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PubMed code 17234410

Compile data set for download or QSAR
Found 82 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SRC


(Homo sapiens (human))
BDBM50202759
PNG
(CHEMBL231720 | N-(4-(4-amino-1-methyl-1H-pyrazolo[...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1nn(C)c2ncnc(N)c12
Show InChI InChI=1S/C23H21N7O2/c1-29-16-7-5-4-6-13(16)10-17(29)23(31)27-15-9-8-14(11-18(15)32-3)20-19-21(24)25-12-26-22(19)30(2)28-20/h4-12H,1-3H3,(H,27,31)(H2,24,25,26)
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n/an/a 31n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202737
PNG
(CHEMBL395665 | N-(4-(4-amino-7-(3-((1r,4r)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24-
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n/an/a 110n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202757
PNG
(CHEMBL396359 | N-(4-(4-amino-7-(3-oxo-3-(piperidin...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2C(CN=C(N)c12)C=CC(=O)NC1CCNCC1
Show InChI InChI=1S/C32H34N6O3S/c1-38-25-6-4-3-5-20(25)15-26(38)32(40)37-24-9-7-19(16-27(24)41-2)23-18-42-30-21(17-35-31(33)29(23)30)8-10-28(39)36-22-11-13-34-14-12-22/h3-10,15-16,18,21-22,34H,11-14,17H2,1-2H3,(H2,33,35)(H,36,39)(H,37,40)
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n/an/a 130n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202733
PNG
(4-amino-N-(2-(dimethylamino)ethyl)-3-(3-methoxy-4-...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(cnc(N)c12)C(=O)NCCN(C)C
Show InChI InChI=1S/C29H30N6O3S/c1-34(2)12-11-31-28(36)19-15-32-27(30)25-20(16-39-26(19)25)17-9-10-21(24(14-17)38-4)33-29(37)23-13-18-7-5-6-8-22(18)35(23)3/h5-10,13-16H,11-12H2,1-4H3,(H2,30,32)(H,31,36)(H,33,37)
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n/an/a 140n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202739
PNG
(CHEMBL395664 | N-(4-(4-amino-7-(3-(piperidin-4-yla...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC3CCNCC3)cnc(N)c12
Show InChI InChI=1S/C32H34N6O2S/c1-38-26-8-4-3-6-21(26)16-27(38)32(39)37-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-36-31(33)29(24)30)7-5-13-35-23-11-14-34-15-12-23/h3-10,16-19,23,34-35H,11-15H2,1-2H3,(H2,33,36)(H,37,39)/b7-5+
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n/an/a 190n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202741
PNG
(CHEMBL233958 | N-(4-(4-amino-7-(3-(4-hydroxypiperi...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCC(O)CC3)cnc(N)c12
Show InChI InChI=1S/C32H33N5O3S/c1-36-26-8-4-3-6-21(26)16-27(36)32(39)35-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-34-31(33)29(24)30)7-5-13-37-14-11-23(38)12-15-37/h3-10,16-19,23,38H,11-15H2,1-2H3,(H2,33,34)(H,35,39)/b7-5+
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n/an/a 210n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202738
PNG
(CHEMBL232127 | trans-N-(4-(4-amino-7-(3-aminoprop-...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN)cnc(N)c12
Show InChI InChI=1S/C27H25N5O2S/c1-32-21-8-4-3-6-17(21)12-22(32)27(33)31-20-10-9-16(13-23(20)34-2)19-15-35-25-18(7-5-11-28)14-30-26(29)24(19)25/h3-10,12-15H,11,28H2,1-2H3,(H2,29,30)(H,31,33)/b7-5+
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n/an/a 230n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202745
PNG
(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-carbo...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(cnc(N)c12)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C31H32N6O3S/c1-36-24-8-4-3-7-20(24)15-25(36)31(39)35-23-10-9-19(16-26(23)40-2)22-18-41-28-21(17-34-29(32)27(22)28)30(38)33-11-14-37-12-5-6-13-37/h3-4,7-10,15-18H,5-6,11-14H2,1-2H3,(H2,32,34)(H,33,38)(H,35,39)
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n/an/a 240n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202734
PNG
(CHEMBL232542 | N-(4-(4-amino-7-(3-(diethylamino)pr...)
Show SMILES CCN(CC)C\C=C\c1cnc(N)c2c(csc12)-c1ccc(NC(=O)c2cc3ccccc3n2C)c(OC)c1
Show InChI InChI=1S/C31H33N5O2S/c1-5-36(6-2)15-9-11-22-18-33-30(32)28-23(19-39-29(22)28)20-13-14-24(27(17-20)38-4)34-31(37)26-16-21-10-7-8-12-25(21)35(26)3/h7-14,16-19H,5-6,15H2,1-4H3,(H2,32,33)(H,34,37)/b11-9+
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n/an/a 290n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202754
PNG
(CHEMBL395662 | N-(4-(4-amino-7-(3-(4-methylpiperaz...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCN(C)CC3)cnc(N)c12
Show InChI InChI=1S/C32H34N6O2S/c1-36-13-15-38(16-14-36)12-6-8-23-19-34-31(33)29-24(20-41-30(23)29)21-10-11-25(28(18-21)40-3)35-32(39)27-17-22-7-4-5-9-26(22)37(27)2/h4-11,17-20H,12-16H2,1-3H3,(H2,33,34)(H,35,39)/b8-6+
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n/an/a 290n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202744
PNG
(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-carbo...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(cnc(N)c12)C(N)=O
Show InChI InChI=1S/C25H21N5O3S/c1-30-18-6-4-3-5-14(18)9-19(30)25(32)29-17-8-7-13(10-20(17)33-2)16-12-34-22-15(24(27)31)11-28-23(26)21(16)22/h3-12H,1-2H3,(H2,26,28)(H2,27,31)(H,29,32)
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n/an/a 380n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202735
PNG
(CHEMBL395666 | N-(4-(4-amino-7-(3-((1s,4s)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24+
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n/an/a 480n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202736
PNG
(CHEMBL231930 | trans-N-(4-(4-amino-7-(3-amino-3-ox...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\C(N)=O)cnc(N)c12
Show InChI InChI=1S/C27H23N5O3S/c1-32-20-6-4-3-5-16(20)11-21(32)27(34)31-19-9-7-15(12-22(19)35-2)18-14-36-25-17(8-10-23(28)33)13-30-26(29)24(18)25/h3-14H,1-2H3,(H2,28,33)(H2,29,30)(H,31,34)/b10-8+
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n/an/a 541n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50202735
PNG
(CHEMBL395666 | N-(4-(4-amino-7-(3-((1s,4s)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24+
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n/an/a 570n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202753
PNG
(CHEMBL232927 | N-(4-(7-(3-acetamidoprop-1-enyl)-4-...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC(C)=O)cnc(N)c12
Show InChI InChI=1S/C29H27N5O3S/c1-17(35)31-12-6-8-20-15-32-28(30)26-21(16-38-27(20)26)18-10-11-22(25(14-18)37-3)33-29(36)24-13-19-7-4-5-9-23(19)34(24)2/h4-11,13-16H,12H2,1-3H3,(H2,30,32)(H,31,35)(H,33,36)/b8-6+
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n/an/a 720n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202740
PNG
(CHEMBL232126 | trans-N-(4-(4-amino-7-(3-hydroxypro...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CO)cnc(N)c12
Show InChI InChI=1S/C27H24N4O3S/c1-31-21-8-4-3-6-17(21)12-22(31)27(33)30-20-10-9-16(13-23(20)34-2)19-15-35-25-18(7-5-11-32)14-29-26(28)24(19)25/h3-10,12-15,32H,11H2,1-2H3,(H2,28,29)(H,30,33)/b7-5+
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n/an/a 770n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50202734
PNG
(CHEMBL232542 | N-(4-(4-amino-7-(3-(diethylamino)pr...)
Show SMILES CCN(CC)C\C=C\c1cnc(N)c2c(csc12)-c1ccc(NC(=O)c2cc3ccccc3n2C)c(OC)c1
Show InChI InChI=1S/C31H33N5O2S/c1-5-36(6-2)15-9-11-22-18-33-30(32)28-23(19-39-29(22)28)20-13-14-24(27(17-20)38-4)34-31(37)26-16-21-10-7-8-12-25(21)35(26)3/h7-14,16-19H,5-6,15H2,1-4H3,(H2,32,33)(H,34,37)/b11-9+
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n/an/a 1.18E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lyn


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202757
PNG
(CHEMBL396359 | N-(4-(4-amino-7-(3-oxo-3-(piperidin...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2C(CN=C(N)c12)C=CC(=O)NC1CCNCC1
Show InChI InChI=1S/C32H34N6O3S/c1-38-25-6-4-3-5-20(25)15-26(38)32(40)37-24-9-7-19(16-27(24)41-2)23-18-42-30-21(17-35-31(33)29(23)30)8-10-28(39)36-22-11-13-34-14-12-22/h3-10,15-16,18,21-22,34H,11-14,17H2,1-2H3,(H2,33,35)(H,36,39)(H,37,40)
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n/an/a 1.29E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202748
PNG
(CHEMBL232731 | N-(4-(4-amino-7-(3-(methylsulfonami...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNS(C)(=O)=O)cnc(N)c12
Show InChI InChI=1S/C28H27N5O4S2/c1-33-22-9-5-4-7-18(22)13-23(33)28(34)32-21-11-10-17(14-24(21)37-2)20-16-38-26-19(15-30-27(29)25(20)26)8-6-12-31-39(3,35)36/h4-11,13-16,31H,12H2,1-3H3,(H2,29,30)(H,32,34)/b8-6+
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n/an/a 1.37E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202744
PNG
(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-carbo...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(cnc(N)c12)C(N)=O
Show InChI InChI=1S/C25H21N5O3S/c1-30-18-6-4-3-5-14(18)9-19(30)25(32)29-17-8-7-13(10-20(17)33-2)16-12-34-22-15(24(27)31)11-28-23(26)21(16)22/h3-12H,1-2H3,(H2,26,28)(H2,27,31)(H,29,32)
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n/an/a 1.41E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202746
PNG
(CHEMBL395663 | N-(4-(4-amino-7-(3-(4-methyl-3-oxop...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(C=CCN3CCN(C)C(=O)C3)cnc(N)c12
Show InChI InChI=1S/C32H32N6O3S/c1-36-13-14-38(18-28(36)39)12-6-8-22-17-34-31(33)29-23(19-42-30(22)29)20-10-11-24(27(16-20)41-3)35-32(40)26-15-21-7-4-5-9-25(21)37(26)2/h4-11,15-17,19H,12-14,18H2,1-3H3,(H2,33,34)(H,35,40)
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n/an/a 1.52E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50202737
PNG
(CHEMBL395665 | N-(4-(4-amino-7-(3-((1r,4r)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24-
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n/an/a 1.90E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202733
PNG
(4-amino-N-(2-(dimethylamino)ethyl)-3-(3-methoxy-4-...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(cnc(N)c12)C(=O)NCCN(C)C
Show InChI InChI=1S/C29H30N6O3S/c1-34(2)12-11-31-28(36)19-15-32-27(30)25-20(16-39-26(19)25)17-9-10-21(24(14-17)38-4)33-29(37)23-13-18-7-5-6-8-22(18)35(23)3/h5-10,13-16H,11-12H2,1-4H3,(H2,30,32)(H,31,36)(H,33,37)
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n/an/a 1.97E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202736
PNG
(CHEMBL231930 | trans-N-(4-(4-amino-7-(3-amino-3-ox...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\C(N)=O)cnc(N)c12
Show InChI InChI=1S/C27H23N5O3S/c1-32-20-6-4-3-5-16(20)11-21(32)27(34)31-19-9-7-15(12-22(19)35-2)18-14-36-25-17(8-10-23(28)33)13-30-26(29)24(18)25/h3-14H,1-2H3,(H2,28,33)(H2,29,30)(H,31,34)/b10-8+
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n/an/a 2.26E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202753
PNG
(CHEMBL232927 | N-(4-(7-(3-acetamidoprop-1-enyl)-4-...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC(C)=O)cnc(N)c12
Show InChI InChI=1S/C29H27N5O3S/c1-17(35)31-12-6-8-20-15-32-28(30)26-21(16-38-27(20)26)18-10-11-22(25(14-18)37-3)33-29(36)24-13-19-7-4-5-9-23(19)34(24)2/h4-11,13-16H,12H2,1-3H3,(H2,30,32)(H,31,35)(H,33,36)/b8-6+
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n/an/a 2.36E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202740
PNG
(CHEMBL232126 | trans-N-(4-(4-amino-7-(3-hydroxypro...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CO)cnc(N)c12
Show InChI InChI=1S/C27H24N4O3S/c1-31-21-8-4-3-6-17(21)12-22(31)27(33)30-20-10-9-16(13-23(20)34-2)19-15-35-25-18(7-5-11-32)14-29-26(28)24(19)25/h3-10,12-15,32H,11H2,1-2H3,(H2,28,29)(H,30,33)/b7-5+
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n/an/a 2.36E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202745
PNG
(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-carbo...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(cnc(N)c12)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C31H32N6O3S/c1-36-24-8-4-3-7-20(24)15-25(36)31(39)35-23-10-9-19(16-26(23)40-2)22-18-41-28-21(17-34-29(32)27(22)28)30(38)33-11-14-37-12-5-6-13-37/h3-4,7-10,15-18H,5-6,11-14H2,1-2H3,(H2,32,34)(H,33,38)(H,35,39)
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n/an/a 2.55E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202756
PNG
(CHEMBL233540 | N-(4-(4-amino-7-(3-(4-phenylpiperaz...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCN(CC3)c3ccccc3)cnc(N)c12
Show InChI InChI=1S/C37H36N6O2S/c1-41-31-13-7-6-9-26(31)21-32(41)37(44)40-30-15-14-25(22-33(30)45-2)29-24-46-35-27(23-39-36(38)34(29)35)10-8-16-42-17-19-43(20-18-42)28-11-4-3-5-12-28/h3-15,21-24H,16-20H2,1-2H3,(H2,38,39)(H,40,44)/b10-8+
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n/an/a 2.95E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50202739
PNG
(CHEMBL395664 | N-(4-(4-amino-7-(3-(piperidin-4-yla...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC3CCNCC3)cnc(N)c12
Show InChI InChI=1S/C32H34N6O2S/c1-38-26-8-4-3-6-21(26)16-27(38)32(39)37-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-36-31(33)29(24)30)7-5-13-35-23-11-14-34-15-12-23/h3-10,16-19,23,34-35H,11-15H2,1-2H3,(H2,33,36)(H,37,39)/b7-5+
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n/an/a 3.70E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50202739
PNG
(CHEMBL395664 | N-(4-(4-amino-7-(3-(piperidin-4-yla...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC3CCNCC3)cnc(N)c12
Show InChI InChI=1S/C32H34N6O2S/c1-38-26-8-4-3-6-21(26)16-27(38)32(39)37-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-36-31(33)29(24)30)7-5-13-35-23-11-14-34-15-12-23/h3-10,16-19,23,34-35H,11-15H2,1-2H3,(H2,33,36)(H,37,39)/b7-5+
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n/an/a 3.70E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lyn


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202748
PNG
(CHEMBL232731 | N-(4-(4-amino-7-(3-(methylsulfonami...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNS(C)(=O)=O)cnc(N)c12
Show InChI InChI=1S/C28H27N5O4S2/c1-33-22-9-5-4-7-18(22)13-23(33)28(34)32-21-11-10-17(14-24(21)37-2)20-16-38-26-19(15-30-27(29)25(20)26)8-6-12-31-39(3,35)36/h4-11,13-16,31H,12H2,1-3H3,(H2,29,30)(H,32,34)/b8-6+
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n/an/a 4.30E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202750
PNG
(CHEMBL391247 | cis-N-(4-(4-amino-7-(3-(diethylamin...)
Show SMILES CCN(CC)C\C=C/c1cnc(N)c2c(csc12)-c1ccc(NC(=O)c2cc3ccccc3n2C)c(OC)c1
Show InChI InChI=1S/C31H33N5O2S/c1-5-36(6-2)15-9-11-22-18-33-30(32)28-23(19-39-29(22)28)20-13-14-24(27(17-20)38-4)34-31(37)26-16-21-10-7-8-12-25(21)35(26)3/h7-14,16-19H,5-6,15H2,1-4H3,(H2,32,33)(H,34,37)/b11-9-
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n/an/a 4.47E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202755
PNG
(CHEMBL391044 | N-(4-(4-amino-7-(3-hydroxypropyl)th...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(CCCO)cnc(N)c12
Show InChI InChI=1S/C27H26N4O3S/c1-31-21-8-4-3-6-17(21)12-22(31)27(33)30-20-10-9-16(13-23(20)34-2)19-15-35-25-18(7-5-11-32)14-29-26(28)24(19)25/h3-4,6,8-10,12-15,32H,5,7,11H2,1-2H3,(H2,28,29)(H,30,33)
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n/an/a 4.81E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202758
PNG
(CHEMBL391475 | N-(4-(4-aminothieno[3,2-c]pyridin-3...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2ccnc(N)c12
Show InChI InChI=1S/C24H20N4O2S/c1-28-18-6-4-3-5-15(18)11-19(28)24(29)27-17-8-7-14(12-20(17)30-2)16-13-31-21-9-10-26-23(25)22(16)21/h3-13H,1-2H3,(H2,25,26)(H,27,29)
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n/an/a 5.20E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50202741
PNG
(CHEMBL233958 | N-(4-(4-amino-7-(3-(4-hydroxypiperi...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCC(O)CC3)cnc(N)c12
Show InChI InChI=1S/C32H33N5O3S/c1-36-26-8-4-3-6-21(26)16-27(36)32(39)35-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-34-31(33)29(24)30)7-5-13-37-14-11-23(38)12-15-37/h3-10,16-19,23,38H,11-15H2,1-2H3,(H2,33,34)(H,35,39)/b7-5+
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n/an/a 5.30E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lyn


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202754
PNG
(CHEMBL395662 | N-(4-(4-amino-7-(3-(4-methylpiperaz...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCN(C)CC3)cnc(N)c12
Show InChI InChI=1S/C32H34N6O2S/c1-36-13-15-38(16-14-36)12-6-8-23-19-34-31(33)29-24(20-41-30(23)29)21-10-11-25(28(18-21)40-3)35-32(39)27-17-22-7-4-5-9-26(22)37(27)2/h4-11,17-20H,12-16H2,1-3H3,(H2,33,34)(H,35,39)/b8-6+
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n/an/a 5.97E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202751
PNG
(1-(3-(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC(=O)Nc3ccccc3)cnc(N)c12
Show InChI InChI=1S/C34H30N6O3S/c1-40-27-13-7-6-9-22(27)17-28(40)33(41)39-26-15-14-21(18-29(26)43-2)25-20-44-31-23(19-37-32(35)30(25)31)10-8-16-36-34(42)38-24-11-4-3-5-12-24/h3-15,17-20H,16H2,1-2H3,(H2,35,37)(H,39,41)(H2,36,38,42)/b10-8+
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n/an/a 6.70E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202752
PNG
(1-(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-ca...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(NC(=O)NCCN3CCCC3)cnc(N)c12
Show InChI InChI=1S/C31H33N7O3S/c1-37-24-8-4-3-7-20(24)15-25(37)30(39)35-22-10-9-19(16-26(22)41-2)21-18-42-28-23(17-34-29(32)27(21)28)36-31(40)33-11-14-38-12-5-6-13-38/h3-4,7-10,15-18H,5-6,11-14H2,1-2H3,(H2,32,34)(H,35,39)(H2,33,36,40)
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n/an/a 6.85E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202738
PNG
(CHEMBL232127 | trans-N-(4-(4-amino-7-(3-aminoprop-...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN)cnc(N)c12
Show InChI InChI=1S/C27H25N5O2S/c1-32-21-8-4-3-6-17(21)12-22(32)27(33)31-20-10-9-16(13-23(20)34-2)19-15-35-25-18(7-5-11-28)14-30-26(29)24(19)25/h3-10,12-15H,11,28H2,1-2H3,(H2,29,30)(H,31,33)/b7-5+
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n/an/a 8.80E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50202734
PNG
(CHEMBL232542 | N-(4-(4-amino-7-(3-(diethylamino)pr...)
Show SMILES CCN(CC)C\C=C\c1cnc(N)c2c(csc12)-c1ccc(NC(=O)c2cc3ccccc3n2C)c(OC)c1
Show InChI InChI=1S/C31H33N5O2S/c1-5-36(6-2)15-9-11-22-18-33-30(32)28-23(19-39-29(22)28)20-13-14-24(27(17-20)38-4)34-31(37)26-16-21-10-7-8-12-25(21)35(26)3/h7-14,16-19H,5-6,15H2,1-4H3,(H2,32,33)(H,34,37)/b11-9+
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n/an/a 9.05E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Src


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202743
PNG
(CHEMBL233965 | N-(4-(4,7-diaminothieno[3,2-c]pyrid...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(N)cnc(N)c12
Show InChI InChI=1S/C24H21N5O2S/c1-29-18-6-4-3-5-14(18)9-19(29)24(30)28-17-8-7-13(10-20(17)31-2)15-12-32-22-16(25)11-27-23(26)21(15)22/h3-12H,25H2,1-2H3,(H2,26,27)(H,28,30)
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n/an/a 9.65E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202741
PNG
(CHEMBL233958 | N-(4-(4-amino-7-(3-(4-hydroxypiperi...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCC(O)CC3)cnc(N)c12
Show InChI InChI=1S/C32H33N5O3S/c1-36-26-8-4-3-6-21(26)16-27(36)32(39)35-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-34-31(33)29(24)30)7-5-13-37-14-11-23(38)12-15-37/h3-10,16-19,23,38H,11-15H2,1-2H3,(H2,33,34)(H,35,39)/b7-5+
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n/an/a 1.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50202741
PNG
(CHEMBL233958 | N-(4-(4-amino-7-(3-(4-hydroxypiperi...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCC(O)CC3)cnc(N)c12
Show InChI InChI=1S/C32H33N5O3S/c1-36-26-8-4-3-6-21(26)16-27(36)32(39)35-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-34-31(33)29(24)30)7-5-13-37-14-11-23(38)12-15-37/h3-10,16-19,23,38H,11-15H2,1-2H3,(H2,33,34)(H,35,39)/b7-5+
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n/an/a 1.01E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202746
PNG
(CHEMBL395663 | N-(4-(4-amino-7-(3-(4-methyl-3-oxop...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(C=CCN3CCN(C)C(=O)C3)cnc(N)c12
Show InChI InChI=1S/C32H32N6O3S/c1-36-13-14-38(18-28(36)39)12-6-8-22-17-34-31(33)29-23(19-42-30(22)29)20-10-11-24(27(16-20)41-3)35-32(40)26-15-21-7-4-5-9-25(21)37(26)2/h4-11,15-17,19H,12-14,18H2,1-3H3,(H2,33,34)(H,35,40)
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n/an/a 1.29E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50202735
PNG
(CHEMBL395666 | N-(4-(4-amino-7-(3-((1s,4s)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24+
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n/an/a 1.29E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lyn


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202734
PNG
(CHEMBL232542 | N-(4-(4-amino-7-(3-(diethylamino)pr...)
Show SMILES CCN(CC)C\C=C\c1cnc(N)c2c(csc12)-c1ccc(NC(=O)c2cc3ccccc3n2C)c(OC)c1
Show InChI InChI=1S/C31H33N5O2S/c1-5-36(6-2)15-9-11-22-18-33-30(32)28-23(19-39-29(22)28)20-13-14-24(27(17-20)38-4)34-31(37)26-16-21-10-7-8-12-25(21)35(26)3/h7-14,16-19H,5-6,15H2,1-4H3,(H2,32,33)(H,34,37)/b11-9+
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n/an/a 1.36E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50202734
PNG
(CHEMBL232542 | N-(4-(4-amino-7-(3-(diethylamino)pr...)
Show SMILES CCN(CC)C\C=C\c1cnc(N)c2c(csc12)-c1ccc(NC(=O)c2cc3ccccc3n2C)c(OC)c1
Show InChI InChI=1S/C31H33N5O2S/c1-5-36(6-2)15-9-11-22-18-33-30(32)28-23(19-39-29(22)28)20-13-14-24(27(17-20)38-4)34-31(37)26-16-21-10-7-8-12-25(21)35(26)3/h7-14,16-19H,5-6,15H2,1-4H3,(H2,32,33)(H,34,37)/b11-9+
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n/an/a 1.41E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Fgr


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50202739
PNG
(CHEMBL395664 | N-(4-(4-amino-7-(3-(piperidin-4-yla...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC3CCNCC3)cnc(N)c12
Show InChI InChI=1S/C32H34N6O2S/c1-38-26-8-4-3-6-21(26)16-27(38)32(39)37-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-36-31(33)29(24)30)7-5-13-35-23-11-14-34-15-12-23/h3-10,16-19,23,34-35H,11-15H2,1-2H3,(H2,33,36)(H,37,39)/b7-5+
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n/an/a 1.44E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Src


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202749
PNG
(CHEMBL232335 | N-(4-(4-amino-7-(1-methylpiperazine...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(cnc(N)c12)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C30H30N6O3S/c1-34-10-12-36(13-11-34)30(38)20-16-32-28(31)26-21(17-40-27(20)26)18-8-9-22(25(15-18)39-3)33-29(37)24-14-19-6-4-5-7-23(19)35(24)2/h4-9,14-17H,10-13H2,1-3H3,(H2,31,32)(H,33,37)
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n/an/a 1.76E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50202737
PNG
(CHEMBL395665 | N-(4-(4-amino-7-(3-((1r,4r)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24-
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n/an/a 1.79E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Fgr


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50202737
PNG
(CHEMBL395665 | N-(4-(4-amino-7-(3-((1r,4r)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24-
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n/an/a 1.85E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lyn


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50202737
PNG
(CHEMBL395665 | N-(4-(4-amino-7-(3-((1r,4r)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24-
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n/an/a 1.85E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50202737
PNG
(CHEMBL395665 | N-(4-(4-amino-7-(3-((1r,4r)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24-
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n/an/a 1.97E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Src


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202735
PNG
(CHEMBL395666 | N-(4-(4-amino-7-(3-((1s,4s)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24+
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n/an/a 2.01E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202742
PNG
(CHEMBL397143 | N-(4-(4-amino-7-(3-(pyrrolidin-1-yl...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(NC(=O)CCN3CCCC3)cnc(N)c12
Show InChI InChI=1S/C31H32N6O3S/c1-36-24-8-4-3-7-20(24)15-25(36)31(39)35-22-10-9-19(16-26(22)40-2)21-18-41-29-23(17-33-30(32)28(21)29)34-27(38)11-14-37-12-5-6-13-37/h3-4,7-10,15-18H,5-6,11-14H2,1-2H3,(H2,32,33)(H,34,38)(H,35,39)
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n/an/a 2.08E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50202735
PNG
(CHEMBL395666 | N-(4-(4-amino-7-(3-((1s,4s)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24+
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n/an/a 2.17E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Fgr


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202751
PNG
(1-(3-(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC(=O)Nc3ccccc3)cnc(N)c12
Show InChI InChI=1S/C34H30N6O3S/c1-40-27-13-7-6-9-22(27)17-28(40)33(41)39-26-15-14-21(18-29(26)43-2)25-20-44-31-23(19-37-32(35)30(25)31)10-8-16-36-34(42)38-24-11-4-3-5-12-24/h3-15,17-20H,16H2,1-2H3,(H2,35,37)(H,39,41)(H2,36,38,42)/b10-8+
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n/an/a 2.19E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202737
PNG
(CHEMBL395665 | N-(4-(4-amino-7-(3-((1r,4r)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24-
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n/an/a 2.41E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202739
PNG
(CHEMBL395664 | N-(4-(4-amino-7-(3-(piperidin-4-yla...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC3CCNCC3)cnc(N)c12
Show InChI InChI=1S/C32H34N6O2S/c1-38-26-8-4-3-6-21(26)16-27(38)32(39)37-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-36-31(33)29(24)30)7-5-13-35-23-11-14-34-15-12-23/h3-10,16-19,23,34-35H,11-15H2,1-2H3,(H2,33,36)(H,37,39)/b7-5+
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n/an/a 2.42E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50202737
PNG
(CHEMBL395665 | N-(4-(4-amino-7-(3-((1r,4r)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24-
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n/an/a 2.59E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Fyn


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50202739
PNG
(CHEMBL395664 | N-(4-(4-amino-7-(3-(piperidin-4-yla...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC3CCNCC3)cnc(N)c12
Show InChI InChI=1S/C32H34N6O2S/c1-38-26-8-4-3-6-21(26)16-27(38)32(39)37-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-36-31(33)29(24)30)7-5-13-35-23-11-14-34-15-12-23/h3-10,16-19,23,34-35H,11-15H2,1-2H3,(H2,33,36)(H,37,39)/b7-5+
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n/an/a 2.62E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Fyn


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50202735
PNG
(CHEMBL395666 | N-(4-(4-amino-7-(3-((1s,4s)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24+
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n/an/a 2.63E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Fyn


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50202739
PNG
(CHEMBL395664 | N-(4-(4-amino-7-(3-(piperidin-4-yla...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC3CCNCC3)cnc(N)c12
Show InChI InChI=1S/C32H34N6O2S/c1-38-26-8-4-3-6-21(26)16-27(38)32(39)37-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-36-31(33)29(24)30)7-5-13-35-23-11-14-34-15-12-23/h3-10,16-19,23,34-35H,11-15H2,1-2H3,(H2,33,36)(H,37,39)/b7-5+
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n/an/a 2.65E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Fgr


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50202735
PNG
(CHEMBL395666 | N-(4-(4-amino-7-(3-((1s,4s)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24+
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n/an/a 2.71E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Src


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50202741
PNG
(CHEMBL233958 | N-(4-(4-amino-7-(3-(4-hydroxypiperi...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCC(O)CC3)cnc(N)c12
Show InChI InChI=1S/C32H33N5O3S/c1-36-26-8-4-3-6-21(26)16-27(36)32(39)35-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-34-31(33)29(24)30)7-5-13-37-14-11-23(38)12-15-37/h3-10,16-19,23,38H,11-15H2,1-2H3,(H2,33,34)(H,35,39)/b7-5+
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n/an/a 3.39E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Src


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50202741
PNG
(CHEMBL233958 | N-(4-(4-amino-7-(3-(4-hydroxypiperi...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCC(O)CC3)cnc(N)c12
Show InChI InChI=1S/C32H33N5O3S/c1-36-26-8-4-3-6-21(26)16-27(36)32(39)35-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-34-31(33)29(24)30)7-5-13-37-14-11-23(38)12-15-37/h3-10,16-19,23,38H,11-15H2,1-2H3,(H2,33,34)(H,35,39)/b7-5+
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n/an/a 3.51E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Fyn


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50202741
PNG
(CHEMBL233958 | N-(4-(4-amino-7-(3-(4-hydroxypiperi...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCC(O)CC3)cnc(N)c12
Show InChI InChI=1S/C32H33N5O3S/c1-36-26-8-4-3-6-21(26)16-27(36)32(39)35-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-34-31(33)29(24)30)7-5-13-37-14-11-23(38)12-15-37/h3-10,16-19,23,38H,11-15H2,1-2H3,(H2,33,34)(H,35,39)/b7-5+
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n/an/a 3.79E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Fgr


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50202734
PNG
(CHEMBL232542 | N-(4-(4-amino-7-(3-(diethylamino)pr...)
Show SMILES CCN(CC)C\C=C\c1cnc(N)c2c(csc12)-c1ccc(NC(=O)c2cc3ccccc3n2C)c(OC)c1
Show InChI InChI=1S/C31H33N5O2S/c1-5-36(6-2)15-9-11-22-18-33-30(32)28-23(19-39-29(22)28)20-13-14-24(27(17-20)38-4)34-31(37)26-16-21-10-7-8-12-25(21)35(26)3/h7-14,16-19H,5-6,15H2,1-4H3,(H2,32,33)(H,34,37)/b11-9+
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n/an/a 4.41E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Fyn


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202742
PNG
(CHEMBL397143 | N-(4-(4-amino-7-(3-(pyrrolidin-1-yl...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(NC(=O)CCN3CCCC3)cnc(N)c12
Show InChI InChI=1S/C31H32N6O3S/c1-36-24-8-4-3-7-20(24)15-25(36)31(39)35-22-10-9-19(16-26(22)40-2)21-18-41-29-23(17-33-30(32)28(21)29)34-27(38)11-14-37-12-5-6-13-37/h3-4,7-10,15-18H,5-6,11-14H2,1-2H3,(H2,32,33)(H,34,38)(H,35,39)
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n/an/a 4.53E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50202734
PNG
(CHEMBL232542 | N-(4-(4-amino-7-(3-(diethylamino)pr...)
Show SMILES CCN(CC)C\C=C\c1cnc(N)c2c(csc12)-c1ccc(NC(=O)c2cc3ccccc3n2C)c(OC)c1
Show InChI InChI=1S/C31H33N5O2S/c1-5-36(6-2)15-9-11-22-18-33-30(32)28-23(19-39-29(22)28)20-13-14-24(27(17-20)38-4)34-31(37)26-16-21-10-7-8-12-25(21)35(26)3/h7-14,16-19H,5-6,15H2,1-4H3,(H2,32,33)(H,34,37)/b11-9+
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202750
PNG
(CHEMBL391247 | cis-N-(4-(4-amino-7-(3-(diethylamin...)
Show SMILES CCN(CC)C\C=C/c1cnc(N)c2c(csc12)-c1ccc(NC(=O)c2cc3ccccc3n2C)c(OC)c1
Show InChI InChI=1S/C31H33N5O2S/c1-5-36(6-2)15-9-11-22-18-33-30(32)28-23(19-39-29(22)28)20-13-14-24(27(17-20)38-4)34-31(37)26-16-21-10-7-8-12-25(21)35(26)3/h7-14,16-19H,5-6,15H2,1-4H3,(H2,32,33)(H,34,37)/b11-9-
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202747
PNG
(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-carbo...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(cnc(N)c12)C(O)=O
Show InChI InChI=1S/C25H20N4O4S/c1-29-18-6-4-3-5-14(18)9-19(29)24(30)28-17-8-7-13(10-20(17)33-2)16-12-34-22-15(25(31)32)11-27-23(26)21(16)22/h3-12H,1-2H3,(H2,26,27)(H,28,30)(H,31,32)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202743
PNG
(CHEMBL233965 | N-(4-(4,7-diaminothieno[3,2-c]pyrid...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(N)cnc(N)c12
Show InChI InChI=1S/C24H21N5O2S/c1-29-18-6-4-3-5-14(18)9-19(29)24(30)28-17-8-7-13(10-20(17)31-2)15-12-32-22-16(25)11-27-23(26)21(15)22/h3-12H,25H2,1-2H3,(H2,26,27)(H,28,30)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202755
PNG
(CHEMBL391044 | N-(4-(4-amino-7-(3-hydroxypropyl)th...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(CCCO)cnc(N)c12
Show InChI InChI=1S/C27H26N4O3S/c1-31-21-8-4-3-6-17(21)12-22(31)27(33)30-20-10-9-16(13-23(20)34-2)19-15-35-25-18(7-5-11-32)14-29-26(28)24(19)25/h3-4,6,8-10,12-15,32H,5,7,11H2,1-2H3,(H2,28,29)(H,30,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50202735
PNG
(CHEMBL395666 | N-(4-(4-amino-7-(3-((1s,4s)-4-amino...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@@H]3CC[C@H](N)CC3)cnc(N)c12
Show InChI InChI=1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24+
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50202734
PNG
(CHEMBL232542 | N-(4-(4-amino-7-(3-(diethylamino)pr...)
Show SMILES CCN(CC)C\C=C\c1cnc(N)c2c(csc12)-c1ccc(NC(=O)c2cc3ccccc3n2C)c(OC)c1
Show InChI InChI=1S/C31H33N5O2S/c1-5-36(6-2)15-9-11-22-18-33-30(32)28-23(19-39-29(22)28)20-13-14-24(27(17-20)38-4)34-31(37)26-16-21-10-7-8-12-25(21)35(26)3/h7-14,16-19H,5-6,15H2,1-4H3,(H2,32,33)(H,34,37)/b11-9+
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50202741
PNG
(CHEMBL233958 | N-(4-(4-amino-7-(3-(4-hydroxypiperi...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCC(O)CC3)cnc(N)c12
Show InChI InChI=1S/C32H33N5O3S/c1-36-26-8-4-3-6-21(26)16-27(36)32(39)35-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-34-31(33)29(24)30)7-5-13-37-14-11-23(38)12-15-37/h3-10,16-19,23,38H,11-15H2,1-2H3,(H2,33,34)(H,35,39)/b7-5+
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202749
PNG
(CHEMBL232335 | N-(4-(4-amino-7-(1-methylpiperazine...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(cnc(N)c12)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C30H30N6O3S/c1-34-10-12-36(13-11-34)30(38)20-16-32-28(31)26-21(17-40-27(20)26)18-8-9-22(25(15-18)39-3)33-29(37)24-14-19-6-4-5-7-23(19)35(24)2/h4-9,14-17H,10-13H2,1-3H3,(H2,31,32)(H,33,37)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202752
PNG
(1-(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-ca...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(NC(=O)NCCN3CCCC3)cnc(N)c12
Show InChI InChI=1S/C31H33N7O3S/c1-37-24-8-4-3-7-20(24)15-25(37)30(39)35-22-10-9-19(16-26(22)41-2)21-18-42-28-23(17-34-29(32)27(21)28)36-31(40)33-11-14-38-12-5-6-13-38/h3-4,7-10,15-18H,5-6,11-14H2,1-2H3,(H2,32,34)(H,35,39)(H2,33,36,40)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50202747
PNG
(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-carbo...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(cnc(N)c12)C(O)=O
Show InChI InChI=1S/C25H20N4O4S/c1-29-18-6-4-3-5-14(18)9-19(29)24(30)28-17-8-7-13(10-20(17)33-2)16-12-34-22-15(25(31)32)11-27-23(26)21(16)22/h3-12H,1-2H3,(H2,26,27)(H,28,30)(H,31,32)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50202739
PNG
(CHEMBL395664 | N-(4-(4-amino-7-(3-(piperidin-4-yla...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CNC3CCNCC3)cnc(N)c12
Show InChI InChI=1S/C32H34N6O2S/c1-38-26-8-4-3-6-21(26)16-27(38)32(39)37-25-10-9-20(17-28(25)40-2)24-19-41-30-22(18-36-31(33)29(24)30)7-5-13-35-23-11-14-34-15-12-23/h3-10,16-19,23,34-35H,11-15H2,1-2H3,(H2,33,36)(H,37,39)/b7-5+
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50202756
PNG
(CHEMBL233540 | N-(4-(4-amino-7-(3-(4-phenylpiperaz...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN3CCN(CC3)c3ccccc3)cnc(N)c12
Show InChI InChI=1S/C37H36N6O2S/c1-41-31-13-7-6-9-26(31)21-32(41)37(44)40-30-15-14-25(22-33(30)45-2)29-24-46-35-27(23-39-36(38)34(29)35)10-8-16-42-17-19-43(20-18-42)28-11-4-3-5-12-28/h3-15,21-24H,16-20H2,1-2H3,(H2,38,39)(H,40,44)/b10-8+
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Hck


Bioorg Med Chem Lett 17: 1167-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.035
BindingDB Entry DOI: 10.7270/Q24Q7TN6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%