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PubMed code 16759099

Compile data set for download or QSAR
Found 130 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15956
PNG
(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Show SMILES COc1cc(c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1)S(C)(=O)=O
Show InChI InChI=1S/C20H24N4O6S/c1-11(2)30-20-13(10-21)14(22)8-18(24-20)23-19(25)7-12-6-16(29-4)17(31(5,26)27)9-15(12)28-3/h6,8-9,11H,7H2,1-5H3,(H3,22,23,24,25)
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1n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15908
PNG
(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
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2n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15939
PNG
(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1C#N
Show InChI InChI=1S/C19H22N4O6S/c1-5-29-19-12(10-20)13(21)8-17(23-19)22-18(24)7-11-6-15(28-3)16(30(4,25)26)9-14(11)27-2/h6,8-9H,5,7H2,1-4H3,(H3,21,22,23,24)
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3n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15976
PNG
(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1Cl
Show InChI InChI=1S/C18H22ClN3O6S/c1-5-28-18-17(19)11(20)8-15(22-18)21-16(23)7-10-6-13(27-3)14(29(4,24)25)9-12(10)26-2/h6,8-9H,5,7H2,1-4H3,(H3,20,21,22,23)
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3n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15908
PNG
(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
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4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15956
PNG
(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Show SMILES COc1cc(c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1)S(C)(=O)=O
Show InChI InChI=1S/C20H24N4O6S/c1-11(2)30-20-13(10-21)14(22)8-18(24-20)23-19(25)7-12-6-16(29-4)17(31(5,26)27)9-15(12)28-3/h6,8-9,11H,7H2,1-5H3,(H3,22,23,24,25)
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4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15939
PNG
(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1C#N
Show InChI InChI=1S/C19H22N4O6S/c1-5-29-19-12(10-20)13(21)8-17(23-19)22-18(24)7-11-6-15(28-3)16(30(4,25)26)9-14(11)27-2/h6,8-9H,5,7H2,1-4H3,(H3,21,22,23,24)
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9n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15976
PNG
(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1Cl
Show InChI InChI=1S/C18H22ClN3O6S/c1-5-28-18-17(19)11(20)8-15(22-18)21-16(23)7-10-6-13(27-3)14(29(4,24)25)9-12(10)26-2/h6,8-9H,5,7H2,1-4H3,(H3,20,21,22,23)
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13n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM15956
PNG
(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Show SMILES COc1cc(c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1)S(C)(=O)=O
Show InChI InChI=1S/C20H24N4O6S/c1-11(2)30-20-13(10-21)14(22)8-18(24-20)23-19(25)7-12-6-16(29-4)17(31(5,26)27)9-15(12)28-3/h6,8-9,11H,7H2,1-5H3,(H3,22,23,24,25)
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18n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM15908
PNG
(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
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52n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM15976
PNG
(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1Cl
Show InChI InChI=1S/C18H22ClN3O6S/c1-5-28-18-17(19)11(20)8-15(22-18)21-16(23)7-10-6-13(27-3)14(29(4,24)25)9-12(10)26-2/h6,8-9H,5,7H2,1-4H3,(H3,20,21,22,23)
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61n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM15939
PNG
(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1C#N
Show InChI InChI=1S/C19H22N4O6S/c1-5-29-19-12(10-20)13(21)8-17(23-19)22-18(24)7-11-6-15(28-3)16(30(4,25)26)9-14(11)27-2/h6,8-9H,5,7H2,1-4H3,(H3,21,22,23,24)
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72n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15907
PNG
(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C10H12N4O2/c1-3-16-10-7(5-11)8(12)4-9(14-10)13-6(2)15/h4H,3H2,1-2H3,(H3,12,13,14,15)
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190n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15907
PNG
(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C10H12N4O2/c1-3-16-10-7(5-11)8(12)4-9(14-10)13-6(2)15/h4H,3H2,1-2H3,(H3,12,13,14,15)
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440n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM15907
PNG
(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C10H12N4O2/c1-3-16-10-7(5-11)8(12)4-9(14-10)13-6(2)15/h4H,3H2,1-2H3,(H3,12,13,14,15)
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520n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15968
PNG
(Aminopyridine-Based Inhibitor 24 | N-(4-Amino-5-cy...)
Show SMILES CC(=O)Nc1cc(N)c(C#N)c(n1)-c1ccccc1
Show InChI InChI=1S/C14H12N4O/c1-9(19)17-13-7-12(16)11(8-15)14(18-13)10-5-3-2-4-6-10/h2-7H,1H3,(H3,16,17,18,19)
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550n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15968
PNG
(Aminopyridine-Based Inhibitor 24 | N-(4-Amino-5-cy...)
Show SMILES CC(=O)Nc1cc(N)c(C#N)c(n1)-c1ccccc1
Show InChI InChI=1S/C14H12N4O/c1-9(19)17-13-7-12(16)11(8-15)14(18-13)10-5-3-2-4-6-10/h2-7H,1H3,(H3,16,17,18,19)
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1.90E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM15968
PNG
(Aminopyridine-Based Inhibitor 24 | N-(4-Amino-5-cy...)
Show SMILES CC(=O)Nc1cc(N)c(C#N)c(n1)-c1ccccc1
Show InChI InChI=1S/C14H12N4O/c1-9(19)17-13-7-12(16)11(8-15)14(18-13)10-5-3-2-4-6-10/h2-7H,1H3,(H3,16,17,18,19)
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3.30E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15956
PNG
(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Show SMILES COc1cc(c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1)S(C)(=O)=O
Show InChI InChI=1S/C20H24N4O6S/c1-11(2)30-20-13(10-21)14(22)8-18(24-20)23-19(25)7-12-6-16(29-4)17(31(5,26)27)9-15(12)28-3/h6,8-9,11H,7H2,1-5H3,(H3,22,23,24,25)
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n/an/a 14n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15938
PNG
(2-(4-Acetylamino-2,5-dimethoxyphenyl)-N-(4-amino-5...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(NC(C)=O)cc2OC)cc(N)c1C#N
Show InChI InChI=1S/C20H23N5O5/c1-5-30-20-13(10-21)14(22)8-18(25-20)24-19(27)7-12-6-17(29-4)15(23-11(2)26)9-16(12)28-3/h6,8-9H,5,7H2,1-4H3,(H,23,26)(H3,22,24,25,27)
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n/an/a 26n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15938
PNG
(2-(4-Acetylamino-2,5-dimethoxyphenyl)-N-(4-amino-5...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(NC(C)=O)cc2OC)cc(N)c1C#N
Show InChI InChI=1S/C20H23N5O5/c1-5-30-20-13(10-21)14(22)8-18(25-20)24-19(27)7-12-6-17(29-4)15(23-11(2)26)9-16(12)28-3/h6,8-9H,5,7H2,1-4H3,(H,23,26)(H3,22,24,25,27)
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n/an/a 35n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15976
PNG
(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1Cl
Show InChI InChI=1S/C18H22ClN3O6S/c1-5-28-18-17(19)11(20)8-15(22-18)21-16(23)7-10-6-13(27-3)14(29(4,24)25)9-12(10)26-2/h6,8-9H,5,7H2,1-4H3,(H3,20,21,22,23)
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n/an/a 36n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15939
PNG
(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1C#N
Show InChI InChI=1S/C19H22N4O6S/c1-5-29-19-12(10-20)13(21)8-17(23-19)22-18(24)7-11-6-15(28-3)16(30(4,25)26)9-14(11)27-2/h6,8-9H,5,7H2,1-4H3,(H3,21,22,23,24)
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n/an/a 38n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15908
PNG
(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
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n/an/a 45n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15956
PNG
(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Show SMILES COc1cc(c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1)S(C)(=O)=O
Show InChI InChI=1S/C20H24N4O6S/c1-11(2)30-20-13(10-21)14(22)8-18(24-20)23-19(25)7-12-6-16(29-4)17(31(5,26)27)9-15(12)28-3/h6,8-9,11H,7H2,1-5H3,(H3,22,23,24,25)
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n/an/a 64n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15941
PNG
(Aminopyridine-Based Inhibitor 6u | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)[N+]([O-])=O)cc(N)c1C#N
Show InChI InChI=1S/C18H19N5O6/c1-4-29-18-11(9-19)12(20)7-16(22-18)21-17(24)6-10-5-15(28-3)13(23(25)26)8-14(10)27-2/h5,7-8H,4,6H2,1-3H3,(H3,20,21,22,24)
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n/an/a 69n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15952
PNG
(1-[(4-Amino-5-cyano-6-ethoxypyridin-2-ylcarbamoyl)...)
Show SMILES CCCCNC(=O)C1CCN(CC(=O)Nc2cc(N)c(C#N)c(OCC)n2)CC1
Show InChI InChI=1S/C20H30N6O3/c1-3-5-8-23-19(28)14-6-9-26(10-7-14)13-18(27)24-17-11-16(22)15(12-21)20(25-17)29-4-2/h11,14H,3-10,13H2,1-2H3,(H,23,28)(H3,22,24,25,27)
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n/an/a 69n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15976
PNG
(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1Cl
Show InChI InChI=1S/C18H22ClN3O6S/c1-5-28-18-17(19)11(20)8-15(22-18)21-16(23)7-10-6-13(27-3)14(29(4,24)25)9-12(10)26-2/h6,8-9H,5,7H2,1-4H3,(H3,20,21,22,23)
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n/an/a 70n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15962
PNG
(Aminopyridine-Based Inhibitor 20a | N-[4-Amino-5-c...)
Show SMILES COc1ccc(OC)c(CC(=O)Nc2cc(N)c(C#N)c(OCCO)n2)c1
Show InChI InChI=1S/C18H20N4O5/c1-25-12-3-4-15(26-2)11(7-12)8-17(24)21-16-9-14(20)13(10-19)18(22-16)27-6-5-23/h3-4,7,9,23H,5-6,8H2,1-2H3,(H3,20,21,22,24)
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n/an/a 74n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15940
PNG
(Aminopyridine-Based Inhibitor 6t | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(Br)cc2OC)cc(N)c1C#N
Show InChI InChI=1S/C18H19BrN4O4/c1-4-27-18-11(9-20)13(21)8-16(23-18)22-17(24)6-10-5-15(26-3)12(19)7-14(10)25-2/h5,7-8H,4,6H2,1-3H3,(H3,21,22,23,24)
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n/an/a 77n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15953
PNG
(1-[(4-Amino-5-cyano-6-ethoxypyridin-2ylcarbamoyl)m...)
Show SMILES CCOc1nc(NC(=O)CN2CCC(CC2)C(=O)NC(C)C)cc(N)c1C#N
Show InChI InChI=1S/C19H28N6O3/c1-4-28-19-14(10-20)15(21)9-16(24-19)23-17(26)11-25-7-5-13(6-8-25)18(27)22-12(2)3/h9,12-13H,4-8,11H2,1-3H3,(H,22,27)(H3,21,23,24,26)
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n/an/a 87n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15941
PNG
(Aminopyridine-Based Inhibitor 6u | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)[N+]([O-])=O)cc(N)c1C#N
Show InChI InChI=1S/C18H19N5O6/c1-4-29-18-11(9-19)12(20)7-16(22-18)21-17(24)6-10-5-15(28-3)13(23(25)26)8-14(10)27-2/h5,7-8H,4,6H2,1-3H3,(H3,20,21,22,24)
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n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15963
PNG
(Aminopyridine-Based Inhibitor 20b | N-[4-Amino-5-c...)
Show SMILES COCCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C19H22N4O5/c1-25-6-7-28-19-14(11-20)15(21)10-17(23-19)22-18(24)9-12-8-13(26-2)4-5-16(12)27-3/h4-5,8,10H,6-7,9H2,1-3H3,(H3,21,22,23,24)
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n/an/a 110n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15933
PNG
(Aminopyridine-Based Inhibitor 6l | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O3/c1-3-24-17-12(10-18)13(19)9-15(21-17)20-16(22)8-11-6-4-5-7-14(11)23-2/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 120n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15953
PNG
(1-[(4-Amino-5-cyano-6-ethoxypyridin-2ylcarbamoyl)m...)
Show SMILES CCOc1nc(NC(=O)CN2CCC(CC2)C(=O)NC(C)C)cc(N)c1C#N
Show InChI InChI=1S/C19H28N6O3/c1-4-28-19-14(10-20)15(21)9-16(24-19)23-17(26)11-25-7-5-13(6-8-25)18(27)22-12(2)3/h9,12-13H,4-8,11H2,1-3H3,(H,22,27)(H3,21,23,24,26)
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n/an/a 130n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15939
PNG
(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1C#N
Show InChI InChI=1S/C19H22N4O6S/c1-5-29-19-12(10-20)13(21)8-17(23-19)22-18(24)7-11-6-15(28-3)16(30(4,25)26)9-14(11)27-2/h6,8-9H,5,7H2,1-4H3,(H3,21,22,23,24)
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n/an/a 150n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15948
PNG
(Aminopyridine-Based Inhibitor 28d | N-(4-Amino-5-c...)
Show SMILES CCCN(CCO)CC(=O)Nc1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C15H23N5O3/c1-3-5-20(6-7-21)10-14(22)18-13-8-12(17)11(9-16)15(19-13)23-4-2/h8,21H,3-7,10H2,1-2H3,(H3,17,18,19,22)
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n/an/a 160n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15940
PNG
(Aminopyridine-Based Inhibitor 6t | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)c(Br)cc2OC)cc(N)c1C#N
Show InChI InChI=1S/C18H19BrN4O4/c1-4-27-18-11(9-20)13(21)8-16(23-18)22-17(24)6-10-5-15(26-3)12(19)7-14(10)25-2/h5,7-8H,4,6H2,1-3H3,(H3,21,22,23,24)
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n/an/a 160n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15908
PNG
(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
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n/an/a 160n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15952
PNG
(1-[(4-Amino-5-cyano-6-ethoxypyridin-2-ylcarbamoyl)...)
Show SMILES CCCCNC(=O)C1CCN(CC(=O)Nc2cc(N)c(C#N)c(OCC)n2)CC1
Show InChI InChI=1S/C20H30N6O3/c1-3-5-8-23-19(28)14-6-9-26(10-7-14)13-18(27)24-17-11-16(22)15(12-21)20(25-17)29-4-2/h11,14H,3-10,13H2,1-2H3,(H,23,28)(H3,22,24,25,27)
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n/an/a 180n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15935
PNG
(Aminopyridine-Based Inhibitor 6n | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccc(OC)cc2)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O3/c1-3-24-17-13(10-18)14(19)9-15(21-17)20-16(22)8-11-4-6-12(23-2)7-5-11/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 180n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15932
PNG
(Aminopyridine-Based Inhibitor 6k | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccc(C)cc2)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O2/c1-3-23-17-13(10-18)14(19)9-15(21-17)20-16(22)8-12-6-4-11(2)5-7-12/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 190n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15934
PNG
(Aminopyridine-Based Inhibitor 6m | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cccc(OC)c2)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O3/c1-3-24-17-13(10-18)14(19)9-15(21-17)20-16(22)8-11-5-4-6-12(7-11)23-2/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 210n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15962
PNG
(Aminopyridine-Based Inhibitor 20a | N-[4-Amino-5-c...)
Show SMILES COc1ccc(OC)c(CC(=O)Nc2cc(N)c(C#N)c(OCCO)n2)c1
Show InChI InChI=1S/C18H20N4O5/c1-25-12-3-4-15(26-2)11(7-12)8-17(24)21-16-9-14(20)13(10-19)18(22-16)27-6-5-23/h3-4,7,9,23H,5-6,8H2,1-2H3,(H3,20,21,22,24)
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n/an/a 240n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15933
PNG
(Aminopyridine-Based Inhibitor 6l | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O3/c1-3-24-17-12(10-18)13(19)9-15(21-17)20-16(22)8-11-6-4-5-7-14(11)23-2/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 260n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15963
PNG
(Aminopyridine-Based Inhibitor 20b | N-[4-Amino-5-c...)
Show SMILES COCCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C19H22N4O5/c1-25-6-7-28-19-14(11-20)15(21)10-17(23-19)22-18(24)9-12-8-13(26-2)4-5-16(12)27-3/h4-5,8,10H,6-7,9H2,1-3H3,(H3,21,22,23,24)
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n/an/a 270n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15950
PNG
(Aminopyridine-Based Inhibitor 30 | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)CN2CCOCC2)cc(N)c1C#N
Show InChI InChI=1S/C14H19N5O3/c1-2-22-14-10(8-15)11(16)7-12(18-14)17-13(20)9-19-3-5-21-6-4-19/h7H,2-6,9H2,1H3,(H3,16,17,18,20)
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n/an/a 270n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15935
PNG
(Aminopyridine-Based Inhibitor 6n | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccc(OC)cc2)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O3/c1-3-24-17-13(10-18)14(19)9-15(21-17)20-16(22)8-11-4-6-12(23-2)7-5-11/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 274n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15951
PNG
(Aminopyridine-Based Inhibitor 31 | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)CN2CCC(O)CC2)cc(N)c1C#N
Show InChI InChI=1S/C15H21N5O3/c1-2-23-15-11(8-16)12(17)7-13(19-15)18-14(22)9-20-5-3-10(21)4-6-20/h7,10,21H,2-6,9H2,1H3,(H3,17,18,19,22)
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n/an/a 300n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15928
PNG
(Aminopyridine-Based Inhibitor 6g | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cccc(Cl)c2)cc(N)c1C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-2-23-16-12(9-18)13(19)8-14(21-16)20-15(22)7-10-4-3-5-11(17)6-10/h3-6,8H,2,7H2,1H3,(H3,19,20,21,22)
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n/an/a 300n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15934
PNG
(Aminopyridine-Based Inhibitor 6m | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cccc(OC)c2)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O3/c1-3-24-17-13(10-18)14(19)9-15(21-17)20-16(22)8-11-5-4-6-12(7-11)23-2/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 310n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15955
PNG
(Aminopyridine-Based Inhibitor 18a | N-(4-Amino-5-c...)
Show SMILES CC(C)Oc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C11H14N4O2/c1-6(2)17-11-8(5-12)9(13)4-10(15-11)14-7(3)16/h4,6H,1-3H3,(H3,13,14,15,16)
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n/an/a 310n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15923
PNG
(Aminopyridine-Based Inhibitor 6b | N-(4-amino-5-cy...)
Show SMILES CCCCC(=O)Nc1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C13H18N4O2/c1-3-5-6-12(18)16-11-7-10(15)9(8-14)13(17-11)19-4-2/h7H,3-6H2,1-2H3,(H3,15,16,17,18)
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n/an/a 350n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15932
PNG
(Aminopyridine-Based Inhibitor 6k | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccc(C)cc2)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O2/c1-3-23-17-13(10-18)14(19)9-15(21-17)20-16(22)8-12-6-4-11(2)5-7-12/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 360n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15964
PNG
(Aminopyridine-Based Inhibitor 20c | N-[4-Amino-5-c...)
Show SMILES COc1ccc(OC)c(CC(=O)Nc2cc(N)c(C#N)c(OCCS(C)(=O)=O)n2)c1
Show InChI InChI=1S/C19H22N4O6S/c1-27-13-4-5-16(28-2)12(8-13)9-18(24)22-17-10-15(21)14(11-20)19(23-17)29-6-7-30(3,25)26/h4-5,8,10H,6-7,9H2,1-3H3,(H3,21,22,23,24)
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n/an/a 400n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15930
PNG
(Aminopyridine-Based Inhibitor 6i | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccccc2C)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O2/c1-3-23-17-13(10-18)14(19)9-15(21-17)20-16(22)8-12-7-5-4-6-11(12)2/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 400n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15931
PNG
(Aminopyridine-Based Inhibitor 6j | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cccc(C)c2)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O2/c1-3-23-17-13(10-18)14(19)9-15(21-17)20-16(22)8-12-6-4-5-11(2)7-12/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 420n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15955
PNG
(Aminopyridine-Based Inhibitor 18a | N-(4-Amino-5-c...)
Show SMILES CC(C)Oc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C11H14N4O2/c1-6(2)17-11-8(5-12)9(13)4-10(15-11)14-7(3)16/h4,6H,1-3H3,(H3,13,14,15,16)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15949
PNG
(Aminopyridine-Based Inhibitor 29 | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)CN2CCCCC2)cc(N)c1C#N
Show InChI InChI=1S/C15H21N5O2/c1-2-22-15-11(9-16)12(17)8-13(19-15)18-14(21)10-20-6-4-3-5-7-20/h8H,2-7,10H2,1H3,(H3,17,18,19,21)
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n/an/a 510n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15926
PNG
(Aminopyridine-Based Inhibitor 6e | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccccc2)cc(N)c1C#N
Show InChI InChI=1S/C16H16N4O2/c1-2-22-16-12(10-17)13(18)9-14(20-16)19-15(21)8-11-6-4-3-5-7-11/h3-7,9H,2,8H2,1H3,(H3,18,19,20,21)
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n/an/a 570n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15929
PNG
(Aminopyridine-Based Inhibitor 6h | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccc(Cl)cc2)cc(N)c1C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-2-23-16-12(9-18)13(19)8-14(21-16)20-15(22)7-10-3-5-11(17)6-4-10/h3-6,8H,2,7H2,1H3,(H3,19,20,21,22)
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n/an/a 580n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15929
PNG
(Aminopyridine-Based Inhibitor 6h | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccc(Cl)cc2)cc(N)c1C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-2-23-16-12(9-18)13(19)8-14(21-16)20-15(22)7-10-3-5-11(17)6-4-10/h3-6,8H,2,7H2,1H3,(H3,19,20,21,22)
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n/an/a 610n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15951
PNG
(Aminopyridine-Based Inhibitor 31 | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)CN2CCC(O)CC2)cc(N)c1C#N
Show InChI InChI=1S/C15H21N5O3/c1-2-23-15-11(8-16)12(17)7-13(19-15)18-14(22)9-20-5-3-10(21)4-6-20/h7,10,21H,2-6,9H2,1H3,(H3,17,18,19,22)
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n/an/a 640n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15923
PNG
(Aminopyridine-Based Inhibitor 6b | N-(4-amino-5-cy...)
Show SMILES CCCCC(=O)Nc1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C13H18N4O2/c1-3-5-6-12(18)16-11-7-10(15)9(8-14)13(17-11)19-4-2/h7H,3-6H2,1-2H3,(H3,15,16,17,18)
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n/an/a 690n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15964
PNG
(Aminopyridine-Based Inhibitor 20c | N-[4-Amino-5-c...)
Show SMILES COc1ccc(OC)c(CC(=O)Nc2cc(N)c(C#N)c(OCCS(C)(=O)=O)n2)c1
Show InChI InChI=1S/C19H22N4O6S/c1-27-13-4-5-16(28-2)12(8-13)9-18(24)22-17-10-15(21)14(11-20)19(23-17)29-6-7-30(3,25)26/h4-5,8,10H,6-7,9H2,1-3H3,(H3,21,22,23,24)
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n/an/a 740n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15930
PNG
(Aminopyridine-Based Inhibitor 6i | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccccc2C)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O2/c1-3-23-17-13(10-18)14(19)9-15(21-17)20-16(22)8-12-7-5-4-6-11(12)2/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 740n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15948
PNG
(Aminopyridine-Based Inhibitor 28d | N-(4-Amino-5-c...)
Show SMILES CCCN(CCO)CC(=O)Nc1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C15H23N5O3/c1-3-5-20(6-7-21)10-14(22)18-13-8-12(17)11(9-16)15(19-13)23-4-2/h8,21H,3-7,10H2,1-2H3,(H3,17,18,19,22)
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n/an/a 740n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15907
PNG
(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C10H12N4O2/c1-3-16-10-7(5-11)8(12)4-9(14-10)13-6(2)15/h4H,3H2,1-2H3,(H3,12,13,14,15)
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n/an/a 750n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15926
PNG
(Aminopyridine-Based Inhibitor 6e | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccccc2)cc(N)c1C#N
Show InChI InChI=1S/C16H16N4O2/c1-2-22-16-12(10-17)13(18)9-14(20-16)19-15(21)8-11-6-4-3-5-7-11/h3-7,9H,2,8H2,1H3,(H3,18,19,20,21)
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n/an/a 770n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15931
PNG
(Aminopyridine-Based Inhibitor 6j | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cccc(C)c2)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O2/c1-3-23-17-13(10-18)14(19)9-15(21-17)20-16(22)8-12-6-4-5-11(2)7-12/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 790n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15959
PNG
(Aminopyridine-Based Inhibitor 19c | N-[4-Amino-5-c...)
Show SMILES CC(=O)Nc1cc(N)c(C#N)c(OC2CCOC2)n1
Show InChI InChI=1S/C12H14N4O3/c1-7(17)15-11-4-10(14)9(5-13)12(16-11)19-8-2-3-18-6-8/h4,8H,2-3,6H2,1H3,(H3,14,15,16,17)
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n/an/a 890n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15928
PNG
(Aminopyridine-Based Inhibitor 6g | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cccc(Cl)c2)cc(N)c1C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-2-23-16-12(9-18)13(19)8-14(21-16)20-15(22)7-10-4-3-5-11(17)6-10/h3-6,8H,2,7H2,1H3,(H3,19,20,21,22)
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n/an/a 900n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15967
PNG
(Aminopyridine-Based Inhibitor 23 | N-(4-Amino-5-cy...)
Show SMILES CC(C)Nc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C11H15N5O/c1-6(2)14-11-8(5-12)9(13)4-10(16-11)15-7(3)17/h4,6H,1-3H3,(H4,13,14,15,16,17)
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n/an/a 910n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15927
PNG
(Aminopyridine-Based Inhibitor 6f | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccccc2Cl)cc(N)c1C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-2-23-16-11(9-18)13(19)8-14(21-16)20-15(22)7-10-5-3-4-6-12(10)17/h3-6,8H,2,7H2,1H3,(H3,19,20,21,22)
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n/an/a 1.10E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15907
PNG
(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C10H12N4O2/c1-3-16-10-7(5-11)8(12)4-9(14-10)13-6(2)15/h4H,3H2,1-2H3,(H3,12,13,14,15)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15950
PNG
(Aminopyridine-Based Inhibitor 30 | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)CN2CCOCC2)cc(N)c1C#N
Show InChI InChI=1S/C14H19N5O3/c1-2-22-14-10(8-15)11(16)7-12(18-14)17-13(20)9-19-3-5-21-6-4-19/h7H,2-6,9H2,1H3,(H3,16,17,18,20)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15925
PNG
(Aminopyridine-Based Inhibitor 6d | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)CC(C)C)cc(N)c1C#N
Show InChI InChI=1S/C13H18N4O2/c1-4-19-13-9(7-14)10(15)6-11(17-13)16-12(18)5-8(2)3/h6,8H,4-5H2,1-3H3,(H3,15,16,17,18)
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n/an/a 1.40E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15954
PNG
(Aminopyridine-Based Inhibitor 17 | N-(4-Amino-6-br...)
Show SMILES COc1ccc(OC)c(CC(=O)Nc2cc(N)c(C#N)c(Br)n2)c1
Show InChI InChI=1S/C16H15BrN4O3/c1-23-10-3-4-13(24-2)9(5-10)6-15(22)20-14-7-12(19)11(8-18)16(17)21-14/h3-5,7H,6H2,1-2H3,(H3,19,20,21,22)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15968
PNG
(Aminopyridine-Based Inhibitor 24 | N-(4-Amino-5-cy...)
Show SMILES CC(=O)Nc1cc(N)c(C#N)c(n1)-c1ccccc1
Show InChI InChI=1S/C14H12N4O/c1-9(19)17-13-7-12(16)11(8-15)14(18-13)10-5-3-2-4-6-10/h2-7H,1H3,(H3,16,17,18,19)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15960
PNG
(Aminopyridine-Based Inhibitor 19d | N-(4-Amino-6-b...)
Show SMILES CCCCOc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C12H16N4O2/c1-3-4-5-18-12-9(7-13)10(14)6-11(16-12)15-8(2)17/h6H,3-5H2,1-2H3,(H3,14,15,16,17)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15961
PNG
(Aminopyridine-Based Inhibitor 19e | N-(4-Amino-5-c...)
Show SMILES COc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C9H10N4O2/c1-5(14)12-8-3-7(11)6(4-10)9(13-8)15-2/h3H,1-2H3,(H3,11,12,13,14)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15966
PNG
(Aminopyridine-Based Inhibitor 22 | N-(4-Amino-5-cy...)
Show SMILES CCNc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C10H13N5O/c1-3-13-10-7(5-11)8(12)4-9(15-10)14-6(2)16/h4H,3H2,1-2H3,(H4,12,13,14,15,16)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15970
PNG
(Aminopyridine-Based Inhibitor 26 | N-(4-Amino-5-cy...)
Show SMILES COc1ccc(OC)c(CC(=O)Nc2cc(N)c(cn2)C#N)c1
Show InChI InChI=1S/C16H16N4O3/c1-22-12-3-4-14(23-2)10(5-12)6-16(21)20-15-7-13(18)11(8-17)9-19-15/h3-5,7,9H,6H2,1-2H3,(H3,18,19,20,21)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15945
PNG
(Aminopyridine-Based Inhibitor 28a | N-(4-Amino-5-c...)
Show SMILES CCOc1nc(NC(=O)CN(CC)CC)cc(N)c1C#N
Show InChI InChI=1S/C14H21N5O2/c1-4-19(5-2)9-13(20)17-12-7-11(16)10(8-15)14(18-12)21-6-3/h7H,4-6,9H2,1-3H3,(H3,16,17,18,20)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15959
PNG
(Aminopyridine-Based Inhibitor 19c | N-[4-Amino-5-c...)
Show SMILES CC(=O)Nc1cc(N)c(C#N)c(OC2CCOC2)n1
Show InChI InChI=1S/C12H14N4O3/c1-7(17)15-11-4-10(14)9(5-13)12(16-11)19-8-2-3-18-6-8/h4,8H,2-3,6H2,1H3,(H3,14,15,16,17)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15967
PNG
(Aminopyridine-Based Inhibitor 23 | N-(4-Amino-5-cy...)
Show SMILES CC(C)Nc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C11H15N5O/c1-6(2)14-11-8(5-12)9(13)4-10(16-11)15-7(3)17/h4,6H,1-3H3,(H4,13,14,15,16,17)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15937
PNG
(Aminopyridine-Based Inhibitor 6q | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(Br)ccc2Br)cc(N)c1C#N
Show InChI InChI=1S/C16H14Br2N4O2/c1-2-24-16-11(8-19)13(20)7-14(22-16)21-15(23)6-9-5-10(17)3-4-12(9)18/h3-5,7H,2,6H2,1H3,(H3,20,21,22,23)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15949
PNG
(Aminopyridine-Based Inhibitor 29 | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)CN2CCCCC2)cc(N)c1C#N
Show InChI InChI=1S/C15H21N5O2/c1-2-22-15-11(9-16)12(17)8-13(19-15)18-14(21)10-20-6-4-3-5-7-20/h8H,2-7,10H2,1H3,(H3,17,18,19,21)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15946
PNG
(Aminopyridine-Based Inhibitor 28b | N-(4-Amino-5-c...)
Show SMILES CCCCN(CCCC)CC(=O)Nc1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C18H29N5O2/c1-4-7-9-23(10-8-5-2)13-17(24)21-16-11-15(20)14(12-19)18(22-16)25-6-3/h11H,4-10,13H2,1-3H3,(H3,20,21,22,24)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15925
PNG
(Aminopyridine-Based Inhibitor 6d | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)CC(C)C)cc(N)c1C#N
Show InChI InChI=1S/C13H18N4O2/c1-4-19-13-9(7-14)10(15)6-11(17-13)16-12(18)5-8(2)3/h6,8H,4-5H2,1-3H3,(H3,15,16,17,18)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15924
PNG
(Aminopyridine-Based Inhibitor 6c | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)C(C)C)cc(N)c1C#N
Show InChI InChI=1S/C12H16N4O2/c1-4-18-12-8(6-13)9(14)5-10(16-12)15-11(17)7(2)3/h5,7H,4H2,1-3H3,(H3,14,15,16,17)
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n/an/a 4.00E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15936
PNG
(Aminopyridine-Based Inhibitor 6p | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(C)ccc2C)cc(N)c1C#N
Show InChI InChI=1S/C18H20N4O2/c1-4-24-18-14(10-19)15(20)9-16(22-18)21-17(23)8-13-7-11(2)5-6-12(13)3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
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n/an/a 4.40E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15961
PNG
(Aminopyridine-Based Inhibitor 19e | N-(4-Amino-5-c...)
Show SMILES COc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C9H10N4O2/c1-5(14)12-8-3-7(11)6(4-10)9(13-8)15-2/h3H,1-2H3,(H3,11,12,13,14)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15960
PNG
(Aminopyridine-Based Inhibitor 19d | N-(4-Amino-6-b...)
Show SMILES CCCCOc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C12H16N4O2/c1-3-4-5-18-12-9(7-13)10(14)6-11(16-12)15-8(2)17/h6H,3-5H2,1-2H3,(H3,14,15,16,17)
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n/an/a 4.66E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15958
PNG
(3-(6-Acetylamino-4-amino-3-cyanopyridin-2-yloxy)pr...)
Show SMILES CC(=O)Nc1cc(N)c(C#N)c(OCCC(O)=O)n1
Show InChI InChI=1S/C11H12N4O4/c1-6(16)14-9-4-8(13)7(5-12)11(15-9)19-3-2-10(17)18/h4H,2-3H2,1H3,(H,17,18)(H3,13,14,15,16)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15958
PNG
(3-(6-Acetylamino-4-amino-3-cyanopyridin-2-yloxy)pr...)
Show SMILES CC(=O)Nc1cc(N)c(C#N)c(OCCC(O)=O)n1
Show InChI InChI=1S/C11H12N4O4/c1-6(16)14-9-4-8(13)7(5-12)11(15-9)19-3-2-10(17)18/h4H,2-3H2,1H3,(H,17,18)(H3,13,14,15,16)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15927
PNG
(Aminopyridine-Based Inhibitor 6f | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccccc2Cl)cc(N)c1C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-2-23-16-11(9-18)13(19)8-14(21-16)20-15(22)7-10-5-3-4-6-12(10)17/h3-6,8H,2,7H2,1H3,(H3,19,20,21,22)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15970
PNG
(Aminopyridine-Based Inhibitor 26 | N-(4-Amino-5-cy...)
Show SMILES COc1ccc(OC)c(CC(=O)Nc2cc(N)c(cn2)C#N)c1
Show InChI InChI=1S/C16H16N4O3/c1-22-12-3-4-14(23-2)10(5-12)6-16(21)20-15-7-13(18)11(8-17)9-19-15/h3-5,7,9H,6H2,1-2H3,(H3,18,19,20,21)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15947
PNG
(Aminopyridine-Based Inhibitor 28c | N-(4-Amino-5-c...)
Show SMILES CCCCNCC(=O)Nc1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C14H21N5O2/c1-3-5-6-17-9-13(20)18-12-7-11(16)10(8-15)14(19-12)21-4-2/h7,17H,3-6,9H2,1-2H3,(H3,16,18,19,20)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15945
PNG
(Aminopyridine-Based Inhibitor 28a | N-(4-Amino-5-c...)
Show SMILES CCOc1nc(NC(=O)CN(CC)CC)cc(N)c1C#N
Show InChI InChI=1S/C14H21N5O2/c1-4-19(5-2)9-13(20)17-12-7-11(16)10(8-15)14(18-12)21-6-3/h7H,4-6,9H2,1-3H3,(H3,16,17,18,20)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15968
PNG
(Aminopyridine-Based Inhibitor 24 | N-(4-Amino-5-cy...)
Show SMILES CC(=O)Nc1cc(N)c(C#N)c(n1)-c1ccccc1
Show InChI InChI=1S/C14H12N4O/c1-9(19)17-13-7-12(16)11(8-15)14(18-13)10-5-3-2-4-6-10/h2-7H,1H3,(H3,16,17,18,19)
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n/an/a 7.70E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15924
PNG
(Aminopyridine-Based Inhibitor 6c | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)C(C)C)cc(N)c1C#N
Show InChI InChI=1S/C12H16N4O2/c1-4-18-12-8(6-13)9(14)5-10(16-12)15-11(17)7(2)3/h5,7H,4H2,1-3H3,(H3,14,15,16,17)
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n/an/a 8.40E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15965
PNG
(Aminopyridine-Based Inhibitor 21 | N-(4-Amino-6-bu...)
Show SMILES CCCCSc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C12H16N4OS/c1-3-4-5-18-12-9(7-13)10(14)6-11(16-12)15-8(2)17/h6H,3-5H2,1-2H3,(H3,14,15,16,17)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15969
PNG
(Aminopyridine-Based Inhibitor 25 | N-(4-Amino-5-cy...)
Show SMILES CCCc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C11H14N4O/c1-3-4-10-8(6-12)9(13)5-11(15-10)14-7(2)16/h5H,3-4H2,1-2H3,(H3,13,14,15,16)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15975
PNG
(Aminopyridine-Based Inhibitor 42 | N-(4-amino-5-cy...)
Show SMILES CCCCC(=O)N(C)c1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C14H20N4O2/c1-4-6-7-13(19)18(3)12-8-11(16)10(9-15)14(17-12)20-5-2/h8H,4-7H2,1-3H3,(H2,16,17)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15946
PNG
(Aminopyridine-Based Inhibitor 28b | N-(4-Amino-5-c...)
Show SMILES CCCCN(CCCC)CC(=O)Nc1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C18H29N5O2/c1-4-7-9-23(10-8-5-2)13-17(24)21-16-11-15(20)14(12-19)18(22-16)25-6-3/h11H,4-10,13H2,1-3H3,(H3,20,21,22,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15966
PNG
(Aminopyridine-Based Inhibitor 22 | N-(4-Amino-5-cy...)
Show SMILES CCNc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C10H13N5O/c1-3-13-10-7(5-11)8(12)4-9(15-10)14-6(2)16/h4H,3H2,1-2H3,(H4,12,13,14,15,16)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15971
PNG
(Aminopyridine-Based Inhibitor 39 | N-(5-Cyano-6-et...)
Show SMILES CCOc1nc(NC(C)=O)cc(C)c1C#N
Show InChI InChI=1S/C11H13N3O2/c1-4-16-11-9(6-12)7(2)5-10(14-11)13-8(3)15/h5H,4H2,1-3H3,(H,13,14,15)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15943
PNG
(1-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-3-ethylur...)
Show SMILES CCNC(=O)Nc1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C11H15N5O2/c1-3-14-11(17)16-9-5-8(13)7(6-12)10(15-9)18-4-2/h5H,3-4H2,1-2H3,(H4,13,14,15,16,17)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15972
PNG
(Aminopyridine-Based Inhibitor 46 | N-(6-ethoxypyri...)
Show SMILES CCOc1cccc(NC(C)=O)n1
Show InChI InChI=1S/C9H12N2O2/c1-3-13-9-6-4-5-8(11-9)10-7(2)12/h4-6H,3H2,1-2H3,(H,10,11,12)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15973
PNG
(Aminopyridine-Based Inhibitor 43 | N-(6-Amino-5-cy...)
Show SMILES CCOc1cc(NC(C)=O)nc(N)c1C#N
Show InChI InChI=1S/C10H12N4O2/c1-3-16-8-4-9(13-6(2)15)14-10(12)7(8)5-11/h4H,3H2,1-2H3,(H3,12,13,14,15)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15974
PNG
(Aminopyridine-Based Inhibitor 41 | N-(4-amino-3-ch...)
Show SMILES CCCCC(=O)Nc1nc(OCC)c(C#N)c(N)c1Cl
Show InChI InChI=1S/C13H17ClN4O2/c1-3-5-6-9(19)17-12-10(14)11(16)8(7-15)13(18-12)20-4-2/h3-6H2,1-2H3,(H3,16,17,18,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15969
PNG
(Aminopyridine-Based Inhibitor 25 | N-(4-Amino-5-cy...)
Show SMILES CCCc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C11H14N4O/c1-3-4-10-8(6-12)9(13)5-11(15-10)14-7(2)16/h5H,3-4H2,1-2H3,(H3,13,14,15,16)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15972
PNG
(Aminopyridine-Based Inhibitor 46 | N-(6-ethoxypyri...)
Show SMILES CCOc1cccc(NC(C)=O)n1
Show InChI InChI=1S/C9H12N2O2/c1-3-13-9-6-4-5-8(11-9)10-7(2)12/h4-6H,3H2,1-2H3,(H,10,11,12)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15973
PNG
(Aminopyridine-Based Inhibitor 43 | N-(6-Amino-5-cy...)
Show SMILES CCOc1cc(NC(C)=O)nc(N)c1C#N
Show InChI InChI=1S/C10H12N4O2/c1-3-16-8-4-9(13-6(2)15)14-10(12)7(8)5-11/h4H,3H2,1-2H3,(H3,12,13,14,15)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15957
PNG
(Aminopyridine-Based Inhibitor 19a | N-[4-Amino-5-c...)
Show SMILES CN(C)CCOc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C12H17N5O2/c1-8(18)15-11-6-10(14)9(7-13)12(16-11)19-5-4-17(2)3/h6H,4-5H2,1-3H3,(H3,14,15,16,18)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15971
PNG
(Aminopyridine-Based Inhibitor 39 | N-(5-Cyano-6-et...)
Show SMILES CCOc1nc(NC(C)=O)cc(C)c1C#N
Show InChI InChI=1S/C11H13N3O2/c1-4-16-11-9(6-12)7(2)5-10(14-11)13-8(3)15/h5H,4H2,1-3H3,(H,13,14,15)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15942
PNG
((4-Amino-5-cyano-6-ethoxypyridin-2-yl)carbamic Aci...)
Show SMILES CCOc1nc(NC(=O)OC)cc(N)c1C#N
Show InChI InChI=1S/C10H12N4O3/c1-3-17-9-6(5-11)7(12)4-8(13-9)14-10(15)16-2/h4H,3H2,1-2H3,(H3,12,13,14,15)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15947
PNG
(Aminopyridine-Based Inhibitor 28c | N-(4-Amino-5-c...)
Show SMILES CCCCNCC(=O)Nc1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C14H21N5O2/c1-3-5-6-17-9-13(20)18-12-7-11(16)10(8-15)14(19-12)21-4-2/h7,17H,3-6,9H2,1-2H3,(H3,16,18,19,20)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15954
PNG
(Aminopyridine-Based Inhibitor 17 | N-(4-Amino-6-br...)
Show SMILES COc1ccc(OC)c(CC(=O)Nc2cc(N)c(C#N)c(Br)n2)c1
Show InChI InChI=1S/C16H15BrN4O3/c1-23-10-3-4-13(24-2)9(5-10)6-15(22)20-14-7-12(19)11(8-18)16(17)21-14/h3-5,7H,6H2,1-2H3,(H3,19,20,21,22)
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Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15957
PNG
(Aminopyridine-Based Inhibitor 19a | N-[4-Amino-5-c...)
Show SMILES CN(C)CCOc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C12H17N5O2/c1-8(18)15-11-6-10(14)9(7-13)12(16-11)19-5-4-17(2)3/h6H,4-5H2,1-3H3,(H3,14,15,16,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



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Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15936
PNG
(Aminopyridine-Based Inhibitor 6p | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(C)ccc2C)cc(N)c1C#N
Show InChI InChI=1S/C18H20N4O2/c1-4-24-18-14(10-19)15(20)9-16(22-18)21-17(23)8-13-7-11(2)5-6-12(13)3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15943
PNG
(1-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-3-ethylur...)
Show SMILES CCNC(=O)Nc1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C11H15N5O2/c1-3-14-11(17)16-9-5-8(13)7(6-12)10(15-9)18-4-2/h5H,3-4H2,1-2H3,(H4,13,14,15,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15942
PNG
((4-Amino-5-cyano-6-ethoxypyridin-2-yl)carbamic Aci...)
Show SMILES CCOc1nc(NC(=O)OC)cc(N)c1C#N
Show InChI InChI=1S/C10H12N4O3/c1-3-17-9-6(5-11)7(12)4-8(13-9)14-10(15)16-2/h4H,3H2,1-2H3,(H3,12,13,14,15)
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Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15965
PNG
(Aminopyridine-Based Inhibitor 21 | N-(4-Amino-6-bu...)
Show SMILES CCCCSc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C12H16N4OS/c1-3-4-5-18-12-9(7-13)10(14)6-11(16-12)15-8(2)17/h6H,3-5H2,1-2H3,(H3,14,15,16,17)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15944
PNG
(4-Amino-6-[2-(2,5-dimethoxyphenyl)ethylamino]-2-et...)
Show SMILES CCOc1nc(NCCc2cc(OC)ccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C18H22N4O3/c1-4-25-18-14(11-19)15(20)10-17(22-18)21-8-7-12-9-13(23-2)5-6-16(12)24-3/h5-6,9-10H,4,7-8H2,1-3H3,(H3,20,21,22)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15974
PNG
(Aminopyridine-Based Inhibitor 41 | N-(4-amino-3-ch...)
Show SMILES CCCCC(=O)Nc1nc(OCC)c(C#N)c(N)c1Cl
Show InChI InChI=1S/C13H17ClN4O2/c1-3-5-6-9(19)17-12-10(14)11(16)8(7-15)13(18-12)20-4-2/h3-6H2,1-2H3,(H3,16,17,18,19)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15975
PNG
(Aminopyridine-Based Inhibitor 42 | N-(4-amino-5-cy...)
Show SMILES CCCCC(=O)N(C)c1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C14H20N4O2/c1-4-6-7-13(19)18(3)12-8-11(16)10(9-15)14(17-12)20-5-2/h8H,4-7H2,1-3H3,(H2,16,17)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15937
PNG
(Aminopyridine-Based Inhibitor 6q | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(Br)ccc2Br)cc(N)c1C#N
Show InChI InChI=1S/C16H14Br2N4O2/c1-2-24-16-11(8-19)13(20)7-14(22-16)21-15(23)6-9-5-10(17)3-4-12(9)18/h3-5,7H,2,6H2,1H3,(H3,20,21,22,23)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM15944
PNG
(4-Amino-6-[2-(2,5-dimethoxyphenyl)ethylamino]-2-et...)
Show SMILES CCOc1nc(NCCc2cc(OC)ccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C18H22N4O3/c1-4-25-18-14(11-19)15(20)10-17(22-18)21-8-7-12-9-13(23-2)5-6-16(12)24-3/h5-6,9-10H,4,7-8H2,1-3H3,(H3,20,21,22)
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Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%