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PubMed code 16759861

Compile data set for download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16385
PNG
(5-[3-(2-ethoxyphenyl)-[1,2,4]triazolo[3,4-a]pyridi...)
Show SMILES CCOc1ccccc1-c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C23H17FN4O2/c1-2-29-19-6-4-3-5-18(19)23-27-26-20-12-9-16(13-28(20)23)22-21(25-14-30-22)15-7-10-17(24)11-8-15/h3-14H,2H2,1H3
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16384
PNG
(4-(4-fluorophenyl)-5-[3-(2-methoxyphenyl)-[1,2,4]t...)
Show SMILES COc1ccccc1-c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C22H15FN4O2/c1-28-18-5-3-2-4-17(18)22-26-25-19-11-8-15(12-27(19)22)21-20(24-13-29-21)14-6-9-16(23)10-7-14/h2-13H,1H3
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16390
PNG
(4-(2,4-difluorophenyl)-5-[3-(1-methylcyclopropyl)-...)
Show SMILES CC1(CC1)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F
Show InChI InChI=1S/C19H14F2N4O/c1-19(6-7-19)18-24-23-15-5-2-11(9-25(15)18)17-16(22-10-26-17)13-4-3-12(20)8-14(13)21/h2-5,8-10H,6-7H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16392
PNG
(4-(2,4-difluorophenyl)-5-[3-(1-methylcyclobutyl)-[...)
Show SMILES CC1(CCC1)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F
Show InChI InChI=1S/C20H16F2N4O/c1-20(7-2-8-20)19-25-24-16-6-3-12(10-26(16)19)18-17(23-11-27-18)14-5-4-13(21)9-15(14)22/h3-6,9-11H,2,7-8H2,1H3
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n/an/a 1.10n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16393
PNG
(5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Show SMILES CC(C)(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F
Show InChI InChI=1S/C19H16F2N4O/c1-19(2,3)18-24-23-15-7-4-11(9-25(15)18)17-16(22-10-26-17)13-6-5-12(20)8-14(13)21/h4-10H,1-3H3
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n/an/a 1.10n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16398
PNG
(4-(2,5-difluorophenyl)-5-[3-(1-methylcyclobutyl)-[...)
Show SMILES CC1(CCC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F
Show InChI InChI=1S/C20H16F2N4O/c1-20(7-2-8-20)19-25-24-16-6-3-12(10-26(16)19)18-17(23-11-27-18)14-9-13(21)4-5-15(14)22/h3-6,9-11H,2,7-8H2,1H3
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16404
PNG
(5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Show SMILES CC(C)(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F
Show InChI InChI=1S/C19H15F3N4O/c1-19(2,3)18-25-24-15-5-4-10(8-26(15)18)17-16(23-9-27-17)11-6-13(21)14(22)7-12(11)20/h4-9H,1-3H3
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16346
PNG
(4-(4-chloro-2-fluorophenyl)-5-[3-(propan-2-yl)-[1,...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(Cl)cc1F
Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(19)7-14(13)20/h3-10H,1-2H3
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n/an/a 2.20n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16401
PNG
(5-[3-(1-methylcyclopropyl)-[1,2,4]triazolo[3,4-a]p...)
Show SMILES CC1(CC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F
Show InChI InChI=1S/C19H13F3N4O/c1-19(4-5-19)18-25-24-15-3-2-10(8-26(15)18)17-16(23-9-27-17)11-6-13(21)14(22)7-12(11)20/h2-3,6-9H,4-5H2,1H3
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n/an/a 2.30n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16348
PNG
(4-(2-chloro-4-fluorophenyl)-5-[3-(propan-2-yl)-[1,...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1Cl
Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(20)7-14(13)19/h3-10H,1-2H3
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n/an/a 2.5n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16403
PNG
(5-[3-(1-methylcyclobutyl)-[1,2,4]triazolo[3,4-a]py...)
Show SMILES CC1(CCC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F
Show InChI InChI=1S/C20H15F3N4O/c1-20(5-2-6-20)19-26-25-16-4-3-11(9-27(16)19)18-17(24-10-28-18)12-7-14(22)15(23)8-13(12)21/h3-4,7-10H,2,5-6H2,1H3
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n/an/a 2.5n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16405
PNG
(3-(2,5-difluorophenyl)-4-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1c[nH]nc1-c1cc(F)ccc1F
Show InChI InChI=1S/C18H15F2N5/c1-10(2)18-24-22-16-6-3-11(9-25(16)18)14-8-21-23-17(14)13-7-12(19)4-5-15(13)20/h3-10H,1-2H3,(H,21,23)
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n/an/a 2.80n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16340
PNG
(4-(2-chlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccccc1Cl
Show InChI InChI=1S/C18H15ClN4O/c1-11(2)18-22-21-15-8-7-12(9-23(15)18)17-16(20-10-24-17)13-5-3-4-6-14(13)19/h3-11H,1-2H3
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n/an/a 3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16396
PNG
(4-(2,5-difluorophenyl)-5-[3-(1-methylcyclopropyl)-...)
Show SMILES CC1(CC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F
Show InChI InChI=1S/C19H14F2N4O/c1-19(6-7-19)18-24-23-15-5-2-11(9-25(15)18)17-16(22-10-26-17)13-8-12(20)3-4-14(13)21/h2-5,8-10H,6-7H2,1H3
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n/an/a 3n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16351
PNG
(5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F
Show InChI InChI=1S/C18H13F3N4O/c1-9(2)18-24-23-15-4-3-10(7-25(15)18)17-16(22-8-26-17)11-5-13(20)14(21)6-12(11)19/h3-9H,1-2H3
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n/an/a 3.20n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16389
PNG
(5-{3-cyclopropyl-[1,2,4]triazolo[3,4-a]pyridin-6-y...)
Show SMILES Fc1ccc(-c2ncoc2-c2ccc3nnc(C4CC4)n3c2)c(F)c1
Show InChI InChI=1S/C18H12F2N4O/c19-12-4-5-13(14(20)7-12)16-17(25-9-21-16)11-3-6-15-22-23-18(10-1-2-10)24(15)8-11/h3-10H,1-2H2
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n/an/a 3.5n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16386
PNG
(5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Show SMILES CC(C)(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C19H17FN4O/c1-19(2,3)18-23-22-15-9-6-13(10-24(15)18)17-16(21-11-25-17)12-4-7-14(20)8-5-12/h4-11H,1-3H3
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n/an/a 3.5n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16391
PNG
(5-{3-cyclobutyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Show SMILES Fc1ccc(-c2ncoc2-c2ccc3nnc(C4CCC4)n3c2)c(F)c1
Show InChI InChI=1S/C19H14F2N4O/c20-13-5-6-14(15(21)8-13)17-18(26-10-22-17)12-4-7-16-23-24-19(25(16)9-12)11-2-1-3-11/h4-11H,1-3H2
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n/an/a 3.75n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16350
PNG
(5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C18H13F3N4O/c1-9(2)18-24-23-14-4-3-10(7-25(14)18)17-16(22-8-26-17)11-5-12(19)15(21)13(20)6-11/h3-9H,1-2H3
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n/an/a 4.10n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16337
PNG
(4-(2-fluoro-5-methylphenyl)-5-[3-(propan-2-yl)-[1,...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(C)ccc1F
Show InChI InChI=1S/C19H17FN4O/c1-11(2)19-23-22-16-7-5-13(9-24(16)19)18-17(21-10-25-18)14-8-12(3)4-6-15(14)20/h4-11H,1-3H3
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n/an/a 4.30n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16341
PNG
(4-(2,4-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F
Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(19)7-14(13)20/h3-10H,1-2H3
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n/an/a 4.60n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16379
PNG
(N-ethyl-6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-N-m...)
Show SMILES CCN(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H16FN5O/c1-3-23(2)18-22-21-15-9-6-13(10-24(15)18)17-16(20-11-25-17)12-4-7-14(19)8-5-12/h4-11H,3H2,1-2H3
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n/an/a 4.70n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15414
PNG
(4-(4-fluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H15FN4O/c1-11(2)18-22-21-15-8-5-13(9-23(15)18)17-16(20-10-24-17)12-3-6-14(19)7-4-12/h3-11H,1-2H3
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n/an/a 5n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16347
PNG
(4-(5-chloro-2-fluorophenyl)-5-[3-(propan-2-yl)-[1,...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(Cl)ccc1F
Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-7-12(19)4-5-14(13)20/h3-10H,1-2H3
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n/an/a 5.10n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16364
PNG
(N-ethyl-6-(4-phenyl-1,3-oxazol-5-yl)-[1,2,4]triazo...)
Show SMILES CCNc1nnc2ccc(cn12)-c1ocnc1-c1ccccc1
Show InChI InChI=1S/C17H15N5O/c1-2-18-17-21-20-14-9-8-13(10-22(14)17)16-15(19-11-23-16)12-6-4-3-5-7-12/h3-11H,2H2,1H3,(H,18,21)
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n/an/a 5.40n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16377
PNG
(6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-N-(propan-2...)
Show SMILES CC(C)Nc1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H16FN5O/c1-11(2)21-18-23-22-15-8-5-13(9-24(15)18)17-16(20-10-25-17)12-3-6-14(19)7-4-12/h3-11H,1-2H3,(H,21,23)
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n/an/a 5.5n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16359
PNG
(4-(2-chloro-4,5-difluorophenyl)-5-[3-(propan-2-yl)...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1Cl
Show InChI InChI=1S/C18H13ClF2N4O/c1-9(2)18-24-23-15-4-3-10(7-25(15)18)17-16(22-8-26-17)11-5-13(20)14(21)6-12(11)19/h3-9H,1-2H3
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n/an/a 5.60n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16342
PNG
(4-(2,5-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F
Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-7-12(19)4-5-14(13)20/h3-10H,1-2H3
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n/an/a 5.80n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16407
PNG
(4-(2,5-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1nc[nH]c1-c1cc(F)ccc1F
Show InChI InChI=1S/C18H15F2N5/c1-10(2)18-24-23-15-6-3-11(8-25(15)18)16-17(22-9-21-16)13-7-12(19)4-5-14(13)20/h3-10H,1-2H3,(H,21,22)
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n/an/a 6.20n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16336
PNG
(4-(4-fluoro-3-methylphenyl)-5-[3-(propan-2-yl)-[1,...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)c(C)c1
Show InChI InChI=1S/C19H17FN4O/c1-11(2)19-23-22-16-7-5-14(9-24(16)19)18-17(21-10-25-18)13-4-6-15(20)12(3)8-13/h4-11H,1-3H3
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n/an/a 6.60n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16352
PNG
(5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1c(F)cc(F)cc1F
Show InChI InChI=1S/C18H13F3N4O/c1-9(2)18-24-23-14-4-3-10(7-25(14)18)17-16(22-8-26-17)15-12(20)5-11(19)6-13(15)21/h3-9H,1-2H3
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n/an/a 7.20n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16372
PNG
(N-ethyl-6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-[1,...)
Show SMILES CCNc1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H14FN5O/c1-2-19-17-22-21-14-8-5-12(9-23(14)17)16-15(20-10-24-16)11-3-6-13(18)7-4-11/h3-10H,2H2,1H3,(H,19,22)
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n/an/a 7.60n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16400
PNG
(5-{3-cyclopropyl-[1,2,4]triazolo[3,4-a]pyridin-6-y...)
Show SMILES Fc1cc(F)c(cc1F)-c1ncoc1-c1ccc2nnc(C3CC3)n2c1
Show InChI InChI=1S/C18H11F3N4O/c19-12-6-14(21)13(20)5-11(12)16-17(26-8-22-16)10-3-4-15-23-24-18(9-1-2-9)25(15)7-10/h3-9H,1-2H2
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n/an/a 7.80n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16360
PNG
(4-(3-bromo-4-fluorophenyl)-5-[3-(propan-2-yl)-[1,2...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)c(Br)c1
Show InChI InChI=1S/C18H14BrFN4O/c1-10(2)18-23-22-15-6-4-12(8-24(15)18)17-16(21-9-25-17)11-3-5-14(20)13(19)7-11/h3-10H,1-2H3
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n/an/a 8n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16356
PNG
(4-(2,4-dichlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H14Cl2N4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(19)7-14(13)20/h3-10H,1-2H3
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n/an/a 8.30n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16399
PNG
(5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Show SMILES CC(C)(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F
Show InChI InChI=1S/C19H16F2N4O/c1-19(2,3)18-24-23-15-7-4-11(9-25(15)18)17-16(22-10-26-17)13-8-12(20)5-6-14(13)21/h4-10H,1-3H3
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n/an/a 8.80n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16376
PNG
(4-(4-fluorophenyl)-5-[3-(2-methylpropyl)-[1,2,4]tr...)
Show SMILES CC(C)Cc1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C19H17FN4O/c1-12(2)9-17-23-22-16-8-5-14(10-24(16)17)19-18(21-11-25-19)13-3-6-15(20)7-4-13/h3-8,10-12H,9H2,1-2H3
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n/an/a 8.80n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16402
PNG
(5-{3-cyclobutyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Show SMILES Fc1cc(F)c(cc1F)-c1ncoc1-c1ccc2nnc(C3CCC3)n2c1
Show InChI InChI=1S/C19H13F3N4O/c20-13-7-15(22)14(21)6-12(13)17-18(27-9-23-17)11-4-5-16-24-25-19(26(16)8-11)10-2-1-3-10/h4-10H,1-3H2
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n/an/a 9.10n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16365
PNG
(N-ethyl-N-methyl-6-(4-phenyl-1,3-oxazol-5-yl)-[1,2...)
Show SMILES CCN(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccccc1
Show InChI InChI=1S/C18H17N5O/c1-3-22(2)18-21-20-15-10-9-14(11-23(15)18)17-16(19-12-24-17)13-7-5-4-6-8-13/h4-12H,3H2,1-2H3
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n/an/a 9.20n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16333
PNG
(4-phenyl-5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c1-12(2)18-21-20-15-9-8-14(10-22(15)18)17-16(19-11-23-17)13-6-4-3-5-7-13/h3-12H,1-2H3
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n/an/a 9.60n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16397
PNG
(5-{3-cyclobutyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Show SMILES Fc1ccc(F)c(c1)-c1ncoc1-c1ccc2nnc(C3CCC3)n2c1
Show InChI InChI=1S/C19H14F2N4O/c20-13-5-6-15(21)14(8-13)17-18(26-10-22-17)12-4-7-16-23-24-19(25(16)9-12)11-2-1-3-11/h4-11H,1-3H2
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n/an/a 9.70n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16375
PNG
(5-{3-cyclopropyl-[1,2,4]triazolo[3,4-a]pyridin-6-y...)
Show SMILES Fc1ccc(cc1)-c1ncoc1-c1ccc2nnc(C3CC3)n2c1
Show InChI InChI=1S/C18H13FN4O/c19-14-6-3-11(4-7-14)16-17(24-10-20-16)13-5-8-15-21-22-18(12-1-2-12)23(15)9-13/h3-10,12H,1-2H2
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n/an/a 10.9n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16354
PNG
(5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)c(F)c1F
Show InChI InChI=1S/C18H13F3N4O/c1-9(2)18-24-23-13-6-3-10(7-25(13)18)17-16(22-8-26-17)11-4-5-12(19)15(21)14(11)20/h3-9H,1-2H3
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n/an/a 11.1n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16387
PNG
(4-{6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-[1,2,4]t...)
Show SMILES Fc1ccc(cc1)-c1ncoc1-c1ccc2nnc(N3CCOCC3)n2c1
Show InChI InChI=1S/C19H16FN5O2/c20-15-4-1-13(2-5-15)17-18(27-12-21-17)14-3-6-16-22-23-19(25(16)11-14)24-7-9-26-10-8-24/h1-6,11-12H,7-10H2
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n/an/a 11.8n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16383
PNG
(4-(4-fluorophenyl)-5-{3-phenyl-[1,2,4]triazolo[3,4...)
Show SMILES Fc1ccc(cc1)-c1ncoc1-c1ccc2nnc(-c3ccccc3)n2c1
Show InChI InChI=1S/C21H13FN4O/c22-17-9-6-14(7-10-17)19-20(27-13-23-19)16-8-11-18-24-25-21(26(18)12-16)15-4-2-1-3-5-15/h1-13H
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n/an/a 12.3n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16345
PNG
(4-(3-chloro-4-fluorophenyl)-5-[3-(propan-2-yl)-[1,...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-4-12(8-24(15)18)17-16(21-9-25-17)11-3-5-14(20)13(19)7-11/h3-10H,1-2H3
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n/an/a 12.4n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16339
PNG
(4-(3-chlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cccc(Cl)c1
Show InChI InChI=1S/C18H15ClN4O/c1-11(2)18-22-21-15-7-6-13(9-23(15)18)17-16(20-10-24-17)12-4-3-5-14(19)8-12/h3-11H,1-2H3
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n/an/a 13.5n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16381
PNG
(4-(4-fluorophenyl)-5-[3-(1-methylcyclobutyl)-[1,2,...)
Show SMILES CC1(CCC1)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C20H17FN4O/c1-20(9-2-10-20)19-24-23-16-8-5-14(11-25(16)19)18-17(22-12-26-18)13-3-6-15(21)7-4-13/h3-8,11-12H,2,9-10H2,1H3
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n/an/a 14n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16357
PNG
(4-(2,3-dichlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H14Cl2N4O/c1-10(2)18-23-22-14-7-6-11(8-24(14)18)17-16(21-9-25-17)12-4-3-5-13(19)15(12)20/h3-10H,1-2H3
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n/an/a 14.5n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16343
PNG
(4-(2,6-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1c(F)cccc1F
Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-14-7-6-11(8-24(14)18)17-16(21-9-25-17)15-12(19)4-3-5-13(15)20/h3-10H,1-2H3
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n/an/a 14.6n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16371
PNG
(6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-N,N-dimethy...)
Show SMILES CN(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H14FN5O/c1-22(2)17-21-20-14-8-5-12(9-23(14)17)16-15(19-10-24-16)11-3-6-13(18)7-4-11/h3-10H,1-2H3
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n/an/a 15.3n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16382
PNG
(4-(4-fluorophenyl)-5-[3-(pyrrolidin-1-yl)-[1,2,4]t...)
Show SMILES Fc1ccc(cc1)-c1ncoc1-c1ccc2nnc(N3CCCC3)n2c1
Show InChI InChI=1S/C19H16FN5O/c20-15-6-3-13(4-7-15)17-18(26-12-21-17)14-5-8-16-22-23-19(25(16)11-14)24-9-1-2-10-24/h3-8,11-12H,1-2,9-10H2
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n/an/a 15.4n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16363
PNG
(5-{3-cyclobutyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Show SMILES C1CC(C1)c1nnc2ccc(cn12)-c1ocnc1-c1ccccc1
Show InChI InChI=1S/C19H16N4O/c1-2-5-13(6-3-1)17-18(24-12-20-17)15-9-10-16-21-22-19(23(16)11-15)14-7-4-8-14/h1-3,5-6,9-12,14H,4,7-8H2
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n/an/a 16.6n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16338
PNG
(4-(4-chlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H15ClN4O/c1-11(2)18-22-21-15-8-5-13(9-23(15)18)17-16(20-10-24-17)12-3-6-14(19)7-4-12/h3-11H,1-2H3
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n/an/a 17.7n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16374
PNG
(5-{3-cyclobutyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Show SMILES Fc1ccc(cc1)-c1ncoc1-c1ccc2nnc(C3CCC3)n2c1
Show InChI InChI=1S/C19H15FN4O/c20-15-7-4-12(5-8-15)17-18(25-11-21-17)14-6-9-16-22-23-19(24(16)10-14)13-2-1-3-13/h4-11,13H,1-3H2
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n/an/a 17.7n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16380
PNG
(4-(4-fluorophenyl)-5-[3-(propan-2-yloxy)-[1,2,4]tr...)
Show SMILES CC(C)Oc1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H15FN4O2/c1-11(2)25-18-22-21-15-8-5-13(9-23(15)18)17-16(20-10-24-17)12-3-6-14(19)7-4-12/h3-11H,1-2H3
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n/an/a 17.9n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16334
PNG
(4-(3-methylphenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cccc(C)c1
Show InChI InChI=1S/C19H18N4O/c1-12(2)19-22-21-16-8-7-15(10-23(16)19)18-17(20-11-24-18)14-6-4-5-13(3)9-14/h4-12H,1-3H3
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n/an/a 18.3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16369
PNG
(4-(4-fluorophenyl)-5-{[1,2,4]triazolo[3,4-a]pyridi...)
Show SMILES Fc1ccc(cc1)-c1ncoc1-c1ccc2nncn2c1
Show InChI InChI=1S/C15H9FN4O/c16-12-4-1-10(2-5-12)14-15(21-9-17-14)11-3-6-13-19-18-8-20(13)7-11/h1-9H
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n/an/a 19.5n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16388
PNG
(5-{3-benzyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl}-4-...)
Show SMILES Fc1ccc(cc1)-c1ncoc1-c1ccc2nnc(Cc3ccccc3)n2c1
Show InChI InChI=1S/C22H15FN4O/c23-18-9-6-16(7-10-18)21-22(28-14-24-21)17-8-11-19-25-26-20(27(19)13-17)12-15-4-2-1-3-5-15/h1-11,13-14H,12H2
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n/an/a 19.9n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16370
PNG
(5-{3-ethyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl}-4-(...)
Show SMILES CCc1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H13FN4O/c1-2-14-20-21-15-8-5-12(9-22(14)15)17-16(19-10-23-17)11-3-6-13(18)7-4-11/h3-10H,2H2,1H3
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n/an/a 21.6n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16344
PNG
(4-(3,4-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-15-6-4-12(8-24(15)18)17-16(21-9-25-17)11-3-5-13(19)14(20)7-11/h3-10H,1-2H3
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n/an/a 22.3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16395
PNG
(5-{3-cyclopropyl-[1,2,4]triazolo[3,4-a]pyridin-6-y...)
Show SMILES Fc1ccc(F)c(c1)-c1ncoc1-c1ccc2nnc(C3CC3)n2c1
Show InChI InChI=1S/C18H12F2N4O/c19-12-4-5-14(20)13(7-12)16-17(25-9-21-16)11-3-6-15-22-23-18(10-1-2-10)24(15)8-11/h3-10H,1-2H2
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n/an/a 24n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16358
PNG
(4-(4-chloro-2,5-difluorophenyl)-5-[3-(propan-2-yl)...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(Cl)cc1F
Show InChI InChI=1S/C18H13ClF2N4O/c1-9(2)18-24-23-15-4-3-10(7-25(15)18)17-16(22-8-26-17)11-5-14(21)12(19)6-13(11)20/h3-9H,1-2H3
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n/an/a 24.5n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16394
PNG
(2-{6-[4-(2,5-difluorophenyl)-1,3-oxazol-5-yl]-[1,2...)
Show SMILES CC(C)(O)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F
Show InChI InChI=1S/C18H14F2N4O2/c1-18(2,25)17-23-22-14-6-3-10(8-24(14)17)16-15(21-9-26-16)12-7-11(19)4-5-13(12)20/h3-9,25H,1-2H3
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n/an/a 25n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16355
PNG
(4-(3,4-dichlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H14Cl2N4O/c1-10(2)18-23-22-15-6-4-12(8-24(15)18)17-16(21-9-25-17)11-3-5-13(19)14(20)7-11/h3-10H,1-2H3
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n/an/a 26.4n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16406
PNG
(5-(2,5-difluorophenyl)-4-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1cnoc1-c1cc(F)ccc1F
Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-16-6-3-11(9-24(16)18)14-8-21-25-17(14)13-7-12(19)4-5-15(13)20/h3-10H,1-2H3
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n/an/a 33.2n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16335
PNG
(4-(3-fluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cccc(F)c1
Show InChI InChI=1S/C18H15FN4O/c1-11(2)18-22-21-15-7-6-13(9-23(15)18)17-16(20-10-24-17)12-4-3-5-14(19)8-12/h3-11H,1-2H3
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n/an/a 37.8n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16349
PNG
(4-(4-chloro-3-fluorophenyl)-5-[3-(propan-2-yl)-[1,...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-4-12(8-24(15)18)17-16(21-9-25-17)11-3-5-13(19)14(20)7-11/h3-10H,1-2H3
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n/an/a 43.2n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16362
PNG
(5-{3-cyclopropyl-[1,2,4]triazolo[3,4-a]pyridin-6-y...)
Show SMILES C1CC1c1nnc2ccc(cn12)-c1ocnc1-c1ccccc1
Show InChI InChI=1S/C18H14N4O/c1-2-4-12(5-3-1)16-17(23-11-19-16)14-8-9-15-20-21-18(13-6-7-13)22(15)10-14/h1-5,8-11,13H,6-7H2
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n/an/a 47.2n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16361
PNG
(5-{3-ethyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl}-4-p...)
Show SMILES CCc1nnc2ccc(cn12)-c1ocnc1-c1ccccc1
Show InChI InChI=1S/C17H14N4O/c1-2-14-19-20-15-9-8-13(10-21(14)15)17-16(18-11-22-17)12-6-4-3-5-7-12/h3-11H,2H2,1H3
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n/an/a 54.5n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16373
PNG
(5-{3-ethoxy-[1,2,4]triazolo[3,4-a]pyridin-6-yl}-4-...)
Show SMILES CCOc1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H13FN4O2/c1-2-23-17-21-20-14-8-5-12(9-22(14)17)16-15(19-10-24-16)11-3-6-13(18)7-4-11/h3-10H,2H2,1H3
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n/an/a 55.5n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16367
PNG
(4-phenyl-5-[3-(2,2,2-trifluoroethyl)-[1,2,4]triazo...)
Show SMILES FC(F)(F)Cc1nnc2ccc(cn12)-c1ocnc1-c1ccccc1
Show InChI InChI=1S/C17H11F3N4O/c18-17(19,20)8-14-23-22-13-7-6-12(9-24(13)14)16-15(21-10-25-16)11-4-2-1-3-5-11/h1-7,9-10H,8H2
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n/an/a 83.2n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16353
PNG
(5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)cc(F)c1F
Show InChI InChI=1S/C18H13F3N4O/c1-9(2)18-24-23-14-4-3-10(7-25(14)18)17-16(22-8-26-17)12-5-11(19)6-13(20)15(12)21/h3-9H,1-2H3
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n/an/a 83.3n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16378
PNG
(6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-N-propyl-[1...)
Show SMILES CCCNc1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H16FN5O/c1-2-9-20-18-23-22-15-8-5-13(10-24(15)18)17-16(21-11-25-17)12-3-6-14(19)7-4-12/h3-8,10-11H,2,9H2,1H3,(H,20,23)
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n/an/a 198n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16368
PNG
(5-[3-(1,2-oxazol-5-yl)-[1,2,4]triazolo[3,4-a]pyrid...)
Show SMILES c1cc(on1)-c1nnc2ccc(cn12)-c1ocnc1-c1ccccc1
Show InChI InChI=1S/C18H11N5O2/c1-2-4-12(5-3-1)16-17(24-11-19-16)13-6-7-15-21-22-18(23(15)10-13)14-8-9-20-25-14/h1-11H
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n/an/a 285n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16366
PNG
(5-[3-(difluoromethyl)-[1,2,4]triazolo[3,4-a]pyridi...)
Show SMILES FC(F)c1nnc2ccc(cn12)-c1ocnc1-c1ccccc1
Show InChI InChI=1S/C16H10F2N4O/c17-15(18)16-21-20-12-7-6-11(8-22(12)16)14-13(19-9-23-14)10-4-2-1-3-5-10/h1-9,15H
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n/an/a 544n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%