Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2223![]() (2-Pyridinone derivative 21 | 3-[2-(4,7-dichloro-1,...) | PDB MMDB B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1317![]() (3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-...) | PDB MMDB B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1314![]() (3-[[(4,7-Dimethylbenzoxazol-2-yl)-methyl]amino]-5-...) | PDB MMDB B.MOAD GoogleScholar | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2215![]() (3-[2-(1,3-benzoxazol-2-yl)ethyl]-5-ethyl-6-methyl-...) | PDB MMDB B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2222![]() (2-Pyridinone derivative 20 | 3-[2-(4,7-dimethyl-1,...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1057![]() (2-{[(5-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-y...) | PDB MMDB B.MOAD GoogleScholar | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1312![]() (3-Aminopyridin-2(1H)-one analogue 32 | 5-ethyl-6-m...) | PDB MMDB B.MOAD GoogleScholar | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2217![]() (2-Pyridinone derivative 12 | 3-[2-(1-benzofuran-2-...) | PDB MMDB B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 77 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1309![]() (3-Aminopyridin-2(1H)-one analogue 29 | 5-ethyl-6-m...) | PDB MMDB B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 125 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1283![]() (3-[(1,3-benzoxazol-2-ylmethyl)amino]-5-ethyl-6-met...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1284![]() (3-Aminopyridin-2(1H)-one analogue 4 | 3-[(1-benzof...) | PDB MMDB B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 235 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1287![]() (3-Aminopyridin-2(1H)-one analogue 7 | 3-[(1,3-benz...) | PDB MMDB B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 350 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2213![]() (2-Pyridinone derivative 8 | 3-[2-(1,3-benzothiazol...) | PDB MMDB B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 370 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1288![]() (3-Aminopyridin-2(1H)-one analogue 8 | 5-ethyl-6-me...) | PDB MMDB B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1066![]() (2-[2-(5-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-...) | PDB MMDB B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1299![]() (3-Aminopyridin-2(1H)-one analogue 19 | 3-[(1H-1,3-...) | PDB MMDB B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair |