SMILES Cc1cccc(c1)N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H33N3O3/c1-19-6-4-7-20(16-19)25-13-11-24(12-14-25)10-5-15-29-26-21(27)17-23(18-22(26)28)8-2-3-9-23/h4,6-7,16H,2-3,5,8-15,17-18H2,1H3
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n/an/a 3.70E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007496
PNG
(8-{3-[4-(3-Methylsulfanyl-phenyl)-piperazin-1-yl]-...)
Show SMILES CSc1cccc(c1)N1CCN(CCCON2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H33N3O3S/c1-30-20-7-4-6-19(16-20)25-13-11-24(12-14-25)10-5-15-29-26-21(27)17-23(18-22(26)28)8-2-3-9-23/h4,6-7,16H,2-3,5,8-15,17-18H2,1H3
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n/an/a 4.09E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007501
PNG
(2-{3-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H22F3N3O3/c23-22(24,25)16-5-3-6-17(15-16)27-12-10-26(11-13-27)9-4-14-31-28-20(29)18-7-1-2-8-19(18)21(28)30/h1-3,5-8,15H,4,9-14H2
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n/an/a 5.30E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50007481
PNG
(8-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C23H30N4O3S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)30-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)31-24-22/h1-2,6-7H,3-5,8-17H2
PDB

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n/an/a 5.53E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
compound was measured for affinity against 5-hydroxytryptamine 1B receptor labelled with [3H]5-HT radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 6.21E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007481
PNG
(8-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C23H30N4O3S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)30-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)31-24-22/h1-2,6-7H,3-5,8-17H2
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n/an/a 6.60E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
compound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007502
PNG
(2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propoxy...)
Show SMILES COc1ccccc1N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O4/c1-28-20-10-5-4-9-19(20)24-14-12-23(13-15-24)11-6-16-29-25-21(26)17-7-2-3-8-18(17)22(25)27/h2-5,7-10H,6,11-16H2,1H3
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n/an/a 6.90E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007500
PNG
(2-[3-(4-o-Tolyl-piperazin-1-yl)-propoxy]-isoindole...)
Show SMILES Cc1ccccc1N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O3/c1-17-7-2-5-10-20(17)24-14-12-23(13-15-24)11-6-16-28-25-21(26)18-8-3-4-9-19(18)22(25)27/h2-5,7-10H,6,11-16H2,1H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007487
PNG
(2-[3-(4-Quinolin-2-yl-piperazin-1-yl)-propoxy]-iso...)
Show SMILES O=C1N(OCCCN2CCN(CC2)c2ccc3ccccc3n2)C(=O)c2ccccc12
Show InChI InChI=1S/C24H24N4O3/c29-23-19-7-2-3-8-20(19)24(30)28(23)31-17-5-12-26-13-15-27(16-14-26)22-11-10-18-6-1-4-9-21(18)25-22/h1-4,6-11H,5,12-17H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007491
PNG
(2-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=C1N(OCCCN2CCN(CC2)c2nsc3ccccc23)C(=O)c2ccccc12
Show InChI InChI=1S/C22H22N4O3S/c27-21-16-6-1-2-7-17(16)22(28)26(21)29-15-5-10-24-11-13-25(14-12-24)20-18-8-3-4-9-19(18)30-23-20/h1-4,6-9H,5,10-15H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007499
PNG
(8-{3-[4-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazo...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)C1=NS(=O)(=O)c2ccccc12
Show InChI InChI=1S/C23H30N4O5S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)32-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)33(30,31)24-22/h1-2,6-7H,3-5,8-17H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007504
PNG
(2-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propoxy}...)
Show SMILES Clc1cccc(c1)N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C21H22ClN3O3/c22-16-5-3-6-17(15-16)24-12-10-23(11-13-24)9-4-14-28-25-20(26)18-7-1-2-8-19(18)21(25)27/h1-3,5-8,15H,4,9-14H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007479
PNG
(2-{3-[4-(3-Methylsulfanyl-phenyl)-piperazin-1-yl]-...)
Show SMILES CSc1cccc(c1)N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O3S/c1-29-18-7-4-6-17(16-18)24-13-11-23(12-14-24)10-5-15-28-25-21(26)19-8-2-3-9-20(19)22(25)27/h2-4,6-9,16H,5,10-15H2,1H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007499
PNG
(8-{3-[4-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazo...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)C1=NS(=O)(=O)c2ccccc12
Show InChI InChI=1S/C23H30N4O5S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)32-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)33(30,31)24-22/h1-2,6-7H,3-5,8-17H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007479
PNG
(2-{3-[4-(3-Methylsulfanyl-phenyl)-piperazin-1-yl]-...)
Show SMILES CSc1cccc(c1)N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O3S/c1-29-18-7-4-6-17(16-18)24-13-11-23(12-14-24)10-5-15-28-25-21(26)19-8-2-3-9-20(19)22(25)27/h2-4,6-9,16H,5,10-15H2,1H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007489
PNG
(8-[2-(4-Pyrimidin-2-yl-piperazin-1-yl)-ethoxy]-8-a...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C19H27N5O3/c25-16-14-19(4-1-2-5-19)15-17(26)24(16)27-13-12-22-8-10-23(11-9-22)18-20-6-3-7-21-18/h3,6-7H,1-2,4-5,8-15H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007491
PNG
(2-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=C1N(OCCCN2CCN(CC2)c2nsc3ccccc23)C(=O)c2ccccc12
Show InChI InChI=1S/C22H22N4O3S/c27-21-16-6-1-2-7-17(16)22(28)26(21)29-15-5-10-24-11-13-25(14-12-24)20-18-8-3-4-9-19(18)30-23-20/h1-4,6-9H,5,10-15H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007501
PNG
(2-{3-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H22F3N3O3/c23-22(24,25)16-5-3-6-17(15-16)27-12-10-26(11-13-27)9-4-14-31-28-20(29)18-7-1-2-8-19(18)21(28)30/h1-3,5-8,15H,4,9-14H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at Dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007488
PNG
(2-[3-(4-m-Tolyl-piperazin-1-yl)-propoxy]-isoindole...)
Show SMILES Cc1cccc(c1)N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O3/c1-17-6-4-7-18(16-17)24-13-11-23(12-14-24)10-5-15-28-25-21(26)19-8-2-3-9-20(19)22(25)27/h2-4,6-9,16H,5,10-15H2,1H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007500
PNG
(2-[3-(4-o-Tolyl-piperazin-1-yl)-propoxy]-isoindole...)
Show SMILES Cc1ccccc1N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O3/c1-17-7-2-5-10-20(17)24-14-12-23(13-15-24)11-6-16-28-25-21(26)18-8-3-4-9-19(18)22(25)27/h2-5,7-10H,6,11-16H2,1H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007488
PNG
(2-[3-(4-m-Tolyl-piperazin-1-yl)-propoxy]-isoindole...)
Show SMILES Cc1cccc(c1)N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O3/c1-17-6-4-7-18(16-17)24-13-11-23(12-14-24)10-5-15-28-25-21(26)19-8-2-3-9-20(19)22(25)27/h2-4,6-9,16H,5,10-15H2,1H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007504
PNG
(2-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propoxy}...)
Show SMILES Clc1cccc(c1)N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C21H22ClN3O3/c22-16-5-3-6-17(15-16)24-12-10-23(11-13-24)9-4-14-28-25-20(26)18-7-1-2-8-19(18)21(25)27/h1-3,5-8,15H,4,9-14H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007490
PNG
(8-[3-(4-Benzothiazol-2-yl-piperazin-1-yl)-propoxy]...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1nc2ccccc2s1
Show InChI InChI=1S/C23H30N4O3S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)30-15-5-10-25-11-13-26(14-12-25)22-24-18-6-1-2-7-19(18)31-22/h1-2,6-7H,3-5,8-17H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007502
PNG
(2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propoxy...)
Show SMILES COc1ccccc1N1CCN(CCCON2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O4/c1-28-20-10-5-4-9-19(20)24-14-12-23(13-15-24)11-6-16-29-25-21(26)17-7-2-3-8-18(17)22(25)27/h2-5,7-10H,6,11-16H2,1H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at Dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007503
PNG
(8-[3-(4-Quinolin-2-yl-piperazin-1-yl)-propoxy]-8-a...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H32N4O3/c30-23-18-25(10-3-4-11-25)19-24(31)29(23)32-17-5-12-27-13-15-28(16-14-27)22-9-8-20-6-1-2-7-21(20)26-22/h1-2,6-9H,3-5,10-19H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%