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PubMed code 17239587

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203095
PNG
(4-((4-bromo-5-methoxy-1-methyl-1H-indol-3-yl)methy...)
Show SMILES COc1ccc2n(C)cc(\C=C3/C(=O)NN=C3c3cnns3)c2c1Br
Show InChI InChI=1S/C16H12BrN5O2S/c1-22-7-8(13-10(22)3-4-11(24-2)14(13)17)5-9-15(19-20-16(9)23)12-6-18-21-25-12/h3-7H,1-2H3,(H,20,23)/b9-5-
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n/an/a 6n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203075
PNG
(4-((4-bromo-1-methyl-1H-indol-3-yl)methylene)-3-(1...)
Show SMILES Cn1cc(\C=C2/C(=O)NN=C2c2cnns2)c2c(Br)cccc12
Show InChI InChI=1S/C15H10BrN5OS/c1-21-7-8(13-10(16)3-2-4-11(13)21)5-9-14(18-19-15(9)22)12-6-17-20-23-12/h2-7H,1H3,(H,19,22)/b9-5-
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n/an/a 8n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203079
PNG
(4-((4,7-dimethoxy-1-methyl-1H-indol-3-yl)methylene...)
Show SMILES COc1ccc(OC)c2n(C)cc(\C=C3/C(=O)NN=C3c3cnns3)c12
Show InChI InChI=1S/C17H15N5O3S/c1-22-8-9(14-11(24-2)4-5-12(25-3)16(14)22)6-10-15(19-20-17(10)23)13-7-18-21-26-13/h4-8H,1-3H3,(H,20,23)/b10-6-
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n/an/a 10n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203103
PNG
(4-((4-bromo-1,6-dimethyl-1H-indol-3-yl)methylene)-...)
Show SMILES Cc1cc(Br)c2c(\C=C3/C(=O)NN=C3c3cnns3)cn(C)c2c1
Show InChI InChI=1S/C16H12BrN5OS/c1-8-3-11(17)14-9(7-22(2)12(14)4-8)5-10-15(19-20-16(10)23)13-6-18-21-24-13/h3-7H,1-2H3,(H,20,23)/b10-5-
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n/an/a 12n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203106
PNG
(4-((4-methoxy-1-methyl-1H-indol-3-yl)methylene)-3-...)
Show SMILES COc1cccc2n(C)cc(\C=C3/C(=O)NN=C3c3cnns3)c12
Show InChI InChI=1S/C16H13N5O2S/c1-21-8-9(14-11(21)4-3-5-12(14)23-2)6-10-15(18-19-16(10)22)13-7-17-20-24-13/h3-8H,1-2H3,(H,19,22)/b10-6-
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n/an/a 13n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50203074
PNG
(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES CCOc1cccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12
Show InChI InChI=1S/C18H17N5O2S/c1-4-25-14-7-5-6-13-15(14)11(9-23(13)3)8-12-16(20-21-18(12)24)17-10(2)19-22-26-17/h5-9,20H,2,4H2,1,3H3,(H,21,24)/b12-8?,17-16-
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n/an/a 16n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203085
PNG
(4-((4-chloro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES Cn1cc(\C=C2/C(=O)NN=C2c2cnns2)c2c(Cl)cccc12
Show InChI InChI=1S/C15H10ClN5OS/c1-21-7-8(13-10(16)3-2-4-11(13)21)5-9-14(18-19-15(9)22)12-6-17-20-23-12/h2-7H,1H3,(H,19,22)/b9-5-
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n/an/a 16n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203097
PNG
(4-((4-fluoro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES Cn1cc(\C=C2/C(=O)NN=C2c2cnns2)c2c(F)cccc12
Show InChI InChI=1S/C15H10FN5OS/c1-21-7-8(13-10(16)3-2-4-11(13)21)5-9-14(18-19-15(9)22)12-6-17-20-23-12/h2-7H,1H3,(H,19,22)/b9-5-
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n/an/a 16n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50203074
PNG
(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES CCOc1cccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12
Show InChI InChI=1S/C18H17N5O2S/c1-4-25-14-7-5-6-13-15(14)11(9-23(13)3)8-12-16(20-21-18(12)24)17-10(2)19-22-26-17/h5-9,20H,2,4H2,1,3H3,(H,21,24)/b12-8?,17-16-
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n/an/a 19n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203091
PNG
(4-((4-methoxy-1-methyl-1H-indol-3-yl)methylene)-3-...)
Show SMILES COc1cccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12
Show InChI InChI=1S/C17H15N5O2S/c1-9-16(25-21-18-9)15-11(17(23)20-19-15)7-10-8-22(2)12-5-4-6-13(24-3)14(10)12/h4-8,19H,1H2,2-3H3,(H,20,23)/b11-7?,16-15-
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n/an/a 19n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203098
PNG
(4-((4,7-dimethoxy-1-methyl-1H-indol-3-yl)methylene...)
Show SMILES COc1ccc(OC)c2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12
Show InChI InChI=1S/C18H17N5O3S/c1-9-17(27-22-19-9)15-11(18(24)21-20-15)7-10-8-23(2)16-13(26-4)6-5-12(25-3)14(10)16/h5-8,20H,1H2,2-4H3,(H,21,24)/b11-7?,17-15-
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n/an/a 20n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203089
PNG
(CHEMBL398459 | methyl 1-methyl-3-((5-oxo-3-(1,2,3-...)
Show SMILES COC(=O)c1cccc2n(C)cc(\C=C3/C(=O)NN=C3c3cnns3)c12
Show InChI InChI=1S/C17H13N5O3S/c1-22-8-9(14-10(17(24)25-2)4-3-5-12(14)22)6-11-15(19-20-16(11)23)13-7-18-21-26-13/h3-8H,1-2H3,(H,20,23)/b11-6-
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n/an/a 22n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203109
PNG
(4-((4-bromo-5-methoxy-1-methyl-1H-indol-3-yl)methy...)
Show SMILES COc1ccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c2c1Br
Show InChI InChI=1S/C17H14BrN5O2S/c1-8-16(26-22-19-8)15-10(17(24)21-20-15)6-9-7-23(2)11-4-5-12(25-3)14(18)13(9)11/h4-7,20H,1H2,2-3H3,(H,21,24)/b10-6?,16-15-
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n/an/a 23n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203108
PNG
(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES CCOc1cccc2n(C)cc(\C=C3/C(=O)NN=C3c3cnns3)c12
Show InChI InChI=1S/C17H15N5O2S/c1-3-24-13-6-4-5-12-15(13)10(9-22(12)2)7-11-16(19-20-17(11)23)14-8-18-21-25-14/h4-9H,3H2,1-2H3,(H,20,23)/b11-7-
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n/an/a 25n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203078
PNG
(4-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)-3-...)
Show SMILES COc1ccc2n(C)cc(\C=C3/C(=O)NN=C3c3cnns3)c2c1
Show InChI InChI=1S/C16H13N5O2S/c1-21-8-9(11-6-10(23-2)3-4-13(11)21)5-12-15(18-19-16(12)22)14-7-17-20-24-14/h3-8H,1-2H3,(H,19,22)/b12-5-
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n/an/a 28n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203090
PNG
(4-((4-bromo-1-methyl-1H-indol-3-yl)methylene)-3-(4...)
Show SMILES Cn1cc(C=c2c(=O)[nH][nH]\c2=c2/snnc2=C)c2c(Br)cccc12
Show InChI InChI=1S/C16H12BrN5OS/c1-8-15(24-21-18-8)14-10(16(23)20-19-14)6-9-7-22(2)12-5-3-4-11(17)13(9)12/h3-7,19H,1H2,2H3,(H,20,23)/b10-6?,15-14-
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n/an/a 34n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203093
PNG
(4-((5-chloro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES Cn1cc(\C=C2/C(=O)NN=C2c2cnns2)c2cc(Cl)ccc12
Show InChI InChI=1S/C15H10ClN5OS/c1-21-7-8(10-5-9(16)2-3-12(10)21)4-11-14(18-19-15(11)22)13-6-17-20-23-13/h2-7H,1H3,(H,19,22)/b11-4-
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n/an/a 34n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203077
PNG
(4-((1,5-dimethyl-1H-indol-3-yl)methylene)-3-(1,2,3...)
Show SMILES Cc1ccc2n(C)cc(\C=C3/C(=O)NN=C3c3cnns3)c2c1
Show InChI InChI=1S/C16H13N5OS/c1-9-3-4-13-11(5-9)10(8-21(13)2)6-12-15(18-19-16(12)22)14-7-17-20-23-14/h3-8H,1-2H3,(H,19,22)/b12-6-
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n/an/a 35n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50203074
PNG
(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES CCOc1cccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12
Show InChI InChI=1S/C18H17N5O2S/c1-4-25-14-7-5-6-13-15(14)11(9-23(13)3)8-12-16(20-21-18(12)24)17-10(2)19-22-26-17/h5-9,20H,2,4H2,1,3H3,(H,21,24)/b12-8?,17-16-
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n/an/a 36n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of TRK A


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203074
PNG
(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES CCOc1cccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12
Show InChI InChI=1S/C18H17N5O2S/c1-4-25-14-7-5-6-13-15(14)11(9-23(13)3)8-12-16(20-21-18(12)24)17-10(2)19-22-26-17/h5-9,20H,2,4H2,1,3H3,(H,21,24)/b12-8?,17-16-
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n/an/a 38n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203099
PNG
(4-((4-chloro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES Cn1cc(C=c2c(=O)[nH][nH]\c2=c2/snnc2=C)c2c(Cl)cccc12
Show InChI InChI=1S/C16H12ClN5OS/c1-8-15(24-21-18-8)14-10(16(23)20-19-14)6-9-7-22(2)12-5-3-4-11(17)13(9)12/h3-7,19H,1H2,2H3,(H,20,23)/b10-6?,15-14-
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n/an/a 45n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203082
PNG
(4-((5-fluoro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES Cn1cc(\C=C2/C(=O)NN=C2c2cnns2)c2cc(F)ccc12
Show InChI InChI=1S/C15H10FN5OS/c1-21-7-8(10-5-9(16)2-3-12(10)21)4-11-14(18-19-15(11)22)13-6-17-20-23-13/h2-7H,1H3,(H,19,22)/b11-4-
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n/an/a 48n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203081
PNG
(4-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)-3-...)
Show SMILES O=C1NN=C(\C1=C\c1cc2CCCCc2[nH]1)c1cnns1
Show InChI InChI=1S/C14H13N5OS/c20-14-10(13(17-18-14)12-7-15-19-21-12)6-9-5-8-3-1-2-4-11(8)16-9/h5-7,16H,1-4H2,(H,18,20)/b10-6-
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n/an/a 56n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203107
PNG
(4-((1,4-dimethyl-1H-indol-3-yl)methylene)-3-(4-met...)
Show SMILES Cc1cccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12
Show InChI InChI=1S/C17H15N5OS/c1-9-5-4-6-13-14(9)11(8-22(13)3)7-12-15(19-20-17(12)23)16-10(2)18-21-24-16/h4-8,19H,2H2,1,3H3,(H,20,23)/b12-7?,16-15-
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n/an/a 58n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203094
PNG
(4-((6-chloro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES Cn1cc(\C=C2/C(=O)NN=C2c2cnns2)c2ccc(Cl)cc12
Show InChI InChI=1S/C15H10ClN5OS/c1-21-7-8(10-3-2-9(16)5-12(10)21)4-11-14(18-19-15(11)22)13-6-17-20-23-13/h2-7H,1H3,(H,19,22)/b11-4-
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n/an/a 73n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203100
PNG
(CHEMBL249381 | methyl 1-methyl-3-((5-oxo-3-(1,2,3-...)
Show SMILES COC(=O)c1ccc2n(C)cc(\C=C3/C(=O)NN=C3c3cnns3)c2c1
Show InChI InChI=1S/C17H13N5O3S/c1-22-8-10(11-5-9(17(24)25-2)3-4-13(11)22)6-12-15(19-20-16(12)23)14-7-18-21-26-14/h3-8H,1-2H3,(H,20,23)/b12-6-
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n/an/a 73n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203096
PNG
(4-((4-bromo-1-methyl-1H-indol-3-yl)methylene)-3-(4...)
Show SMILES Cn1cc(\C=C2/C(=O)NN=C2c2snnc2-c2ccccc2)c2c(Br)cccc12
Show InChI InChI=1S/C21H14BrN5OS/c1-27-11-13(17-15(22)8-5-9-16(17)27)10-14-19(23-25-21(14)28)20-18(24-26-29-20)12-6-3-2-4-7-12/h2-11H,1H3,(H,25,28)/b14-10-
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n/an/a 89n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203102
PNG
(4-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)-3-...)
Show SMILES COc1ccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c2c1
Show InChI InChI=1S/C17H15N5O2S/c1-9-16(25-21-18-9)15-13(17(23)20-19-15)6-10-8-22(2)14-5-4-11(24-3)7-12(10)14/h4-8,19H,1H2,2-3H3,(H,20,23)/b13-6?,16-15-
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n/an/a 90n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203092
PNG
(3-(4-methyl-1,2,3-thiadiazol-5-yl)-4-((1-methyl-1H...)
Show SMILES Cn1cc(C=c2c(=O)[nH][nH]\c2=c2/snnc2=C)c2ccccc12
Show InChI InChI=1S/C16H13N5OS/c1-9-15(23-20-17-9)14-12(16(22)19-18-14)7-10-8-21(2)13-6-4-3-5-11(10)13/h3-8,18H,1H2,2H3,(H,19,22)/b12-7?,15-14-
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n/an/a 95n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203083
PNG
(4-((5-fluoro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES Cn1cc(C=c2c(=O)[nH][nH]\c2=c2/snnc2=C)c2cc(F)ccc12
Show InChI InChI=1S/C16H12FN5OS/c1-8-15(24-21-18-8)14-12(16(23)20-19-14)5-9-7-22(2)13-4-3-10(17)6-11(9)13/h3-7,19H,1H2,2H3,(H,20,23)/b12-5?,15-14-
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n/an/a 99n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203105
PNG
(4-((7-methoxy-1-methyl-1H-indol-3-yl)methylene)-3-...)
Show SMILES COc1cccc2c(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)cn(C)c12
Show InChI InChI=1S/C17H15N5O2S/c1-9-16(25-21-18-9)14-12(17(23)20-19-14)7-10-8-22(2)15-11(10)5-4-6-13(15)24-3/h4-8,19H,1H2,2-3H3,(H,20,23)/b12-7?,16-14-
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n/an/a 109n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203086
PNG
(4-((5-bromo-1-methyl-1H-indol-3-yl)methylene)-3-(1...)
Show SMILES Cn1cc(\C=C2/C(=O)NN=C2c2cnns2)c2cc(Br)ccc12
Show InChI InChI=1S/C15H10BrN5OS/c1-21-7-8(10-5-9(16)2-3-12(10)21)4-11-14(18-19-15(11)22)13-6-17-20-23-13/h2-7H,1H3,(H,19,22)/b11-4-
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n/an/a 110n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203088
PNG
(4-((4-fluoro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES Cn1cc(C=c2c(=O)[nH][nH]\c2=c2/snnc2=C)c2c(F)cccc12
Show InChI InChI=1S/C16H12FN5OS/c1-8-15(24-21-18-8)14-10(16(23)20-19-14)6-9-7-22(2)12-5-3-4-11(17)13(9)12/h3-7,19H,1H2,2H3,(H,20,23)/b10-6?,15-14-
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n/an/a 137n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203084
PNG
(4-((5-chloro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES Cn1cc(C=c2c(=O)[nH][nH]\c2=c2/snnc2=C)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H12ClN5OS/c1-8-15(24-21-18-8)14-12(16(23)20-19-14)5-9-7-22(2)13-4-3-10(17)6-11(9)13/h3-7,19H,1H2,2H3,(H,20,23)/b12-5?,15-14-
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n/an/a 152n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203076
PNG
(1-methyl-3-((5-oxo-3-(1,2,3-thiadiazol-5-yl)-1H-py...)
Show SMILES Cn1cc(\C=C2/C(=O)NN=C2c2cnns2)c2cc(ccc12)C#N
Show InChI InChI=1S/C16H10N6OS/c1-22-8-10(11-4-9(6-17)2-3-13(11)22)5-12-15(19-20-16(12)23)14-7-18-21-24-14/h2-5,7-8H,1H3,(H,20,23)/b12-5-
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n/an/a 174n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203101
PNG
(4-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-(4-me...)
Show SMILES Cc1cc(C)c(C=c2c(=O)[nH][nH]\c2=c2\snnc2=C)[nH]1
Show InChI InChI=1S/C13H13N5OS/c1-6-4-7(2)14-10(6)5-9-11(16-17-13(9)19)12-8(3)15-18-20-12/h4-5,14,16H,3H2,1-2H3,(H,17,19)/b9-5?,12-11+
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n/an/a 197n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203080
PNG
(4-((5-chloro-1H-indol-3-yl)methylene)-3-(4-methyl-...)
Show SMILES Clc1ccc2[nH]cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c2c1
Show InChI InChI=1S/C15H10ClN5OS/c1-7-14(23-21-18-7)13-11(15(22)20-19-13)4-8-6-17-12-3-2-9(16)5-10(8)12/h2-6,17,19H,1H2,(H,20,22)/b11-4?,14-13-
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n/an/a>300n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203087
PNG
(1-methyl-3-((3-(4-methyl-1,2,3-thiadiazol-5-yl)-5-...)
Show SMILES Cn1cc(C=c2c(=O)[nH][nH]\c2=c2/snnc2=C)c2cc(ccc12)C#N
Show InChI InChI=1S/C17H12N6OS/c1-9-16(25-22-19-9)15-13(17(24)21-20-15)6-11-8-23(2)14-4-3-10(7-18)5-12(11)14/h3-6,8,20H,1H2,2H3,(H,21,24)/b13-6?,16-15-
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Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50203074
PNG
(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES CCOc1cccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12
Show InChI InChI=1S/C18H17N5O2S/c1-4-25-14-7-5-6-13-15(14)11(9-23(13)3)8-12-16(20-21-18(12)24)17-10(2)19-22-26-17/h5-9,20H,2,4H2,1,3H3,(H,21,24)/b12-8?,17-16-
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n/an/a 463n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of SRC


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50203104
PNG
(4-((1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thi...)
Show SMILES C=c1nns\c1=c1/[nH][nH]c(=O)c1=Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C15H11N5OS/c1-8-14(22-20-17-8)13-11(15(21)19-18-13)6-9-7-16-12-5-3-2-4-10(9)12/h2-7,16,18H,1H2,(H,19,21)/b11-6?,14-13-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50203074
PNG
(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES CCOc1cccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12
Show InChI InChI=1S/C18H17N5O2S/c1-4-25-14-7-5-6-13-15(14)11(9-23(13)3)8-12-16(20-21-18(12)24)17-10(2)19-22-26-17/h5-9,20H,2,4H2,1,3H3,(H,21,24)/b12-8?,17-16-
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n/an/a>3.00E+3n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50203074
PNG
(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES CCOc1cccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12
Show InChI InChI=1S/C18H17N5O2S/c1-4-25-14-7-5-6-13-15(14)11(9-23(13)3)8-12-16(20-21-18(12)24)17-10(2)19-22-26-17/h5-9,20H,2,4H2,1,3H3,(H,21,24)/b12-8?,17-16-
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n/an/a 3.70E+3n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of cMet


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50203074
PNG
(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Show SMILES CCOc1cccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12
Show InChI InChI=1S/C18H17N5O2S/c1-4-25-14-7-5-6-13-15(14)11(9-23(13)3)8-12-16(20-21-18(12)24)17-10(2)19-22-26-17/h5-9,20H,2,4H2,1,3H3,(H,21,24)/b12-8?,17-16-
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 17: 1793-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.054
BindingDB Entry DOI: 10.7270/Q20001SB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%