BindingDB logo
myBDB logout

PubMed code 17107791

Compile data set for download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50241095
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H29FN2O/c1-29(2)18-19-4-5-24-17-26(15-12-23(24)16-19)30(3)27(31)22-8-6-20(7-9-22)21-10-13-25(28)14-11-21/h4-11,13-14,16,26H,12,15,17-18H2,1-3H3/t26-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7.40n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198501
PNG
((S)-5-(4-chlorophenyl)-N-(6-((dimethylamino)methyl...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)25-13-9-22(16-28-25)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198502
PNG
((S)-6-(4-chlorophenyl)-N-(6-((dimethylamino)methyl...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(nc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)22-9-13-25(28-16-22)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
12n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198499
PNG
((S)-4-(5-chloropyridin-2-yl)-N-(6-((dimethylamino)...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-22-15-24(12-10-21(22)14-18)30(3)26(31)20-8-6-19(7-9-20)25-13-11-23(27)16-28-25/h4-9,11,13-14,16,24H,10,12,15,17H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
18n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198495
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H28FN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)25-13-9-22(16-28-25)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198500
PNG
((S)-N-(6-(((2-(dimethylamino)-2-oxoethyl)(methyl)a...)
Show SMILES CN(CC(=O)N(C)C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H34FN3O2/c1-32(2)29(35)20-33(3)19-21-5-6-26-18-28(16-13-25(26)17-21)34(4)30(36)24-9-7-22(8-10-24)23-11-14-27(31)15-12-23/h5-12,14-15,17,28H,13,16,18-20H2,1-4H3/t28-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
24n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198494
PNG
((S)-N-(6-((4-acetylpiperazin-1-yl)methyl)-1,2,3,4-...)
Show SMILES CN([C@H]1CCc2cc(CN3CCN(CC3)C(C)=O)ccc2C1)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H34FN3O2/c1-22(36)35-17-15-34(16-18-35)21-23-3-4-28-20-30(14-11-27(28)19-23)33(2)31(37)26-7-5-24(6-8-26)25-9-12-29(32)13-10-25/h3-10,12-13,19,30H,11,14-18,20-21H2,1-2H3/t30-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
103n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198490
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C26H29N3O/c1-28(2)18-19-9-10-22-16-24(13-11-21(22)15-19)29(3)26(30)25-14-12-23(17-27-25)20-7-5-4-6-8-20/h4-10,12,14-15,17,24H,11,13,16,18H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
118n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50241096
PNG
((S)-4-((6-(4'-fluoro-N-methylbiphenyl-4-ylcarboxam...)
Show SMILES CN([C@H]1CCc2cc(CN3CCN(CC3)C(N)=O)ccc2C1)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H33FN4O2/c1-33(29(36)24-6-4-22(5-7-24)23-8-11-27(31)12-9-23)28-13-10-25-18-21(2-3-26(25)19-28)20-34-14-16-35(17-15-34)30(32)37/h2-9,11-12,18,28H,10,13-17,19-20H2,1H3,(H2,32,37)/t28-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
129n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198498
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C26H29N3O/c1-28(2)18-19-7-8-23-17-24(14-13-22(23)16-19)29(3)26(30)21-11-9-20(10-12-21)25-6-4-5-15-27-25/h4-12,15-16,24H,13-14,17-18H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
140n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198504
PNG
((S)-4'-fluoro-N-methyl-N-(6-((3-oxopiperazin-1-yl)...)
Show SMILES CN([C@H]1CCc2cc(CN3CCNC(=O)C3)ccc2C1)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H30FN3O2/c1-32(29(35)23-6-4-21(5-7-23)22-8-11-26(30)12-9-22)27-13-10-24-16-20(2-3-25(24)17-27)18-33-15-14-31-28(34)19-33/h2-9,11-12,16,27H,10,13-15,17-19H2,1H3,(H,31,34)/t27-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
145n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198491
PNG
((S)-1-(((S)-6-(4'-fluoro-N-methylbiphenyl-4-ylcarb...)
Show SMILES CN(C)C(=O)[C@@H]1CCCN1Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H36FN3O2/c1-34(2)32(38)30-5-4-18-36(30)21-22-6-7-27-20-29(17-14-26(27)19-22)35(3)31(37)25-10-8-23(9-11-25)24-12-15-28(33)16-13-24/h6-13,15-16,19,29-30H,4-5,14,17-18,20-21H2,1-3H3/t29-,30-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
146n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198493
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(nc1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H28FN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)22-9-13-25(28-16-22)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
184n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198487
PNG
((S)-N-(6-((4-acetylpiperazin-1-yl)methyl)-1,2,3,4-...)
Show SMILES CN([C@H]1CCc2cc(CN3CCN(CC3)C(C)=O)ccc2C1)C(=O)c1ccc(cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H33FN4O2/c1-21(36)35-15-13-34(14-16-35)20-22-3-4-25-18-28(11-7-24(25)17-22)33(2)30(37)29-12-8-26(19-32-29)23-5-9-27(31)10-6-23/h3-6,8-10,12,17,19,28H,7,11,13-16,18,20H2,1-2H3/t28-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
302n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198489
PNG
((S)-N-(6-((4-acetylpiperazin-1-yl)methyl)-1,2,3,4-...)
Show SMILES CN([C@H]1CCc2cc(CN3CCN(CC3)C(C)=O)ccc2C1)C(=O)c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C30H34N4O2/c1-22(35)34-17-15-33(16-18-34)21-23-6-7-27-20-28(13-12-26(27)19-23)32(2)30(36)25-10-8-24(9-11-25)29-5-3-4-14-31-29/h3-11,14,19,28H,12-13,15-18,20-21H2,1-2H3/t28-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
727n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198492
PNG
(CHEMBL217860 | N-[(2S)-6-[(1,1-dioxo-1,4-thiomorph...)
Show SMILES CN([C@H]1CCc2cc(CN3CCS(=O)(=O)CC3)ccc2C1)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H31FN2O3S/c1-31(29(33)24-6-4-22(5-7-24)23-8-11-27(30)12-9-23)28-13-10-25-18-21(2-3-26(25)19-28)20-32-14-16-36(34,35)17-15-32/h2-9,11-12,18,28H,10,13-17,19-20H2,1H3/t28-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
755n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198503
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C26H29N3O/c1-28(2)18-19-6-7-23-16-25(13-12-22(23)15-19)29(3)26(30)21-10-8-20(9-11-21)24-5-4-14-27-17-24/h4-11,14-15,17,25H,12-13,16,18H2,1-3H3/t25-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
890n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198488
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C26H29N3O/c1-28(2)18-19-4-5-24-17-25(11-10-23(24)16-19)29(3)26(30)22-8-6-20(7-9-22)21-12-14-27-15-13-21/h4-9,12-16,25H,10-11,17-18H2,1-3H3/t25-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.48E+3n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50198497
PNG
((S)-6-(4-fluorophenyl)-N-methyl-N-(6-((3-oxopipera...)
Show SMILES CN([C@H]1CCc2cc(CN3CCNC(=O)C3)ccc2C1)C(=O)c1ccc(nc1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H29FN4O2/c1-32(28(35)23-7-11-26(31-16-23)20-4-8-24(29)9-5-20)25-10-6-21-14-19(2-3-22(21)15-25)17-33-13-12-30-27(34)18-33/h2-5,7-9,11,14,16,25H,6,10,12-13,15,17-18H2,1H3,(H,30,34)/t25-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.47E+3n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50198500
PNG
((S)-N-(6-(((2-(dimethylamino)-2-oxoethyl)(methyl)a...)
Show SMILES CN(CC(=O)N(C)C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H34FN3O2/c1-32(2)29(35)20-33(3)19-21-5-6-26-18-28(16-13-25(26)17-21)34(4)30(36)24-9-7-22(8-10-24)23-11-14-27(31)15-12-23/h5-12,14-15,17,28H,13,16,18-20H2,1-4H3/t28-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to hERG


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50241095
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H29FN2O/c1-29(2)18-19-4-5-24-17-26(15-12-23(24)16-19)30(3)27(31)22-8-6-20(7-9-22)21-10-13-25(28)14-11-21/h4-11,13-14,16,26H,12,15,17-18H2,1-3H3/t26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to hERG


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50198501
PNG
((S)-5-(4-chlorophenyl)-N-(6-((dimethylamino)methyl...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)25-13-9-22(16-28-25)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to hERG


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50198491
PNG
((S)-1-(((S)-6-(4'-fluoro-N-methylbiphenyl-4-ylcarb...)
Show SMILES CN(C)C(=O)[C@@H]1CCCN1Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H36FN3O2/c1-34(2)32(38)30-5-4-18-36(30)21-22-6-7-27-20-29(17-14-26(27)19-22)35(3)31(37)25-10-8-23(9-11-25)24-12-15-28(33)16-13-24/h6-13,15-16,19,29-30H,4-5,14,17-18,20-21H2,1-3H3/t29-,30-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to hERG


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50198502
PNG
((S)-6-(4-chlorophenyl)-N-(6-((dimethylamino)methyl...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(nc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)22-9-13-25(28-16-22)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.10E+3n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to hERG


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50198495
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H28FN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)25-13-9-22(16-28-25)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.20E+3n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to hERG


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50241096
PNG
((S)-4-((6-(4'-fluoro-N-methylbiphenyl-4-ylcarboxam...)
Show SMILES CN([C@H]1CCc2cc(CN3CCN(CC3)C(N)=O)ccc2C1)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H33FN4O2/c1-33(29(36)24-6-4-22(5-7-24)23-8-11-27(31)12-9-23)28-13-10-25-18-21(2-3-26(25)19-28)20-34-14-16-35(17-15-34)30(32)37/h2-9,11-12,18,28H,10,13-17,19-20H2,1H3,(H2,32,37)/t28-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.70E+3n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to hERG


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198502
PNG
((S)-6-(4-chlorophenyl)-N-(6-((dimethylamino)methyl...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(nc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)22-9-13-25(28-16-22)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.50E+3n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50198493
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(nc1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H28FN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)22-9-13-25(28-16-22)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to hERG


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50198499
PNG
((S)-4-(5-chloropyridin-2-yl)-N-(6-((dimethylamino)...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-22-15-24(12-10-21(22)14-18)30(3)26(31)20-8-6-19(7-9-20)25-13-11-23(27)16-28-25/h4-9,11,13-14,16,24H,10,12,15,17H2,1-3H3/t24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to hERG


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198493
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(nc1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H28FN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)22-9-13-25(28-16-22)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.60E+4n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198495
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H28FN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)25-13-9-22(16-28-25)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50198490
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C26H29N3O/c1-28(2)18-19-9-10-22-16-24(13-11-21(22)15-19)29(3)26(30)25-14-12-23(17-27-25)20-7-5-4-6-8-20/h4-10,12,14-15,17,24H,11,13,16,18H2,1-3H3/t24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to hERG


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198490
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C26H29N3O/c1-28(2)18-19-9-10-22-16-24(13-11-21(22)15-19)29(3)26(30)25-14-12-23(17-27-25)20-7-5-4-6-8-20/h4-10,12,14-15,17,24H,11,13,16,18H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+4n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198499
PNG
((S)-4-(5-chloropyridin-2-yl)-N-(6-((dimethylamino)...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-22-15-24(12-10-21(22)14-18)30(3)26(31)20-8-6-19(7-9-20)25-13-11-23(27)16-28-25/h4-9,11,13-14,16,24H,10,12,15,17H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.70E+4n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50198498
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C26H29N3O/c1-28(2)18-19-7-8-23-17-24(14-13-22(23)16-19)29(3)26(30)21-11-9-20(10-12-21)25-6-4-5-15-27-25/h4-12,15-16,24H,13-14,17-18H2,1-3H3/t24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to hERG


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50241095
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H29FN2O/c1-29(2)18-19-4-5-24-17-26(15-12-23(24)16-19)30(3)27(31)22-8-6-20(7-9-22)21-10-13-25(28)14-11-21/h4-11,13-14,16,26H,12,15,17-18H2,1-3H3/t26-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.50E+4n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198501
PNG
((S)-5-(4-chlorophenyl)-N-(6-((dimethylamino)methyl...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)25-13-9-22(16-28-25)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.60E+4n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198488
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C26H29N3O/c1-28(2)18-19-4-5-24-17-25(11-10-23(24)16-19)29(3)26(30)22-8-6-20(7-9-22)21-12-14-27-15-13-21/h4-9,12-16,25H,10-11,17-18H2,1-3H3/t25-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198489
PNG
((S)-N-(6-((4-acetylpiperazin-1-yl)methyl)-1,2,3,4-...)
Show SMILES CN([C@H]1CCc2cc(CN3CCN(CC3)C(C)=O)ccc2C1)C(=O)c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C30H34N4O2/c1-22(35)34-17-15-33(16-18-34)21-23-6-7-27-20-28(13-12-26(27)19-23)32(2)30(36)25-10-8-24(9-11-25)29-5-3-4-14-31-29/h3-11,14,19,28H,12-13,15-18,20-21H2,1-2H3/t28-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50241096
PNG
((S)-4-((6-(4'-fluoro-N-methylbiphenyl-4-ylcarboxam...)
Show SMILES CN([C@H]1CCc2cc(CN3CCN(CC3)C(N)=O)ccc2C1)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H33FN4O2/c1-33(29(36)24-6-4-22(5-7-24)23-8-11-27(31)12-9-23)28-13-10-25-18-21(2-3-26(25)19-28)20-34-14-16-35(17-15-34)30(32)37/h2-9,11-12,18,28H,10,13-17,19-20H2,1H3,(H2,32,37)/t28-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198492
PNG
(CHEMBL217860 | N-[(2S)-6-[(1,1-dioxo-1,4-thiomorph...)
Show SMILES CN([C@H]1CCc2cc(CN3CCS(=O)(=O)CC3)ccc2C1)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H31FN2O3S/c1-31(29(33)24-6-4-22(5-7-24)23-8-11-27(30)12-9-23)28-13-10-25-18-21(2-3-26(25)19-28)20-32-14-16-36(34,35)17-15-32/h2-9,11-12,18,28H,10,13-17,19-20H2,1H3/t28-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198496
PNG
(CHEMBL217501 | N-[(2S)-6-[(1,1-dioxo-1,4-thiomorph...)
Show SMILES CN([C@H]1CCc2cc(CN3CCS(=O)(=O)CC3)ccc2C1)C(=O)c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C28H31N3O3S/c1-30(28(32)23-9-7-22(8-10-23)27-4-2-3-13-29-27)26-12-11-24-18-21(5-6-25(24)19-26)20-31-14-16-35(33,34)17-15-31/h2-10,13,18,26H,11-12,14-17,19-20H2,1H3/t26-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198487
PNG
((S)-N-(6-((4-acetylpiperazin-1-yl)methyl)-1,2,3,4-...)
Show SMILES CN([C@H]1CCc2cc(CN3CCN(CC3)C(C)=O)ccc2C1)C(=O)c1ccc(cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H33FN4O2/c1-21(36)35-15-13-34(14-16-35)20-22-3-4-25-18-28(11-7-24(25)17-22)33(2)30(37)29-12-8-26(19-32-29)23-5-9-27(31)10-6-23/h3-6,8-10,12,17,19,28H,7,11,13-16,18,20H2,1-2H3/t28-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198504
PNG
((S)-4'-fluoro-N-methyl-N-(6-((3-oxopiperazin-1-yl)...)
Show SMILES CN([C@H]1CCc2cc(CN3CCNC(=O)C3)ccc2C1)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H30FN3O2/c1-32(29(35)23-6-4-21(5-7-23)22-8-11-26(30)12-9-22)27-13-10-24-16-20(2-3-25(24)17-27)18-33-15-14-31-28(34)19-33/h2-9,11-12,16,27H,10,13-15,17-19H2,1H3,(H,31,34)/t27-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198498
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C26H29N3O/c1-28(2)18-19-7-8-23-17-24(14-13-22(23)16-19)29(3)26(30)21-11-9-20(10-12-21)25-6-4-5-15-27-25/h4-12,15-16,24H,13-14,17-18H2,1-3H3/t24-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198497
PNG
((S)-6-(4-fluorophenyl)-N-methyl-N-(6-((3-oxopipera...)
Show SMILES CN([C@H]1CCc2cc(CN3CCNC(=O)C3)ccc2C1)C(=O)c1ccc(nc1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H29FN4O2/c1-32(28(35)23-7-11-26(31-16-23)20-4-8-24(29)9-5-20)25-10-6-21-14-19(2-3-22(21)15-25)17-33-13-12-30-27(34)18-33/h2-5,7-9,11,14,16,25H,6,10,12-13,15,17-18H2,1H3,(H,30,34)/t25-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198491
PNG
((S)-1-(((S)-6-(4'-fluoro-N-methylbiphenyl-4-ylcarb...)
Show SMILES CN(C)C(=O)[C@@H]1CCCN1Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H36FN3O2/c1-34(2)32(38)30-5-4-18-36(30)21-22-6-7-27-20-29(17-14-26(27)19-22)35(3)31(37)25-10-8-23(9-11-25)24-12-15-28(33)16-13-24/h6-13,15-16,19,29-30H,4-5,14,17-18,20-21H2,1-3H3/t29-,30-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198500
PNG
((S)-N-(6-(((2-(dimethylamino)-2-oxoethyl)(methyl)a...)
Show SMILES CN(CC(=O)N(C)C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H34FN3O2/c1-32(2)29(35)20-33(3)19-21-5-6-26-18-28(16-13-25(26)17-21)34(4)30(36)24-9-7-22(8-10-24)23-11-14-27(31)15-12-23/h5-12,14-15,17,28H,13,16,18-20H2,1-4H3/t28-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198494
PNG
((S)-N-(6-((4-acetylpiperazin-1-yl)methyl)-1,2,3,4-...)
Show SMILES CN([C@H]1CCc2cc(CN3CCN(CC3)C(C)=O)ccc2C1)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H34FN3O2/c1-22(36)35-17-15-34(16-18-35)21-23-3-4-28-20-30(14-11-27(28)19-23)33(2)31(37)26-7-5-24(6-8-26)25-9-12-29(32)13-10-25/h3-10,12-13,19,30H,11,14-18,20-21H2,1-2H3/t30-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50198503
PNG
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)
Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C26H29N3O/c1-28(2)18-19-6-7-23-16-25(13-12-22(23)15-19)29(3)26(30)21-10-8-20(9-11-21)24-5-4-14-27-17-24/h4-11,14-15,17,25H,12-13,16,18H2,1-3H3/t25-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of binding to serotonin receptor 5HT2C


Bioorg Med Chem Lett 17: 814-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%