BindingDB logo
myBDB logout

PubMed code 16759855

Compile data set for download or QSAR
Found 130 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188749
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H31F3N6OS/c1-37-10-12-39(13-11-37)17-19-6-7-20-15-25-27(24(20)14-19)35-36-28(25)26-9-8-23(41-26)18-38(2)29(40)34-22-5-3-4-21(16-22)30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188753
PNG
(3-(3-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-10-12-36(13-11-34)17-19-6-7-20-15-25-27(24(20)14-19)32-33-28(25)26-9-8-23(38-26)18-35(2)29(37)31-22-5-3-4-21(30)16-22/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,31,37)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188731
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccc(cc4)C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-10-12-38(13-11-37)17-18-2-8-23-19(14-18)15-24-26(23)35-36-27(24)25-9-7-22(40-25)16-33-28(39)34-21-5-3-20(4-6-21)29(30,31)32/h2-9,14H,10-13,15-17H2,1H3,(H,35,36)(H2,33,34,39)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188749
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H31F3N6OS/c1-37-10-12-39(13-11-37)17-19-6-7-20-15-25-27(24(20)14-19)35-36-28(25)26-9-8-23(41-26)18-38(2)29(40)34-22-5-3-4-21(16-22)30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188764
PNG
(3-(4-fluorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C29H31FN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188759
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-11-13-39(14-12-37)17-19-3-4-20-16-25-27(24(20)15-19)35-36-28(25)26-10-9-23(42-26)18-38(2)29(40)34-21-5-7-22(8-6-21)41-30(31,32)33/h3-10,15H,11-14,16-18H2,1-2H3,(H,34,40)(H,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188754
PNG
(3-(4-bromophenyl)-1-methyl-1-((5-(7-((4-methylpipe...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C29H31BrN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188748
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(c4)C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-9-11-38(12-10-37)17-18-5-7-23-19(13-18)14-24-26(23)35-36-27(24)25-8-6-22(40-25)16-33-28(39)34-21-4-2-3-20(15-21)29(30,31)32/h2-8,13,15H,9-12,14,16-17H2,1H3,(H,35,36)(H2,33,34,39)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188749
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H31F3N6OS/c1-37-10-12-39(13-11-37)17-19-6-7-20-15-25-27(24(20)14-19)35-36-28(25)26-9-8-23(41-26)18-38(2)29(40)34-22-5-3-4-21(16-22)30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188769
PNG
(3-(3,4-dichlorophenyl)-1-methyl-1-((5-(7-((4-methy...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H30Cl2N6OS/c1-35-9-11-37(12-10-35)16-18-3-4-19-14-23-27(22(19)13-18)33-34-28(23)26-8-6-21(39-26)17-36(2)29(38)32-20-5-7-24(30)25(31)15-20/h3-8,13,15H,9-12,14,16-17H2,1-2H3,(H,32,38)(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188727
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-10-12-39(13-11-37)17-19-6-8-24-20(14-19)15-25-27(24)35-36-28(25)26-9-7-23(42-26)18-38(2)29(40)34-21-4-3-5-22(16-21)41-30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188754
PNG
(3-(4-bromophenyl)-1-methyl-1-((5-(7-((4-methylpipe...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C29H31BrN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188759
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-11-13-39(14-12-37)17-19-3-4-20-16-25-27(24(20)15-19)35-36-28(25)26-10-9-23(42-26)18-38(2)29(40)34-21-5-7-22(8-6-21)41-30(31,32)33/h3-10,15H,11-14,16-18H2,1-2H3,(H,34,40)(H,35,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188736
PNG
(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-1-...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H30F4N6OS/c1-38-7-9-40(10-8-38)16-18-3-5-24-19(11-18)12-25-27(24)36-37-28(25)26-6-4-23(42-26)17-39(2)29(41)35-22-14-20(30(32,33)34)13-21(31)15-22/h3-6,11,13-15H,7-10,12,16-17H2,1-2H3,(H,35,41)(H,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188753
PNG
(3-(3-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-10-12-36(13-11-34)17-19-6-7-20-15-25-27(24(20)14-19)32-33-28(25)26-9-8-23(38-26)18-35(2)29(37)31-22-5-3-4-21(30)16-22/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,31,37)(H,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188752
PNG
(3-(4-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188732
PNG
(1-cyclopropyl-1-((5-(6-((4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CN(C4CC4)C(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C32H36N6OS/c1-21-4-3-5-24(16-21)33-32(39)38(25-7-8-25)20-26-9-11-29(40-26)31-28-18-23-17-22(6-10-27(23)30(28)34-35-31)19-37-14-12-36(2)13-15-37/h3-6,9-11,16-17,25H,7-8,12-15,18-20H2,1-2H3,(H,33,39)(H,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188761
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccc(C)cc4)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-3-6-22(7-4-19)31-29(36)30-17-23-8-10-26(37-23)28-25-16-21-15-20(5-9-24(21)27(25)32-33-28)18-35-13-11-34(2)12-14-35/h3-10,15H,11-14,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188736
PNG
(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-1-...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H30F4N6OS/c1-38-7-9-40(10-8-38)16-18-3-5-24-19(11-18)12-25-27(24)36-37-28(25)26-6-4-23(42-26)17-39(2)29(41)35-22-14-20(30(32,33)34)13-21(31)15-22/h3-6,11,13-15H,7-10,12,16-17H2,1-2H3,(H,35,41)(H,36,37)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188759
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-11-13-39(14-12-37)17-19-3-4-20-16-25-27(24(20)15-19)35-36-28(25)26-10-9-23(42-26)18-38(2)29(40)34-21-5-7-22(8-6-21)41-30(31,32)33/h3-10,15H,11-14,16-18H2,1-2H3,(H,34,40)(H,35,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188737
PNG
(1-(3,5-dimethylphenyl)-3-((5-(6-((4-methylpiperazi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cc(C)cc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C30H34N6OS/c1-19-12-20(2)14-23(13-19)32-30(37)31-17-24-5-7-27(38-24)29-26-16-22-15-21(4-6-25(22)28(26)33-34-29)18-36-10-8-35(3)9-11-36/h4-7,12-15H,8-11,16-18H2,1-3H3,(H,33,34)(H2,31,32,37)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188727
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-10-12-39(13-11-37)17-19-6-8-24-20(14-19)15-25-27(24)35-36-28(25)26-9-7-23(42-26)18-38(2)29(40)34-21-4-3-5-22(16-21)41-30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188769
PNG
(3-(3,4-dichlorophenyl)-1-methyl-1-((5-(7-((4-methy...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H30Cl2N6OS/c1-35-9-11-37(12-10-35)16-18-3-4-19-14-23-27(22(19)13-18)33-34-28(23)26-8-6-21(39-26)17-36(2)29(38)32-20-5-7-24(30)25(31)15-20/h3-8,13,15H,9-12,14,16-17H2,1-2H3,(H,32,38)(H,33,34)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 28n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188736
PNG
(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-1-...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H30F4N6OS/c1-38-7-9-40(10-8-38)16-18-3-5-24-19(11-18)12-25-27(24)36-37-28(25)26-6-4-23(42-26)17-39(2)29(41)35-22-14-20(30(32,33)34)13-21(31)15-22/h3-6,11,13-15H,7-10,12,16-17H2,1-2H3,(H,35,41)(H,36,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188748
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(c4)C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-9-11-38(12-10-37)17-18-5-7-23-19(13-18)14-24-26(23)35-36-27(24)25-8-6-22(40-25)16-33-28(39)34-21-4-2-3-20(15-21)29(30,31)32/h2-8,13,15H,9-12,14,16-17H2,1H3,(H,35,36)(H2,33,34,39)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188733
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CCCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6OS/c1-4-12-38(32(39)33-25-7-5-6-22(2)17-25)21-26-9-11-29(40-26)31-28-19-24-18-23(8-10-27(24)30(28)34-35-31)20-37-15-13-36(3)14-16-37/h5-11,17-18H,4,12-16,19-21H2,1-3H3,(H,33,39)(H,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188769
PNG
(3-(3,4-dichlorophenyl)-1-methyl-1-((5-(7-((4-methy...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H30Cl2N6OS/c1-35-9-11-37(12-10-35)16-18-3-4-19-14-23-27(22(19)13-18)33-34-28(23)26-8-6-21(39-26)17-36(2)29(38)32-20-5-7-24(30)25(31)15-20/h3-8,13,15H,9-12,14,16-17H2,1-2H3,(H,32,38)(H,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 36n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188752
PNG
(3-(4-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 36n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188754
PNG
(3-(4-bromophenyl)-1-methyl-1-((5-(7-((4-methylpipe...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C29H31BrN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188753
PNG
(3-(3-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-10-12-36(13-11-34)17-19-6-7-20-15-25-27(24(20)14-19)32-33-28(25)26-9-8-23(38-26)18-35(2)29(37)31-22-5-3-4-21(30)16-22/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,31,37)(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188735
PNG
(1-(3,5-dichlorophenyl)-3-((5-(6-((4-methylpiperazi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cc(Cl)cc(Cl)c4)s3)c2)CC1
Show InChI InChI=1S/C28H28Cl2N6OS/c1-35-6-8-36(9-7-35)16-17-2-4-23-18(10-17)11-24-26(23)33-34-27(24)25-5-3-22(38-25)15-31-28(37)32-21-13-19(29)12-20(30)14-21/h2-5,10,12-14H,6-9,11,15-16H2,1H3,(H,33,34)(H2,31,32,37)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188732
PNG
(1-cyclopropyl-1-((5-(6-((4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CN(C4CC4)C(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C32H36N6OS/c1-21-4-3-5-24(16-21)33-32(39)38(25-7-8-25)20-26-9-11-29(40-26)31-28-18-23-17-22(6-10-27(23)30(28)34-35-31)19-37-14-12-36(2)13-15-37/h3-6,9-11,16-17,25H,7-8,12-15,18-20H2,1-2H3,(H,33,39)(H,34,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188751
PNG
((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydro...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(COC(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C29H31N5O2S/c1-19-4-3-5-22(14-19)30-29(35)36-18-23-7-9-26(37-23)28-25-16-21-15-20(6-8-24(21)27(25)31-32-28)17-34-12-10-33(2)11-13-34/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,30,35)(H,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50210283
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)31-30(37)35(3)19-24-9-10-27(38-24)29-26-17-22-8-7-21(16-25(22)28(26)32-33-29)18-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 44n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188756
PNG
(1-ethyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)-...)
Show SMILES CCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C31H36N6OS/c1-4-37(31(38)32-24-7-5-6-21(2)16-24)20-25-9-11-28(39-25)30-27-18-23-17-22(8-10-26(23)29(27)33-34-30)19-36-14-12-35(3)13-15-36/h5-11,16-17H,4,12-15,18-20H2,1-3H3,(H,32,38)(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 45n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188757
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5cccc(C)c5)s4)-c3c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-22(14-19)31-29(36)30-17-23-8-9-26(37-23)28-25-16-21-7-6-20(15-24(21)27(25)32-33-28)18-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50210283
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)31-30(37)35(3)19-24-9-10-27(38-24)29-26-17-22-8-7-21(16-25(22)28(26)32-33-29)18-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 51n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188727
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-10-12-39(13-11-37)17-19-6-8-24-20(14-19)15-25-27(24)35-36-28(25)26-9-7-23(42-26)18-38(2)29(40)34-21-4-3-5-22(16-21)41-30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188733
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CCCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6OS/c1-4-12-38(32(39)33-25-7-5-6-22(2)17-25)21-26-9-11-29(40-26)31-28-19-24-18-23(8-10-27(24)30(28)34-35-31)20-37-15-13-36(3)14-16-37/h5-11,17-18H,4,12-16,19-21H2,1-3H3,(H,33,39)(H,34,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 59n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188764
PNG
(3-(4-fluorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C29H31FN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 59n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188739
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-22(14-19)31-29(36)30-17-23-7-9-26(37-23)28-25-16-21-15-20(6-8-24(21)27(25)32-33-28)18-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 61n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188737
PNG
(1-(3,5-dimethylphenyl)-3-((5-(6-((4-methylpiperazi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cc(C)cc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C30H34N6OS/c1-19-12-20(2)14-23(13-19)32-30(37)31-17-24-5-7-27(38-24)29-26-16-22-15-21(4-6-25(22)28(26)33-34-29)18-36-10-8-35(3)9-11-36/h4-7,12-15H,8-11,16-18H2,1-3H3,(H,33,34)(H2,31,32,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 63n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188752
PNG
(3-(4-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 64n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188757
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5cccc(C)c5)s4)-c3c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-22(14-19)31-29(36)30-17-23-8-9-26(37-23)28-25-16-21-7-6-20(15-24(21)27(25)32-33-28)18-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 69n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188733
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CCCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6OS/c1-4-12-38(32(39)33-25-7-5-6-22(2)17-25)21-26-9-11-29(40-26)31-28-19-24-18-23(8-10-27(24)30(28)34-35-31)20-37-15-13-36(3)14-16-37/h5-11,17-18H,4,12-16,19-21H2,1-3H3,(H,33,39)(H,34,35)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 75n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188735
PNG
(1-(3,5-dichlorophenyl)-3-((5-(6-((4-methylpiperazi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cc(Cl)cc(Cl)c4)s3)c2)CC1
Show InChI InChI=1S/C28H28Cl2N6OS/c1-35-6-8-36(9-7-35)16-17-2-4-23-18(10-17)11-24-26(23)33-34-27(24)25-5-3-22(38-25)15-31-28(37)32-21-13-19(29)12-20(30)14-21/h2-5,10,12-14H,6-9,11,15-16H2,1H3,(H,33,34)(H2,31,32,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 79n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188764
PNG
(3-(4-fluorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C29H31FN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 83n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188739
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-22(14-19)31-29(36)30-17-23-7-9-26(37-23)28-25-16-21-15-20(6-8-24(21)27(25)32-33-28)18-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 86n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50210283
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)31-30(37)35(3)19-24-9-10-27(38-24)29-26-17-22-8-7-21(16-25(22)28(26)32-33-29)18-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 96n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188728
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5ccccc5)s4)-c3c2)CC1
Show InChI InChI=1S/C28H30N6OS/c1-33-11-13-34(14-12-33)18-19-7-8-20-16-24-26(23(20)15-19)31-32-27(24)25-10-9-22(36-25)17-29-28(35)30-21-5-3-2-4-6-21/h2-10,15H,11-14,16-18H2,1H3,(H,31,32)(H2,29,30,35)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 101n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188750
PNG
(1-((4-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4csc(CNC(=O)Nc5cccc(C)c5)c4)-c3c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-23(12-19)31-29(36)30-16-24-14-22(18-37-24)27-26-15-21-7-6-20(13-25(21)28(26)33-32-27)17-35-10-8-34(2)9-11-35/h3-7,12-14,18H,8-11,15-17H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 102n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188755
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C30H34N6OS/c1-20-6-4-5-7-26(20)31-30(37)35(3)19-23-9-11-27(38-23)29-25-17-22-16-21(8-10-24(22)28(25)32-33-29)18-36-14-12-34(2)13-15-36/h4-11,16H,12-15,17-19H2,1-3H3,(H,31,37)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 122n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188740
PNG
(1-isopropyl-1-((5-(6-((4-methylpiperazin-1-yl)meth...)
Show SMILES CC(C)N(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6OS/c1-21(2)38(32(39)33-25-7-5-6-22(3)16-25)20-26-9-11-29(40-26)31-28-18-24-17-23(8-10-27(24)30(28)34-35-31)19-37-14-12-36(4)13-15-37/h5-11,16-17,21H,12-15,18-20H2,1-4H3,(H,33,39)(H,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 123n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188756
PNG
(1-ethyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)-...)
Show SMILES CCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C31H36N6OS/c1-4-37(31(38)32-24-7-5-6-21(2)16-24)20-25-9-11-28(39-25)30-27-18-23-17-22(8-10-26(23)29(27)33-34-30)19-36-14-12-35(3)13-15-36/h5-11,16-17H,4,12-15,18-20H2,1-3H3,(H,32,38)(H,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 131n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188732
PNG
(1-cyclopropyl-1-((5-(6-((4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CN(C4CC4)C(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C32H36N6OS/c1-21-4-3-5-24(16-21)33-32(39)38(25-7-8-25)20-26-9-11-29(40-26)31-28-18-23-17-22(6-10-27(23)30(28)34-35-31)19-37-14-12-36(2)13-15-37/h3-6,9-11,16-17,25H,7-8,12-15,18-20H2,1-2H3,(H,33,39)(H,34,35)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 136n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188746
PNG
(1-methyl-3-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(C(=O)NCc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)c1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)35(3)30(37)31-18-24-8-10-27(38-24)29-26-17-22-16-21(7-9-25(22)28(26)32-33-29)19-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 139n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50210290
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)31-30(37)35(3)19-24-8-10-27(38-24)29-26-17-22-16-21(7-9-25(22)28(26)32-33-29)18-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 146n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR phosphorylation in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188739
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-22(14-19)31-29(36)30-17-23-7-9-26(37-23)28-25-16-21-15-20(6-8-24(21)27(25)32-33-28)18-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 146n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR phosphorylation in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 147n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50210290
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)31-30(37)35(3)19-24-8-10-27(38-24)29-26-17-22-16-21(7-9-25(22)28(26)32-33-29)18-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 159n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188762
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5ccccc5C)s4)-c3c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-5-3-4-6-25(19)31-29(36)30-17-22-9-10-26(37-22)28-24-16-21-8-7-20(15-23(21)27(24)32-33-28)18-35-13-11-34(2)12-14-35/h3-10,15H,11-14,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 159n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188738
PNG
(1-isobutyl-1-((5-(6-((4-methylpiperazin-1-yl)methy...)
Show SMILES CC(C)CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C33H40N6OS/c1-22(2)19-39(33(40)34-26-7-5-6-23(3)16-26)21-27-9-11-30(41-27)32-29-18-25-17-24(8-10-28(25)31(29)35-36-32)20-38-14-12-37(4)13-15-38/h5-11,16-17,22H,12-15,18-21H2,1-4H3,(H,34,40)(H,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 164n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188732
PNG
(1-cyclopropyl-1-((5-(6-((4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CN(C4CC4)C(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C32H36N6OS/c1-21-4-3-5-24(16-21)33-32(39)38(25-7-8-25)20-26-9-11-29(40-26)31-28-18-23-17-22(6-10-27(23)30(28)34-35-31)19-37-14-12-36(2)13-15-37/h3-6,9-11,16-17,25H,7-8,12-15,18-20H2,1-2H3,(H,33,39)(H,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 171n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR phosphorylation in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188767
PNG
(1-(2-methoxyethyl)-1-((5-(6-((4-methylpiperazin-1-...)
Show SMILES COCCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6O2S/c1-22-5-4-6-25(17-22)33-32(39)38(15-16-40-3)21-26-8-10-29(41-26)31-28-19-24-18-23(7-9-27(24)30(28)34-35-31)20-37-13-11-36(2)12-14-37/h4-10,17-18H,11-16,19-21H2,1-3H3,(H,33,39)(H,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 171n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188772
PNG
(1-((4-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(CNC(=O)Nc4cccc(C)c4)c3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-23(12-19)31-29(36)30-16-24-14-22(18-37-24)27-26-15-21-13-20(6-7-25(21)28(26)33-32-27)17-35-10-8-34(2)9-11-35/h3-7,12-14,18H,8-11,15-17H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188743
PNG
(3-(2-chlorophenyl)-1-methyl-1-((5-(6-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C29H31ClN6OS/c1-34-11-13-36(14-12-34)17-19-7-9-22-20(15-19)16-23-27(22)32-33-28(23)26-10-8-21(38-26)18-35(2)29(37)31-25-6-4-3-5-24(25)30/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188728
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5ccccc5)s4)-c3c2)CC1
Show InChI InChI=1S/C28H30N6OS/c1-33-11-13-34(14-12-33)18-19-7-8-20-16-24-26(23(20)15-19)31-32-27(24)25-10-9-22(36-25)17-29-28(35)30-21-5-3-2-4-6-21/h2-10,15H,11-14,16-18H2,1H3,(H,31,32)(H2,29,30,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 184n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188749
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H31F3N6OS/c1-37-10-12-39(13-11-37)17-19-6-7-20-15-25-27(24(20)14-19)35-36-28(25)26-9-8-23(41-26)18-38(2)29(40)34-22-5-3-4-21(16-22)30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 195n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR phosphorylation in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188733
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CCCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6OS/c1-4-12-38(32(39)33-25-7-5-6-22(2)17-25)21-26-9-11-29(40-26)31-28-19-24-18-23(8-10-27(24)30(28)34-35-31)20-37-15-13-36(3)14-16-37/h5-11,17-18H,4,12-16,19-21H2,1-3H3,(H,33,39)(H,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 198n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR phosphorylation in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188742
PNG
(1-(2-chlorophenyl)-3-((5-(6-((4-methylpiperazin-1-...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccccc4Cl)s3)c2)CC1
Show InChI InChI=1S/C28H29ClN6OS/c1-34-10-12-35(13-11-34)17-18-6-8-21-19(14-18)15-22-26(21)32-33-27(22)25-9-7-20(37-25)16-30-28(36)31-24-5-3-2-4-23(24)29/h2-9,14H,10-13,15-17H2,1H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 199n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188741
PNG
(3-(5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihyd...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CCC(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C30H33N5OS/c1-20-4-3-5-23(16-20)31-28(36)11-8-24-7-10-27(37-24)30-26-18-22-17-21(6-9-25(22)29(26)32-33-30)19-35-14-12-34(2)13-15-35/h3-7,9-10,16-17H,8,11-15,18-19H2,1-2H3,(H,31,36)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 212n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188727
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-10-12-39(13-11-37)17-19-6-8-24-20(14-19)15-25-27(24)35-36-28(25)26-9-7-23(42-26)18-38(2)29(40)34-21-4-3-5-22(16-21)41-30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 218n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR phosphorylation in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188736
PNG
(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-1-...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H30F4N6OS/c1-38-7-9-40(10-8-38)16-18-3-5-24-19(11-18)12-25-27(24)36-37-28(25)26-6-4-23(42-26)17-39(2)29(41)35-22-14-20(30(32,33)34)13-21(31)15-22/h3-6,11,13-15H,7-10,12,16-17H2,1-2H3,(H,35,41)(H,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 233n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR phosphorylation in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188744
PNG
(1-methoxy-1-((5-(6-((4-methylpiperazin-1-yl)methyl...)
Show SMILES CON(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6O2S/c1-20-5-4-6-23(15-20)31-30(37)36(38-3)19-24-8-10-27(39-24)29-26-17-22-16-21(7-9-25(22)28(26)32-33-29)18-35-13-11-34(2)12-14-35/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 237n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 254n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4 in human liver microsome


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50188749
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H31F3N6OS/c1-37-10-12-39(13-11-37)17-19-6-7-20-15-25-27(24(20)14-19)35-36-28(25)26-9-8-23(41-26)18-38(2)29(40)34-22-5-3-4-21(16-22)30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 259n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Tie2 at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188744
PNG
(1-methoxy-1-((5-(6-((4-methylpiperazin-1-yl)methyl...)
Show SMILES CON(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6O2S/c1-20-5-4-6-23(15-20)31-30(37)36(38-3)19-24-8-10-27(39-24)29-26-17-22-16-21(7-9-25(22)28(26)32-33-29)18-35-13-11-34(2)12-14-35/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 259n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188763
PNG
(1-isopentyl-1-((5-(6-((4-methylpiperazin-1-yl)meth...)
Show SMILES CC(C)CCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C34H42N6OS/c1-23(2)12-13-40(34(41)35-27-7-5-6-24(3)18-27)22-28-9-11-31(42-28)33-30-20-26-19-25(8-10-29(26)32(30)36-37-33)21-39-16-14-38(4)15-17-39/h5-11,18-19,23H,12-17,20-22H2,1-4H3,(H,35,41)(H,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 262n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188731
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccc(cc4)C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-10-12-38(13-11-37)17-18-2-8-23-19(14-18)15-24-26(23)35-36-27(24)25-9-7-22(40-25)16-33-28(39)34-21-5-3-20(4-6-21)29(30,31)32/h2-9,14H,10-13,15-17H2,1H3,(H,35,36)(H2,33,34,39)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 281n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188761
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccc(C)cc4)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-3-6-22(7-4-19)31-29(36)30-17-23-8-10-26(37-23)28-25-16-21-15-20(5-9-24(21)27(25)32-33-28)18-35-13-11-34(2)12-14-35/h3-10,15H,11-14,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 308n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188747
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccccc4C)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-5-3-4-6-25(19)31-29(36)30-17-22-8-10-26(37-22)28-24-16-21-15-20(7-9-23(21)27(24)32-33-28)18-35-13-11-34(2)12-14-35/h3-10,15H,11-14,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 444n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188770
PNG
(2-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3cc4CCN(Cc4s3)C(=O)Nc3cccc(C)c3)c2)CC1
Show InChI InChI=1S/C31H34N6OS/c1-20-4-3-5-24(14-20)32-31(38)37-9-8-22-17-27(39-28(22)19-37)30-26-16-23-15-21(6-7-25(23)29(26)33-34-30)18-36-12-10-35(2)11-13-36/h3-7,14-15,17H,8-13,16,18-19H2,1-2H3,(H,32,38)(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 459n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188757
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5cccc(C)c5)s4)-c3c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-22(14-19)31-29(36)30-17-23-8-9-26(37-23)28-25-16-21-7-6-20(15-24(21)27(25)32-33-28)18-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 592n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188762
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5ccccc5C)s4)-c3c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-5-3-4-6-25(19)31-29(36)30-17-22-9-10-26(37-22)28-24-16-21-8-7-20(15-23(21)27(24)32-33-28)18-35-13-11-34(2)12-14-35/h3-10,15H,11-14,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 674n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188748
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(c4)C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-9-11-38(12-10-37)17-18-5-7-23-19(13-18)14-24-26(23)35-36-27(24)25-8-6-22(40-25)16-33-28(39)34-21-4-2-3-20(15-21)29(30,31)32/h2-8,13,15H,9-12,14,16-17H2,1H3,(H,35,36)(H2,33,34,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 863n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188742
PNG
(1-(2-chlorophenyl)-3-((5-(6-((4-methylpiperazin-1-...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccccc4Cl)s3)c2)CC1
Show InChI InChI=1S/C28H29ClN6OS/c1-34-10-12-35(13-11-34)17-18-6-8-21-19(14-18)15-22-26(21)32-33-27(22)25-9-7-20(37-25)16-30-28(36)31-24-5-3-2-4-23(24)29/h2-9,14H,10-13,15-17H2,1H3,(H,32,33)(H2,30,31,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 921n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188744
PNG
(1-methoxy-1-((5-(6-((4-methylpiperazin-1-yl)methyl...)
Show SMILES CON(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6O2S/c1-20-5-4-6-23(15-20)31-30(37)36(38-3)19-24-8-10-27(39-24)29-26-17-22-16-21(7-9-25(22)28(26)32-33-29)18-35-13-11-34(2)12-14-35/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.35E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188747
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccccc4C)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-5-3-4-6-25(19)31-29(36)30-17-22-8-10-26(37-22)28-24-16-21-15-20(7-9-23(21)27(24)32-33-28)18-35-13-11-34(2)12-14-35/h3-10,15H,11-14,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.39E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188738
PNG
(1-isobutyl-1-((5-(6-((4-methylpiperazin-1-yl)methy...)
Show SMILES CC(C)CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C33H40N6OS/c1-22(2)19-39(33(40)34-26-7-5-6-23(3)16-26)21-27-9-11-30(41-27)32-29-18-25-17-24(8-10-28(25)31(29)35-36-32)20-38-14-12-37(4)13-15-38/h5-11,16-17,22H,12-15,18-21H2,1-4H3,(H,34,40)(H,35,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.59E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188737
PNG
(1-(3,5-dimethylphenyl)-3-((5-(6-((4-methylpiperazi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cc(C)cc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C30H34N6OS/c1-19-12-20(2)14-23(13-19)32-30(37)31-17-24-5-7-27(38-24)29-26-16-22-15-21(4-6-25(22)28(26)33-34-29)18-36-10-8-35(3)9-11-36/h4-7,12-15H,8-11,16-18H2,1-3H3,(H,33,34)(H2,31,32,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.67E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188751
PNG
((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydro...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(COC(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C29H31N5O2S/c1-19-4-3-5-22(14-19)30-29(35)36-18-23-7-9-26(37-23)28-25-16-21-15-20(6-8-24(21)27(25)31-32-28)17-34-12-10-33(2)11-13-34/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,30,35)(H,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR phosphorylation in NIH3T3 cells by ELISA


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188762
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5ccccc5C)s4)-c3c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-5-3-4-6-25(19)31-29(36)30-17-22-9-10-26(37-22)28-24-16-21-8-7-20(15-23(21)27(24)32-33-28)18-35-13-11-34(2)12-14-35/h3-10,15H,11-14,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.06E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188756
PNG
(1-ethyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)-...)
Show SMILES CCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C31H36N6OS/c1-4-37(31(38)32-24-7-5-6-21(2)16-24)20-25-9-11-28(39-25)30-27-18-23-17-22(8-10-26(23)29(27)33-34-30)19-36-14-12-35(3)13-15-36/h5-11,16-17H,4,12-15,18-20H2,1-3H3,(H,32,38)(H,33,34)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.19E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188767
PNG
(1-(2-methoxyethyl)-1-((5-(6-((4-methylpiperazin-1-...)
Show SMILES COCCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6O2S/c1-22-5-4-6-25(17-22)33-32(39)38(15-16-40-3)21-26-8-10-29(41-26)31-28-19-24-18-23(7-9-27(24)30(28)34-35-31)20-37-13-11-36(2)12-14-37/h4-10,17-18H,11-16,19-21H2,1-3H3,(H,33,39)(H,34,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.26E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188735
PNG
(1-(3,5-dichlorophenyl)-3-((5-(6-((4-methylpiperazi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cc(Cl)cc(Cl)c4)s3)c2)CC1
Show InChI InChI=1S/C28H28Cl2N6OS/c1-35-6-8-36(9-7-35)16-17-2-4-23-18(10-17)11-24-26(23)33-34-27(24)25-5-3-22(38-25)15-31-28(37)32-21-13-19(29)12-20(30)14-21/h2-5,10,12-14H,6-9,11,15-16H2,1H3,(H,33,34)(H2,31,32,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.28E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188730
PNG
(CHEMBL213138 | N-((5-(6-((4-methylpiperazin-1-yl)m...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Cc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C30H33N5OS/c1-20-4-3-5-21(14-20)16-28(36)31-18-24-7-9-27(37-24)30-26-17-23-15-22(6-8-25(23)29(26)32-33-30)19-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-19H2,1-2H3,(H,31,36)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.78E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188740
PNG
(1-isopropyl-1-((5-(6-((4-methylpiperazin-1-yl)meth...)
Show SMILES CC(C)N(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6OS/c1-21(2)38(32(39)33-25-7-5-6-22(3)16-25)20-26-9-11-29(40-26)31-28-18-24-17-23(8-10-27(24)30(28)34-35-31)19-37-14-12-36(4)13-15-37/h5-11,16-17,21H,12-15,18-20H2,1-4H3,(H,33,39)(H,34,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.82E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188768
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccccc4C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-10-12-38(13-11-37)17-18-6-8-21-19(14-18)15-22-26(21)35-36-27(22)25-9-7-20(40-25)16-33-28(39)34-24-5-3-2-4-23(24)29(30,31)32/h2-9,14H,10-13,15-17H2,1H3,(H,35,36)(H2,33,34,39)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.88E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188739
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-22(14-19)31-29(36)30-17-23-7-9-26(37-23)28-25-16-21-15-20(6-8-24(21)27(25)32-33-28)18-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188763
PNG
(1-isopentyl-1-((5-(6-((4-methylpiperazin-1-yl)meth...)
Show SMILES CC(C)CCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C34H42N6OS/c1-23(2)12-13-40(34(41)35-27-7-5-6-24(3)18-27)22-28-9-11-31(42-28)33-30-20-26-19-25(8-10-29(26)32(30)36-37-33)21-39-16-14-38(4)15-17-39/h5-11,18-19,23H,12-17,20-22H2,1-4H3,(H,35,41)(H,36,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.62E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188728
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5ccccc5)s4)-c3c2)CC1
Show InChI InChI=1S/C28H30N6OS/c1-33-11-13-34(14-12-33)18-19-7-8-20-16-24-26(23(20)15-19)31-32-27(24)25-10-9-22(36-25)17-29-28(35)30-21-5-3-2-4-6-21/h2-10,15H,11-14,16-18H2,1H3,(H,31,32)(H2,29,30,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.79E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188743
PNG
(3-(2-chlorophenyl)-1-methyl-1-((5-(6-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C29H31ClN6OS/c1-34-11-13-36(14-12-34)17-19-7-9-22-20(15-19)16-23-27(22)32-33-28(23)26-10-8-21(38-26)18-35(2)29(37)31-25-6-4-3-5-24(25)30/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.84E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188731
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccc(cc4)C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-10-12-38(13-11-37)17-18-2-8-23-19(14-18)15-24-26(23)35-36-27(24)25-9-7-22(40-25)16-33-28(39)34-21-5-3-20(4-6-21)29(30,31)32/h2-9,14H,10-13,15-17H2,1H3,(H,35,36)(H2,33,34,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50210290
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)31-30(37)35(3)19-24-8-10-27(38-24)29-26-17-22-16-21(7-9-25(22)28(26)32-33-29)18-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.72E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188746
PNG
(1-methyl-3-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(C(=O)NCc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)c1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)35(3)30(37)31-18-24-8-10-27(38-24)29-26-17-22-16-21(7-9-25(22)28(26)32-33-29)19-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.81E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188763
PNG
(1-isopentyl-1-((5-(6-((4-methylpiperazin-1-yl)meth...)
Show SMILES CC(C)CCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C34H42N6OS/c1-23(2)12-13-40(34(41)35-27-7-5-6-24(3)18-27)22-28-9-11-31(42-28)33-30-20-26-19-25(8-10-29(26)32(30)36-37-33)21-39-16-14-38(4)15-17-39/h5-11,18-19,23H,12-17,20-22H2,1-4H3,(H,35,41)(H,36,37)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.84E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188755
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C30H34N6OS/c1-20-6-4-5-7-26(20)31-30(37)35(3)19-23-9-11-27(38-23)29-25-17-22-16-21(8-10-24(22)28(25)32-33-29)18-36-14-12-34(2)13-15-36/h4-11,16H,12-15,17-19H2,1-3H3,(H,31,37)(H,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.95E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188755
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C30H34N6OS/c1-20-6-4-5-7-26(20)31-30(37)35(3)19-23-9-11-27(38-23)29-25-17-22-16-21(8-10-24(22)28(25)32-33-29)18-36-14-12-34(2)13-15-36/h4-11,16H,12-15,17-19H2,1-3H3,(H,31,37)(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.71E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188760
PNG
(1,3-dimethyl-1-((5-(6-((4-methylpiperazin-1-yl)met...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)N(C)c1cccc(C)c1
Show InChI InChI=1S/C31H36N6OS/c1-21-6-5-7-24(16-21)36(4)31(38)35(3)20-25-9-11-28(39-25)30-27-18-23-17-22(8-10-26(23)29(27)32-33-30)19-37-14-12-34(2)13-15-37/h5-11,16-17H,12-15,18-20H2,1-4H3,(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.46E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188740
PNG
(1-isopropyl-1-((5-(6-((4-methylpiperazin-1-yl)meth...)
Show SMILES CC(C)N(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6OS/c1-21(2)38(32(39)33-25-7-5-6-22(3)16-25)20-26-9-11-29(40-26)31-28-18-24-17-23(8-10-27(24)30(28)34-35-31)19-37-14-12-36(4)13-15-37/h5-11,16-17,21H,12-15,18-20H2,1-4H3,(H,33,39)(H,34,35)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.75E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4 in human liver microsome


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188761
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccc(C)cc4)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-3-6-22(7-4-19)31-29(36)30-17-23-8-10-26(37-23)28-25-16-21-15-20(5-9-24(21)27(25)32-33-28)18-35-13-11-34(2)12-14-35/h3-10,15H,11-14,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.15E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188766
PNG
(3-methyl-N-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)c4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C29H31N5OS/c1-19-4-3-5-21(14-19)29(35)30-17-23-7-9-26(36-23)28-25-16-22-15-20(6-8-24(22)27(25)31-32-28)18-34-12-10-33(2)11-13-34/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,30,35)(H,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.23E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188746
PNG
(1-methyl-3-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(C(=O)NCc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)c1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)35(3)30(37)31-18-24-8-10-27(38-24)29-26-17-22-16-21(7-9-25(22)28(26)32-33-29)19-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.46E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50210290
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)31-30(37)35(3)19-24-8-10-27(38-24)29-26-17-22-16-21(7-9-25(22)28(26)32-33-29)18-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.47E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188738
PNG
(1-isobutyl-1-((5-(6-((4-methylpiperazin-1-yl)methy...)
Show SMILES CC(C)CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C33H40N6OS/c1-22(2)19-39(33(40)34-26-7-5-6-23(3)16-26)21-27-9-11-30(41-27)32-29-18-25-17-24(8-10-28(25)31(29)35-36-32)20-38-14-12-37(4)13-15-38/h5-11,16-17,22H,12-15,18-21H2,1-4H3,(H,34,40)(H,35,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.72E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188771
PNG
(CHEMBL213230 | N-((4-(6-((4-methylpiperazin-1-yl)m...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(CNS(=O)(=O)c4ccccc4)c3)c2)CC1
Show InChI InChI=1S/C27H29N5O2S2/c1-31-9-11-32(12-10-31)17-19-7-8-24-20(13-19)15-25-26(29-30-27(24)25)21-14-22(35-18-21)16-28-36(33,34)23-5-3-2-4-6-23/h2-8,13-14,18,28H,9-12,15-17H2,1H3,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.28E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188768
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccccc4C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-10-12-38(13-11-37)17-18-6-8-21-19(14-18)15-22-26(21)35-36-27(22)25-9-7-20(40-25)16-33-28(39)34-24-5-3-2-4-23(24)29(30,31)32/h2-9,14H,10-13,15-17H2,1H3,(H,35,36)(H2,33,34,39)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.38E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188773
PNG
(CHEMBL384939 | phenyl (5-(6-((4-methylpiperazin-1-...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Oc4ccccc4)s3)c2)CC1
Show InChI InChI=1S/C28H29N5O2S/c1-32-11-13-33(14-12-32)18-19-7-9-23-20(15-19)16-24-26(23)30-31-27(24)25-10-8-22(36-25)17-29-28(34)35-21-5-3-2-4-6-21/h2-10,15H,11-14,16-18H2,1H3,(H,29,34)(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.42E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188747
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccccc4C)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-5-3-4-6-25(19)31-29(36)30-17-22-8-10-26(37-22)28-24-16-21-15-20(7-9-23(21)27(24)32-33-28)18-35-13-11-34(2)12-14-35/h3-10,15H,11-14,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188760
PNG
(1,3-dimethyl-1-((5-(6-((4-methylpiperazin-1-yl)met...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)N(C)c1cccc(C)c1
Show InChI InChI=1S/C31H36N6OS/c1-21-6-5-7-24(16-21)36(4)31(38)35(3)20-25-9-11-28(39-25)30-27-18-23-17-22(8-10-26(23)29(27)32-33-30)19-37-14-12-34(2)13-15-37/h5-11,16-17H,12-15,18-20H2,1-4H3,(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.68E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188760
PNG
(1,3-dimethyl-1-((5-(6-((4-methylpiperazin-1-yl)met...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)N(C)c1cccc(C)c1
Show InChI InChI=1S/C31H36N6OS/c1-21-6-5-7-24(16-21)36(4)31(38)35(3)20-25-9-11-28(39-25)30-27-18-23-17-22(8-10-26(23)29(27)32-33-30)19-37-14-12-34(2)13-15-37/h5-11,16-17H,12-15,18-20H2,1-4H3,(H,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.79E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188767
PNG
(1-(2-methoxyethyl)-1-((5-(6-((4-methylpiperazin-1-...)
Show SMILES COCCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6O2S/c1-22-5-4-6-25(17-22)33-32(39)38(15-16-40-3)21-26-8-10-29(41-26)31-28-19-24-18-23(7-9-27(24)30(28)34-35-31)20-37-13-11-36(2)12-14-37/h4-10,17-18H,11-16,19-21H2,1-3H3,(H,33,39)(H,34,35)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188734
PNG
(CHEMBL211567 | N-((4-(6-((4-methylpiperazin-1-yl)m...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(CNS(=O)(=O)Cc4ccccc4)c3)c2)CC1
Show InChI InChI=1S/C28H31N5O2S2/c1-32-9-11-33(12-10-32)17-21-7-8-25-22(13-21)15-26-27(30-31-28(25)26)23-14-24(36-18-23)16-29-37(34,35)19-20-5-3-2-4-6-20/h2-8,13-14,18,29H,9-12,15-17,19H2,1H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188745
PNG
(1-cyano-3-(3-methylphenyl)-2-[(5-{6-[(4-methylpipe...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CN=C(NC#N)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C30H32N8S/c1-20-4-3-5-23(14-20)34-30(33-19-31)32-17-24-7-9-27(39-24)29-26-16-22-15-21(6-8-25(22)28(26)35-36-29)18-38-12-10-37(2)11-13-38/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,35,36)(H2,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188765
PNG
(6-methyl-N-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNc4nc5ccc(C)cc5[nH]4)s3)c2)CC1
Show InChI InChI=1S/C29H31N7S/c1-18-3-7-24-25(13-18)32-29(31-24)30-16-21-5-8-26(37-21)28-23-15-20-14-19(4-6-22(20)27(23)33-34-28)17-36-11-9-35(2)10-12-36/h3-8,13-14H,9-12,15-17H2,1-2H3,(H,33,34)(H2,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188742
PNG
(1-(2-chlorophenyl)-3-((5-(6-((4-methylpiperazin-1-...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccccc4Cl)s3)c2)CC1
Show InChI InChI=1S/C28H29ClN6OS/c1-34-10-12-35(13-11-34)17-18-6-8-21-19(14-18)15-22-26(21)32-33-27(22)25-9-7-20(37-25)16-30-28(36)31-24-5-3-2-4-23(24)29/h2-9,14H,10-13,15-17H2,1H3,(H,32,33)(H2,30,31,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50188743
PNG
(3-(2-chlorophenyl)-1-methyl-1-((5-(6-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C29H31ClN6OS/c1-34-11-13-36(14-12-34)17-19-7-9-22-20(15-19)16-23-27(22)32-33-28(23)26-10-8-21(38-26)18-35(2)29(37)31-25-6-4-3-5-24(25)30/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188768
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccccc4C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-10-12-38(13-11-37)17-18-6-8-21-19(14-18)15-22-26(21)35-36-27(22)25-9-7-20(40-25)16-33-28(39)34-24-5-3-2-4-23(24)29(30,31)32/h2-9,14H,10-13,15-17H2,1H3,(H,35,36)(H2,33,34,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%