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PubMed code 17113301

Compile data set for download or QSAR
Found 83 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50166315
PNG
(6-((3S,5S)-5-((S)-2-cyanopyrrolidine-1-carbonyl)py...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)Nc1ccc(cn1)C#N)N1CCC[C@H]1C#N
Show InChI InChI=1S/C16H18N6O/c17-7-11-3-4-15(20-9-11)21-12-6-14(19-10-12)16(23)22-5-1-2-13(22)8-18/h3-4,9,12-14,19H,1-2,5-6,10H2,(H,20,21)/t12-,13-,14-/m0/s1
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n/an/a 0.25n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM11113
PNG
(6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl...)
Show SMILES O=C(CNCCNc1ccc(cn1)C#N)N1CCC[C@H]1C#N
Show InChI InChI=1S/C15H18N6O/c16-8-12-3-4-14(20-10-12)19-6-5-18-11-15(22)21-7-1-2-13(21)9-17/h3-4,10,13,18H,1-2,5-7,11H2,(H,19,20)/t13-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM11056
PNG
((2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2...)
Show SMILES O=C([C@@H]1CCCN1)N1CCC[C@H]1C#N
Show InChI InChI=1S/C10H15N3O/c11-7-8-3-2-6-13(8)10(14)9-4-1-5-12-9/h8-9,12H,1-6H2/t8-,9-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198855
PNG
(3-[(2S,4S)-4-(5-methoxy-1-indolinyl)-2-pyrrolidiny...)
Show SMILES COc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C17H23N3O2S/c1-22-14-2-3-16-12(8-14)4-5-20(16)13-9-15(18-10-13)17(21)19-6-7-23-11-19/h2-3,8,13,15,18H,4-7,9-11H2,1H3/t13-,15-/m0/s1
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n/an/a 4.80n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198844
PNG
(3-{(2S,4S)-4-[N-butyl-N-(4-cyanophenylmethyl)amino...)
Show SMILES CCCCN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C20H28N4OS/c1-2-3-8-23(14-17-6-4-16(12-21)5-7-17)18-11-19(22-13-18)20(25)24-9-10-26-15-24/h4-7,18-19,22H,2-3,8-11,13-15H2,1H3/t18-,19-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198847
PNG
(3-[(2S,4S)-4-(5-fluoro-1-indolinyl)-2-pyrrolidinyl...)
Show SMILES Fc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C16H20FN3OS/c17-12-1-2-15-11(7-12)3-4-20(15)13-8-14(18-9-13)16(21)19-5-6-22-10-19/h1-2,7,13-14,18H,3-6,8-10H2/t13-,14-/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198855
PNG
(3-[(2S,4S)-4-(5-methoxy-1-indolinyl)-2-pyrrolidiny...)
Show SMILES COc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C17H23N3O2S/c1-22-14-2-3-16-12(8-14)4-5-20(16)13-9-15(18-10-13)17(21)19-6-7-23-11-19/h2-3,8,13,15,18H,4-7,9-11H2,1H3/t13-,15-/m0/s1
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n/an/a 6.10n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198849
PNG
(3-{(2S,4S)-4-[bis(4-cyanophenylmethyl)]amino-2-pyr...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N(Cc1ccc(cc1)C#N)Cc1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C24H25N5OS/c25-12-18-1-5-20(6-2-18)15-29(16-21-7-3-19(13-26)4-8-21)22-11-23(27-14-22)24(30)28-9-10-31-17-28/h1-8,22-23,27H,9-11,14-17H2/t22-,23-/m0/s1
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n/an/a 6.40n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198875
PNG
(3-[(2S,4S)-4-(5-bromo-1-indolinyl)-2-pyrrolidinylc...)
Show SMILES Brc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C16H20BrN3OS/c17-12-1-2-15-11(7-12)3-4-20(15)13-8-14(18-9-13)16(21)19-5-6-22-10-19/h1-2,7,13-14,18H,3-6,8-10H2/t13-,14-/m0/s1
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n/an/a 6.5n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50166314
PNG
(6-((3S,5S)-5-((S)-2-cyanopyrrolidine-1-carbonyl)py...)
Show SMILES O=C([C@@H]1C[C@H](CN1)Nc1ccc(cn1)C#N)N1CCC[C@H]1C#N
Show InChI InChI=1S/C16H18N6O/c17-7-11-3-4-15(20-9-11)21-12-6-14(19-10-12)16(23)22-5-1-2-13(22)8-18/h3-4,9,12-14,19H,1-2,5-6,10H2,(H,20,21)/t12-,13+,14+/m1/s1
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n/an/a 6.60n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198868
PNG
(3-[(2S,4S)-4-(5-chloro-1-indolinyl)-2-pyrrolidinyl...)
Show SMILES Clc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C16H20ClN3OS/c17-12-1-2-15-11(7-12)3-4-20(15)13-8-14(18-9-13)16(21)19-5-6-22-10-19/h1-2,7,13-14,18H,3-6,8-10H2/t13-,14-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198848
PNG
(3-{(2S,4S)-4-[N-(4-cyanophenylmethyl)-N-isopropyla...)
Show SMILES CC(C)N(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C19H26N4OS/c1-14(2)23(12-16-5-3-15(10-20)4-6-16)17-9-18(21-11-17)19(24)22-7-8-25-13-22/h3-6,14,17-18,21H,7-9,11-13H2,1-2H3/t17-,18-/m0/s1
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n/an/a 7.10n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198861
PNG
(3-[(2S,4S)-4-(5-nitro-1-indolinyl)-2-pyrrolidinylc...)
Show SMILES [O-][N+](=O)c1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C16H20N4O3S/c21-16(18-5-6-24-10-18)14-8-13(9-17-14)19-4-3-11-7-12(20(22)23)1-2-15(11)19/h1-2,7,13-14,17H,3-6,8-10H2/t13-,14-/m0/s1
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n/an/a 7.90n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198844
PNG
(3-{(2S,4S)-4-[N-butyl-N-(4-cyanophenylmethyl)amino...)
Show SMILES CCCCN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C20H28N4OS/c1-2-3-8-23(14-17-6-4-16(12-21)5-7-17)18-11-19(22-13-18)20(25)24-9-10-26-15-24/h4-7,18-19,22H,2-3,8-11,13-15H2,1H3/t18-,19-/m0/s1
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n/an/a 9.10n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198849
PNG
(3-{(2S,4S)-4-[bis(4-cyanophenylmethyl)]amino-2-pyr...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N(Cc1ccc(cc1)C#N)Cc1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C24H25N5OS/c25-12-18-1-5-20(6-2-18)15-29(16-21-7-3-19(13-26)4-8-21)22-11-23(27-14-22)24(30)28-9-10-31-17-28/h1-8,22-23,27H,9-11,14-17H2/t22-,23-/m0/s1
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n/an/a 9.30n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198852
PNG
(3-{(2S,4S)-4-[N-(4-cyanophenylmethyl)-N-methylamin...)
Show SMILES CN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C17H22N4OS/c1-20(11-14-4-2-13(9-18)3-5-14)15-8-16(19-10-15)17(22)21-6-7-23-12-21/h2-5,15-16,19H,6-8,10-12H2,1H3/t15-,16-/m0/s1
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n/an/a 9.60n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198847
PNG
(3-[(2S,4S)-4-(5-fluoro-1-indolinyl)-2-pyrrolidinyl...)
Show SMILES Fc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C16H20FN3OS/c17-12-1-2-15-11(7-12)3-4-20(15)13-8-14(18-9-13)16(21)19-5-6-22-10-19/h1-2,7,13-14,18H,3-6,8-10H2/t13-,14-/m0/s1
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n/an/a 10.1n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198861
PNG
(3-[(2S,4S)-4-(5-nitro-1-indolinyl)-2-pyrrolidinylc...)
Show SMILES [O-][N+](=O)c1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C16H20N4O3S/c21-16(18-5-6-24-10-18)14-8-13(9-17-14)19-4-3-11-7-12(20(22)23)1-2-15(11)19/h1-2,7,13-14,17H,3-6,8-10H2/t13-,14-/m0/s1
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n/an/a 10.3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198875
PNG
(3-[(2S,4S)-4-(5-bromo-1-indolinyl)-2-pyrrolidinylc...)
Show SMILES Brc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C16H20BrN3OS/c17-12-1-2-15-11(7-12)3-4-20(15)13-8-14(18-9-13)16(21)19-5-6-22-10-19/h1-2,7,13-14,18H,3-6,8-10H2/t13-,14-/m0/s1
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n/an/a 10.7n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198841
PNG
(3-[(2S,4S)-4-(1-indolinyl)-2-pyrrolidinylcarbonyl]...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCc2ccccc12)N1CCSC1
Show InChI InChI=1S/C16H21N3OS/c20-16(18-7-8-21-11-18)14-9-13(10-17-14)19-6-5-12-3-1-2-4-15(12)19/h1-4,13-14,17H,5-11H2/t13-,14-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198848
PNG
(3-{(2S,4S)-4-[N-(4-cyanophenylmethyl)-N-isopropyla...)
Show SMILES CC(C)N(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C19H26N4OS/c1-14(2)23(12-16-5-3-15(10-20)4-6-16)17-9-18(21-11-17)19(24)22-7-8-25-13-22/h3-6,14,17-18,21H,7-9,11-13H2,1-2H3/t17-,18-/m0/s1
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n/an/a 12.5n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198868
PNG
(3-[(2S,4S)-4-(5-chloro-1-indolinyl)-2-pyrrolidinyl...)
Show SMILES Clc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C16H20ClN3OS/c17-12-1-2-15-11(7-12)3-4-20(15)13-8-14(18-9-13)16(21)19-5-6-22-10-19/h1-2,7,13-14,18H,3-6,8-10H2/t13-,14-/m0/s1
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n/an/a 13.4n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198852
PNG
(3-{(2S,4S)-4-[N-(4-cyanophenylmethyl)-N-methylamin...)
Show SMILES CN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C17H22N4OS/c1-20(11-14-4-2-13(9-18)3-5-14)15-8-16(19-10-15)17(22)21-6-7-23-12-21/h2-5,15-16,19H,6-8,10-12H2,1H3/t15-,16-/m0/s1
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n/an/a 13.6n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198858
PNG
(3-{(2S,4S)-4-[N-(4-cyanophenylmethyl)-N-(ethoxycar...)
Show SMILES CCOC(=O)CN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C20H26N4O3S/c1-2-27-19(25)13-24(12-16-5-3-15(10-21)4-6-16)17-9-18(22-11-17)20(26)23-7-8-28-14-23/h3-6,17-18,22H,2,7-9,11-14H2,1H3/t17-,18-/m0/s1
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n/an/a 13.6n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198845
PNG
(3-{(2S,4S)-4-[N-(carbamoylmethyl)-N-(4-cyanophenyl...)
Show SMILES NC(=O)CN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C18H23N5O2S/c19-8-13-1-3-14(4-2-13)10-23(11-17(20)24)15-7-16(21-9-15)18(25)22-5-6-26-12-22/h1-4,15-16,21H,5-7,9-12H2,(H2,20,24)/t15-,16-/m0/s1
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n/an/a 13.9n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198858
PNG
(3-{(2S,4S)-4-[N-(4-cyanophenylmethyl)-N-(ethoxycar...)
Show SMILES CCOC(=O)CN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C20H26N4O3S/c1-2-27-19(25)13-24(12-16-5-3-15(10-21)4-6-16)17-9-18(22-11-17)20(26)23-7-8-28-14-23/h3-6,17-18,22H,2,7-9,11-14H2,1H3/t17-,18-/m0/s1
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n/an/a 15.3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198867
PNG
(3-{(2S,4S)-4-[N-(carboxymethyl)-N-(4-cyanophenylme...)
Show SMILES OC(=O)CN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C18H22N4O3S/c19-8-13-1-3-14(4-2-13)10-22(11-17(23)24)15-7-16(20-9-15)18(25)21-5-6-26-12-21/h1-4,15-16,20H,5-7,9-12H2,(H,23,24)/t15-,16-/m0/s1
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n/an/a 16.3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198845
PNG
(3-{(2S,4S)-4-[N-(carbamoylmethyl)-N-(4-cyanophenyl...)
Show SMILES NC(=O)CN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C18H23N5O2S/c19-8-13-1-3-14(4-2-13)10-23(11-17(20)24)15-7-16(21-9-15)18(25)22-5-6-26-12-22/h1-4,15-16,21H,5-7,9-12H2,(H2,20,24)/t15-,16-/m0/s1
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n/an/a 16.5n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198867
PNG
(3-{(2S,4S)-4-[N-(carboxymethyl)-N-(4-cyanophenylme...)
Show SMILES OC(=O)CN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C18H22N4O3S/c19-8-13-1-3-14(4-2-13)10-22(11-17(23)24)15-7-16(20-9-15)18(25)21-5-6-26-12-21/h1-4,15-16,20H,5-7,9-12H2,(H,23,24)/t15-,16-/m0/s1
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n/an/a 16.8n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198874
PNG
(3-{(2S,4S)-4-[N-(4-cyanophenylmethyl)-N-(2-hydroxy...)
Show SMILES OCCN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C18H24N4O2S/c19-10-14-1-3-15(4-2-14)12-21(5-7-23)16-9-17(20-11-16)18(24)22-6-8-25-13-22/h1-4,16-17,20,23H,5-9,11-13H2/t16-,17-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198873
PNG
(((2S,4S)-4-(4-nitrophenylamino)pyrrolidin-2-yl)(th...)
Show SMILES [O-][N+](=O)c1ccc(N[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)cc1
Show InChI InChI=1S/C14H18N4O3S/c19-14(17-5-6-22-9-17)13-7-11(8-15-13)16-10-1-3-12(4-2-10)18(20)21/h1-4,11,13,15-16H,5-9H2/t11-,13-/m0/s1
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n/an/a 19.2n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198841
PNG
(3-[(2S,4S)-4-(1-indolinyl)-2-pyrrolidinylcarbonyl]...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCc2ccccc12)N1CCSC1
Show InChI InChI=1S/C16H21N3OS/c20-16(18-7-8-21-11-18)14-9-13(10-17-14)19-6-5-12-3-1-2-4-15(12)19/h1-4,13-14,17H,5-11H2/t13-,14-/m0/s1
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n/an/a 19.5n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198873
PNG
(((2S,4S)-4-(4-nitrophenylamino)pyrrolidin-2-yl)(th...)
Show SMILES [O-][N+](=O)c1ccc(N[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)cc1
Show InChI InChI=1S/C14H18N4O3S/c19-14(17-5-6-22-9-17)13-7-11(8-15-13)16-10-1-3-12(4-2-10)18(20)21/h1-4,11,13,15-16H,5-9H2/t11-,13-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198874
PNG
(3-{(2S,4S)-4-[N-(4-cyanophenylmethyl)-N-(2-hydroxy...)
Show SMILES OCCN(Cc1ccc(cc1)C#N)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C18H24N4O2S/c19-10-14-1-3-15(4-2-14)12-21(5-7-23)16-9-17(20-11-16)18(24)22-6-8-25-13-22/h1-4,16-17,20,23H,5-9,11-13H2/t16-,17-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198859
PNG
(4-((3S,5S)-5-(thiazolidine-3-carbonyl)pyrrolidin-3...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)Nc1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C15H18N4OS/c16-8-11-1-3-12(4-2-11)18-13-7-14(17-9-13)15(20)19-5-6-21-10-19/h1-4,13-14,17-18H,5-7,9-10H2/t13-,14-/m0/s1
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n/an/a 25.2n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198863
PNG
(6-((3S,5S)-5-(thiazolidine-3-carbonyl)pyrrolidin-3...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)Nc1ccc(cn1)C#N)N1CCSC1
Show InChI InChI=1S/C14H17N5OS/c15-6-10-1-2-13(17-7-10)18-11-5-12(16-8-11)14(20)19-3-4-21-9-19/h1-2,7,11-12,16H,3-5,8-9H2,(H,17,18)/t11-,12-/m0/s1
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n/an/a 25.4n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198864
PNG
(3-[(2S,4S)-4-(2-isoindolinyl)-2-pyrrolidinylcarbon...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1Cc2ccccc2C1)N1CCSC1
Show InChI InChI=1S/C16H21N3OS/c20-16(18-5-6-21-11-18)15-7-14(8-17-15)19-9-12-3-1-2-4-13(12)10-19/h1-4,14-15,17H,5-11H2/t14-,15-/m0/s1
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n/an/a 26.4n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198859
PNG
(4-((3S,5S)-5-(thiazolidine-3-carbonyl)pyrrolidin-3...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)Nc1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C15H18N4OS/c16-8-11-1-3-12(4-2-11)18-13-7-14(17-9-13)15(20)19-5-6-21-10-19/h1-4,13-14,17-18H,5-7,9-10H2/t13-,14-/m0/s1
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n/an/a 33.6n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198854
PNG
(3-[(2S,4S)-4-(4-cyanophenylmethyl)amino-2-pyrrolid...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NCc1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C16H20N4OS/c17-8-12-1-3-13(4-2-12)9-18-14-7-15(19-10-14)16(21)20-5-6-22-11-20/h1-4,14-15,18-19H,5-7,9-11H2/t14-,15-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198842
PNG
(3-[(2S,4S)-4-(4-cyanobenzoyl)amino-2-pyrrolidinylc...)
Show SMILES O=C(N[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)c1ccc(cc1)C#N
Show InChI InChI=1S/C16H18N4O2S/c17-8-11-1-3-12(4-2-11)15(21)19-13-7-14(18-9-13)16(22)20-5-6-23-10-20/h1-4,13-14,18H,5-7,9-10H2,(H,19,21)/t13-,14-/m0/s1
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n/an/a 34.1n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198854
PNG
(3-[(2S,4S)-4-(4-cyanophenylmethyl)amino-2-pyrrolid...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NCc1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C16H20N4OS/c17-8-12-1-3-13(4-2-12)9-18-14-7-15(19-10-14)16(21)20-5-6-22-11-20/h1-4,14-15,18-19H,5-7,9-11H2/t14-,15-/m0/s1
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n/an/a 34.3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198842
PNG
(3-[(2S,4S)-4-(4-cyanobenzoyl)amino-2-pyrrolidinylc...)
Show SMILES O=C(N[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)c1ccc(cc1)C#N
Show InChI InChI=1S/C16H18N4O2S/c17-8-11-1-3-12(4-2-11)15(21)19-13-7-14(18-9-13)16(22)20-5-6-23-10-20/h1-4,13-14,18H,5-7,9-10H2,(H,19,21)/t13-,14-/m0/s1
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n/an/a 37.2n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198864
PNG
(3-[(2S,4S)-4-(2-isoindolinyl)-2-pyrrolidinylcarbon...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1Cc2ccccc2C1)N1CCSC1
Show InChI InChI=1S/C16H21N3OS/c20-16(18-5-6-21-11-18)15-7-14(8-17-15)19-9-12-3-1-2-4-13(12)10-19/h1-4,14-15,17H,5-11H2/t14-,15-/m0/s1
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n/an/a 39n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198853
PNG
(((2S,4S)-4-(4-chlorophenylamino)pyrrolidin-2-yl)(t...)
Show SMILES Clc1ccc(N[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)cc1
Show InChI InChI=1S/C14H18ClN3OS/c15-10-1-3-11(4-2-10)17-12-7-13(16-8-12)14(19)18-5-6-20-9-18/h1-4,12-13,16-17H,5-9H2/t12-,13-/m0/s1
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n/an/a 45.4n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198866
PNG
(((2S,4S)-4-(4-methoxyphenylamino)pyrrolidin-2-yl)(...)
Show SMILES COc1ccc(N[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)cc1
Show InChI InChI=1S/C15H21N3O2S/c1-20-13-4-2-11(3-5-13)17-12-8-14(16-9-12)15(19)18-6-7-21-10-18/h2-5,12,14,16-17H,6-10H2,1H3/t12-,14-/m0/s1
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n/an/a 51.5n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198866
PNG
(((2S,4S)-4-(4-methoxyphenylamino)pyrrolidin-2-yl)(...)
Show SMILES COc1ccc(N[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)cc1
Show InChI InChI=1S/C15H21N3O2S/c1-20-13-4-2-11(3-5-13)17-12-8-14(16-9-12)15(19)18-6-7-21-10-18/h2-5,12,14,16-17H,6-10H2,1H3/t12-,14-/m0/s1
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n/an/a 54.9n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198853
PNG
(((2S,4S)-4-(4-chlorophenylamino)pyrrolidin-2-yl)(t...)
Show SMILES Clc1ccc(N[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)cc1
Show InChI InChI=1S/C14H18ClN3OS/c15-10-1-3-11(4-2-10)17-12-7-13(16-8-12)14(19)18-5-6-20-9-18/h1-4,12-13,16-17H,5-9H2/t12-,13-/m0/s1
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n/an/a 55.1n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198871
PNG
(3-{[2S,4S]-4-[3-(4-cyanophenyl)ureido]-2-pyrrolidi...)
Show SMILES O=C(N[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C16H19N5O2S/c17-8-11-1-3-12(4-2-11)19-16(23)20-13-7-14(18-9-13)15(22)21-5-6-24-10-21/h1-4,13-14,18H,5-7,9-10H2,(H2,19,20,23)/t13-,14-/m0/s1
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n/an/a 76.2n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198871
PNG
(3-{[2S,4S]-4-[3-(4-cyanophenyl)ureido]-2-pyrrolidi...)
Show SMILES O=C(N[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C16H19N5O2S/c17-8-11-1-3-12(4-2-11)19-16(23)20-13-7-14(18-9-13)15(22)21-5-6-24-10-21/h1-4,13-14,18H,5-7,9-10H2,(H2,19,20,23)/t13-,14-/m0/s1
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n/an/a 85.9n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198843
PNG
(3-[(2S,4S)-4-(1,2,3,4-tetrahydro-1-quinolyl)-2-pyr...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCCc2ccccc12)N1CCSC1
Show InChI InChI=1S/C17H23N3OS/c21-17(19-8-9-22-12-19)15-10-14(11-18-15)20-7-3-5-13-4-1-2-6-16(13)20/h1-2,4,6,14-15,18H,3,5,7-12H2/t14-,15-/m0/s1
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n/an/a 99.8n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198843
PNG
(3-[(2S,4S)-4-(1,2,3,4-tetrahydro-1-quinolyl)-2-pyr...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCCc2ccccc12)N1CCSC1
Show InChI InChI=1S/C17H23N3OS/c21-17(19-8-9-22-12-19)15-10-14(11-18-15)20-7-3-5-13-4-1-2-6-16(13)20/h1-2,4,6,14-15,18H,3,5,7-12H2/t14-,15-/m0/s1
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n/an/a 112n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198846
PNG
(((2S,4S)-4-(phenylamino)pyrrolidin-2-yl)(thiazolid...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)Nc1ccccc1)N1CCSC1
Show InChI InChI=1S/C14H19N3OS/c18-14(17-6-7-19-10-17)13-8-12(9-15-13)16-11-4-2-1-3-5-11/h1-5,12-13,15-16H,6-10H2/t12-,13-/m0/s1
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n/an/a 147n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198856
PNG
(3-[(2S,4S)-4-(3-phenylureido)-2-pyrrolidinylcarbon...)
Show SMILES O=C(N[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)Nc1ccccc1
Show InChI InChI=1S/C15H20N4O2S/c20-14(19-6-7-22-10-19)13-8-12(9-16-13)18-15(21)17-11-4-2-1-3-5-11/h1-5,12-13,16H,6-10H2,(H2,17,18,21)/t12-,13-/m0/s1
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n/an/a 151n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198856
PNG
(3-[(2S,4S)-4-(3-phenylureido)-2-pyrrolidinylcarbon...)
Show SMILES O=C(N[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)Nc1ccccc1
Show InChI InChI=1S/C15H20N4O2S/c20-14(19-6-7-22-10-19)13-8-12(9-16-13)18-15(21)17-11-4-2-1-3-5-11/h1-5,12-13,16H,6-10H2,(H2,17,18,21)/t12-,13-/m0/s1
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n/an/a 154n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198862
PNG
(3-{(2S,4S)-4-[N-(4-cyanobenzoyl)-N-(4-cyanophenylm...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N(Cc1ccc(cc1)C#N)C(=O)c1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C24H23N5O2S/c25-12-17-1-3-19(4-2-17)15-29(23(30)20-7-5-18(13-26)6-8-20)21-11-22(27-14-21)24(31)28-9-10-32-16-28/h1-8,21-22,27H,9-11,14-16H2/t21-,22-/m0/s1
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n/an/a 168n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198870
PNG
(3-((2S,4S)-4-benzylamino-2-pyrrolidinylcarbonyl)-1...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NCc1ccccc1)N1CCSC1
Show InChI InChI=1S/C15H21N3OS/c19-15(18-6-7-20-11-18)14-8-13(10-17-14)16-9-12-4-2-1-3-5-12/h1-5,13-14,16-17H,6-11H2/t13-,14-/m0/s1
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n/an/a 171n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198870
PNG
(3-((2S,4S)-4-benzylamino-2-pyrrolidinylcarbonyl)-1...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NCc1ccccc1)N1CCSC1
Show InChI InChI=1S/C15H21N3OS/c19-15(18-6-7-20-11-18)14-8-13(10-17-14)16-9-12-4-2-1-3-5-12/h1-5,13-14,16-17H,6-11H2/t13-,14-/m0/s1
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n/an/a 181n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198846
PNG
(((2S,4S)-4-(phenylamino)pyrrolidin-2-yl)(thiazolid...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)Nc1ccccc1)N1CCSC1
Show InChI InChI=1S/C14H19N3OS/c18-14(17-6-7-19-10-17)13-8-12(9-15-13)16-11-4-2-1-3-5-11/h1-5,12-13,15-16H,6-10H2/t12-,13-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198862
PNG
(3-{(2S,4S)-4-[N-(4-cyanobenzoyl)-N-(4-cyanophenylm...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N(Cc1ccc(cc1)C#N)C(=O)c1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C24H23N5O2S/c25-12-17-1-3-19(4-2-17)15-29(23(30)20-7-5-18(13-26)6-8-20)21-11-22(27-14-21)24(31)28-9-10-32-16-28/h1-8,21-22,27H,9-11,14-16H2/t21-,22-/m0/s1
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n/an/a 228n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198865
PNG
(3-((2S,4S)-4-benzoylamino-2-pyrrolidinylcarbonyl)-...)
Show SMILES O=C(N[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)c1ccccc1
Show InChI InChI=1S/C15H19N3O2S/c19-14(11-4-2-1-3-5-11)17-12-8-13(16-9-12)15(20)18-6-7-21-10-18/h1-5,12-13,16H,6-10H2,(H,17,19)/t12-,13-/m0/s1
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n/an/a 236n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198872
PNG
(6-(2-(2-oxo-2-(thiazolidin-3-yl)ethylamino)ethylam...)
Show SMILES O=C(CNCCNc1ccc(cn1)C#N)N1CCSC1
Show InChI InChI=1S/C13H17N5OS/c14-7-11-1-2-12(17-8-11)16-4-3-15-9-13(19)18-5-6-20-10-18/h1-2,8,15H,3-6,9-10H2,(H,16,17)
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n/an/a 270n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198857
PNG
(3-[(2S,4S)-4-(4-cyanophenylsulfonyl)amino-2-pyrrol...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NS(=O)(=O)c1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C15H18N4O3S2/c16-8-11-1-3-13(4-2-11)24(21,22)18-12-7-14(17-9-12)15(20)19-5-6-23-10-19/h1-4,12,14,17-18H,5-7,9-10H2/t12-,14-/m0/s1
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n/an/a>300n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198850
PNG
(3-[(2S,4S)-4-(4-cyanobenzoyl)oxy-2-pyrrolidinylcar...)
Show SMILES O=C(O[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)c1ccc(cc1)C#N
Show InChI InChI=1S/C16H17N3O3S/c17-8-11-1-3-12(4-2-11)16(21)22-13-7-14(18-9-13)15(20)19-5-6-23-10-19/h1-4,13-14,18H,5-7,9-10H2/t13-,14-/m0/s1
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Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198865
PNG
(3-((2S,4S)-4-benzoylamino-2-pyrrolidinylcarbonyl)-...)
Show SMILES O=C(N[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)c1ccccc1
Show InChI InChI=1S/C15H19N3O2S/c19-14(11-4-2-1-3-5-11)17-12-8-13(16-9-12)15(20)18-6-7-21-10-18/h1-5,12-13,16H,6-10H2,(H,17,19)/t12-,13-/m0/s1
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Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198850
PNG
(3-[(2S,4S)-4-(4-cyanobenzoyl)oxy-2-pyrrolidinylcar...)
Show SMILES O=C(O[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)c1ccc(cc1)C#N
Show InChI InChI=1S/C16H17N3O3S/c17-8-11-1-3-12(4-2-11)16(21)22-13-7-14(18-9-13)15(20)19-5-6-23-10-19/h1-4,13-14,18H,5-7,9-10H2/t13-,14-/m0/s1
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Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198851
PNG
(3-((2S,4S)-4-phenylsulfonylamino-2-pyrrolidinylcar...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NS(=O)(=O)c1ccccc1)N1CCSC1
Show InChI InChI=1S/C14H19N3O3S2/c18-14(17-6-7-21-10-17)13-8-11(9-15-13)16-22(19,20)12-4-2-1-3-5-12/h1-5,11,13,15-16H,6-10H2/t11-,13-/m0/s1
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Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198869
PNG
(3-((2S,4S)-4-benzoyloxy-2-pyrrolidinylcarbonyl)-1,...)
Show SMILES O=C(O[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)c1ccccc1
Show InChI InChI=1S/C15H18N2O3S/c18-14(17-6-7-21-10-17)13-8-12(9-16-13)20-15(19)11-4-2-1-3-5-11/h1-5,12-13,16H,6-10H2/t12-,13-/m0/s1
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Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198869
PNG
(3-((2S,4S)-4-benzoyloxy-2-pyrrolidinylcarbonyl)-1,...)
Show SMILES O=C(O[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1)c1ccccc1
Show InChI InChI=1S/C15H18N2O3S/c18-14(17-6-7-21-10-17)13-8-12(9-16-13)20-15(19)11-4-2-1-3-5-11/h1-5,12-13,16H,6-10H2/t12-,13-/m0/s1
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Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198851
PNG
(3-((2S,4S)-4-phenylsulfonylamino-2-pyrrolidinylcar...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NS(=O)(=O)c1ccccc1)N1CCSC1
Show InChI InChI=1S/C14H19N3O3S2/c18-14(17-6-7-21-10-17)13-8-11(9-15-13)16-22(19,20)12-4-2-1-3-5-12/h1-5,11,13,15-16H,6-10H2/t11-,13-/m0/s1
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Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50198857
PNG
(3-[(2S,4S)-4-(4-cyanophenylsulfonyl)amino-2-pyrrol...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NS(=O)(=O)c1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C15H18N4O3S2/c16-8-11-1-3-13(4-2-11)24(21,22)18-12-7-14(17-9-12)15(20)19-5-6-23-10-19/h1-4,12,14,17-18H,5-7,9-10H2/t12-,14-/m0/s1
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Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in rat plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50198855
PNG
(3-[(2S,4S)-4-(5-methoxy-1-indolinyl)-2-pyrrolidiny...)
Show SMILES COc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C17H23N3O2S/c1-22-14-2-3-16-12(8-14)4-5-20(16)13-9-15(18-10-13)17(21)19-6-7-23-11-19/h2-3,8,13,15,18H,4-7,9-11H2,1H3/t13-,15-/m0/s1
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n/an/a 379n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP8


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50198841
PNG
(3-[(2S,4S)-4-(1-indolinyl)-2-pyrrolidinylcarbonyl]...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCc2ccccc12)N1CCSC1
Show InChI InChI=1S/C16H21N3OS/c20-16(18-7-8-21-11-18)14-9-13(10-17-14)19-6-5-12-3-1-2-4-15(12)19/h1-4,13-14,17H,5-11H2/t13-,14-/m0/s1
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n/an/a 501n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP9


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50198847
PNG
(3-[(2S,4S)-4-(5-fluoro-1-indolinyl)-2-pyrrolidinyl...)
Show SMILES Fc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C16H20FN3OS/c17-12-1-2-15-11(7-12)3-4-20(15)13-8-14(18-9-13)16(21)19-5-6-22-10-19/h1-2,7,13-14,18H,3-6,8-10H2/t13-,14-/m0/s1
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n/an/a 519n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP9


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50198860
PNG
((S)-pyrrolidin-2-yl(thiazolidin-3-yl)methanone | C...)
Show SMILES O=C([C@@H]1CCCN1)N1CCSC1
Show InChI InChI=1S/C8H14N2OS/c11-8(7-2-1-3-9-7)10-4-5-12-6-10/h7,9H,1-6H2/t7-/m0/s1
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n/an/a 558n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human plasma by fluorescence assay


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50198847
PNG
(3-[(2S,4S)-4-(5-fluoro-1-indolinyl)-2-pyrrolidinyl...)
Show SMILES Fc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C16H20FN3OS/c17-12-1-2-15-11(7-12)3-4-20(15)13-8-14(18-9-13)16(21)19-5-6-22-10-19/h1-2,7,13-14,18H,3-6,8-10H2/t13-,14-/m0/s1
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n/an/a 563n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP8


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50198854
PNG
(3-[(2S,4S)-4-(4-cyanophenylmethyl)amino-2-pyrrolid...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NCc1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C16H20N4OS/c17-8-12-1-3-13(4-2-12)9-18-14-7-15(19-10-14)16(21)20-5-6-22-11-20/h1-4,14-15,18-19H,5-7,9-11H2/t14-,15-/m0/s1
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n/an/a 679n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP8


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50198855
PNG
(3-[(2S,4S)-4-(5-methoxy-1-indolinyl)-2-pyrrolidiny...)
Show SMILES COc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C17H23N3O2S/c1-22-14-2-3-16-12(8-14)4-5-20(16)13-9-15(18-10-13)17(21)19-6-7-23-11-19/h2-3,8,13,15,18H,4-7,9-11H2,1H3/t13-,15-/m0/s1
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n/an/a 711n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP9


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50198841
PNG
(3-[(2S,4S)-4-(1-indolinyl)-2-pyrrolidinylcarbonyl]...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCc2ccccc12)N1CCSC1
Show InChI InChI=1S/C16H21N3OS/c20-16(18-7-8-21-11-18)14-9-13(10-17-14)19-6-5-12-3-1-2-4-15(12)19/h1-4,13-14,17H,5-11H2/t13-,14-/m0/s1
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n/an/a 737n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP8


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50198854
PNG
(3-[(2S,4S)-4-(4-cyanophenylmethyl)amino-2-pyrrolid...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NCc1ccc(cc1)C#N)N1CCSC1
Show InChI InChI=1S/C16H20N4OS/c17-8-12-1-3-13(4-2-12)9-18-14-7-15(19-10-14)16(21)20-5-6-22-11-20/h1-4,14-15,18-19H,5-7,9-11H2/t14-,15-/m0/s1
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n/an/a 749n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP9


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50198863
PNG
(6-((3S,5S)-5-(thiazolidine-3-carbonyl)pyrrolidin-3...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)Nc1ccc(cn1)C#N)N1CCSC1
Show InChI InChI=1S/C14H17N5OS/c15-6-10-1-2-13(17-7-10)18-11-5-12(16-8-11)14(20)19-3-4-21-9-19/h1-2,7,11-12,16H,3-5,8-9H2,(H,17,18)/t11-,12-/m0/s1
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n/an/a 3.74E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP9


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50198860
PNG
((S)-pyrrolidin-2-yl(thiazolidin-3-yl)methanone | C...)
Show SMILES O=C([C@@H]1CCCN1)N1CCSC1
Show InChI InChI=1S/C8H14N2OS/c11-8(7-2-1-3-9-7)10-4-5-12-6-10/h7,9H,1-6H2/t7-/m0/s1
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n/an/a 4.69E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP8


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50198863
PNG
(6-((3S,5S)-5-(thiazolidine-3-carbonyl)pyrrolidin-3...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)Nc1ccc(cn1)C#N)N1CCSC1
Show InChI InChI=1S/C14H17N5OS/c15-6-10-1-2-13(17-7-10)18-11-5-12(16-8-11)14(20)19-3-4-21-9-19/h1-2,7,11-12,16H,3-5,8-9H2,(H,17,18)/t11-,12-/m0/s1
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n/an/a 4.76E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP8


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50198860
PNG
((S)-pyrrolidin-2-yl(thiazolidin-3-yl)methanone | C...)
Show SMILES O=C([C@@H]1CCCN1)N1CCSC1
Show InChI InChI=1S/C8H14N2OS/c11-8(7-2-1-3-9-7)10-4-5-12-6-10/h7,9H,1-6H2/t7-/m0/s1
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n/an/a 6.13E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP9


Bioorg Med Chem 15: 641-55 (2006)


Article DOI: 10.1016/j.bmc.2006.10.059
BindingDB Entry DOI: 10.7270/Q21N81X1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%