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PubMed code 17188869

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201303
PNG
(1-(4-(4-amino-7-(pyrimidin-5-yl)thieno[3,2-c]pyrid...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cncnc2)c1
Show InChI InChI=1S/C25H20N6OS/c1-15-3-2-4-19(9-15)31-25(32)30-18-7-5-16(6-8-18)21-13-33-23-20(12-29-24(26)22(21)23)17-10-27-14-28-11-17/h2-14H,1H3,(H2,26,29)(H2,30,31,32)
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n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201323
PNG
(1-(4-(4-amino-7-(pyridin-3-yl)thieno[3,2-c]pyridin...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cccnc2)c1
Show InChI InChI=1S/C26H21N5OS/c1-16-4-2-6-20(12-16)31-26(32)30-19-9-7-17(8-10-19)22-15-33-24-21(14-29-25(27)23(22)24)18-5-3-11-28-13-18/h2-15H,1H3,(H2,27,29)(H2,30,31,32)
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n/an/a 4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201330
PNG
(1-(4-(4-amino-7-(pyridin-4-yl)thieno[3,2-c]pyridin...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2ccncc2)c1
Show InChI InChI=1S/C26H21N5OS/c1-16-3-2-4-20(13-16)31-26(32)30-19-7-5-17(6-8-19)22-15-33-24-21(14-29-25(27)23(22)24)18-9-11-28-12-10-18/h2-15H,1H3,(H2,27,29)(H2,30,31,32)
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n/an/a 4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201330
PNG
(1-(4-(4-amino-7-(pyridin-4-yl)thieno[3,2-c]pyridin...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2ccncc2)c1
Show InChI InChI=1S/C26H21N5OS/c1-16-3-2-4-20(13-16)31-26(32)30-19-7-5-17(6-8-19)22-15-33-24-21(14-29-25(27)23(22)24)18-9-11-28-12-10-18/h2-15H,1H3,(H2,27,29)(H2,30,31,32)
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n/an/a 5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201303
PNG
(1-(4-(4-amino-7-(pyrimidin-5-yl)thieno[3,2-c]pyrid...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cncnc2)c1
Show InChI InChI=1S/C25H20N6OS/c1-15-3-2-4-19(9-15)31-25(32)30-18-7-5-16(6-8-18)21-13-33-23-20(12-29-24(26)22(21)23)17-10-27-14-28-11-17/h2-14H,1H3,(H2,26,29)(H2,30,31,32)
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n/an/a 8n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201307
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-m...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ccnc(N)c23)c1
Show InChI InChI=1S/C21H18N4OS/c1-13-3-2-4-16(11-13)25-21(26)24-15-7-5-14(6-8-15)17-12-27-18-9-10-23-20(22)19(17)18/h2-12H,1H3,(H2,22,23)(H2,24,25,26)
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n/an/a 9n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201323
PNG
(1-(4-(4-amino-7-(pyridin-3-yl)thieno[3,2-c]pyridin...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cccnc2)c1
Show InChI InChI=1S/C26H21N5OS/c1-16-4-2-6-20(12-16)31-26(32)30-19-9-7-17(8-10-19)22-15-33-24-21(14-29-25(27)23(22)24)18-5-3-11-28-13-18/h2-15H,1H3,(H2,27,29)(H2,30,31,32)
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n/an/a 9n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201314
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2csc3ccnc(N)c23)cc1C
Show InChI InChI=1S/C22H20N4OS/c1-13-3-6-17(11-14(13)2)26-22(27)25-16-7-4-15(5-8-16)18-12-28-19-9-10-24-21(23)20(18)19/h3-12H,1-2H3,(H2,23,24)(H2,25,26,27)
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n/an/a 10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201327
PNG
(1-(4-(4-amino-7-(4-hydroxyphenyl)thieno[3,2-c]pyri...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2ccc(O)cc2)c1
Show InChI InChI=1S/C27H22N4O2S/c1-16-3-2-4-20(13-16)31-27(33)30-19-9-5-18(6-10-19)23-15-34-25-22(14-29-26(28)24(23)25)17-7-11-21(32)12-8-17/h2-15,32H,1H3,(H2,28,29)(H2,30,31,33)
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n/an/a 11n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201319
PNG
(1-(4-(4-amino-7-(3-(methylcarbamoyl)phenyl)thieno[...)
Show SMILES CNC(=O)c1cccc(c1)-c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C29H25N5O2S/c1-17-5-3-8-22(13-17)34-29(36)33-21-11-9-18(10-12-21)24-16-37-26-23(15-32-27(30)25(24)26)19-6-4-7-20(14-19)28(35)31-2/h3-16H,1-2H3,(H2,30,32)(H,31,35)(H2,33,34,36)
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n/an/a 11n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201302
PNG
(1-(4-(4-amino-7-phenylthieno[3,2-c]pyridin-3-yl)ph...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2ccccc2)c1
Show InChI InChI=1S/C27H22N4OS/c1-17-6-5-9-21(14-17)31-27(32)30-20-12-10-19(11-13-20)23-16-33-25-22(15-29-26(28)24(23)25)18-7-3-2-4-8-18/h2-16H,1H3,(H2,28,29)(H2,30,31,32)
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n/an/a 13n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201308
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4ccc5ccccc5c4)cc3)c12
Show InChI InChI=1S/C24H18N4OS/c25-23-22-20(14-30-21(22)11-12-26-23)16-6-8-18(9-7-16)27-24(29)28-19-10-5-15-3-1-2-4-17(15)13-19/h1-14H,(H2,25,26)(H2,27,28,29)
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n/an/a 15n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201318
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H15FN4OS/c21-13-2-1-3-15(10-13)25-20(26)24-14-6-4-12(5-7-14)16-11-27-17-8-9-23-19(22)18(16)17/h1-11H,(H2,22,23)(H2,24,25,26)
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n/an/a 15n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201320
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Cc1cc(C)cc(NC(=O)Nc2ccc(cc2)-c2csc3ccnc(N)c23)c1
Show InChI InChI=1S/C22H20N4OS/c1-13-9-14(2)11-17(10-13)26-22(27)25-16-5-3-15(4-6-16)18-12-28-19-7-8-24-21(23)20(18)19/h3-12H,1-2H3,(H2,23,24)(H2,25,26,27)
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n/an/a 16n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201308
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4ccc5ccccc5c4)cc3)c12
Show InChI InChI=1S/C24H18N4OS/c25-23-22-20(14-30-21(22)11-12-26-23)16-6-8-18(9-7-16)27-24(29)28-19-10-5-15-3-1-2-4-17(15)13-19/h1-14H,(H2,25,26)(H2,27,28,29)
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n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201311
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Show InChI InChI=1S/C20H15ClN4OS/c21-13-2-1-3-15(10-13)25-20(26)24-14-6-4-12(5-7-14)16-11-27-17-8-9-23-19(22)18(16)17/h1-11H,(H2,22,23)(H2,24,25,26)
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n/an/a 22n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201328
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-1-m...)
Show SMILES CN(C(=O)Nc1cccc(C)c1)c1ccc(cc1)-c1csc2ccnc(N)c12
Show InChI InChI=1S/C22H20N4OS/c1-14-4-3-5-16(12-14)25-22(27)26(2)17-8-6-15(7-9-17)18-13-28-19-10-11-24-21(23)20(18)19/h3-13H,1-2H3,(H2,23,24)(H,25,27)
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n/an/a 23n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201310
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ccnc(N)c23)c1
Show InChI InChI=1S/C22H20N4OS/c1-2-14-4-3-5-17(12-14)26-22(27)25-16-8-6-15(7-9-16)18-13-28-19-10-11-24-21(23)20(18)19/h3-13H,2H2,1H3,(H2,23,24)(H2,25,26,27)
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n/an/a 25n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201322
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-p...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2csc3ccnc(N)c23)cc1
Show InChI InChI=1S/C21H18N4OS/c1-13-2-6-15(7-3-13)24-21(26)25-16-8-4-14(5-9-16)17-12-27-18-10-11-23-20(22)19(17)18/h2-12H,1H3,(H2,22,23)(H2,24,25,26)
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n/an/a 26n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201325
PNG
(1-(4-(4-amino-2-methylthieno[3,2-c]pyridin-3-yl)ph...)
Show SMILES Cc1sc2ccnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C22H20N4OS/c1-13-4-3-5-17(12-13)26-22(27)25-16-8-6-15(7-9-16)19-14(2)28-18-10-11-24-21(23)20(18)19/h3-12H,1-2H3,(H2,23,24)(H2,25,26,27)
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n/an/a 27n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201327
PNG
(1-(4-(4-amino-7-(4-hydroxyphenyl)thieno[3,2-c]pyri...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2ccc(O)cc2)c1
Show InChI InChI=1S/C27H22N4O2S/c1-16-3-2-4-20(13-16)31-27(33)30-19-9-5-18(6-10-19)23-15-34-25-22(14-29-26(28)24(23)25)17-7-11-21(32)12-8-17/h2-15,32H,1H3,(H2,28,29)(H2,30,31,33)
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n/an/a 29n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201309
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccs4)cc3)c12
Show InChI InChI=1S/C18H14N4OS2/c19-17-16-13(10-25-14(16)7-8-20-17)11-3-5-12(6-4-11)21-18(23)22-15-2-1-9-24-15/h1-10H,(H2,19,20)(H2,21,22,23)
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n/an/a 30n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201307
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-m...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ccnc(N)c23)c1
Show InChI InChI=1S/C21H18N4OS/c1-13-3-2-4-16(11-13)25-21(26)24-15-7-5-14(6-8-15)17-12-27-18-9-10-23-20(22)19(17)18/h2-12H,1H3,(H2,22,23)(H2,24,25,26)
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n/an/a 32n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201310
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ccnc(N)c23)c1
Show InChI InChI=1S/C22H20N4OS/c1-2-14-4-3-5-17(12-14)26-22(27)25-16-8-6-15(7-9-16)18-13-28-19-10-11-24-21(23)20(18)19/h3-13H,2H2,1H3,(H2,23,24)(H2,25,26,27)
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n/an/a 32n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201302
PNG
(1-(4-(4-amino-7-phenylthieno[3,2-c]pyridin-3-yl)ph...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2ccccc2)c1
Show InChI InChI=1S/C27H22N4OS/c1-17-6-5-9-21(14-17)31-27(32)30-20-12-10-19(11-13-20)23-16-33-25-22(15-29-26(28)24(23)25)18-7-3-2-4-8-18/h2-16H,1H3,(H2,28,29)(H2,30,31,32)
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n/an/a 33n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201301
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12
Show InChI InChI=1S/C18H14N4OS2/c19-17-16-14(10-25-15(16)5-7-20-17)11-1-3-12(4-2-11)21-18(23)22-13-6-8-24-9-13/h1-10H,(H2,19,20)(H2,21,22,23)
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n/an/a 38n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201314
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2csc3ccnc(N)c23)cc1C
Show InChI InChI=1S/C22H20N4OS/c1-13-3-6-17(11-14(13)2)26-22(27)25-16-7-4-15(5-8-16)18-12-28-19-9-10-24-21(23)20(18)19/h3-12H,1-2H3,(H2,23,24)(H2,25,26,27)
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n/an/a 41n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201305
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(c4)C#N)cc3)c12
Show InChI InChI=1S/C21H15N5OS/c22-11-13-2-1-3-16(10-13)26-21(27)25-15-6-4-14(5-7-15)17-12-28-18-8-9-24-20(23)19(17)18/h1-10,12H,(H2,23,24)(H2,25,26,27)
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n/an/a 45n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201320
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Cc1cc(C)cc(NC(=O)Nc2ccc(cc2)-c2csc3ccnc(N)c23)c1
Show InChI InChI=1S/C22H20N4OS/c1-13-9-14(2)11-17(10-13)26-22(27)25-16-5-3-15(4-6-16)18-12-28-19-7-8-24-21(23)20(18)19/h3-12H,1-2H3,(H2,23,24)(H2,25,26,27)
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n/an/a 48n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201309
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccs4)cc3)c12
Show InChI InChI=1S/C18H14N4OS2/c19-17-16-13(10-25-14(16)7-8-20-17)11-3-5-12(6-4-11)21-18(23)22-15-2-1-9-24-15/h1-10H,(H2,19,20)(H2,21,22,23)
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n/an/a 48n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201317
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-p...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12
Show InChI InChI=1S/C20H16N4OS/c21-19-18-16(12-26-17(18)10-11-22-19)13-6-8-15(9-7-13)24-20(25)23-14-4-2-1-3-5-14/h1-12H,(H2,21,22)(H2,23,24,25)
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n/an/a 56n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201319
PNG
(1-(4-(4-amino-7-(3-(methylcarbamoyl)phenyl)thieno[...)
Show SMILES CNC(=O)c1cccc(c1)-c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C29H25N5O2S/c1-17-5-3-8-22(13-17)34-29(36)33-21-11-9-18(10-12-21)24-16-37-26-23(15-32-27(30)25(24)26)19-6-4-7-20(14-19)28(35)31-2/h3-16H,1-2H3,(H2,30,32)(H,31,35)(H2,33,34,36)
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n/an/a 56n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201311
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Show InChI InChI=1S/C20H15ClN4OS/c21-13-2-1-3-15(10-13)25-20(26)24-14-6-4-12(5-7-14)16-11-27-17-8-9-23-19(22)18(16)17/h1-11H,(H2,22,23)(H2,24,25,26)
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n/an/a 56n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201301
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12
Show InChI InChI=1S/C18H14N4OS2/c19-17-16-14(10-25-15(16)5-7-20-17)11-1-3-12(4-2-11)21-18(23)22-13-6-8-24-9-13/h1-10H,(H2,19,20)(H2,21,22,23)
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n/an/a 61n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201317
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-p...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12
Show InChI InChI=1S/C20H16N4OS/c21-19-18-16(12-26-17(18)10-11-22-19)13-6-8-15(9-7-13)24-20(25)23-14-4-2-1-3-5-14/h1-12H,(H2,21,22)(H2,23,24,25)
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n/an/a 72n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201304
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc5ccccc45)cc3)c12
Show InChI InChI=1S/C24H18N4OS/c25-23-22-19(14-30-21(22)12-13-26-23)16-8-10-17(11-9-16)27-24(29)28-20-7-3-5-15-4-1-2-6-18(15)20/h1-14H,(H2,25,26)(H2,27,28,29)
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n/an/a 75n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201315
PNG
(2-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-N-m...)
Show SMILES Cc1cccc(NC(=O)Cc2ccc(cc2)-c2csc3ccnc(N)c23)c1
Show InChI InChI=1S/C22H19N3OS/c1-14-3-2-4-17(11-14)25-20(26)12-15-5-7-16(8-6-15)18-13-27-19-9-10-24-22(23)21(18)19/h2-11,13H,12H2,1H3,(H2,23,24)(H,25,26)
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n/an/a 94n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201322
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-p...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2csc3ccnc(N)c23)cc1
Show InChI InChI=1S/C21H18N4OS/c1-13-2-6-15(7-3-13)24-21(26)25-16-8-4-14(5-9-16)17-12-27-18-10-11-23-20(22)19(17)18/h2-12H,1H3,(H2,22,23)(H2,24,25,26)
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n/an/a 141n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201318
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H15FN4OS/c21-13-2-1-3-15(10-13)25-20(26)24-14-6-4-12(5-7-14)16-11-27-17-8-9-23-19(22)18(16)17/h1-11H,(H2,22,23)(H2,24,25,26)
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n/an/a 147n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201331
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-o...)
Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1csc2ccnc(N)c12
Show InChI InChI=1S/C21H18N4OS/c1-13-4-2-3-5-17(13)25-21(26)24-15-8-6-14(7-9-15)16-12-27-18-10-11-23-20(22)19(16)18/h2-12H,1H3,(H2,22,23)(H2,24,25,26)
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n/an/a 152n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201305
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(c4)C#N)cc3)c12
Show InChI InChI=1S/C21H15N5OS/c22-11-13-2-1-3-16(10-13)26-21(27)25-15-6-4-14(5-7-15)17-12-28-18-8-9-24-20(23)19(17)18/h1-10,12H,(H2,23,24)(H2,25,26,27)
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n/an/a 198n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201324
PNG
(1-(3-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-m...)
Show SMILES Cc1cccc(NC(=O)Nc2cccc(c2)-c2csc3ccnc(N)c23)c1
Show InChI InChI=1S/C21H18N4OS/c1-13-4-2-6-15(10-13)24-21(26)25-16-7-3-5-14(11-16)17-12-27-18-8-9-23-20(22)19(17)18/h2-12H,1H3,(H2,22,23)(H2,24,25,26)
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n/an/a 250n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (human))
BDBM50201323
PNG
(1-(4-(4-amino-7-(pyridin-3-yl)thieno[3,2-c]pyridin...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cccnc2)c1
Show InChI InChI=1S/C26H21N5OS/c1-16-4-2-6-20(12-16)31-26(32)30-19-9-7-17(8-10-19)22-15-33-24-21(14-29-25(27)23(22)24)18-5-3-11-28-13-18/h2-15H,1H3,(H2,27,29)(H2,30,31,32)
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n/an/a 250n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201321
PNG
(1-(4-(4-amino-7-(isoquinolin-4-yl)thieno[3,2-c]pyr...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cncc3ccccc23)c1
Show InChI InChI=1S/C30H23N5OS/c1-18-5-4-7-22(13-18)35-30(36)34-21-11-9-19(10-12-21)26-17-37-28-25(16-33-29(31)27(26)28)24-15-32-14-20-6-2-3-8-23(20)24/h2-17H,1H3,(H2,31,33)(H2,34,35,36)
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n/an/a 388n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201326
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-m...)
Show SMILES Cc1cccc(NC(=S)Nc2ccc(cc2)-c2csc3ccnc(N)c23)c1
Show InChI InChI=1S/C21H18N4S2/c1-13-3-2-4-16(11-13)25-21(26)24-15-7-5-14(6-8-15)17-12-27-18-9-10-23-20(22)19(17)18/h2-12H,1H3,(H2,22,23)(H2,24,25,26)
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n/an/a 410n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201332
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-c...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)NC4CCCC4)cc3)c12
Show InChI InChI=1S/C19H20N4OS/c20-18-17-15(11-25-16(17)9-10-21-18)12-5-7-14(8-6-12)23-19(24)22-13-3-1-2-4-13/h5-11,13H,1-4H2,(H2,20,21)(H2,22,23,24)
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n/an/a 420n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201329
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-c...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)NC4CCCCC4)cc3)c12
Show InChI InChI=1S/C20H22N4OS/c21-19-18-16(12-26-17(18)10-11-22-19)13-6-8-15(9-7-13)24-20(25)23-14-4-2-1-3-5-14/h6-12,14H,1-5H2,(H2,21,22)(H2,23,24,25)
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n/an/a 491n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201313
PNG
(CHEMBL394620 | N-(4-(4-aminothieno[3,2-c]pyridin-3...)
Show SMILES Cc1cccc(CC(=O)Nc2ccc(cc2)-c2csc3ccnc(N)c23)c1
Show InChI InChI=1S/C22H19N3OS/c1-14-3-2-4-15(11-14)12-20(26)25-17-7-5-16(6-8-17)18-13-27-19-9-10-24-22(23)21(18)19/h2-11,13H,12H2,1H3,(H2,23,24)(H,25,26)
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n/an/a 520n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201304
PNG
(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc5ccccc45)cc3)c12
Show InChI InChI=1S/C24H18N4OS/c25-23-22-19(14-30-21(22)12-13-26-23)16-8-10-17(11-9-16)27-24(29)28-20-7-3-5-15-4-1-2-6-18(15)20/h1-14H,(H2,25,26)(H2,27,28,29)
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n/an/a 895n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201316
PNG
(3-(4-aminophenyl)thieno[3,2-c]pyridin-4-amine | CH...)
Show SMILES Nc1ccc(cc1)-c1csc2ccnc(N)c12
Show InChI InChI=1S/C13H11N3S/c14-9-3-1-8(2-4-9)10-7-17-11-5-6-16-13(15)12(10)11/h1-7H,14H2,(H2,15,16)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201306
PNG
(3-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-1-m...)
Show SMILES CN(C(=O)Nc1ccc(cc1)-c1csc2ccnc(N)c12)c1cccc(C)c1
Show InChI InChI=1S/C22H20N4OS/c1-14-4-3-5-17(12-14)26(2)22(27)25-16-8-6-15(7-9-16)18-13-28-19-10-11-24-21(23)20(18)19/h3-13H,1-2H3,(H2,23,24)(H,25,27)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201312
PNG
(CHEMBL231254 | N-(4-(4-aminothieno[3,2-c]pyridin-3...)
Show SMILES Nc1nccc2scc(-c3ccc(NC(=O)c4ccccc4)cc3)c12
Show InChI InChI=1S/C20H15N3OS/c21-19-18-16(12-25-17(18)10-11-22-19)13-6-8-15(9-7-13)23-20(24)14-4-2-1-3-5-14/h1-12H,(H2,21,22)(H,23,24)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201333
PNG
(3-phenylthieno[3,2-c]pyridin-4-amine | CHEMBL43737...)
Show SMILES Nc1nccc2scc(-c3ccccc3)c12
Show InChI InChI=1S/C13H10N2S/c14-13-12-10(9-4-2-1-3-5-9)8-16-11(12)6-7-15-13/h1-8H,(H2,14,15)
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1246-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.015
BindingDB Entry DOI: 10.7270/Q28K78RS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%