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PubMed code 17064071

Compile data set for download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Excitatory Amino Acid EAAT2


()
BDBM50197103
PNG
((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1
UniProtKB/SwissProt

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PC sid
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Article
PubMed
6.60E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by FLIPR membrane potential assay


J Med Chem 49: 6532-8 (2006)


Article DOI: 10.1021/jm060822s
BindingDB Entry DOI: 10.7270/Q2S46RMK
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50197103
PNG
((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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CHEMBL
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PC sid
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UniChem

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Article
PubMed
1.00E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay


J Med Chem 49: 6532-8 (2006)


Article DOI: 10.1021/jm060822s
BindingDB Entry DOI: 10.7270/Q2S46RMK
More data for this
Ligand-Target Pair
Excitatory Amino Acid EAAT2


()
BDBM50197104
PNG
((2S,1'R,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4-,5+/m1/s1
UniProtKB/SwissProt

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AffyNet 
CHEMBL
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PC sid
UniChem

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Article
PubMed
2.20E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by FLIPR membrane potential assay


J Med Chem 49: 6532-8 (2006)


Article DOI: 10.1021/jm060822s
BindingDB Entry DOI: 10.7270/Q2S46RMK
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50197104
PNG
((2S,1'R,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4-,5+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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Article
PubMed
4.90E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay


J Med Chem 49: 6532-8 (2006)


Article DOI: 10.1021/jm060822s
BindingDB Entry DOI: 10.7270/Q2S46RMK
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50197105
PNG
((2S,1'S,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@H]1CC[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.20E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay


J Med Chem 49: 6532-8 (2006)


Article DOI: 10.1021/jm060822s
BindingDB Entry DOI: 10.7270/Q2S46RMK
More data for this
Ligand-Target Pair
Excitatory Amino Acid EAAT2


()
BDBM50197105
PNG
((2S,1'S,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@H]1CC[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.10E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by FLIPR membrane potential assay


J Med Chem 49: 6532-8 (2006)


Article DOI: 10.1021/jm060822s
BindingDB Entry DOI: 10.7270/Q2S46RMK
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50197103
PNG
((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
2.00E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by FLIPR membrane potential assay


J Med Chem 49: 6532-8 (2006)


Article DOI: 10.1021/jm060822s
BindingDB Entry DOI: 10.7270/Q2S46RMK
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50197105
PNG
((2S,1'S,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@H]1CC[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.00E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by FLIPR membrane potential assay


J Med Chem 49: 6532-8 (2006)


Article DOI: 10.1021/jm060822s
BindingDB Entry DOI: 10.7270/Q2S46RMK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%