BindingDB logo
myBDB logout

PubMed code 1714956

Compile data set for download or QSAR
Found 17 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007957
PNG
(CHEMBL438191 | pGlu-His-Trp-Ser-NicLys-DNicLys-Leu...)
Show SMILES CCCCNC(NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCNC(=O)c1cccnc1)NC(=O)[C@H](CCCCNC(=O)c1cccnc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O)=NC#N
Show InChI InChI=1S/C75H104N22O14/c1-5-6-30-83-75(86-43-76)84-33-14-11-24-56(74(111)97-34-17-25-61(97)73(110)88-46(4)63(77)100)92-69(106)57(35-45(2)3)93-67(104)54(23-10-13-32-82-65(102)48-19-16-29-79-39-48)90-66(103)53(22-9-12-31-81-64(101)47-18-15-28-78-38-47)91-72(109)60(42-98)96-70(107)58(36-49-40-85-52-21-8-7-20-51(49)52)94-71(108)59(37-50-41-80-44-87-50)95-68(105)55-26-27-62(99)89-55/h7-8,15-16,18-21,28-29,38-41,44-46,53-61,85,98H,5-6,9-14,17,22-27,30-37,42H2,1-4H3,(H2,77,100)(H,80,87)(H,81,101)(H,82,102)(H,88,110)(H,89,99)(H,90,103)(H,91,109)(H,92,106)(H,93,104)(H,94,108)(H,95,105)(H,96,107)(H2,83,84,86)/t46-,53+,54-,55+,56+,57+,58+,59+,60+,61+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 0.450n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007955
PNG
(CHEMBL218396 | pGlu-His-DLys(atz)-Ser-Tyr-DArg-Leu...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](CCCCNc1nnc(N)[nH]1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C60H96N22O13/c1-32(2)26-42(52(90)74-41(13-7-8-22-66-33(3)4)57(95)82-25-11-15-46(82)56(94)70-34(5)48(61)86)75-49(87)39(14-10-24-67-58(62)63)73-53(91)43(27-35-16-18-37(84)19-17-35)76-55(93)45(30-83)78-50(88)38(12-6-9-23-68-60-79-59(64)80-81-60)72-54(92)44(28-36-29-65-31-69-36)77-51(89)40-20-21-47(85)71-40/h16-19,29,31-34,38-46,66,83-84H,6-15,20-28,30H2,1-5H3,(H2,61,86)(H,65,69)(H,70,94)(H,71,85)(H,72,92)(H,73,91)(H,74,90)(H,75,87)(H,76,93)(H,77,89)(H,78,88)(H4,62,63,67)(H4,64,68,79,80,81)/t34-,38-,39-,40+,41+,42+,43+,44+,45+,46+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 0.270n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007948
PNG
(CHEMBL412802 | pGlu-His-DPal-Ser-Tyr-DHar(bCN)-Leu...)
Show SMILES CCCCNC(NCCCC[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O)=NC#N
Show InChI InChI=1S/C63H93N19O13/c1-5-6-25-69-63(71-35-65)70-26-10-8-14-43(54(87)77-46(28-37(2)3)56(89)76-45(15-7-9-23-64)62(95)82-27-12-16-51(82)61(94)73-38(4)53(66)86)75-57(90)47(29-39-17-19-42(84)20-18-39)79-60(93)50(34-83)81-58(91)48(30-40-13-11-24-67-32-40)78-59(92)49(31-41-33-68-36-72-41)80-55(88)44-21-22-52(85)74-44/h11,13,17-20,24,32-33,36-38,43-51,83-84H,5-10,12,14-16,21-23,25-31,34,64H2,1-4H3,(H2,66,86)(H,68,72)(H,73,94)(H,74,85)(H,75,90)(H,76,89)(H,77,87)(H,78,92)(H,79,93)(H,80,88)(H,81,91)(H2,69,70,71)/t38-,43-,44+,45+,46+,47+,48+,49+,50+,51+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 1.70n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007949
PNG
(CHEMBL411586 | pGlu-His-Trp-Ser-Har(bCN)-DHar(bCN)...)
Show SMILES CCCCNC(NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@H](CCCCNC(NCCCC)=NC#N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O)=NC#N
Show InChI InChI=1S/C72H113N23O12/c1-8-10-29-78-71(83-41-73)80-32-18-14-23-51(89-68(105)58(40-96)94-66(103)56(36-47-38-82-50-22-13-12-21-49(47)50)92-67(104)57(37-48-39-76-43-85-48)93-64(101)53-27-28-60(97)87-53)62(99)88-52(24-15-19-33-81-72(84-42-74)79-30-11-9-2)63(100)91-55(35-44(3)4)65(102)90-54(25-16-17-31-77-45(5)6)70(107)95-34-20-26-59(95)69(106)86-46(7)61(75)98/h12-13,21-22,38-39,43-46,51-59,77,82,96H,8-11,14-20,23-37,40H2,1-7H3,(H2,75,98)(H,76,85)(H,86,106)(H,87,97)(H,88,99)(H,89,105)(H,90,102)(H,91,100)(H,92,104)(H,93,101)(H,94,103)(H2,78,80,83)(H2,79,81,84)/t46-,51+,52-,53+,54+,55+,56+,57+,58+,59+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 1.30n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007960
PNG
(CHEMBL261999 | pGlu-His-Trp-Ser-Arg(2mpCN)-DArg(2m...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](CCCNC(NCc1ccccn1)=NC#N)NC(=O)[C@H](CCCNC(NCc1ccccn1)=NC#N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C74H103N25O12/c1-44(2)33-57(67(106)94-56(21-10-13-27-79-45(3)4)72(111)99-32-16-24-61(99)71(110)90-46(5)63(77)102)95-65(104)54(23-15-31-83-74(88-42-76)86-39-49-18-9-12-29-81-49)92-64(103)53(22-14-30-82-73(87-41-75)85-38-48-17-8-11-28-80-48)93-70(109)60(40-100)98-68(107)58(34-47-36-84-52-20-7-6-19-51(47)52)96-69(108)59(35-50-37-78-43-89-50)97-66(105)55-25-26-62(101)91-55/h6-9,11-12,17-20,28-29,36-37,43-46,53-61,79,84,100H,10,13-16,21-27,30-35,38-40H2,1-5H3,(H2,77,102)(H,78,89)(H,90,110)(H,91,101)(H,92,103)(H,93,109)(H,94,106)(H,95,104)(H,96,108)(H,97,105)(H,98,107)(H2,82,85,87)(H2,83,86,88)/t46-,53+,54-,55+,56+,57+,58+,59+,60+,61+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 0.410n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007959
PNG
(CHEMBL438762 | pGlu-His-Trp-Ser-Har(iCN)-DHar(iCN)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](CCCCNC(NC(C)C)=NC#N)NC(=O)[C@H](CCCCNC(NC(C)C)=NC#N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C70H109N23O12/c1-40(2)31-53(63(100)88-52(23-14-15-27-75-41(3)4)68(105)93-30-18-24-57(93)67(104)84-44(9)59(73)96)89-61(98)50(22-13-17-29-77-70(80-38-72)83-43(7)8)86-60(97)49(21-12-16-28-76-69(79-37-71)82-42(5)6)87-66(103)56(36-94)92-64(101)54(32-45-34-78-48-20-11-10-19-47(45)48)90-65(102)55(33-46-35-74-39-81-46)91-62(99)51-25-26-58(95)85-51/h10-11,19-20,34-35,39-44,49-57,75,78,94H,12-18,21-33,36H2,1-9H3,(H2,73,96)(H,74,81)(H,84,104)(H,85,95)(H,86,97)(H,87,103)(H,88,100)(H,89,98)(H,90,102)(H,91,99)(H,92,101)(H2,76,79,82)(H2,77,80,83)/t44-,49+,50-,51+,52+,53+,54+,55+,56+,57+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 0.320n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007958
PNG
(CHEMBL2369860 | pGlu-His-Trp-Ser-Orn(atz)-DOrn(atz...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](CCCNc1n[nH]c(N)n1)NC(=O)[C@H](CCCNc1n[nH]c(N)n1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C62H95N25O12/c1-32(2)25-43(53(94)76-42(15-8-9-21-67-33(3)4)58(99)87-24-12-18-47(87)57(98)72-34(5)49(63)90)77-51(92)40(17-11-23-69-62-82-60(65)84-86-62)74-50(91)39(16-10-22-68-61-81-59(64)83-85-61)75-56(97)46(30-88)80-54(95)44(26-35-28-70-38-14-7-6-13-37(35)38)78-55(96)45(27-36-29-66-31-71-36)79-52(93)41-19-20-48(89)73-41/h6-7,13-14,28-29,31-34,39-47,67,70,88H,8-12,15-27,30H2,1-5H3,(H2,63,90)(H,66,71)(H,72,98)(H,73,89)(H,74,91)(H,75,97)(H,76,94)(H,77,92)(H,78,96)(H,79,93)(H,80,95)(H4,64,68,81,83,85)(H4,65,69,82,84,86)/t34-,39+,40-,41+,42+,43+,44+,45+,46+,47+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 0.210n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007952
PNG
(CHEMBL414391 | pGlu-His-Trp-Ser-Har(mCN)-DHar(mCN)...)
Show SMILES CNC(NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@H](CCCCNC(NC)=NC#N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O)=NC#N
Show InChI InChI=1S/C66H101N23O12/c1-38(2)29-49(59(96)84-48(21-12-13-25-73-39(3)4)64(101)89-28-16-22-53(89)63(100)80-40(5)55(69)92)85-57(94)46(20-11-15-27-75-66(71-7)78-36-68)82-56(93)45(19-10-14-26-74-65(70-6)77-35-67)83-62(99)52(34-90)88-60(97)50(30-41-32-76-44-18-9-8-17-43(41)44)86-61(98)51(31-42-33-72-37-79-42)87-58(95)47-23-24-54(91)81-47/h8-9,17-18,32-33,37-40,45-53,73,76,90H,10-16,19-31,34H2,1-7H3,(H2,69,92)(H,72,79)(H,80,100)(H,81,91)(H,82,93)(H,83,99)(H,84,96)(H,85,94)(H,86,98)(H,87,95)(H,88,97)(H2,70,74,77)(H2,71,75,78)/t40-,45+,46-,47+,48+,49+,50+,51+,52+,53+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 0.240n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007956
PNG
(CHEMBL265522 | pGlu-His-Trp-Ser-Har(hCN)-DHar(hCN)...)
Show SMILES CCCCCCNC(NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@H](CCCCNC(NCCCCCC)=NC#N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O)=NC#N
Show InChI InChI=1S/C76H121N23O12/c1-8-10-12-19-34-82-75(87-45-77)84-36-22-16-27-55(93-72(109)62(44-100)98-70(107)60(40-51-42-86-54-26-15-14-25-53(51)54)96-71(108)61(41-52-43-80-47-89-52)97-68(105)57-31-32-64(101)91-57)66(103)92-56(28-17-23-37-85-76(88-46-78)83-35-20-13-11-9-2)67(104)95-59(39-48(3)4)69(106)94-58(29-18-21-33-81-49(5)6)74(111)99-38-24-30-63(99)73(110)90-50(7)65(79)102/h14-15,25-26,42-43,47-50,55-63,81,86,100H,8-13,16-24,27-41,44H2,1-7H3,(H2,79,102)(H,80,89)(H,90,110)(H,91,101)(H,92,103)(H,93,109)(H,94,106)(H,95,104)(H,96,108)(H,97,105)(H,98,107)(H2,82,84,87)(H2,83,85,88)/t50-,55+,56-,57+,58+,59+,60+,61+,62+,63+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 3.30n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007946
PNG
(CHEMBL428837 | pGlu-His-Trp-Ser-Arg(bCN)-DArg(bCN)...)
Show SMILES CCCCNC(NCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@H](CCCNC(NCCCC)=NC#N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O)=NC#N
Show InChI InChI=1S/C70H109N23O12/c1-8-10-27-76-69(81-39-71)78-30-16-22-49(87-66(103)56(38-94)92-64(101)54(34-45-36-80-48-20-13-12-19-47(45)48)90-65(102)55(35-46-37-74-41-83-46)91-62(99)51-25-26-58(95)85-51)60(97)86-50(23-17-31-79-70(82-40-72)77-28-11-9-2)61(98)89-53(33-42(3)4)63(100)88-52(21-14-15-29-75-43(5)6)68(105)93-32-18-24-57(93)67(104)84-44(7)59(73)96/h12-13,19-20,36-37,41-44,49-57,75,80,94H,8-11,14-18,21-35,38H2,1-7H3,(H2,73,96)(H,74,83)(H,84,104)(H,85,95)(H,86,97)(H,87,103)(H,88,100)(H,89,98)(H,90,102)(H,91,99)(H,92,101)(H2,76,78,81)(H2,77,79,82)/t44-,49+,50-,51+,52+,53+,54+,55+,56+,57+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 2.10n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007953
PNG
(CHEMBL414113 | pGlu-His-DPal-Ser-Tyr-DPal-Leu-ILys...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C62H86N16O13/c1-35(2)25-45(55(84)71-44(13-6-7-23-67-36(3)4)62(91)78-24-10-14-51(78)61(90)69-37(5)53(63)82)72-57(86)47(27-39-11-8-21-64-30-39)73-56(85)46(26-38-15-17-42(80)18-16-38)75-60(89)50(33-79)77-58(87)48(28-40-12-9-22-65-31-40)74-59(88)49(29-41-32-66-34-68-41)76-54(83)43-19-20-52(81)70-43/h8-9,11-12,15-18,21-22,30-32,34-37,43-51,67,79-80H,6-7,10,13-14,19-20,23-29,33H2,1-5H3,(H2,63,82)(H,66,68)(H,69,90)(H,70,81)(H,71,84)(H,72,86)(H,73,85)(H,74,88)(H,75,89)(H,76,83)(H,77,87)/t37-,43+,44+,45+,46+,47-,48-,49+,50+,51+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 0.0800n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007950
PNG
(CHEMBL439359 | pGlu-His-Trp-Ser-Har(chCN)-DHar(chC...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](CCCCNC(NC1CCCCC1)=NC#N)NC(=O)[C@H](CCCCNC(NC1CCCCC1)=NC#N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C76H117N23O12/c1-46(2)37-59(69(106)94-58(29-16-17-33-81-47(3)4)74(111)99-36-20-30-63(99)73(110)88-48(5)65(79)102)95-67(104)56(28-15-19-35-83-76(86-44-78)90-51-23-10-7-11-24-51)92-66(103)55(27-14-18-34-82-75(85-43-77)89-50-21-8-6-9-22-50)93-72(109)62(42-100)98-70(107)60(38-49-40-84-54-26-13-12-25-53(49)54)96-71(108)61(39-52-41-80-45-87-52)97-68(105)57-31-32-64(101)91-57/h12-13,25-26,40-41,45-48,50-51,55-63,81,84,100H,6-11,14-24,27-39,42H2,1-5H3,(H2,79,102)(H,80,87)(H,88,110)(H,91,101)(H,92,103)(H,93,109)(H,94,106)(H,95,104)(H,96,108)(H,97,105)(H,98,107)(H2,82,85,89)(H2,83,86,90)/t48-,55+,56-,57+,58+,59+,60+,61+,62+,63+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 1.20n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007951
PNG
(CHEMBL407482 | pGlu-His-DPal-Ser-Tyr-DArg-Leu-Har(...)
Show SMILES CCCCNC(NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O)=NC#N
Show InChI InChI=1S/C63H93N21O13/c1-5-6-23-71-63(73-34-64)72-24-8-7-13-44(61(97)84-26-11-15-50(84)60(96)75-37(4)52(65)88)78-55(91)45(27-36(2)3)79-53(89)42(14-10-25-70-62(66)67)77-56(92)46(28-38-16-18-41(86)19-17-38)81-59(95)49(33-85)83-57(93)47(29-39-12-9-22-68-31-39)80-58(94)48(30-40-32-69-35-74-40)82-54(90)43-20-21-51(87)76-43/h9,12,16-19,22,31-32,35-37,42-50,85-86H,5-8,10-11,13-15,20-21,23-30,33H2,1-4H3,(H2,65,88)(H,69,74)(H,75,96)(H,76,87)(H,77,92)(H,78,91)(H,79,89)(H,80,94)(H,81,95)(H,82,90)(H,83,93)(H4,66,67,70)(H2,71,72,73)/t37-,42-,43+,44+,45+,46+,47-,48+,49+,50+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 1n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007945
PNG
(CHEMBL2369851 | pGlu-His-Trp-Ser-Lys(atz)-DLys(atz...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](CCCCNc1n[nH]c(N)n1)NC(=O)[C@H](CCCCNc1n[nH]c(N)n1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C64H99N25O12/c1-34(2)27-45(55(96)78-44(19-10-11-23-69-35(3)4)60(101)89-26-14-20-49(89)59(100)74-36(5)51(65)92)79-53(94)42(18-9-13-25-71-64-84-62(67)86-88-64)76-52(93)41(17-8-12-24-70-63-83-61(66)85-87-63)77-58(99)48(32-90)82-56(97)46(28-37-30-72-40-16-7-6-15-39(37)40)80-57(98)47(29-38-31-68-33-73-38)81-54(95)43-21-22-50(91)75-43/h6-7,15-16,30-31,33-36,41-49,69,72,90H,8-14,17-29,32H2,1-5H3,(H2,65,92)(H,68,73)(H,74,100)(H,75,91)(H,76,93)(H,77,99)(H,78,96)(H,79,94)(H,80,98)(H,81,95)(H,82,97)(H4,66,70,83,85,87)(H4,67,71,84,86,88)/t36-,41+,42-,43+,44+,45+,46+,47+,48+,49+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 0.480n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007947
PNG
(CHEMBL269583 | pGlu-His-Trp-Ser-Har(2mpCN)-DHar(2m...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](CCCCNC(NCc1ccccn1)=NC#N)NC(=O)[C@H](CCCCNC(NCc1ccccn1)=NC#N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C76H107N25O12/c1-46(2)35-59(69(108)96-58(25-12-15-29-81-47(3)4)74(113)101-34-18-26-63(101)73(112)92-48(5)65(79)104)97-67(106)56(24-11-17-33-85-76(90-44-78)88-41-51-20-9-14-31-83-51)94-66(105)55(23-10-16-32-84-75(89-43-77)87-40-50-19-8-13-30-82-50)95-72(111)62(42-102)100-70(109)60(36-49-38-86-54-22-7-6-21-53(49)54)98-71(110)61(37-52-39-80-45-91-52)99-68(107)57-27-28-64(103)93-57/h6-9,13-14,19-22,30-31,38-39,45-48,55-63,81,86,102H,10-12,15-18,23-29,32-37,40-42H2,1-5H3,(H2,79,104)(H,80,91)(H,92,112)(H,93,103)(H,94,105)(H,95,111)(H,96,108)(H,97,106)(H,98,110)(H,99,107)(H,100,109)(H2,84,87,89)(H2,85,88,90)/t48-,55+,56-,57+,58+,59+,60+,61+,62+,63+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 0.270n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007954
PNG
(CHEMBL407023 | pGlu-His-DHar(bCN)-Ser-Tyr-DArg-Leu...)
Show SMILES CCCCNC(NCCCC[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O)=NC#N
Show InChI InChI=1S/C64H103N21O13/c1-7-8-25-72-64(74-35-65)73-27-12-9-15-43(78-59(95)49(32-41-33-69-36-75-41)83-56(92)45-23-24-52(88)77-45)55(91)84-50(34-86)60(96)82-48(31-40-19-21-42(87)22-20-40)58(94)79-44(17-13-28-71-63(67)68)54(90)81-47(30-37(2)3)57(93)80-46(16-10-11-26-70-38(4)5)62(98)85-29-14-18-51(85)61(97)76-39(6)53(66)89/h19-22,33,36-39,43-51,70,86-87H,7-18,23-32,34H2,1-6H3,(H2,66,89)(H,69,75)(H,76,97)(H,77,88)(H,78,95)(H,79,94)(H,80,93)(H,81,90)(H,82,96)(H,83,92)(H,84,91)(H4,67,68,71)(H2,72,73,74)/t39-,43-,44-,45+,46+,47+,48+,49+,50+,51+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 1.20n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50007944
PNG
(CHEMBL386314 | pGlu-His-Trp-Ser-NicLys-DNicLys-Leu...)
Show SMILES CCCCN=C(NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCNC(=O)c1cccnc1)NC(=O)[C@H](CCCCNC(=O)c1cccnc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O)NC(N)=O
Show InChI InChI=1S/C75H106N22O15/c1-5-6-30-83-75(96-74(77)112)84-33-14-11-24-55(73(111)97-34-17-25-60(97)72(110)87-45(4)62(76)100)91-68(106)56(35-44(2)3)92-66(104)53(23-10-13-32-82-64(102)47-19-16-29-79-39-47)89-65(103)52(22-9-12-31-81-63(101)46-18-15-28-78-38-46)90-71(109)59(42-98)95-69(107)57(36-48-40-85-51-21-8-7-20-50(48)51)93-70(108)58(37-49-41-80-43-86-49)94-67(105)54-26-27-61(99)88-54/h7-8,15-16,18-21,28-29,38-41,43-45,52-60,85,98H,5-6,9-14,17,22-27,30-37,42H2,1-4H3,(H2,76,100)(H,80,86)(H,81,101)(H,82,102)(H,87,110)(H,88,99)(H,89,103)(H,90,109)(H,91,106)(H,92,104)(H,93,108)(H,94,105)(H,95,107)(H4,77,83,84,96,112)/t45-,52+,53-,54+,55+,56+,57+,58+,59+,60+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 0.110n/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%