Affinity Data by PubMed id=1684995

PubMed code 1684995

Found 27 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dopamine D1 and D2 receptor (Homo sapiens (Human))	BDBM50007702 (6-Chloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine D1 and D2 receptor (Homo sapiens (Human))	BDBM50007700 (6-Bromo-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-be...) Show SMILES CN1CCc2c(Br)c(O)c(O)cc2C(C1)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine D1 and D2 receptor (Homo sapiens (Human))	BDBM50004922 (3-Allyl-6-bromo-1-phenyl-2,3,4,5-tetrahydro-1H-ben...) Show SMILES Oc1cc2C(CN(CC=C)CCc2c(Br)c1O)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine D1 and D2 receptor (Homo sapiens (Human))	BDBM50004917 (3-Allyl-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-be...) Show SMILES Oc1cc2C(CN(CC=C)CCc2c(Cl)c1O)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine D1 and D2 receptor (Homo sapiens (Human))	BDBM86282 (6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...) Show SMILES Oc1cc2C(CNCCc2c(Cl)c1O)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine D1 and D2 receptor (Homo sapiens (Human))	BDBM81986 (3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...) Show SMILES CN1CCc2cc(O)c(O)cc2C(C1)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	8.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine D1 and D2 receptor (Homo sapiens (Human))	BDBM50007698 (6-Bromo-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]aze...) Show SMILES Oc1cc2C(CNCCc2c(Br)c1O)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine D1 and D2 receptor (Homo sapiens (Human))	BDBM50004918 ((+/-)-APD3-Allyl-1-phenyl-2,3,4,5-tetrahydro-1H-be...) Show SMILES Oc1cc2CCN(CC=C)CC(c3ccccc3)c2cc1O Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50004922 (3-Allyl-6-bromo-1-phenyl-2,3,4,5-tetrahydro-1H-ben...) Show SMILES Oc1cc2C(CN(CC=C)CCc2c(Br)c1O)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards dopamine receptor D2 at high affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine D1 and D2 receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine D1 and D2 receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50007698 (6-Bromo-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]aze...) Show SMILES Oc1cc2C(CNCCc2c(Br)c1O)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards Dopamine receptor D2 at high affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50004917 (3-Allyl-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-be...) Show SMILES Oc1cc2C(CN(CC=C)CCc2c(Cl)c1O)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards Dopamine receptor D2 at high affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50007702 (6-Chloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	77	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards dopamine receptor D2 at high affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards Dopamine receptor D2 at high affinity state				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM86282 (6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...) Show SMILES Oc1cc2C(CNCCc2c(Cl)c1O)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards dopamine receptor D2 at high affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50007700 (6-Bromo-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-be...) Show SMILES CN1CCc2c(Br)c(O)c(O)cc2C(C1)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards dopamine receptor D2 at high affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50004917 (3-Allyl-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-be...) Show SMILES Oc1cc2C(CN(CC=C)CCc2c(Cl)c1O)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards Dopamine receptor D2 at low affinity state				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM81986 (3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...) Show SMILES CN1CCc2cc(O)c(O)cc2C(C1)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards dopamine receptor D2 at high affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50007698 (6-Bromo-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]aze...) Show SMILES Oc1cc2C(CNCCc2c(Br)c1O)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards Dopamine receptor D2 at low affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine D1 and D2 receptor (Homo sapiens (Human))	BDBM50007703 (6,9-Dichloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50007702 (6-Chloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards dopamine receptor D2 at low affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50007700 (6-Bromo-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-be...) Show SMILES CN1CCc2c(Br)c(O)c(O)cc2C(C1)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards dopamine receptor D2 at low affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM86282 (6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...) Show SMILES Oc1cc2C(CNCCc2c(Cl)c1O)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards dopamine receptor D2 at low affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards Dopamine receptor D2 at low affinity state				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50004922 (3-Allyl-6-bromo-1-phenyl-2,3,4,5-tetrahydro-1H-ben...) Show SMILES Oc1cc2C(CN(CC=C)CCc2c(Br)c1O)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards dopamine receptor D2 at low affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50007703 (6,9-Dichloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	8.10E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the binding affinity towards Dopamine receptor D2 at high affinity state.				Citation and Details
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%