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PubMed code 16890434

Compile data set for download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192705
PNG
(1-(2-fluoro-5-methylphenyl)-3-{19-methyl-14-oxo-3-...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3cc(C)ccc3F)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H29FN6O2/c1-4-11-38-25-10-6-17(34-31(40)35-24-12-16(2)5-8-22(24)32)13-19(25)27-20-14-33-30(39)28(20)26-18(29(27)38)7-9-23-21(26)15-37(3)36-23/h5-6,8,10,12-13,15H,4,7,9,11,14H2,1-3H3,(H,33,39)(H2,34,35,40)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192712
PNG
(1-methyl-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-t...)
Show SMILES CCCn1c2ccc(NC(=O)N(C)c3ccccc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H30N6O2/c1-4-14-37-25-13-10-18(33-31(39)36(3)19-8-6-5-7-9-19)15-21(25)27-22-16-32-30(38)28(22)26-20(29(27)37)11-12-24-23(26)17-35(2)34-24/h5-10,13,15,17H,4,11-12,14,16H2,1-3H3,(H,32,38)(H,33,39)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192722
PNG
(1-(4-fluorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(F)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27FN6O2/c1-3-12-37-24-11-8-18(34-30(39)33-17-6-4-16(31)5-7-17)13-20(24)26-21-14-32-29(38)27(21)25-19(28(26)37)9-10-23-22(25)15-36(2)35-23/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192714
PNG
(1-(4-methoxyphenyl)-3-{19-methyl-14-oxo-3-propyl-3...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(OC)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H30N6O3/c1-4-13-37-25-12-7-18(34-31(39)33-17-5-8-19(40-3)9-6-17)14-21(25)27-22-15-32-30(38)28(22)26-20(29(27)37)10-11-24-23(26)16-36(2)35-24/h5-9,12,14,16H,4,10-11,13,15H2,1-3H3,(H,32,38)(H2,33,34,39)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192708
PNG
(1-(2-fluorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccccc3F)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27FN6O2/c1-3-12-37-24-11-8-16(33-30(39)34-23-7-5-4-6-21(23)31)13-18(24)26-19-14-32-29(38)27(19)25-17(28(26)37)9-10-22-20(25)15-36(2)35-22/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192727
PNG
(CHEMBL219493 | ethyl N-{19-methyl-14-oxo-3-propyl-...)
Show SMILES CCCn1c2ccc(NC(=O)OCC)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C26H27N5O3/c1-4-10-31-20-9-6-14(28-26(33)34-5-2)11-16(20)22-17-12-27-25(32)23(17)21-15(24(22)31)7-8-19-18(21)13-30(3)29-19/h6,9,11,13H,4-5,7-8,10,12H2,1-3H3,(H,27,32)(H,28,33)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192709
PNG
(1-(3-fluorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3cccc(F)c3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27FN6O2/c1-3-11-37-24-10-7-18(34-30(39)33-17-6-4-5-16(31)12-17)13-20(24)26-21-14-32-29(38)27(21)25-19(28(26)37)8-9-23-22(25)15-36(2)35-23/h4-7,10,12-13,15H,3,8-9,11,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192710
PNG
(CHEMBL425109 | N-{19-methyl-14-oxo-3-propyl-3,13,1...)
Show SMILES CCCn1c2ccc(NC(=O)c3ccco3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C28H25N5O3/c1-3-10-33-21-9-6-15(30-27(34)22-5-4-11-36-22)12-17(21)24-18-13-29-28(35)25(18)23-16(26(24)33)7-8-20-19(23)14-32(2)31-20/h4-6,9,11-12,14H,3,7-8,10,13H2,1-2H3,(H,29,35)(H,30,34)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192726
PNG
(1-(2-chlorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccccc3Cl)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27ClN6O2/c1-3-12-37-24-11-8-16(33-30(39)34-23-7-5-4-6-21(23)31)13-18(24)26-19-14-32-29(38)27(19)25-17(28(26)37)9-10-22-20(25)15-36(2)35-22/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192723
PNG
(3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahe...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(SC)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H30N6O2S/c1-4-13-37-25-12-7-18(34-31(39)33-17-5-8-19(40-3)9-6-17)14-21(25)27-22-15-32-30(38)28(22)26-20(29(27)37)10-11-24-23(26)16-36(2)35-24/h5-9,12,14,16H,4,10-11,13,15H2,1-3H3,(H,32,38)(H2,33,34,39)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192732
PNG
(CHEMBL373575 | propyl N-{19-methyl-14-oxo-3-propyl...)
Show SMILES CCCOC(=O)Nc1ccc2n(CCC)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O3/c1-4-10-32-21-9-6-15(29-27(34)35-11-5-2)12-17(21)23-18-13-28-26(33)24(18)22-16(25(23)32)7-8-20-19(22)14-31(3)30-20/h6,9,12,14H,4-5,7-8,10-11,13H2,1-3H3,(H,28,33)(H,29,34)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192724
PNG
(3-{10-carboximidoyl-5-oxo-14-propyl-4,14-diazapent...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(C)cc3)cc2c2c3CNC(=O)c3c3CC=C(Cc3c12)C=N
Show InChI InChI=1S/C30H29N5O2/c1-3-12-35-25-11-9-20(34-30(37)33-19-7-4-17(2)5-8-19)14-23(25)26-24-16-32-29(36)27(24)21-10-6-18(15-31)13-22(21)28(26)35/h4-9,11,14-15,31H,3,10,12-13,16H2,1-2H3,(H,32,36)(H2,33,34,37)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192701
PNG
(1-(4-methoxyphenyl)-3-[19-methyl-3-(2-methylpropyl...)
Show SMILES COc1ccc(NC(=O)Nc2ccc3n(CC(C)C)c4c5CCc6nn(C)cc6-c5c5C(=O)NCc5c4c3c2)cc1
Show InChI InChI=1S/C32H32N6O3/c1-17(2)15-38-26-12-7-19(35-32(40)34-18-5-8-20(41-4)9-6-18)13-22(26)28-23-14-33-31(39)29(23)27-21(30(28)38)10-11-25-24(27)16-37(3)36-25/h5-9,12-13,16-17H,10-11,14-15H2,1-4H3,(H,33,39)(H2,34,35,40)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192706
PNG
(1-(3-methoxyphenyl)-3-[19-methyl-3-(2-methylpropyl...)
Show SMILES COc1cccc(NC(=O)Nc2ccc3n(CC(C)C)c4c5CCc6nn(C)cc6-c5c5C(=O)NCc5c4c3c2)c1
Show InChI InChI=1S/C32H32N6O3/c1-17(2)15-38-26-11-8-19(35-32(40)34-18-6-5-7-20(12-18)41-4)13-22(26)28-23-14-33-31(39)29(23)27-21(30(28)38)9-10-25-24(27)16-37(3)36-25/h5-8,11-13,16-17H,9-10,14-15H2,1-4H3,(H,33,39)(H2,34,35,40)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192703
PNG
(1-(2-bromophenyl)-3-{19-methyl-14-oxo-3-propyl-3,1...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccccc3Br)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27BrN6O2/c1-3-12-37-24-11-8-16(33-30(39)34-23-7-5-4-6-21(23)31)13-18(24)26-19-14-32-29(38)27(19)25-17(28(26)37)9-10-22-20(25)15-36(2)35-22/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192716
PNG
(CHEMBL220406 | N-{19-methyl-14-oxo-3-propyl-3,13,1...)
Show SMILES CCCn1c2ccc(NC(=O)c3cccs3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C28H25N5O2S/c1-3-10-33-21-9-6-15(30-27(34)22-5-4-11-36-22)12-17(21)24-18-13-29-28(35)25(18)23-16(26(24)33)7-8-20-19(23)14-32(2)31-20/h4-6,9,11-12,14H,3,7-8,10,13H2,1-2H3,(H,29,35)(H,30,34)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192721
PNG
(1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-{19-methy...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H26F4N6O2/c1-3-10-41-24-9-5-16(37-30(43)38-23-11-15(31(33,34)35)4-7-21(23)32)12-18(24)26-19-13-36-29(42)27(19)25-17(28(26)41)6-8-22-20(25)14-40(2)39-22/h4-5,7,9,11-12,14H,3,6,8,10,13H2,1-2H3,(H,36,42)(H2,37,38,43)
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192713
PNG
(3-{3-ethyl-19-methyl-14-oxo-3,13,19,20-tetraazahex...)
Show SMILES CCn1c2ccc(NC(=O)Nc3ccc(OC)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H28N6O3/c1-4-36-24-12-7-17(33-30(38)32-16-5-8-18(39-3)9-6-16)13-20(24)26-21-14-31-29(37)27(21)25-19(28(26)36)10-11-23-22(25)15-35(2)34-23/h5-9,12-13,15H,4,10-11,14H2,1-3H3,(H,31,37)(H2,32,33,38)
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192707
PNG
(4-methoxyphenyl N-{19-methyl-14-oxo-3-propyl-3,13,...)
Show SMILES CCCn1c2ccc(NC(=O)Oc3ccc(OC)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H29N5O4/c1-4-13-36-25-12-5-17(33-31(38)40-19-8-6-18(39-3)7-9-19)14-21(25)27-22-15-32-30(37)28(22)26-20(29(27)36)10-11-24-23(26)16-35(2)34-24/h5-9,12,14,16H,4,10-11,13,15H2,1-3H3,(H,32,37)(H,33,38)
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n/an/a 5n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192711
PNG
(CHEMBL219080 | N-[19-methyl-3-(2-methylpropyl)-14-...)
Show SMILES CC(C)Cn1c2ccc(NC(=O)c3ccco3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C29H27N5O3/c1-15(2)13-34-22-9-6-16(31-28(35)23-5-4-10-37-23)11-18(22)25-19-12-30-29(36)26(19)24-17(27(25)34)7-8-21-20(24)14-33(3)32-21/h4-6,9-11,14-15H,7-8,12-13H2,1-3H3,(H,30,36)(H,31,35)
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n/an/a 5n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192728
PNG
(CHEMBL219492 | propan-2-yl N-{19-methyl-14-oxo-3-p...)
Show SMILES CCCn1c2ccc(NC(=O)OC(C)C)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C27H29N5O3/c1-5-10-32-21-9-6-15(29-27(34)35-14(2)3)11-17(21)23-18-12-28-26(33)24(18)22-16(25(23)32)7-8-20-19(22)13-31(4)30-20/h6,9,11,13-14H,5,7-8,10,12H2,1-4H3,(H,28,33)(H,29,34)
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n/an/a 5n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192704
PNG
(3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahe...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccccc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H28N6O2/c1-3-13-36-24-12-9-18(33-30(38)32-17-7-5-4-6-8-17)14-20(24)26-21-15-31-29(37)27(21)25-19(28(26)36)10-11-23-22(25)16-35(2)34-23/h4-9,12,14,16H,3,10-11,13,15H2,1-2H3,(H,31,37)(H2,32,33,38)
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n/an/a 5n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192725
PNG
(1-[4-(dimethylamino)phenyl]-3-{19-methyl-14-oxo-3-...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(cc3)N(C)C)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C32H33N7O2/c1-5-14-39-26-13-8-19(35-32(41)34-18-6-9-20(10-7-18)37(2)3)15-22(26)28-23-16-33-31(40)29(23)27-21(30(28)39)11-12-25-24(27)17-38(4)36-25/h6-10,13,15,17H,5,11-12,14,16H2,1-4H3,(H,33,40)(H2,34,35,41)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192720
PNG
(1-(4-chlorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27ClN6O2/c1-3-12-37-24-11-8-18(34-30(39)33-17-6-4-16(31)5-7-17)13-20(24)26-21-14-32-29(38)27(21)25-19(28(26)37)9-10-23-22(25)15-36(2)35-23/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192719
PNG
(3-{3-butyl-19-methyl-14-oxo-3,13,19,20-tetraazahex...)
Show SMILES CCCCn1c2ccc(NC(=O)Nc3ccc(OC)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C32H32N6O3/c1-4-5-14-38-26-13-8-19(35-32(40)34-18-6-9-20(41-3)10-7-18)15-22(26)28-23-16-33-31(39)29(23)27-21(30(28)38)11-12-25-24(27)17-37(2)36-25/h6-10,13,15,17H,4-5,11-12,14,16H2,1-3H3,(H,33,39)(H2,34,35,40)
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192730
PNG
(CHEMBL426703 | N-[19-methyl-3-(2-methylpropyl)-14-...)
Show SMILES CC(C)Cn1c2ccc(NC(=O)c3cccs3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C29H27N5O2S/c1-15(2)13-34-22-9-6-16(31-28(35)23-5-4-10-37-23)11-18(22)25-19-12-30-29(36)26(19)24-17(27(25)34)7-8-21-20(24)14-33(3)32-21/h4-6,9-11,14-15H,7-8,12-13H2,1-3H3,(H,30,36)(H,31,35)
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192712
PNG
(1-methyl-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-t...)
Show SMILES CCCn1c2ccc(NC(=O)N(C)c3ccccc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H30N6O2/c1-4-14-37-25-13-10-18(33-31(39)36(3)19-8-6-5-7-9-19)15-21(25)27-22-16-32-30(38)28(22)26-20(29(27)37)11-12-24-23(26)17-35(2)34-24/h5-10,13,15,17H,4,11-12,14,16H2,1-3H3,(H,32,38)(H,33,39)
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192732
PNG
(CHEMBL373575 | propyl N-{19-methyl-14-oxo-3-propyl...)
Show SMILES CCCOC(=O)Nc1ccc2n(CCC)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O3/c1-4-10-32-21-9-6-15(29-27(34)35-11-5-2)12-17(21)23-18-13-28-26(33)24(18)22-16(25(23)32)7-8-20-19(22)14-31(3)30-20/h6,9,12,14H,4-5,7-8,10-11,13H2,1-3H3,(H,28,33)(H,29,34)
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192729
PNG
(1-(2-methoxyphenyl)-3-[19-methyl-3-(2-methylpropyl...)
Show SMILES COc1ccccc1NC(=O)Nc1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C32H32N6O3/c1-17(2)15-38-25-12-9-18(34-32(40)35-24-7-5-6-8-26(24)41-4)13-20(25)28-21-14-33-31(39)29(21)27-19(30(28)38)10-11-23-22(27)16-37(3)36-23/h5-9,12-13,16-17H,10-11,14-15H2,1-4H3,(H,33,39)(H2,34,35,40)
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n/an/a 8n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192724
PNG
(3-{10-carboximidoyl-5-oxo-14-propyl-4,14-diazapent...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(C)cc3)cc2c2c3CNC(=O)c3c3CC=C(Cc3c12)C=N
Show InChI InChI=1S/C30H29N5O2/c1-3-12-35-25-11-9-20(34-30(37)33-19-7-4-17(2)5-8-19)14-23(25)26-24-16-32-29(36)27(24)21-10-6-18(15-31)13-22(21)28(26)35/h4-9,11,14-15,31H,3,10,12-13,16H2,1-2H3,(H,32,36)(H2,33,34,37)
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n/an/a 8n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192726
PNG
(1-(2-chlorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccccc3Cl)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27ClN6O2/c1-3-12-37-24-11-8-16(33-30(39)34-23-7-5-4-6-21(23)31)13-18(24)26-19-14-32-29(38)27(19)25-17(28(26)37)9-10-22-20(25)15-36(2)35-22/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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n/an/a 9n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192708
PNG
(1-(2-fluorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccccc3F)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27FN6O2/c1-3-12-37-24-11-8-16(33-30(39)34-23-7-5-4-6-21(23)31)13-18(24)26-19-14-32-29(38)27(19)25-17(28(26)37)9-10-22-20(25)15-36(2)35-22/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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n/an/a 9n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192717
PNG
(7-amino-19-methyl-3-propyl-3,13,19,20-tetraazahexa...)
Show SMILES CCCn1c2ccc(N)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C23H23N5O/c1-3-8-28-18-7-4-12(24)9-14(18)20-15-10-25-23(29)21(15)19-13(22(20)28)5-6-17-16(19)11-27(2)26-17/h4,7,9,11H,3,5-6,8,10,24H2,1-2H3,(H,25,29)
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n/an/a 9n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192730
PNG
(CHEMBL426703 | N-[19-methyl-3-(2-methylpropyl)-14-...)
Show SMILES CC(C)Cn1c2ccc(NC(=O)c3cccs3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C29H27N5O2S/c1-15(2)13-34-22-9-6-16(31-28(35)23-5-4-10-37-23)11-18(22)25-19-12-30-29(36)26(19)24-17(27(25)34)7-8-21-20(24)14-33(3)32-21/h4-6,9-11,14-15H,7-8,12-13H2,1-3H3,(H,30,36)(H,31,35)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192703
PNG
(1-(2-bromophenyl)-3-{19-methyl-14-oxo-3-propyl-3,1...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccccc3Br)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27BrN6O2/c1-3-12-37-24-11-8-16(33-30(39)34-23-7-5-4-6-21(23)31)13-18(24)26-19-14-32-29(38)27(19)25-17(28(26)37)9-10-22-20(25)15-36(2)35-22/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192718
PNG
(7-amino-19-methyl-3-(2-methylpropyl)-3,13,19,20-te...)
Show SMILES CC(C)Cn1c2ccc(N)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C24H25N5O/c1-12(2)10-29-19-7-4-13(25)8-15(19)21-16-9-26-24(30)22(16)20-14(23(21)29)5-6-18-17(20)11-28(3)27-18/h4,7-8,11-12H,5-6,9-10,25H2,1-3H3,(H,26,30)
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n/an/a 11n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192728
PNG
(CHEMBL219492 | propan-2-yl N-{19-methyl-14-oxo-3-p...)
Show SMILES CCCn1c2ccc(NC(=O)OC(C)C)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C27H29N5O3/c1-5-10-32-21-9-6-15(29-27(34)35-14(2)3)11-17(21)23-18-12-28-26(33)24(18)22-16(25(23)32)7-8-20-19(22)13-31(4)30-20/h6,9,11,13-14H,5,7-8,10,12H2,1-4H3,(H,28,33)(H,29,34)
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n/an/a 11n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192715
PNG
(4-fluorophenyl N-{19-methyl-14-oxo-3-propyl-3,13,1...)
Show SMILES CCCn1c2ccc(NC(=O)Oc3ccc(F)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H26FN5O3/c1-3-12-36-24-11-6-17(33-30(38)39-18-7-4-16(31)5-8-18)13-20(24)26-21-14-32-29(37)27(21)25-19(28(26)36)9-10-23-22(25)15-35(2)34-23/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,37)(H,33,38)
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n/an/a 11n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192713
PNG
(3-{3-ethyl-19-methyl-14-oxo-3,13,19,20-tetraazahex...)
Show SMILES CCn1c2ccc(NC(=O)Nc3ccc(OC)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H28N6O3/c1-4-36-24-12-7-17(33-30(38)32-16-5-8-18(39-3)9-6-16)13-20(24)26-21-14-31-29(37)27(21)25-19(28(26)36)10-11-23-22(25)15-35(2)34-23/h5-9,12-13,15H,4,10-11,14H2,1-3H3,(H,31,37)(H2,32,33,38)
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n/an/a 11n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192716
PNG
(CHEMBL220406 | N-{19-methyl-14-oxo-3-propyl-3,13,1...)
Show SMILES CCCn1c2ccc(NC(=O)c3cccs3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C28H25N5O2S/c1-3-10-33-21-9-6-15(30-27(34)22-5-4-11-36-22)12-17(21)24-18-13-29-28(35)25(18)23-16(26(24)33)7-8-20-19(23)14-32(2)31-20/h4-6,9,11-12,14H,3,7-8,10,13H2,1-2H3,(H,29,35)(H,30,34)
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n/an/a 12n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192722
PNG
(1-(4-fluorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(F)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27FN6O2/c1-3-12-37-24-11-8-18(34-30(39)33-17-6-4-16(31)5-7-17)13-20(24)26-21-14-32-29(38)27(21)25-19(28(26)37)9-10-23-22(25)15-36(2)35-23/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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n/an/a 12n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192707
PNG
(4-methoxyphenyl N-{19-methyl-14-oxo-3-propyl-3,13,...)
Show SMILES CCCn1c2ccc(NC(=O)Oc3ccc(OC)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H29N5O4/c1-4-13-36-25-12-5-17(33-31(38)40-19-8-6-18(39-3)7-9-19)14-21(25)27-22-15-32-30(37)28(22)26-20(29(27)36)10-11-24-23(26)16-35(2)34-24/h5-9,12,14,16H,4,10-11,13,15H2,1-3H3,(H,32,37)(H,33,38)
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n/an/a 12n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192709
PNG
(1-(3-fluorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3cccc(F)c3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27FN6O2/c1-3-11-37-24-10-7-18(34-30(39)33-17-6-4-5-16(31)12-17)13-20(24)26-21-14-32-29(38)27(21)25-19(28(26)37)8-9-23-22(25)15-36(2)35-23/h4-7,10,12-13,15H,3,8-9,11,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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n/an/a 12n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192723
PNG
(3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahe...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(SC)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H30N6O2S/c1-4-13-37-25-12-7-18(34-31(39)33-17-5-8-19(40-3)9-6-17)14-21(25)27-22-15-32-30(38)28(22)26-20(29(27)37)10-11-24-23(26)16-36(2)35-24/h5-9,12,14,16H,4,10-11,13,15H2,1-3H3,(H,32,38)(H2,33,34,39)
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n/an/a 14n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192714
PNG
(1-(4-methoxyphenyl)-3-{19-methyl-14-oxo-3-propyl-3...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(OC)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H30N6O3/c1-4-13-37-25-12-7-18(34-31(39)33-17-5-8-19(40-3)9-6-17)14-21(25)27-22-15-32-30(38)28(22)26-20(29(27)37)10-11-24-23(26)16-36(2)35-24/h5-9,12,14,16H,4,10-11,13,15H2,1-3H3,(H,32,38)(H2,33,34,39)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192704
PNG
(3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahe...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccccc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H28N6O2/c1-3-13-36-24-12-9-18(33-30(38)32-17-7-5-4-6-8-17)14-20(24)26-21-15-31-29(37)27(21)25-19(28(26)36)10-11-23-22(25)16-35(2)34-23/h4-9,12,14,16H,3,10-11,13,15H2,1-2H3,(H,31,37)(H2,32,33,38)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192727
PNG
(CHEMBL219493 | ethyl N-{19-methyl-14-oxo-3-propyl-...)
Show SMILES CCCn1c2ccc(NC(=O)OCC)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C26H27N5O3/c1-4-10-31-20-9-6-14(28-26(33)34-5-2)11-16(20)22-17-12-27-25(32)23(17)21-15(24(22)31)7-8-19-18(21)13-30(3)29-19/h6,9,11,13H,4-5,7-8,10,12H2,1-3H3,(H,27,32)(H,28,33)
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192701
PNG
(1-(4-methoxyphenyl)-3-[19-methyl-3-(2-methylpropyl...)
Show SMILES COc1ccc(NC(=O)Nc2ccc3n(CC(C)C)c4c5CCc6nn(C)cc6-c5c5C(=O)NCc5c4c3c2)cc1
Show InChI InChI=1S/C32H32N6O3/c1-17(2)15-38-26-12-7-19(35-32(40)34-18-5-8-20(41-4)9-6-18)13-22(26)28-23-14-33-31(39)29(23)27-21(30(28)38)10-11-25-24(27)16-37(3)36-25/h5-9,12-13,16-17H,10-11,14-15H2,1-4H3,(H,33,39)(H2,34,35,40)
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192702
PNG
(3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahe...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3cccs3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C28H26N6O2S/c1-3-10-34-21-9-6-15(30-28(36)31-22-5-4-11-37-22)12-17(21)24-18-13-29-27(35)25(18)23-16(26(24)34)7-8-20-19(23)14-33(2)32-20/h4-6,9,11-12,14H,3,7-8,10,13H2,1-2H3,(H,29,35)(H2,30,31,36)
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n/an/a 19n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192711
PNG
(CHEMBL219080 | N-[19-methyl-3-(2-methylpropyl)-14-...)
Show SMILES CC(C)Cn1c2ccc(NC(=O)c3ccco3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C29H27N5O3/c1-15(2)13-34-22-9-6-16(31-28(35)23-5-4-10-37-23)11-18(22)25-19-12-30-29(36)26(19)24-17(27(25)34)7-8-21-20(24)14-33(3)32-21/h4-6,9-11,14-15H,7-8,12-13H2,1-3H3,(H,30,36)(H,31,35)
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n/an/a 20n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192702
PNG
(3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahe...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3cccs3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C28H26N6O2S/c1-3-10-34-21-9-6-15(30-28(36)31-22-5-4-11-37-22)12-17(21)24-18-13-29-27(35)25(18)23-16(26(24)34)7-8-20-19(23)14-33(2)32-20/h4-6,9,11-12,14H,3,7-8,10,13H2,1-2H3,(H,29,35)(H2,30,31,36)
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n/an/a 21n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192725
PNG
(1-[4-(dimethylamino)phenyl]-3-{19-methyl-14-oxo-3-...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(cc3)N(C)C)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C32H33N7O2/c1-5-14-39-26-13-8-19(35-32(41)34-18-6-9-20(10-7-18)37(2)3)15-22(26)28-23-16-33-31(40)29(23)27-21(30(28)39)11-12-25-24(27)17-38(4)36-25/h6-10,13,15,17H,5,11-12,14,16H2,1-4H3,(H,33,40)(H2,34,35,41)
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n/an/a 24n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192706
PNG
(1-(3-methoxyphenyl)-3-[19-methyl-3-(2-methylpropyl...)
Show SMILES COc1cccc(NC(=O)Nc2ccc3n(CC(C)C)c4c5CCc6nn(C)cc6-c5c5C(=O)NCc5c4c3c2)c1
Show InChI InChI=1S/C32H32N6O3/c1-17(2)15-38-26-11-8-19(35-32(40)34-18-6-5-7-20(12-18)41-4)13-22(26)28-23-14-33-31(39)29(23)27-21(30(28)38)9-10-25-24(27)16-37(3)36-25/h5-8,11-13,16-17H,9-10,14-15H2,1-4H3,(H,33,39)(H2,34,35,40)
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n/an/a 25n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192710
PNG
(CHEMBL425109 | N-{19-methyl-14-oxo-3-propyl-3,13,1...)
Show SMILES CCCn1c2ccc(NC(=O)c3ccco3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C28H25N5O3/c1-3-10-33-21-9-6-15(30-27(34)22-5-4-11-36-22)12-17(21)24-18-13-29-28(35)25(18)23-16(26(24)33)7-8-20-19(23)14-32(2)31-20/h4-6,9,11-12,14H,3,7-8,10,13H2,1-2H3,(H,29,35)(H,30,34)
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n/an/a 29n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192705
PNG
(1-(2-fluoro-5-methylphenyl)-3-{19-methyl-14-oxo-3-...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3cc(C)ccc3F)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H29FN6O2/c1-4-11-38-25-10-6-17(34-31(40)35-24-12-16(2)5-8-22(24)32)13-19(25)27-20-14-33-30(39)28(20)26-18(29(27)38)7-9-23-21(26)15-37(3)36-23/h5-6,8,10,12-13,15H,4,7,9,11,14H2,1-3H3,(H,33,39)(H2,34,35,40)
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n/an/a 29n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192717
PNG
(7-amino-19-methyl-3-propyl-3,13,19,20-tetraazahexa...)
Show SMILES CCCn1c2ccc(N)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C23H23N5O/c1-3-8-28-18-7-4-12(24)9-14(18)20-15-10-25-23(29)21(15)19-13(22(20)28)5-6-17-16(19)11-27(2)26-17/h4,7,9,11H,3,5-6,8,10,24H2,1-2H3,(H,25,29)
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n/an/a 36n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192729
PNG
(1-(2-methoxyphenyl)-3-[19-methyl-3-(2-methylpropyl...)
Show SMILES COc1ccccc1NC(=O)Nc1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C32H32N6O3/c1-17(2)15-38-25-12-9-18(34-32(40)35-24-7-5-6-8-26(24)41-4)13-20(25)28-21-14-33-31(39)29(21)27-19(30(28)38)10-11-23-22(27)16-37(3)36-23/h5-9,12-13,16-17H,10-11,14-15H2,1-4H3,(H,33,39)(H2,34,35,40)
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n/an/a 41n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192715
PNG
(4-fluorophenyl N-{19-methyl-14-oxo-3-propyl-3,13,1...)
Show SMILES CCCn1c2ccc(NC(=O)Oc3ccc(F)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H26FN5O3/c1-3-12-36-24-11-6-17(33-30(38)39-18-7-4-16(31)5-8-18)13-20(24)26-21-14-32-29(37)27(21)25-19(28(26)36)9-10-23-22(25)15-35(2)34-23/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,37)(H,33,38)
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n/an/a 46n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192720
PNG
(1-(4-chlorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C30H27ClN6O2/c1-3-12-37-24-11-8-18(34-30(39)33-17-6-4-16(31)5-7-17)13-20(24)26-21-14-32-29(38)27(21)25-19(28(26)37)9-10-23-22(25)15-36(2)35-23/h4-8,11,13,15H,3,9-10,12,14H2,1-2H3,(H,32,38)(H2,33,34,39)
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n/an/a 48n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192718
PNG
(7-amino-19-methyl-3-(2-methylpropyl)-3,13,19,20-te...)
Show SMILES CC(C)Cn1c2ccc(N)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C24H25N5O/c1-12(2)10-29-19-7-4-13(25)8-15(19)21-16-9-26-24(30)22(16)20-14(23(21)29)5-6-18-17(20)11-28(3)27-18/h4,7-8,11-12H,5-6,9-10,25H2,1-3H3,(H,26,30)
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n/an/a 48n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192731
PNG
(7-amino-3-butyl-19-methyl-3,13,19,20-tetraazahexac...)
Show SMILES CCCCn1c2ccc(N)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C24H25N5O/c1-3-4-9-29-19-8-5-13(25)10-15(19)21-16-11-26-24(30)22(16)20-14(23(21)29)6-7-18-17(20)12-28(2)27-18/h5,8,10,12H,3-4,6-7,9,11,25H2,1-2H3,(H,26,30)
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n/an/a 88n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192719
PNG
(3-{3-butyl-19-methyl-14-oxo-3,13,19,20-tetraazahex...)
Show SMILES CCCCn1c2ccc(NC(=O)Nc3ccc(OC)cc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C32H32N6O3/c1-4-5-14-38-26-13-8-19(35-32(40)34-18-6-9-20(41-3)10-7-18)15-22(26)28-23-16-33-31(39)29(23)27-21(30(28)38)11-12-25-24(27)17-37(2)36-25/h6-10,13,15,17H,4-5,11-12,14,16H2,1-3H3,(H,33,39)(H2,34,35,40)
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n/an/a 101n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50192721
PNG
(1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-{19-methy...)
Show SMILES CCCn1c2ccc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C31H26F4N6O2/c1-3-10-41-24-9-5-16(37-30(43)38-23-11-15(31(33,34)35)4-7-21(23)32)12-18(24)26-19-13-36-29(42)27(19)25-17(28(26)41)6-8-22-20(25)14-40(2)39-22/h4-5,7,9,11-12,14H,3,6,8,10,13H2,1-2H3,(H,36,42)(H2,37,38,43)
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n/an/a 159n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50192731
PNG
(7-amino-3-butyl-19-methyl-3,13,19,20-tetraazahexac...)
Show SMILES CCCCn1c2ccc(N)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C24H25N5O/c1-3-4-9-29-19-8-5-13(25)10-15(19)21-16-11-26-24(30)22(16)20-14(23(21)29)6-7-18-17(20)12-28(2)27-18/h5,8,10,12H,3-4,6-7,9,11,25H2,1-2H3,(H,26,30)
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n/an/a 230n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5368-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.066
BindingDB Entry DOI: 10.7270/Q2SQ901V
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%