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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity determined in radioreceptor binding assay by using [3H]-SCH-23,390 radioligand against dopamine receptor D1 | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity determined in radioreceptor binding assay by using [3H]-SCH-23,390 radioligand against dopamine receptor D1 | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 2 (5-HT2) receptor (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity determined in radioreceptor binding assay by using [3H]-SCH-23,390 radioligand against dopamine receptor D1 | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against dopamine receptor D2 using raclopride as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 2 (5-HT2) receptor (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against dopamine receptor D2 using raclopride as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 2 (5-HT2) receptor (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity determined in radioreceptor binding assay by using [3H]-SCH-23,390 radioligand against dopamine receptor D1 | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against dopamine receptor D2 using raclopride as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dopamine D1 and D2 receptor (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Muscarinic acetylcholine receptor (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against Alpha-1 adrenergic receptor using WB4101 as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against Dopamine receptor D2 using raclopride as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Muscarinic acetylcholine receptor (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against sigma receptor using DTG as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against Alpha-1 adrenergic receptor using WB-4101 as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 2 (5-HT2) receptor (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against dopamine receptor D2 using raclopride as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against Alpha-1 adrenergic receptor using WB4101 as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Muscarinic acetylcholine receptor (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against muscarinic acetylcholine receptor using QNB as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against sigma receptor using DTG as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dopamine D1 and D2 receptor (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1 | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Muscarinic acetylcholine receptor (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against muscarinic acetylcholine receptor using QNB as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against Alpha-1 adrenergic receptor using WB4101 as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | PDB UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against sigma receptor using DTG as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against Alpha-1 adrenergic receptor using WB4101 as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | PDB UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against Sigma opioid receptor using DTG as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50007551 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | PDB UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against sigma receptor using DTG as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50007550 (3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro...) | PDB UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description The compound was tested for binding affinity against Sigma opioid receptor using DTG as radioligand | J Med Chem 34: 1707-14 (1991) Article DOI: 10.1021/jm00109a026 BindingDB Entry DOI: 10.7270/Q2ZP4534 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
