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PubMed code 1676428

Compile data set for download or QSAR
Found 47 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4293
PNG
((2E)-3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphen...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)c2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C16H11NO5/c17-8-11(5-9-1-3-12(18)14(20)6-9)16(22)10-2-4-13(19)15(21)7-10/h1-7,18-21H/b11-5+
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n/an/a 370n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4302
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phe...)
Show SMILES C[C@@H](NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N)c1ccccc1
Show InChI InChI=1S/C18H16N2O3/c1-12(14-5-3-2-4-6-14)20-18(23)15(11-19)9-13-7-8-16(21)17(22)10-13/h2-10,12,21-22H,1H3,(H,20,23)/b15-9+/t12-/m1/s1
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n/an/a 400n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4284
PNG
((5,6-Dihydroxyindanylidene)malononitrile | 2-(5,6-...)
Show SMILES Oc1cc2CCC(=C(C#N)C#N)c2cc1O
Show InChI InChI=1S/C12H8N2O2/c13-5-8(6-14)9-2-1-7-3-11(15)12(16)4-10(7)9/h3-4,15-16H,1-2H2
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n/an/a 500n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4294
PNG
((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-fluorophenyl)ca...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)c2ccc(F)cc2)cc1O
Show InChI InChI=1S/C16H10FNO3/c17-13-4-2-11(3-5-13)16(21)12(9-18)7-10-1-6-14(19)15(20)8-10/h1-8,19-20H/b12-7+
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n/an/a 560n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4304
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)Nc2ccccc2)cc1O
Show InChI InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+
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n/an/a 700n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4303
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpr...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCc2ccccc2)cc1O
Show InChI InChI=1S/C19H18N2O3/c20-13-16(11-15-8-9-17(22)18(23)12-15)19(24)21-10-4-7-14-5-2-1-3-6-14/h1-3,5-6,8-9,11-12,22-23H,4,7,10H2,(H,21,24)/b16-11+
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n/an/a 700n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4305
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phe...)
Show SMILES C[C@H](NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N)c1ccccc1
Show InChI InChI=1S/C18H16N2O3/c1-12(14-5-3-2-4-6-14)20-18(23)15(11-19)9-13-7-8-16(21)17(22)10-13/h2-10,12,21-22H,1H3,(H,20,23)/b15-9+/t12-/m0/s1
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n/an/a 860n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4295
PNG
((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)ca...)
Show SMILES Cc1ccc(cc1)C(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C17H13NO3/c1-11-2-5-13(6-3-11)17(21)14(10-18)8-12-4-7-15(19)16(20)9-12/h2-9,19-20H,1H3/b14-8+
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n/an/a 880n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4306
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2-phenylet...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCc2ccccc2)cc1O
Show InChI InChI=1S/C18H16N2O3/c19-12-15(10-14-6-7-16(21)17(22)11-14)18(23)20-9-8-13-4-2-1-3-5-13/h1-7,10-11,21-22H,8-9H2,(H,20,23)/b15-10+
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n/an/a 930n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4307
PNG
((2E)-N-(2-chlorophenyl)-2-cyano-3-(3,4-dihydroxyph...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)Nc2ccccc2Cl)cc1O
Show InChI InChI=1S/C16H11ClN2O3/c17-12-3-1-2-4-13(12)19-16(22)11(9-18)7-10-5-6-14(20)15(21)8-10/h1-8,20-21H,(H,19,22)/b11-7+
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n/an/a 1.10E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4308
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbu...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCc2ccccc2)cc1O
Show InChI InChI=1S/C20H20N2O3/c21-14-17(12-16-9-10-18(23)19(24)13-16)20(25)22-11-5-4-8-15-6-2-1-3-7-15/h1-3,6-7,9-10,12-13,23-24H,4-5,8,11H2,(H,22,25)/b17-12+
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n/an/a 1.10E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4296
PNG
((2E)-2-benzoyl-3-(3,4-dihydroxyphenyl)prop-2-eneni...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)c2ccccc2)cc1O
Show InChI InChI=1S/C16H11NO3/c17-10-13(16(20)12-4-2-1-3-5-12)8-11-6-7-14(18)15(19)9-11/h1-9,18-19H/b13-8+
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n/an/a 1.30E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4309
PNG
(Tyrphostin deriv. 58 | ethyl 2-[(2E)-2-cyano-3-(3,...)
Show SMILES CCOC(=O)C(Cc1ccccc1)NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C21H20N2O5/c1-2-28-21(27)17(11-14-6-4-3-5-7-14)23-20(26)16(13-22)10-15-8-9-18(24)19(25)12-15/h3-10,12,17,24-25H,2,11H2,1H3,(H,23,26)/b16-10+
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n/an/a 1.53E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4297
PNG
((2E)-2-[(2-chlorophenyl)carbonyl]-3-(3,4-dihydroxy...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)c2ccccc2Cl)cc1O
Show InChI InChI=1S/C16H10ClNO3/c17-13-4-2-1-3-12(13)16(21)11(9-18)7-10-5-6-14(19)15(20)8-10/h1-8,19-20H/b11-7+
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n/an/a 1.54E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4310
PNG
((2E)-2-cyano-N-cyclohexyl-3-(3,4-dihydroxyphenyl)p...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NC2CCCCC2)cc1O
Show InChI InChI=1S/C16H18N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h6-9,13,19-20H,1-5H2,(H,18,21)/b12-8+
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n/an/a 1.60E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4311
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[2-(3,4-dim...)
Show SMILES COc1ccc(CCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1OC
Show InChI InChI=1S/C20H20N2O5/c1-26-18-6-4-13(11-19(18)27-2)7-8-22-20(25)15(12-21)9-14-3-5-16(23)17(24)10-14/h3-6,9-11,23-24H,7-8H2,1-2H3,(H,22,25)/b15-9+
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n/an/a 1.70E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4312
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimeth...)
Show SMILES COc1ccc(NC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)c(OC)c1
Show InChI InChI=1S/C18H16N2O5/c1-24-13-4-5-14(17(9-13)25-2)20-18(23)12(10-19)7-11-3-6-15(21)16(22)8-11/h3-9,21-22H,1-2H3,(H,20,23)/b12-7+
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n/an/a 1.70E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4313
PNG
((2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCc2ccccc2)cc1O
Show InChI InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
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n/an/a 2.00E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4314
PNG
((2E)-2-(2,3-dihydro-1H-indol-1-ylcarbonyl)-3-(3,4-...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)N2CCc3ccccc23)cc1O
Show InChI InChI=1S/C18H14N2O3/c19-11-14(9-12-5-6-16(21)17(22)10-12)18(23)20-8-7-13-3-1-2-4-15(13)20/h1-6,9-10,21-22H,7-8H2/b14-9+
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n/an/a 2.10E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4298
PNG
((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-nitrophenyl)car...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)c2ccc(cc2)[N+]([O-])=O)cc1O
Show InChI InChI=1S/C16H10N2O5/c17-9-12(7-10-1-6-14(19)15(20)8-10)16(21)11-2-4-13(5-3-11)18(22)23/h1-8,19-20H/b12-7+
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n/an/a 2.30E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4285
PNG
((5,6-Dihydroxy-2-oxo-3-indolinidene)malononitrile ...)
Show SMILES Oc1cc2NC(=O)C(=C(C#N)C#N)c2cc1O
Show InChI InChI=1S/C11H5N3O3/c12-3-5(4-13)10-6-1-8(15)9(16)2-7(6)14-11(10)17/h1-2,15-16H,(H,14,17)
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n/an/a 2.50E+3n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4299
PNG
((2E)-3-(3,4-dihydroxyphenyl)-2-(thiophen-2-ylcarbo...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)c2cccs2)cc1O
Show InChI InChI=1S/C14H9NO3S/c15-8-10(14(18)13-2-1-5-19-13)6-9-3-4-11(16)12(17)7-9/h1-7,16-17H/b10-6+
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n/an/a 3.10E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4315
PNG
((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-phenylpiperazin...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)N2CCN(CC2)c2ccccc2)cc1O
Show InChI InChI=1S/C20H19N3O3/c21-14-16(12-15-6-7-18(24)19(25)13-15)20(26)23-10-8-22(9-11-23)17-4-2-1-3-5-17/h1-7,12-13,24-25H,8-11H2/b16-12+
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n/an/a 4.30E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4316
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,6-dimeth...)
Show SMILES Cc1cccc(C)c1NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C18H16N2O3/c1-11-4-3-5-12(2)17(11)20-18(23)14(10-19)8-13-6-7-15(21)16(22)9-13/h3-9,21-22H,1-2H3,(H,20,23)/b14-8+
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n/an/a 5.10E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4286
PNG
((4,5-Dihydroxyindanylidene)malononitrile | 2-(4,5-...)
Show SMILES Oc1ccc2C(CCc2c1O)=C(C#N)C#N
Show InChI InChI=1S/C12H8N2O2/c13-5-7(6-14)8-1-2-10-9(8)3-4-11(15)12(10)16/h3-4,15-16H,1-2H2
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n/an/a 7.00E+3n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4301
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Show SMILES NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
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n/an/a 1.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4300
PNG
((2E)-3-(3,4-dihydroxyphenyl)-2-[(2,4,6-trimethylph...)
Show SMILES Cc1cc(C)c(C(=O)C(=Cc2ccc(O)c(O)c2)C#N)c(C)c1
Show InChI InChI=1S/C19H17NO3/c1-11-6-12(2)18(13(3)7-11)19(23)15(10-20)8-14-4-5-16(21)17(22)9-14/h4-9,21-22H,1-3H3
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n/an/a 1.07E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4287
PNG
((5-Hydroxy-2-oxo-3-indolinidene)malononitrile | 2-...)
Show SMILES Oc1ccc2NC(=O)C(=C(C#N)C#N)c2c1
Show InChI InChI=1S/C11H5N3O2/c12-4-6(5-13)10-8-3-7(15)1-2-9(8)14-11(10)16/h1-3,15H,(H,14,16)
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n/an/a 1.25E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4288
PNG
((N-Methyl-5-hydroxy-2-oxo-3-indolinidene)malononit...)
Show SMILES CN1C(=O)C(=C(C#N)C#N)c2cc(O)ccc12
Show InChI InChI=1S/C12H7N3O2/c1-15-10-3-2-8(16)4-9(10)11(12(15)17)7(5-13)6-14/h2-4,16H,1H3
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n/an/a 2.60E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4289
PNG
(2-(5-nitro-2-oxo-2,3-dihydro-1H-indol-3-ylidene)pr...)
Show SMILES [O-][N+](=O)c1ccc2NC(=O)C(=C(C#N)C#N)c2c1
Show InChI InChI=1S/C11H4N4O3/c12-4-6(5-13)10-8-3-7(15(17)18)1-2-9(8)14-11(10)16/h1-3H,(H,14,16)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4290
PNG
((5-Methoxy-6-hydroxy-2-oxo-3-indolinidene)malononi...)
Show SMILES COc1cc2C(=C(C#N)C#N)C(=O)Nc2cc1O
Show InChI InChI=1S/C12H7N3O3/c1-18-10-2-7-8(3-9(10)16)15-12(17)11(7)6(4-13)5-14/h2-3,16H,1H3,(H,15,17)
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n/an/a 6.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4271
PNG
(2-(pyridin-3-ylmethylidene)propanedinitrile | Tyrp...)
Show SMILES N#CC(=Cc1cccnc1)C#N
Show InChI InChI=1S/C9H5N3/c10-5-9(6-11)4-8-2-1-3-12-7-8/h1-4,7H
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n/an/a 2.25E+5n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4272
PNG
((5-Sulfofurfural)Sodium Salt | Tyrphostin deriv. 2...)
Show SMILES [O-]S(=O)(=O)c1ccc(C=C(C#N)C#N)o1
Show InChI InChI=1S/C8H4N2O4S/c9-4-6(5-10)3-7-1-2-8(14-7)15(11,12)13/h1-3H,(H,11,12,13)/p-1
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n/an/a>2.50E+5n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4291
PNG
((2-Oxo-3-indolinidene)malononitrile | 2-(2-oxo-2,3...)
Show SMILES O=C1Nc2ccccc2C1=C(C#N)C#N
Show InChI InChI=1S/C11H5N3O/c12-5-7(6-13)10-8-3-1-2-4-9(8)14-11(10)15/h1-4H,(H,14,15)
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n/an/a>2.50E+5n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4273
PNG
(N-[4-(2,2-dicyanoeth-1-en-1-yl)phenyl]acetamide | ...)
Show SMILES CC(=O)Nc1ccc(C=C(C#N)C#N)cc1
Show InChI InChI=1S/C12H9N3O/c1-9(16)15-12-4-2-10(3-5-12)6-11(7-13)8-14/h2-6H,1H3,(H,15,16)
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n/an/a>3.25E+5n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4274
PNG
(2-(1H-imidazol-2-ylmethylidene)propanedinitrile | ...)
Show SMILES N#CC(=Cc1ncc[nH]1)C#N
Show InChI InChI=1S/C7H4N4/c8-4-6(5-9)3-7-10-1-2-11-7/h1-3H,(H,10,11)
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n/an/a 5.32E+5n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4275
PNG
(2-{[4-(methylsulfanyl)phenyl]methylidene}propanedi...)
Show SMILES CSc1ccc(C=C(C#N)C#N)cc1
Show InChI InChI=1S/C11H8N2S/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
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n/an/a>6.25E+5n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4276
PNG
(2-[(3-fluoro-4-methoxyphenyl)methylidene]propanedi...)
Show SMILES COc1ccc(C=C(C#N)C#N)cc1F
Show InChI InChI=1S/C11H7FN2O/c1-15-11-3-2-8(5-10(11)12)4-9(6-13)7-14/h2-5H,1H3
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n/an/a 8.00E+5n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4277
PNG
((3Z)-2-amino-3-(1H-indol-5-ylmethylidene)prop-1-en...)
Show SMILES N=C(C(C#N)C#N)C(=Cc1ccc2[nH]ccc2c1)C#N
Show InChI InChI=1S/C15H9N5/c16-7-12(15(19)13(8-17)9-18)6-10-1-2-14-11(5-10)3-4-20-14/h1-6,13,19-20H
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n/an/a 8.20E+5n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4421
PNG
((2E)-3-(3,4-dihydroxyphenyl)-2-(piperidin-1-ylcarb...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)N2CCCCC2)cc1O
Show InChI InChI=1S/C15H16N2O3/c16-10-12(15(20)17-6-2-1-3-7-17)8-11-4-5-13(18)14(19)9-11/h4-5,8-9,18-19H,1-3,6-7H2/b12-8+
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n/an/a>1.00E+6n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4292
PNG
(2-(5-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yliden...)
Show SMILES Oc1cccc2C(CCCc12)=C(C#N)C#N
Show InChI InChI=1S/C13H10N2O/c14-7-9(8-15)10-3-1-5-12-11(10)4-2-6-13(12)16/h2,4,6,16H,1,3,5H2
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n/an/a 1.20E+6n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4278
PNG
(2-(furan-2-ylmethylidene)propanedinitrile | Tyrpho...)
Show SMILES N#CC(=Cc1ccco1)C#N
Show InChI InChI=1S/C8H4N2O/c9-5-7(6-10)4-8-2-1-3-11-8/h1-4H
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n/an/a>1.25E+6n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4279
PNG
(2-[(4-cyanophenyl)methylidene]propanedinitrile | T...)
Show SMILES N#CC(=Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C11H5N3/c12-6-10-3-1-9(2-4-10)5-11(7-13)8-14/h1-5H
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n/an/a 1.40E+6n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4280
PNG
(2-(1H-pyrazol-5-ylmethylidene)propanedinitrile | T...)
Show SMILES N#CC(=Cc1ccn[nH]1)C#N
Show InChI InChI=1S/C7H4N4/c8-4-6(5-9)3-7-1-2-10-11-7/h1-3H,(H,10,11)
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n/an/a 1.48E+6n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4281
PNG
(2-[(4-methanesulfinylphenyl)methylidene]propanedin...)
Show SMILES CS(=O)c1ccc(C=C(C#N)C#N)cc1
Show InChI InChI=1S/C11H8N2OS/c1-15(14)11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
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n/an/a 1.80E+6n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4282
PNG
(2-(1H-indol-5-ylmethylidene)propanedinitrile | Tyr...)
Show SMILES N#CC(=Cc1ccc2[nH]ccc2c1)C#N
Show InChI InChI=1S/C12H7N3/c13-7-10(8-14)5-9-1-2-12-11(6-9)3-4-15-12/h1-6,15H
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n/an/a 2.20E+6n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4283
PNG
(2-[(1-benzyl-2,3-dihydro-1H-indol-5-yl)methylidene...)
Show SMILES N#CC(=Cc1ccc2N(Cc3ccccc3)CCc2c1)C#N
Show InChI InChI=1S/C19H15N3/c20-12-17(13-21)10-16-6-7-19-18(11-16)8-9-22(19)14-15-4-2-1-3-5-15/h1-7,10-11H,8-9,14H2
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n/an/a>2.50E+6n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 34: 1896-907 (1991)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%