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PubMed code 17125263

Compile data set for download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199266
PNG
(6-(4-chlorophenyl)-3-[6-(1-piperidinylmethyl)-2-na...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4cc(CN5CCCCC5)ccc4c3)c(=O)c2s1
Show InChI InChI=1S/C28H24ClN3OS/c29-23-9-6-20(7-10-23)26-16-25-27(34-26)28(33)32(18-30-25)24-11-8-21-14-19(4-5-22(21)15-24)17-31-12-2-1-3-13-31/h4-11,14-16,18H,1-3,12-13,17H2
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n/an/a 0.390n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199251
PNG
(6-(4-chlorophenyl)-3-[6-(1-piperidinylmethyl)-7,8-...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4C=C(CN5CCCCC5)CCc4c3)c(=O)c2s1
Show InChI InChI=1S/C28H26ClN3OS/c29-23-9-6-20(7-10-23)26-16-25-27(34-26)28(33)32(18-30-25)24-11-8-21-14-19(4-5-22(21)15-24)17-31-12-2-1-3-13-31/h6-11,14-16,18H,1-5,12-13,17H2
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n/an/a 0.75n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199249
PNG
(6-(4-chlorophenyl)-3-[6-(1-pyrrolidinylmethyl)-7,8...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4C=C(CN5CCCC5)CCc4c3)c(=O)c2s1
Show InChI InChI=1S/C27H24ClN3OS/c28-22-8-5-19(6-9-22)25-15-24-26(33-25)27(32)31(17-29-24)23-10-7-20-13-18(3-4-21(20)14-23)16-30-11-1-2-12-30/h5-10,13-15,17H,1-4,11-12,16H2
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n/an/a 0.870n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199254
PNG
(6-(4-chlorophenyl)-3-[2-(1-pyrrolidinylmethyl)-1-b...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4sc(CN5CCCC5)cc4c3)c(=O)c2s1
Show InChI InChI=1S/C25H20ClN3OS2/c26-18-5-3-16(4-6-18)23-13-21-24(32-23)25(30)29(15-27-21)19-7-8-22-17(11-19)12-20(31-22)14-28-9-1-2-10-28/h3-8,11-13,15H,1-2,9-10,14H2
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n/an/a 0.910n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199256
PNG
(6-(4-chlorophenyl)-3-{6-[(dimethylamino)methyl]-5,...)
Show SMILES CN(C)CC1CCc2cc(ccc2C1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H24ClN3OS/c1-28(2)14-16-3-4-19-12-21(10-7-18(19)11-16)29-15-27-22-13-23(31-24(22)25(29)30)17-5-8-20(26)9-6-17/h5-10,12-13,15-16H,3-4,11,14H2,1-2H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199258
PNG
(6-(4-chlorophenyl)-3-[1-methyl-2-(pyrrolidin-1-ylm...)
Show SMILES Cn1c(CN2CCCC2)cc2cc(ccc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H23ClN4OS/c1-29-21(15-30-10-2-3-11-30)13-18-12-20(8-9-23(18)29)31-16-28-22-14-24(33-25(22)26(31)32)17-4-6-19(27)7-5-17/h4-9,12-14,16H,2-3,10-11,15H2,1H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199248
PNG
(6-(4-methylphenyl)-3-[2-(pyrrolidin-1-ylmethyl)-1-...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4oc(CN5CCCC5)cc4c3)c(=O)c2s1
Show InChI InChI=1S/C25H20ClN3O2S/c26-18-5-3-16(4-6-18)23-13-21-24(32-23)25(30)29(15-27-21)19-7-8-22-17(11-19)12-20(31-22)14-28-9-1-2-10-28/h3-8,11-13,15H,1-2,9-10,14H2
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199253
PNG
(6-(4-chlorophenyl)-3-[6-(1-pyrrolidinylmethyl)-5,6...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4CC(CN5CCCC5)CCc4c3)c(=O)c2s1
Show InChI InChI=1S/C27H26ClN3OS/c28-22-8-5-19(6-9-22)25-15-24-26(33-25)27(32)31(17-29-24)23-10-7-20-13-18(3-4-21(20)14-23)16-30-11-1-2-12-30/h5-10,14-15,17-18H,1-4,11-13,16H2
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199260
PNG
(6-(4-chlorophenyl)-3-{2-[(dimethylamino)methyl]-1-...)
Show SMILES CN(C)Cc1cc2cc(ccc2s1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18ClN3OS2/c1-26(2)12-18-10-15-9-17(7-8-20(15)29-18)27-13-25-19-11-21(30-22(19)23(27)28)14-3-5-16(24)6-4-14/h3-11,13H,12H2,1-2H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199265
PNG
(6-(4-chlorophenyl)-3-(2-{[(2R)-2-(methoxymethyl)py...)
Show SMILES COC[C@H]1CCCN1Cc1cc2cc(ccc2n1C)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C28H27ClN4O2S/c1-31-23(15-32-11-3-4-22(32)16-35-2)13-19-12-21(9-10-25(19)31)33-17-30-24-14-26(36-27(24)28(33)34)18-5-7-20(29)8-6-18/h5-10,12-14,17,22H,3-4,11,15-16H2,1-2H3/t22-/m1/s1
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n/an/a 1.40n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199252
PNG
(6-(4-chlorophenyl)-3-[2-(piperidin-1-ylmethyl)-1-b...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4sc(CN5CCCCC5)cc4c3)c(=O)c2s1
Show InChI InChI=1S/C26H22ClN3OS2/c27-19-6-4-17(5-7-19)24-14-22-25(33-24)26(31)30(16-28-22)20-8-9-23-18(12-20)13-21(32-23)15-29-10-2-1-3-11-29/h4-9,12-14,16H,1-3,10-11,15H2
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199261
PNG
(6-(4-chlorophenyl)-3-(2-{[(3R)-3-hydroxypyrrolidin...)
Show SMILES O[C@@H]1CCN(Cc2cc3cc(ccc3s2)-n2cnc3cc(sc3c2=O)-c2ccc(Cl)cc2)C1
Show InChI InChI=1S/C25H20ClN3O2S2/c26-17-3-1-15(2-4-17)23-11-21-24(33-23)25(31)29(14-27-21)18-5-6-22-16(9-18)10-20(32-22)13-28-8-7-19(30)12-28/h1-6,9-11,14,19,30H,7-8,12-13H2/t19-/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199262
PNG
(6-(4-chlorophenyl)-3-{6-[(dimethylamino)methyl]-7,...)
Show SMILES CN(C)CC1=Cc2ccc(cc2CC1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H22ClN3OS/c1-28(2)14-16-3-4-19-12-21(10-7-18(19)11-16)29-15-27-22-13-23(31-24(22)25(29)30)17-5-8-20(26)9-6-17/h5-13,15H,3-4,14H2,1-2H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199257
PNG
(6-(4-chlorophenyl)-3-[6-(1-piperidinylmethyl)-5,6,...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4CC(CN5CCCCC5)CCc4c3)c(=O)c2s1
Show InChI InChI=1S/C28H28ClN3OS/c29-23-9-6-20(7-10-23)26-16-25-27(34-26)28(33)32(18-30-25)24-11-8-21-14-19(4-5-22(21)15-24)17-31-12-2-1-3-13-31/h6-11,15-16,18-19H,1-5,12-14,17H2
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199263
PNG
(6-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4cc(ccc4c3)C(=O)NCCN3CCCC3)c(=O)c2s1
Show InChI InChI=1S/C29H25ClN4O2S/c30-23-8-5-19(6-9-23)26-17-25-27(37-26)29(36)34(18-32-25)24-10-7-20-15-22(4-3-21(20)16-24)28(35)31-11-14-33-12-1-2-13-33/h3-10,15-18H,1-2,11-14H2,(H,31,35)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199255
PNG
(6-(4-chlorophenyl)-3-{2-[(4-phenylpiperidin-1-yl)m...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4sc(CN5CCC(CC5)c5ccccc5)cc4c3)c(=O)c2s1
Show InChI InChI=1S/C32H26ClN3OS2/c33-25-8-6-23(7-9-25)30-18-28-31(39-30)32(37)36(20-34-28)26-10-11-29-24(16-26)17-27(38-29)19-35-14-12-22(13-15-35)21-4-2-1-3-5-21/h1-11,16-18,20,22H,12-15,19H2
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199246
PNG
(3-(2-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]methy...)
Show SMILES COC[C@H]1CCCN1Cc1cc2cc(ccc2o1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H24ClN3O3S/c1-33-15-21-3-2-10-30(21)14-22-12-18-11-20(8-9-24(18)34-22)31-16-29-23-13-25(35-26(23)27(31)32)17-4-6-19(28)7-5-17/h4-9,11-13,16,21H,2-3,10,14-15H2,1H3/t21-/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199247
PNG
(6-(4-chlorophenyl)-3-{2-[(4-methylpiperazin-1-yl)m...)
Show SMILES CN1CCN(Cc2cc3cc(ccc3s2)-n2cnc3cc(sc3c2=O)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C26H23ClN4OS2/c1-29-8-10-30(11-9-29)15-21-13-18-12-20(6-7-23(18)33-21)31-16-28-22-14-24(34-25(22)26(31)32)17-2-4-19(27)5-3-17/h2-7,12-14,16H,8-11,15H2,1H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199259
PNG
(6-(4-chlorophenyl)-3-{2-[(4-phenylpiperazin-1-yl)m...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4sc(CN5CCN(CC5)c5ccccc5)cc4c3)c(=O)c2s1
Show InChI InChI=1S/C31H25ClN4OS2/c32-23-8-6-21(7-9-23)29-18-27-30(39-29)31(37)36(20-33-27)25-10-11-28-22(16-25)17-26(38-28)19-34-12-14-35(15-13-34)24-4-2-1-3-5-24/h1-11,16-18,20H,12-15,19H2
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n/an/a 29n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199267
PNG
(6-(4-chlorophenyl)-3-[6-(hydroxymethyl)-2-naphthal...)
Show SMILES OCc1ccc2cc(ccc2c1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H15ClN2O2S/c24-18-6-3-15(4-7-18)21-11-20-22(29-21)23(28)26(13-25-20)19-8-5-16-9-14(12-27)1-2-17(16)10-19/h1-11,13,27H,12H2
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n/an/a 32n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199264
PNG
(6-(4-chlorophenyl)-3-[2-(morpholin-4-ylmethyl)-1-b...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4sc(CN5CCOCC5)cc4c3)c(=O)c2s1
Show InChI InChI=1S/C25H20ClN3O2S2/c26-18-3-1-16(2-4-18)23-13-21-24(33-23)25(30)29(15-27-21)19-5-6-22-17(11-19)12-20(32-22)14-28-7-9-31-10-8-28/h1-6,11-13,15H,7-10,14H2
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n/an/a 38n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199250
PNG
(6-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4cc(ccc4c3)C(=O)NCCCN3CCCC3)c(=O)c2s1
Show InChI InChI=1S/C30H27ClN4O2S/c31-24-9-6-20(7-10-24)27-18-26-28(38-27)30(37)35(19-33-26)25-11-8-21-16-23(5-4-22(21)17-25)29(36)32-12-3-15-34-13-1-2-14-34/h4-11,16-19H,1-3,12-15H2,(H,32,36)
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n/an/a 1.41E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199243
PNG
(6-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-...)
Show SMILES OC(=O)c1ccc2cc(ccc2c1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H13ClN2O3S/c24-17-6-3-13(4-7-17)20-11-19-21(30-20)22(27)26(12-25-19)18-8-5-14-9-16(23(28)29)2-1-15(14)10-18/h1-12H,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199245
PNG
(6-(4-chlorophenyl)-3-[6-(1-pyrrolidinylcarbonyl)-2...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4cc(ccc4c3)C(=O)N3CCCC3)c(=O)c2s1
Show InChI InChI=1S/C27H20ClN3O2S/c28-21-8-5-17(6-9-21)24-15-23-25(34-24)27(33)31(16-29-23)22-10-7-18-13-20(4-3-19(18)14-22)26(32)30-11-1-2-12-30/h3-10,13-16H,1-2,11-12H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199244
PNG
(6-(4-chlorophenyl)-3-(2-naphthalenyl)thieno[3,2-d]...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4ccccc4c3)c(=O)c2s1
Show InChI InChI=1S/C22H13ClN2OS/c23-17-8-5-15(6-9-17)20-12-19-21(27-20)22(26)25(13-24-19)18-10-7-14-3-1-2-4-16(14)11-18/h1-13H
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%