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PubMed code 16750628

Compile data set for download or QSAR
Found 47 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a 103n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a 145n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a 169n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT4 by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a 180n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a 293n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188283
PNG
(6-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccsc3)c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-17-16(10-14)11-18-19(21-22-20(17)18)15-4-9-25-13-15/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a 400n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188281
PNG
(4-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c(n[nH]c-34)-c3ccc(O)cc3)c2)CC1
Show InChI InChI=1S/C22H24N4O/c1-25-8-10-26(11-9-25)14-15-2-7-19-17(12-15)13-20-21(23-24-22(19)20)16-3-5-18(27)6-4-16/h2-7,12,27H,8-11,13-14H2,1H3,(H,23,24)
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n/an/a 500n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188290
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-phenyl-1,4-di...)
Show SMILES CN1CCN(Cc2ccc3Cc4c([nH]nc4-c4ccccc4)-c3c2)CC1
Show InChI InChI=1S/C22H24N4/c1-25-9-11-26(12-10-25)15-16-7-8-18-14-20-21(17-5-3-2-4-6-17)23-24-22(20)19(18)13-16/h2-8,13H,9-12,14-15H2,1H3,(H,23,24)
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n/an/a 600n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a 601n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188275
PNG
(6-((4-methylpiperazin-1-yl)methyl)-3-phenyl-1,4-di...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3[nH]nc4-c3ccccc3)c2)CC1
Show InChI InChI=1S/C22H24N4/c1-25-9-11-26(12-10-25)15-16-7-8-19-18(13-16)14-20-21(23-24-22(19)20)17-5-3-2-4-6-17/h2-8,13H,9-12,14-15H2,1H3,(H,23,24)
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n/an/a 700n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188292
PNG
(3-(thiophen-2-yl)-1,4-dihydroindeno[1,2-c]pyrazole...)
Show SMILES C1c2ccccc2-c2n[nH]c(c12)-c1cccs1
Show InChI InChI=1S/C14H10N2S/c1-2-5-10-9(4-1)8-11-13(10)15-16-14(11)12-6-3-7-17-12/h1-7H,8H2,(H,15,16)
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n/an/a 930n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a 970n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188271
PNG
(6-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-2-y...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3cccs3)c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-6-8-24(9-7-23)13-14-4-5-16-15(11-14)12-17-19(16)21-22-20(17)18-3-2-10-25-18/h2-5,10-11H,6-9,12-13H2,1H3,(H,21,22)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188284
PNG
(3-phenyl-1,4-dihydroindeno[1,2-c]pyrazole | CHEMBL...)
Show SMILES C1c2ccccc2-c2[nH]nc(c12)-c1ccccc1
Show InChI InChI=1S/C16H12N2/c1-2-6-11(7-3-1)15-14-10-12-8-4-5-9-13(12)16(14)18-17-15/h1-9H,10H2,(H,17,18)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188269
PNG
(3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1,4-d...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2[nH]nc-3c2Cc2ccccc-32)CC1
Show InChI InChI=1S/C22H24N4/c1-25-10-12-26(13-11-25)15-16-6-8-17(9-7-16)21-20-14-18-4-2-3-5-19(18)22(20)24-23-21/h2-9H,10-15H2,1H3,(H,23,24)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a 1.57E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT4 by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188277
PNG
(6-((4-methylpiperazin-1-yl)methyl)-3-(thiazol-5-yl...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3cncs3)c2)CC1
Show InChI InChI=1S/C19H21N5S/c1-23-4-6-24(7-5-23)11-13-2-3-15-14(8-13)9-16-18(15)21-22-19(16)17-10-20-12-25-17/h2-3,8,10,12H,4-7,9,11H2,1H3,(H,21,22)
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n/an/a 2.84E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188289
PNG
(3-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1,4-d...)
Show SMILES CN1CCN(Cc2cccc(c2)-c2[nH]nc-3c2Cc2ccccc-32)CC1
Show InChI InChI=1S/C22H24N4/c1-25-9-11-26(12-10-25)15-16-5-4-7-18(13-16)21-20-14-17-6-2-3-8-19(17)22(20)24-23-21/h2-8,13H,9-12,14-15H2,1H3,(H,23,24)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188273
PNG
(6-((4-methylpiperazin-1-yl)methyl)-3-(5-methylthio...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(C)s3)c2)CC1
Show InChI InChI=1S/C21H24N4S/c1-14-3-6-19(26-14)21-18-12-16-11-15(4-5-17(16)20(18)22-23-21)13-25-9-7-24(2)8-10-25/h3-6,11H,7-10,12-13H2,1-2H3,(H,22,23)
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n/an/a 5.47E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188274
PNG
(6-((4-methylpiperazin-1-yl)methyl)-3-(thiazol-4-yl...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3cscn3)c2)CC1
Show InChI InChI=1S/C19H21N5S/c1-23-4-6-24(7-5-23)10-13-2-3-15-14(8-13)9-16-18(15)21-22-19(16)17-11-25-12-20-17/h2-3,8,11-12H,4-7,9-10H2,1H3,(H,21,22)
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n/an/a 7.48E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188279
PNG
(6-((4-methylpiperazin-1-yl)methyl)-3-(pyridin-3-yl...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c(n[nH]c-34)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C21H23N5/c1-25-7-9-26(10-8-25)14-15-4-5-18-17(11-15)12-19-20(23-24-21(18)19)16-3-2-6-22-13-16/h2-6,11,13H,7-10,12,14H2,1H3,(H,23,24)
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n/an/a 9.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188265
PNG
(6-((4-methylpiperazin-1-yl)methyl)-3-(4-methylthio...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3cc(C)cs3)c2)CC1
Show InChI InChI=1S/C21H24N4S/c1-14-9-19(26-13-14)21-18-11-16-10-15(3-4-17(16)20(18)22-23-21)12-25-7-5-24(2)6-8-25/h3-4,9-10,13H,5-8,11-12H2,1-2H3,(H,22,23)
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n/an/a 1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188268
PNG
(5-((4-methylpiperazin-1-yl)methyl)-3-phenyl-1,4-di...)
Show SMILES CN1CCN(Cc2cccc-3c2Cc2c-3[nH]nc2-c2ccccc2)CC1
Show InChI InChI=1S/C22H24N4/c1-25-10-12-26(13-11-25)15-17-8-5-9-18-19(17)14-20-21(23-24-22(18)20)16-6-3-2-4-7-16/h2-9H,10-15H2,1H3,(H,23,24)
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n/an/a 1.41E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188287
PNG
(6-((4-methylpiperazin-1-yl)methyl)-3-(thiazol-2-yl...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c(n[nH]c-34)-c3nccs3)c2)CC1
Show InChI InChI=1S/C19H21N5S/c1-23-5-7-24(8-6-23)12-13-2-3-15-14(10-13)11-16-17(15)21-22-18(16)19-20-4-9-25-19/h2-4,9-10H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a 1.66E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a 1.76E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Tie2 by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a 2.11E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a 3.44E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a 4.78E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Tie2 by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cMet by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188291
PNG
(6-((4-methylpiperazin-1-yl)methyl)-3-(3-methylthio...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3sccc3C)c2)CC1
Show InChI InChI=1S/C21H24N4S/c1-14-5-10-26-21(14)20-18-12-16-11-15(3-4-17(16)19(18)22-23-20)13-25-8-6-24(2)7-9-25/h3-5,10-11H,6-9,12-13H2,1-2H3,(H,22,23)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188278
PNG
(3-(benzo[b]thiophen-2-yl)-6-((4-methylpiperazin-1-...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3cc4ccccc4s3)c2)CC1
Show InChI InChI=1S/C24H24N4S/c1-27-8-10-28(11-9-27)15-16-6-7-19-18(12-16)13-20-23(19)25-26-24(20)22-14-17-4-2-3-5-21(17)29-22/h2-7,12,14H,8-11,13,15H2,1H3,(H,25,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PDGFR by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cMet by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PDGFR by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188286
PNG
(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(thiophen-3-yl...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1cncn1
Show InChI InChI=1S/C17H13N5S/c1-2-12-6-15-16(13-3-4-23-8-13)20-21-17(15)14(12)5-11(1)7-22-10-18-9-19-22/h1-5,8-10H,6-7H2,(H,20,21)
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n/an/a 1.08E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188276
PNG
(7-(2-(4-methylpiperazin-1-yl)ethyl)-3-(thiophen-3-...)
Show SMILES CN1CCN(CCc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C21H24N4S/c1-24-7-9-25(10-8-24)6-4-15-2-3-16-13-19-20(17-5-11-26-14-17)22-23-21(19)18(16)12-15/h2-3,5,11-12,14H,4,6-10,13H2,1H3,(H,22,23)
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n/an/a 1.43E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a 1.47E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR-mediated biotin-Ahx-AEEEYFFLFA-amide substrate phosphorylation in presence of 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188282
PNG
(7-((1H-1,2,3-triazol-1-yl)methyl)-3-(thiophen-3-yl...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnn1
Show InChI InChI=1S/C17H13N5S/c1-2-12-8-15-16(13-3-6-23-10-13)19-20-17(15)14(12)7-11(1)9-22-5-4-18-21-22/h1-7,10H,8-9H2,(H,19,20)
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n/an/a 1.90E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188285
PNG
(7-((4-isopropylpiperazin-1-yl)methyl)-3-(thiophen-...)
Show SMILES CC(C)N1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C22H26N4S/c1-15(2)26-8-6-25(7-9-26)13-16-3-4-17-12-20-21(18-5-10-27-14-18)23-24-22(20)19(17)11-16/h3-5,10-11,14-15H,6-9,12-13H2,1-2H3,(H,23,24)
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n/an/a 1.90E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188280
PNG
(4-((3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyra...)
Show SMILES O=CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H20N4OS/c25-13-24-6-4-23(5-7-24)11-14-1-2-15-10-18-19(16-3-8-26-12-16)21-22-20(18)17(15)9-14/h1-3,8-9,12-13H,4-7,10-11H2,(H,21,22)
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n/an/a 6.65E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188270
PNG
(CHEMBL213531 | N-ethyl-N-((3-(thiophen-3-yl)-1,4-d...)
Show SMILES CCN(CC)Cc1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1
Show InChI InChI=1S/C19H21N3S/c1-3-22(4-2)11-13-5-6-14-10-17-18(15-7-8-23-12-15)20-21-19(17)16(14)9-13/h5-9,12H,3-4,10-11H2,1-2H3,(H,20,21)
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n/an/a 8.24E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188288
PNG
(6-(4-methylpiperazin-1-yl)-3-(thiophen-2-yl)-1,4-d...)
Show SMILES CN1CCN(CC1)c1ccc-2c(Cc3c-2n[nH]c3-c2cccs2)c1
Show InChI InChI=1S/C19H20N4S/c1-22-6-8-23(9-7-22)14-4-5-15-13(11-14)12-16-18(15)20-21-19(16)17-3-2-10-24-17/h2-5,10-11H,6-9,12H2,1H3,(H,20,21)
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n/an/a 1.01E+6n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188267
PNG
((4-methylpiperazin-1-yl)(3-(thiophen-3-yl)-1,4-dih...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1
Show InChI InChI=1S/C20H20N4OS/c1-23-5-7-24(8-6-23)20(25)14-3-2-13-10-17-18(15-4-9-26-12-15)21-22-19(17)16(13)11-14/h2-4,9,11-12H,5-8,10H2,1H3,(H,21,22)
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n/an/a 4.08E+6n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%