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PubMed code 16904318

Compile data set for download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422916
PNG
(CHEMBL215643)
Show SMILES CN(C)c1nc2ccc(cc2n1C)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClN5OS/c1-26(2)22-25-16-9-8-15(10-18(16)27(22)3)28-12-24-17-11-19(30-20(17)21(28)29)13-4-6-14(23)7-5-13/h4-12H,1-3H3
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n/an/a 1.60n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422890
PNG
(CHEMBL213813)
Show SMILES Cc1nc2cc(ccc2n1CCCO)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19ClN4O2S/c1-14-26-18-11-17(7-8-20(18)27(14)9-2-10-29)28-13-25-19-12-21(31-22(19)23(28)30)15-3-5-16(24)6-4-15/h3-8,11-13,29H,2,9-10H2,1H3
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n/an/a 1.60n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422893
PNG
(CHEMBL384724)
Show SMILES Cc1nc2cc(ccc2n1CCN1CCCC1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H24ClN5OS/c1-17-29-21-14-20(8-9-23(21)31(17)13-12-30-10-2-3-11-30)32-16-28-22-15-24(34-25(22)26(32)33)18-4-6-19(27)7-5-18/h4-9,14-16H,2-3,10-13H2,1H3
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422903
PNG
(CHEMBL214716)
Show SMILES CN(C)c1nc2ccc(cc2[nH]1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H16ClN5OS/c1-26(2)21-24-15-8-7-14(9-16(15)25-21)27-11-23-17-10-18(29-19(17)20(27)28)12-3-5-13(22)6-4-12/h3-11H,1-2H3,(H,24,25)
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n/an/a 2.5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422896
PNG
(CHEMBL214705)
Show SMILES CCOc1ccc(cc1)-n1c(C)nc2cc(ccc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C28H21ClN4O2S/c1-3-35-22-11-8-20(9-12-22)33-17(2)31-23-14-21(10-13-25(23)33)32-16-30-24-15-26(36-27(24)28(32)34)18-4-6-19(29)7-5-18/h4-16H,3H2,1-2H3
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422887
PNG
(CHEMBL215868)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4nc([nH]c4c3)N3CCCC3)c(=O)c2s1
Show InChI InChI=1S/C23H18ClN5OS/c24-15-5-3-14(4-6-15)20-12-19-21(31-20)22(30)29(13-25-19)16-7-8-17-18(11-16)27-23(26-17)28-9-1-2-10-28/h3-8,11-13H,1-2,9-10H2,(H,26,27)
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422912
PNG
(CHEMBL214476)
Show SMILES CNc1nc2ccc(cc2[nH]1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H14ClN5OS/c1-22-20-24-14-7-6-13(8-15(14)25-20)26-10-23-16-9-17(28-18(16)19(26)27)11-2-4-12(21)5-3-11/h2-10H,1H3,(H2,22,24,25)
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n/an/a 4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422911
PNG
(CHEMBL387217)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4nc([nH]c4c3)N3CCCCC3)c(=O)c2s1
Show InChI InChI=1S/C24H20ClN5OS/c25-16-6-4-15(5-7-16)21-13-20-22(32-21)23(31)30(14-26-20)17-8-9-18-19(12-17)28-24(27-18)29-10-2-1-3-11-29/h4-9,12-14H,1-3,10-11H2,(H,27,28)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422892
PNG
(CHEMBL214908)
Show SMILES CN(C)c1ccc(cc1)-n1c(C)nc2cc(ccc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C28H22ClN5OS/c1-17-31-23-14-22(12-13-25(23)34(17)21-10-8-20(9-11-21)32(2)3)33-16-30-24-15-26(36-27(24)28(33)35)18-4-6-19(29)7-5-18/h4-16H,1-3H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422909
PNG
(CHEMBL384233)
Show SMILES CCCn1c(nc2ccc(cc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1)N(C)C
Show InChI InChI=1S/C24H22ClN5OS/c1-4-11-29-20-12-17(9-10-18(20)27-24(29)28(2)3)30-14-26-19-13-21(32-22(19)23(30)31)15-5-7-16(25)8-6-15/h5-10,12-14H,4,11H2,1-3H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422918
PNG
(CHEMBL384132)
Show SMILES CN(CCN1CCCC1)c1nc2ccc(cc2[nH]1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H25ClN6OS/c1-31(12-13-32-10-2-3-11-32)26-29-20-9-8-19(14-21(20)30-26)33-16-28-22-15-23(35-24(22)25(33)34)17-4-6-18(27)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3,(H,29,30)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422886
PNG
(CHEMBL385410)
Show SMILES CCCn1c(nc2cc(ccc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1)N(C)C
Show InChI InChI=1S/C24H22ClN5OS/c1-4-11-29-20-10-9-17(12-18(20)27-24(29)28(2)3)30-14-26-19-13-21(32-22(19)23(30)31)15-5-7-16(25)8-6-15/h5-10,12-14H,4,11H2,1-3H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422905
PNG
(CHEMBL215256)
Show SMILES COCCCn1c(C)nc2cc(ccc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H21ClN4O2S/c1-15-27-19-12-18(8-9-21(19)28(15)10-3-11-31-2)29-14-26-20-13-22(32-23(20)24(29)30)16-4-6-17(25)7-5-16/h4-9,12-14H,3,10-11H2,1-2H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422900
PNG
(CHEMBL215008)
Show SMILES COc1ccc(cc1)-n1c(C)nc2cc(ccc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H19ClN4O2S/c1-16-30-22-13-20(9-12-24(22)32(16)19-7-10-21(34-2)11-8-19)31-15-29-23-14-25(35-26(23)27(31)33)17-3-5-18(28)6-4-17/h3-15H,1-2H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422908
PNG
(CHEMBL384346)
Show SMILES Cc1nc2cc(ccc2n1CCN1CCOCC1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H24ClN5O2S/c1-17-29-21-14-20(6-7-23(21)31(17)9-8-30-10-12-34-13-11-30)32-16-28-22-15-24(35-25(22)26(32)33)18-2-4-19(27)5-3-18/h2-7,14-16H,8-13H2,1H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422888
PNG
(CHEMBL214824)
Show SMILES Cn1c(nc2ccc(cc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1)N1CCCC1
Show InChI InChI=1S/C24H20ClN5OS/c1-28-20-12-17(8-9-18(20)27-24(28)29-10-2-3-11-29)30-14-26-19-13-21(32-22(19)23(30)31)15-4-6-16(25)7-5-15/h4-9,12-14H,2-3,10-11H2,1H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422913
PNG
(CHEMBL384806)
Show SMILES CN(C)c1nc2cc(ccc2n1C)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClN5OS/c1-26(2)22-25-16-10-15(8-9-18(16)27(22)3)28-12-24-17-11-19(30-20(17)21(28)29)13-4-6-14(23)7-5-13/h4-12H,1-3H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422901
PNG
(CHEMBL384988)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4nc(NCCN5CCCC5)[nH]c4c3)c(=O)c2s1
Show InChI InChI=1S/C25H23ClN6OS/c26-17-5-3-16(4-6-17)22-14-21-23(34-22)24(33)32(15-28-21)18-7-8-19-20(13-18)30-25(29-19)27-9-12-31-10-1-2-11-31/h3-8,13-15H,1-2,9-12H2,(H2,27,29,30)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422894
PNG
(CHEMBL215234)
Show SMILES Cc1nc2cc(ccc2n1C1CCCCC1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H23ClN4OS/c1-16-29-21-13-20(11-12-23(21)31(16)19-5-3-2-4-6-19)30-15-28-22-14-24(33-25(22)26(30)32)17-7-9-18(27)10-8-17/h7-15,19H,2-6H2,1H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422915
PNG
(CHEMBL215298)
Show SMILES CC(C)Oc1ccc(cc1)-n1c(C)nc2cc(ccc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C29H23ClN4O2S/c1-17(2)36-23-11-8-21(9-12-23)34-18(3)32-24-14-22(10-13-26(24)34)33-16-31-25-15-27(37-28(25)29(33)35)19-4-6-20(30)7-5-19/h4-17H,1-3H3
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n/an/a 7.90n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422902
PNG
(CHEMBL214512)
Show SMILES CC(C)Nc1nc2ccc(cc2[nH]1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClN5OS/c1-12(2)25-22-26-16-8-7-15(9-17(16)27-22)28-11-24-18-10-19(30-20(18)21(28)29)13-3-5-14(23)6-4-13/h3-12H,1-2H3,(H2,25,26,27)
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n/an/a 7.90n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422895
PNG
(CHEMBL213766)
Show SMILES COc1ccc(cc1)-n1c(nc2cc(ccc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1)N(C)C
Show InChI InChI=1S/C28H22ClN5O2S/c1-32(2)28-31-22-14-20(10-13-24(22)34(28)19-8-11-21(36-3)12-9-19)33-16-30-23-15-25(37-26(23)27(33)35)17-4-6-18(29)7-5-17/h4-16H,1-3H3
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422917
PNG
(CHEMBL216005)
Show SMILES CN(C)c1nc2cc(ccc2n1CCO)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20ClN5O2S/c1-27(2)23-26-17-11-16(7-8-19(17)28(23)9-10-30)29-13-25-18-12-20(32-21(18)22(29)31)14-3-5-15(24)6-4-14/h3-8,11-13,30H,9-10H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422898
PNG
(CHEMBL213824)
Show SMILES COc1ccc(Cn2c(nc3cc(ccc23)-n2cnc3cc(sc3c2=O)-c2ccc(Cl)cc2)N(C)C)cc1
Show InChI InChI=1S/C29H24ClN5O2S/c1-33(2)29-32-23-14-21(10-13-25(23)34(29)16-18-4-11-22(37-3)12-5-18)35-17-31-24-15-26(38-27(24)28(35)36)19-6-8-20(30)9-7-19/h4-15,17H,16H2,1-3H3
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422899
PNG
(CHEMBL218186)
Show SMILES CN(C)c1nc2ccc(cc2n1CCO)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20ClN5O2S/c1-27(2)23-26-17-8-7-16(11-19(17)28(23)9-10-30)29-13-25-18-12-20(32-21(18)22(29)31)14-3-5-15(24)6-4-14/h3-8,11-13,30H,9-10H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422914
PNG
(CHEMBL215932)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4nc(NC5CC5)[nH]c4c3)c(=O)c2s1
Show InChI InChI=1S/C22H16ClN5OS/c23-13-3-1-12(2-4-13)19-10-18-20(30-19)21(29)28(11-24-18)15-7-8-16-17(9-15)27-22(26-16)25-14-5-6-14/h1-4,7-11,14H,5-6H2,(H2,25,26,27)
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n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422919
PNG
(CHEMBL387438)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4nc([nH]c4c3)N3CCOCC3)c(=O)c2s1
Show InChI InChI=1S/C23H18ClN5O2S/c24-15-3-1-14(2-4-15)20-12-19-21(32-20)22(30)29(13-25-19)16-5-6-17-18(11-16)27-23(26-17)28-7-9-31-10-8-28/h1-6,11-13H,7-10H2,(H,26,27)
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n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422891
PNG
(CHEMBL214733)
Show SMILES Cc1nc2cc(ccc2n1-c1ccc(C)cc1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H19ClN4OS/c1-16-3-9-20(10-4-16)32-17(2)30-22-13-21(11-12-24(22)32)31-15-29-23-14-25(34-26(23)27(31)33)18-5-7-19(28)8-6-18/h3-15H,1-2H3
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n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422910
PNG
(CHEMBL385883)
Show SMILES Cn1c(nc2cc(ccc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1)N1CCCC1
Show InChI InChI=1S/C24H20ClN5OS/c1-28-20-9-8-17(12-18(20)27-24(28)29-10-2-3-11-29)30-14-26-19-13-21(32-22(19)23(30)31)15-4-6-16(25)7-5-15/h4-9,12-14H,2-3,10-11H2,1H3
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n/an/a 25n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422906
PNG
(CHEMBL386188)
Show SMILES Cc1nc2ccc(cc2[nH]1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H13ClN4OS/c1-11-23-15-7-6-14(8-16(15)24-11)25-10-22-17-9-18(27-19(17)20(25)26)12-2-4-13(21)5-3-12/h2-10H,1H3,(H,23,24)
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n/an/a 25n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422889
PNG
(CHEMBL213864)
Show SMILES COCCNc1nc2ccc(cc2[nH]1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClN5O2S/c1-30-9-8-24-22-26-16-7-6-15(10-17(16)27-22)28-12-25-18-11-19(31-20(18)21(28)29)13-2-4-14(23)5-3-13/h2-7,10-12H,8-9H2,1H3,(H2,24,26,27)
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n/an/a 32n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422907
PNG
(CHEMBL425982)
Show SMILES Nc1nc2ccc(cc2[nH]1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H12ClN5OS/c20-11-3-1-10(2-4-11)16-8-15-17(27-16)18(26)25(9-22-15)12-5-6-13-14(7-12)24-19(21)23-13/h1-9H,(H3,21,23,24)
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n/an/a 32n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422920
PNG
(CHEMBL386460)
Show SMILES Cc1nc2cc(ccc2n1-c1ccccc1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H17ClN4OS/c1-16-29-21-13-20(11-12-23(21)31(16)19-5-3-2-4-6-19)30-15-28-22-14-24(33-25(22)26(30)32)17-7-9-18(27)10-8-17/h2-15H,1H3
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n/an/a 32n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422897
PNG
(CHEMBL216649)
Show SMILES CN1CCN(CC1)c1nc2ccc(cc2[nH]1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H21ClN6OS/c1-29-8-10-30(11-9-29)24-27-18-7-6-17(12-19(18)28-24)31-14-26-20-13-21(33-22(20)23(31)32)15-2-4-16(25)5-3-15/h2-7,12-14H,8-11H2,1H3,(H,27,28)
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50422904
PNG
(CHEMBL386397)
Show SMILES COc1ccc(Cn2c(nc3ccc(cc23)-n2cnc3cc(sc3c2=O)-c2ccc(Cl)cc2)N(C)C)cc1
Show InChI InChI=1S/C29H24ClN5O2S/c1-33(2)29-32-23-13-10-21(14-25(23)34(29)16-18-4-11-22(37-3)12-5-18)35-17-31-24-15-26(38-27(24)28(35)36)19-6-8-20(30)9-7-19/h4-15,17H,16H2,1-3H3
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n/an/a 2.51E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against MCH1R expressed in CHO cells assessed as inhibition of MCH-induced EC80 thrombin response by luciferase reporter gene ass...


Bioorg Med Chem Lett 16: 4994-5000 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.054
BindingDB Entry DOI: 10.7270/Q2833T97
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%