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PubMed code 16870430

Compile data set for download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50191795
PNG
(CHEMBL386256 | N-3-(4-bromophenyl)propyl imidazole)
Show SMILES Brc1ccc(CCCn2ccnc2)cc1
Show InChI InChI=1S/C12H13BrN2/c13-12-5-3-11(4-6-12)2-1-8-15-9-7-14-10-15/h3-7,9-10H,1-2,8H2
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n/an/a 330n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17,20 lyase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50191792
PNG
(1-(3-(4-chlorophenyl)propyl)-1H-imidazole | CHEMBL...)
Show SMILES Clc1ccc(CCCn2ccnc2)cc1
Show InChI InChI=1S/C12H13ClN2/c13-12-5-3-11(4-6-12)2-1-8-15-9-7-14-10-15/h3-7,9-10H,1-2,8H2
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n/an/a 550n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17,20 lyase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM31768
PNG
(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
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n/an/a 1.66E+3n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17,20 lyase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50191794
PNG
(1-(3-(4-fluorophenyl)propyl)-1H-imidazole | CHEMBL...)
Show SMILES Fc1ccc(CCCn2ccnc2)cc1
Show InChI InChI=1S/C12H13FN2/c13-12-5-3-11(4-6-12)2-1-8-15-9-7-14-10-15/h3-7,9-10H,1-2,8H2
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n/an/a 1.96E+3n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17,20 lyase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50188088
PNG
(1-(4-bromobenzyl)-1H-imidazole | CHEMBL211207)
Show SMILES Brc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9BrN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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n/an/a 2.85E+3n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17,20 lyase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50191795
PNG
(CHEMBL386256 | N-3-(4-bromophenyl)propyl imidazole)
Show SMILES Brc1ccc(CCCn2ccnc2)cc1
Show InChI InChI=1S/C12H13BrN2/c13-12-5-3-11(4-6-12)2-1-8-15-9-7-14-10-15/h3-7,9-10H,1-2,8H2
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n/an/a 2.95E+3n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM31768
PNG
(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
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n/an/a 3.76E+3n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50188097
PNG
(1-(4-Chlorobenzyl)-1H-imidazole | CHEMBL441367)
Show SMILES Clc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9ClN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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n/an/a 4.94E+3n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17,20 lyase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50191792
PNG
(1-(3-(4-chlorophenyl)propyl)-1H-imidazole | CHEMBL...)
Show SMILES Clc1ccc(CCCn2ccnc2)cc1
Show InChI InChI=1S/C12H13ClN2/c13-12-5-3-11(4-6-12)2-1-8-15-9-7-14-10-15/h3-7,9-10H,1-2,8H2
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n/an/a 5.85E+3n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50191796
PNG
(1-(3-phenylpropyl)-1H-imidazole | CHEMBL380271)
Show SMILES C(Cc1ccccc1)Cn1ccnc1
Show InChI InChI=1S/C12H14N2/c1-2-5-12(6-3-1)7-4-9-14-10-8-13-11-14/h1-3,5-6,8,10-11H,4,7,9H2
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n/an/a 6.14E+3n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17,20 lyase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50188085
PNG
(1-(4-Fluorobenzyl)-1H-imidazole | CHEMBL377770)
Show SMILES Fc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9FN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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n/an/a 1.13E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17,20 lyase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50188088
PNG
(1-(4-bromobenzyl)-1H-imidazole | CHEMBL211207)
Show SMILES Brc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9BrN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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n/an/a 1.66E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50191794
PNG
(1-(3-(4-fluorophenyl)propyl)-1H-imidazole | CHEMBL...)
Show SMILES Fc1ccc(CCCn2ccnc2)cc1
Show InChI InChI=1S/C12H13FN2/c13-12-5-3-11(4-6-12)2-1-8-15-9-7-14-10-15/h3-7,9-10H,1-2,8H2
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n/an/a 2.78E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50188097
PNG
(1-(4-Chlorobenzyl)-1H-imidazole | CHEMBL441367)
Show SMILES Clc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9ClN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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n/an/a 2.98E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50191797
PNG
(1-(4-bromophenethyl)-1H-imidazole | CHEMBL215320)
Show SMILES Brc1ccc(CCn2ccnc2)cc1
Show InChI InChI=1S/C11H11BrN2/c12-11-3-1-10(2-4-11)5-7-14-8-6-13-9-14/h1-4,6,8-9H,5,7H2
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n/an/a 3.07E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50191796
PNG
(1-(3-phenylpropyl)-1H-imidazole | CHEMBL380271)
Show SMILES C(Cc1ccccc1)Cn1ccnc1
Show InChI InChI=1S/C12H14N2/c1-2-5-12(6-3-1)7-4-9-14-10-8-13-11-14/h1-3,5-6,8,10-11H,4,7,9H2
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n/an/a 3.10E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50191793
PNG
(1-(4-chlorophenethyl)-1H-imidazole | CHEMBL379290)
Show SMILES Clc1ccc(CCn2ccnc2)cc1
Show InChI InChI=1S/C11H11ClN2/c12-11-3-1-10(2-4-11)5-7-14-8-6-13-9-14/h1-4,6,8-9H,5,7H2
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n/an/a 4.96E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM7887
PNG
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
Show SMILES C(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C10H10N2/c1-2-4-10(5-3-1)8-12-7-6-11-9-12/h1-7,9H,8H2
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n/an/a 5.09E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17,20 lyase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50188085
PNG
(1-(4-Fluorobenzyl)-1H-imidazole | CHEMBL377770)
Show SMILES Fc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9FN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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n/an/a 9.65E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50191791
PNG
(1-(4-fluorophenethyl)-1H-imidazole | CHEMBL215425)
Show SMILES Fc1ccc(CCn2ccnc2)cc1
Show InChI InChI=1S/C11H11FN2/c12-11-3-1-10(2-4-11)5-7-14-8-6-13-9-14/h1-4,6,8-9H,5,7H2
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n/an/a 1.20E+5n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM7887
PNG
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
Show SMILES C(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C10H10N2/c1-2-4-10(5-3-1)8-12-7-6-11-9-12/h1-7,9H,8H2
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n/an/a 1.54E+5n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%