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PubMed code 17290978

Compile data set for download or QSAR
Found 101 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204883
PNG
((6-hydroxy-1H-benzimidazol-2-yl)-(4-p-tolyloxy-pip...)
Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)cc1
Show InChI InChI=1S/C20H21N3O4/c1-12-2-4-13(5-3-12)27-14-6-8-23(9-7-14)20(26)19-21-15-10-17(24)18(25)11-16(15)22-19/h2-5,10-11,14,24-25H,6-9H2,1H3,(H,21,22)
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n/an/a 1.10n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204865
PNG
(CHEMBL220611 | [4-(4-fluoro-benzyl)-piperidin-1-yl...)
Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C20H20FN3O3/c21-14-3-1-12(2-4-14)9-13-5-7-24(8-6-13)20(27)19-22-15-10-17(25)18(26)11-16(15)23-19/h1-4,10-11,13,25-26H,5-9H2,(H,22,23)
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n/an/a 1.20n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204868
PNG
(CHEMBL424752 | N-[2-(4-benzyl-piperidin-1-carbonyl...)
Show SMILES CS(=O)(=O)Nc1cc2nc([nH]c2cc1NS(C)(=O)=O)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H27N5O5S2/c1-33(29,30)25-19-13-17-18(14-20(19)26-34(2,31)32)24-21(23-17)22(28)27-10-8-16(9-11-27)12-15-6-4-3-5-7-15/h3-7,13-14,16,25-26H,8-12H2,1-2H3,(H,23,24)
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n/an/a 1.30n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204882
PNG
(CHEMBL375615 | [4-(4-chloro-phenoxy)-piperidin-1-y...)
Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C19H18ClN3O4/c20-11-1-3-12(4-2-11)27-13-5-7-23(8-6-13)19(26)18-21-14-9-16(24)17(25)10-15(14)22-18/h1-4,9-10,13,24-25H,5-8H2,(H,21,22)
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n/an/a 1.70n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204899
PNG
((4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimi...)
Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H21N3O3/c24-17-11-15-16(12-18(17)25)22-19(21-15)20(26)23-8-6-14(7-9-23)10-13-4-2-1-3-5-13/h1-5,11-12,14,24-25H,6-10H2,(H,21,22)
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n/an/a 2.20n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204887
PNG
((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methyl-benz...)
Show SMILES Cc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1
Show InChI InChI=1S/C21H23N3O3/c1-13-3-2-4-15(9-13)10-14-5-7-24(8-6-14)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,9,11-12,14,25-26H,5-8,10H2,1H3,(H,22,23)
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n/an/a 2.40n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204861
PNG
((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methoxy-ben...)
Show SMILES COc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1
Show InChI InChI=1S/C21H23N3O4/c1-28-15-4-2-3-14(10-15)9-13-5-7-24(8-6-13)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,10-13,25-26H,5-9H2,1H3,(H,22,23)
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n/an/a 2.5n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204864
PNG
(CHEMBL220474 | [4-(4-fluoro-phenoxy)-piperidin-1-y...)
Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(CC1)Oc1ccc(F)cc1
Show InChI InChI=1S/C19H18FN3O4/c20-11-1-3-12(4-2-11)27-13-5-7-23(8-6-13)19(26)18-21-14-9-16(24)17(25)10-15(14)22-18/h1-4,9-10,13,24-25H,5-8H2,(H,21,22)
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n/an/a 2.90n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204861
PNG
((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methoxy-ben...)
Show SMILES COc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1
Show InChI InChI=1S/C21H23N3O4/c1-28-15-4-2-3-14(10-15)9-13-5-7-24(8-6-13)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,10-13,25-26H,5-9H2,1H3,(H,22,23)
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n/an/a 3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204863
PNG
((4-benzyl-piperidin-1-yl)-[4(7)-hydroxy-1H-benzimi...)
Show SMILES Oc1ccc(O)c2[nH]c(nc12)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H21N3O3/c24-15-6-7-16(25)18-17(15)21-19(22-18)20(26)23-10-8-14(9-11-23)12-13-4-2-1-3-5-13/h1-7,14,24-25H,8-12H2,(H,21,22)
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n/an/a 3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204868
PNG
(CHEMBL424752 | N-[2-(4-benzyl-piperidin-1-carbonyl...)
Show SMILES CS(=O)(=O)Nc1cc2nc([nH]c2cc1NS(C)(=O)=O)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H27N5O5S2/c1-33(29,30)25-19-13-17-18(14-20(19)26-34(2,31)32)24-21(23-17)22(28)27-10-8-16(9-11-27)12-15-6-4-3-5-7-15/h3-7,13-14,16,25-26H,8-12H2,1-2H3,(H,23,24)
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n/an/a 3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204883
PNG
((6-hydroxy-1H-benzimidazol-2-yl)-(4-p-tolyloxy-pip...)
Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)cc1
Show InChI InChI=1S/C20H21N3O4/c1-12-2-4-13(5-3-12)27-14-6-8-23(9-7-14)20(26)19-21-15-10-17(24)18(25)11-16(15)22-19/h2-5,10-11,14,24-25H,6-9H2,1H3,(H,21,22)
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n/an/a 3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204862
PNG
(CHEMBL436521 | N-(2-((4-benzylpiperidin-1-yl)methy...)
Show SMILES CS(=O)(=O)Nc1ccc2nc(CN3CCC(Cc4ccccc4)CC3)[nH]c2c1
Show InChI InChI=1S/C21H26N4O2S/c1-28(26,27)24-18-7-8-19-20(14-18)23-21(22-19)15-25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14,17,24H,9-13,15H2,1H3,(H,22,23)
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n/an/a 3.5n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204865
PNG
(CHEMBL220611 | [4-(4-fluoro-benzyl)-piperidin-1-yl...)
Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C20H20FN3O3/c21-14-3-1-12(2-4-14)9-13-5-7-24(8-6-13)20(27)19-22-15-10-17(25)18(26)11-16(15)23-19/h1-4,10-11,13,25-26H,5-9H2,(H,22,23)
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n/an/a 4n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204899
PNG
((4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimi...)
Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H21N3O3/c24-17-11-15-16(12-18(17)25)22-19(21-15)20(26)23-8-6-14(7-9-23)10-13-4-2-1-3-5-13/h1-5,11-12,14,24-25H,6-10H2,(H,21,22)
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n/an/a 4n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204884
PNG
(6-(2-(4-(4-fluorobenzyl)piperidin-1-yl)ethylsulfin...)
Show SMILES Fc1ccc(CC2CCN(CCS(=O)c3ccc4[nH]c(=O)oc4c3)CC2)cc1
Show InChI InChI=1S/C21H23FN2O3S/c22-17-3-1-15(2-4-17)13-16-7-9-24(10-8-16)11-12-28(26)18-5-6-19-20(14-18)27-21(25)23-19/h1-6,14,16H,7-13H2,(H,23,25)
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n/an/a 4n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204895
PNG
((4-amino-1H-indol-2-yl)-(4-benzyl-piperidin-1-yl)-...)
Show SMILES Nc1cccc2[nH]c(cc12)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23N3O/c22-18-7-4-8-19-17(18)14-20(23-19)21(25)24-11-9-16(10-12-24)13-15-5-2-1-3-6-15/h1-8,14,16,23H,9-13,22H2
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n/an/a 4.30n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204887
PNG
((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methyl-benz...)
Show SMILES Cc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1
Show InChI InChI=1S/C21H23N3O3/c1-13-3-2-4-15(9-13)10-14-5-7-24(8-6-14)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,9,11-12,14,25-26H,5-8,10H2,1H3,(H,22,23)
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n/an/a 5n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204873
PNG
((4-benzylpiperidin-1-yl)-(3,6-dihydro-pirrolo[3,2-...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2c(ccc3[nH]ncc23)[nH]1
Show InChI InChI=1S/C22H22N4O/c27-22(21-13-17-18-14-23-25-20(18)7-6-19(17)24-21)26-10-8-16(9-11-26)12-15-4-2-1-3-5-15/h1-7,13-14,16,24H,8-12H2,(H,23,25)
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n/an/a 5n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204864
PNG
(CHEMBL220474 | [4-(4-fluoro-phenoxy)-piperidin-1-y...)
Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(CC1)Oc1ccc(F)cc1
Show InChI InChI=1S/C19H18FN3O4/c20-11-1-3-12(4-2-11)27-13-5-7-23(8-6-13)19(26)18-21-14-9-16(24)17(25)10-15(14)22-18/h1-4,9-10,13,24-25H,5-8H2,(H,21,22)
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n/an/a 6n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134652
PNG
((4-Benzyl-piperidin-1-yl)-(4,6-dihydroxy-1H-indol-...)
Show SMILES Oc1cc(O)c2cc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O3/c24-16-11-18-17(20(25)12-16)13-19(22-18)21(26)23-8-6-15(7-9-23)10-14-4-2-1-3-5-14/h1-5,11-13,15,22,24-25H,6-10H2
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n/an/a 6n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50080029
PNG
(4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...)
Show SMILES C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1
Show InChI InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204891
PNG
((4-benzylpiperidin-1-yl)-(3,6-dihydro-imidazo[4,5-...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2c(ccc3[nH]cnc23)[nH]1
Show InChI InChI=1S/C22H22N4O/c27-22(20-13-17-18(25-20)6-7-19-21(17)24-14-23-19)26-10-8-16(9-11-26)12-15-4-2-1-3-5-15/h1-7,13-14,16,25H,8-12H2,(H,23,24)
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n/an/a 6n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134652
PNG
((4-Benzyl-piperidin-1-yl)-(4,6-dihydroxy-1H-indol-...)
Show SMILES Oc1cc(O)c2cc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O3/c24-16-11-18-17(20(25)12-16)13-19(22-18)21(26)23-8-6-15(7-9-23)10-14-4-2-1-3-5-14/h1-5,11-13,15,22,24-25H,6-10H2
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n/an/a 6.5n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204884
PNG
(6-(2-(4-(4-fluorobenzyl)piperidin-1-yl)ethylsulfin...)
Show SMILES Fc1ccc(CC2CCN(CCS(=O)c3ccc4[nH]c(=O)oc4c3)CC2)cc1
Show InChI InChI=1S/C21H23FN2O3S/c22-17-3-1-15(2-4-17)13-16-7-9-24(10-8-16)11-12-28(26)18-5-6-19-20(14-18)27-21(25)23-19/h1-6,14,16H,7-13H2,(H,23,25)
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n/an/a 6.60n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134648
PNG
((6-Hydroxy-1H-indol-2-yl)-(4-phenoxymethyl-piperid...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(COc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O3/c24-17-7-6-16-12-20(22-19(16)13-17)21(25)23-10-8-15(9-11-23)14-26-18-4-2-1-3-5-18/h1-7,12-13,15,22,24H,8-11,14H2
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n/an/a 7n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50032651
PNG
(1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-y...)
Show SMILES C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(O)(CC1)c1ccccc1
Show InChI InChI=1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204870
PNG
(2-[(4-benzyl-piperidin-1-yl)-imino-methyl]-1H-indo...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=N)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23N3O/c22-21(20-13-17-6-7-18(25)14-19(17)23-20)24-10-8-16(9-11-24)12-15-4-2-1-3-5-15/h1-7,13-14,16,22-23,25H,8-12H2
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n/an/a 8.5n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204862
PNG
(CHEMBL436521 | N-(2-((4-benzylpiperidin-1-yl)methy...)
Show SMILES CS(=O)(=O)Nc1ccc2nc(CN3CCC(Cc4ccccc4)CC3)[nH]c2c1
Show InChI InChI=1S/C21H26N4O2S/c1-28(26,27)24-18-7-8-19-20(14-18)23-21(22-19)15-25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14,17,24H,9-13,15H2,1H3,(H,22,23)
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n/an/a 8.60n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204885
PNG
(CHEMBL222197 | N-[2-(4-benzyl-piperidine-1-carbony...)
Show SMILES CS(=O)(=O)Nc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H25N3O3S/c1-29(27,28)24-19-8-7-18-14-21(23-20(18)15-19)22(26)25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14-15,17,23-24H,9-13H2,1H3
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n/an/a 9n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204863
PNG
((4-benzyl-piperidin-1-yl)-[4(7)-hydroxy-1H-benzimi...)
Show SMILES Oc1ccc(O)c2[nH]c(nc12)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H21N3O3/c24-15-6-7-16(25)18-17(15)21-19(22-18)20(26)23-10-8-14(9-11-23)12-13-4-2-1-3-5-13/h1-7,14,24-25H,8-12H2,(H,21,22)
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n/an/a 10n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204870
PNG
(2-[(4-benzyl-piperidin-1-yl)-imino-methyl]-1H-indo...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=N)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23N3O/c22-21(20-13-17-6-7-18(25)14-19(17)23-20)24-10-8-16(9-11-24)12-15-4-2-1-3-5-15/h1-7,13-14,16,22-23,25H,8-12H2
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n/an/a 10n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134651
PNG
((4-Benzyl-piperidin-1-yl)-(6-hydroxy-1H-indol-2-yl...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O2/c24-18-7-6-17-13-20(22-19(17)14-18)21(25)23-10-8-16(9-11-23)12-15-4-2-1-3-5-15/h1-7,13-14,16,22,24H,8-12H2
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n/an/a 12n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204895
PNG
((4-amino-1H-indol-2-yl)-(4-benzyl-piperidin-1-yl)-...)
Show SMILES Nc1cccc2[nH]c(cc12)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23N3O/c22-18-7-4-8-19-17(18)14-20(23-19)21(25)24-11-9-16(10-12-24)13-15-5-2-1-3-6-15/h1-8,14,16,23H,9-13,22H2
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n/an/a 12n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204877
PNG
(CHEMBL373891 | [4-(4-fluorobenzyl)piperidine-1-yl]...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C21H21FN2O2/c22-17-4-1-14(2-5-17)11-15-7-9-24(10-8-15)21(26)20-12-16-3-6-18(25)13-19(16)23-20/h1-6,12-13,15,23,25H,7-11H2
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n/an/a 12n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204882
PNG
(CHEMBL375615 | [4-(4-chloro-phenoxy)-piperidin-1-y...)
Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C19H18ClN3O4/c20-11-1-3-12(4-2-11)27-13-5-7-23(8-6-13)19(26)18-21-14-9-16(24)17(25)10-15(14)22-18/h1-4,9-10,13,24-25H,5-8H2,(H,21,22)
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n/an/a 14n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134656
PNG
((4-Benzyloxy-piperidin-1-yl)-(6-hydroxy-1H-indol-2...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CC1)OCc1ccccc1
Show InChI InChI=1S/C21H22N2O3/c24-17-7-6-16-12-20(22-19(16)13-17)21(25)23-10-8-18(9-11-23)26-14-15-4-2-1-3-5-15/h1-7,12-13,18,22,24H,8-11,14H2
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n/an/a 16n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134653
PNG
((4-Benzyl-piperidin-1-yl)-(4-hydroxy-1H-indol-2-yl...)
Show SMILES Oc1cccc2[nH]c(cc12)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O2/c24-20-8-4-7-18-17(20)14-19(22-18)21(25)23-11-9-16(10-12-23)13-15-5-2-1-3-6-15/h1-8,14,16,22,24H,9-13H2
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n/an/a 16n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204871
PNG
((6-hydroxy-1H-indole-2-yl)-[4-(4-methoxy-benzyl)-p...)
Show SMILES COc1ccc(CC2CCN(CC2)C(=O)c2cc3ccc(O)cc3[nH]2)cc1
Show InChI InChI=1S/C22H24N2O3/c1-27-19-6-2-15(3-7-19)12-16-8-10-24(11-9-16)22(26)21-13-17-4-5-18(25)14-20(17)23-21/h2-7,13-14,16,23,25H,8-12H2,1H3
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n/an/a 17n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204901
PNG
(6-(4-benzylpiperidin-1-carbonyl)-1,5-dihydro-oxazo...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2cc3[nH]c(=O)oc3cc2[nH]1
Show InChI InChI=1S/C22H21N3O3/c26-21(25-8-6-15(7-9-25)10-14-4-2-1-3-5-14)19-12-16-11-18-20(13-17(16)23-19)28-22(27)24-18/h1-5,11-13,15,23H,6-10H2,(H,24,27)
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n/an/a 17n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134653
PNG
((4-Benzyl-piperidin-1-yl)-(4-hydroxy-1H-indol-2-yl...)
Show SMILES Oc1cccc2[nH]c(cc12)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O2/c24-20-8-4-7-18-17(20)14-19(22-18)21(25)23-11-9-16(10-12-23)13-15-5-2-1-3-6-15/h1-8,14,16,22,24H,9-13H2
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n/an/a 18n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134651
PNG
((4-Benzyl-piperidin-1-yl)-(6-hydroxy-1H-indol-2-yl...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O2/c24-18-7-6-17-13-20(22-19(17)14-18)21(25)23-10-8-16(9-11-23)12-15-4-2-1-3-5-15/h1-7,13-14,16,22,24H,8-12H2
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n/an/a 18n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204873
PNG
((4-benzylpiperidin-1-yl)-(3,6-dihydro-pirrolo[3,2-...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2c(ccc3[nH]ncc23)[nH]1
Show InChI InChI=1S/C22H22N4O/c27-22(21-13-17-18-14-23-25-20(18)7-6-19(17)24-21)26-10-8-16(9-11-26)12-15-4-2-1-3-5-15/h1-7,13-14,16,24H,8-12H2,(H,23,25)
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n/an/a 20n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204901
PNG
(6-(4-benzylpiperidin-1-carbonyl)-1,5-dihydro-oxazo...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2cc3[nH]c(=O)oc3cc2[nH]1
Show InChI InChI=1S/C22H21N3O3/c26-21(25-8-6-15(7-9-25)10-14-4-2-1-3-5-14)19-12-16-11-18-20(13-17(16)23-19)28-22(27)24-18/h1-5,11-13,15,23H,6-10H2,(H,24,27)
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n/an/a 23n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134657
PNG
((4-Benzyl-piperidin-1-yl)-(5-hydroxy-1H-indol-2-yl...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O2/c24-18-6-7-19-17(13-18)14-20(22-19)21(25)23-10-8-16(9-11-23)12-15-4-2-1-3-5-15/h1-7,13-14,16,22,24H,8-12H2
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n/an/a 25n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204879
PNG
((6-hydroxy-1H-indole-2-yl)-[4-(4-methylbenzyl)-pip...)
Show SMILES Cc1ccc(CC2CCN(CC2)C(=O)c2cc3ccc(O)cc3[nH]2)cc1
Show InChI InChI=1S/C22H24N2O2/c1-15-2-4-16(5-3-15)12-17-8-10-24(11-9-17)22(26)21-13-18-6-7-19(25)14-20(18)23-21/h2-7,13-14,17,23,25H,8-12H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204885
PNG
(CHEMBL222197 | N-[2-(4-benzyl-piperidine-1-carbony...)
Show SMILES CS(=O)(=O)Nc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H25N3O3S/c1-29(27,28)24-19-8-7-18-14-21(23-20(18)15-19)22(26)25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14-15,17,23-24H,9-13H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134657
PNG
((4-Benzyl-piperidin-1-yl)-(5-hydroxy-1H-indol-2-yl...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O2/c24-18-6-7-19-17(13-18)14-20(22-19)21(25)23-10-8-16(9-11-23)12-15-4-2-1-3-5-15/h1-7,13-14,16,22,24H,8-12H2
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n/an/a 31n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204888
PNG
(CHEMBL223695 | [4-(3-fluorobenzyl)-piperidine-1-yl...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2cccc(F)c2)CC1
Show InChI InChI=1S/C21H21FN2O2/c22-17-3-1-2-15(11-17)10-14-6-8-24(9-7-14)21(26)20-12-16-4-5-18(25)13-19(16)23-20/h1-5,11-14,23,25H,6-10H2
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n/an/a 31n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134654
PNG
((4-Benzyl-piperidin-1-yl)-(5,7-dihydroxy-1H-indol-...)
Show SMILES Oc1cc(O)c2[nH]c(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O3/c24-17-11-16-12-18(22-20(16)19(25)13-17)21(26)23-8-6-15(7-9-23)10-14-4-2-1-3-5-14/h1-5,11-13,15,22,24-25H,6-10H2
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n/an/a 31n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204888
PNG
(CHEMBL223695 | [4-(3-fluorobenzyl)-piperidine-1-yl...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2cccc(F)c2)CC1
Show InChI InChI=1S/C21H21FN2O2/c22-17-3-1-2-15(11-17)10-14-6-8-24(9-7-14)21(26)20-12-16-4-5-18(25)13-19(16)23-20/h1-5,11-14,23,25H,6-10H2
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n/an/a 38n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204875
PNG
(CHEMBL374012 | [5(6)-amino-1H-benzimidazol-2-yl]-(...)
Show SMILES Nc1cc2nc([nH]c2cc1N)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23N5O/c21-15-11-17-18(12-16(15)22)24-19(23-17)20(26)25-8-6-14(7-9-25)10-13-4-2-1-3-5-13/h1-5,11-12,14H,6-10,21-22H2,(H,23,24)
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n/an/a 40n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134648
PNG
((6-Hydroxy-1H-indol-2-yl)-(4-phenoxymethyl-piperid...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(COc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O3/c24-17-7-6-16-12-20(22-19(16)13-17)21(25)23-10-8-15(9-11-23)14-26-18-4-2-1-3-5-18/h1-7,12-13,15,22,24H,8-11,14H2
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n/an/a 41n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50032651
PNG
(1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-y...)
Show SMILES C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(O)(CC1)c1ccccc1
Show InChI InChI=1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1
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n/an/a 41n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134656
PNG
((4-Benzyloxy-piperidin-1-yl)-(6-hydroxy-1H-indol-2...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CC1)OCc1ccccc1
Show InChI InChI=1S/C21H22N2O3/c24-17-7-6-16-12-20(22-19(16)13-17)21(25)23-10-8-18(9-11-23)26-14-15-4-2-1-3-5-15/h1-7,12-13,18,22,24H,8-11,14H2
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n/an/a 47n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204878
PNG
((4-benzylamino-1H-indol-2-yl)-(4-benzyl-piperidin-...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2c(NCc3ccccc3)cccc2[nH]1
Show InChI InChI=1S/C28H29N3O/c32-28(31-16-14-22(15-17-31)18-21-8-3-1-4-9-21)27-19-24-25(12-7-13-26(24)30-27)29-20-23-10-5-2-6-11-23/h1-13,19,22,29-30H,14-18,20H2
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n/an/a 47n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204891
PNG
((4-benzylpiperidin-1-yl)-(3,6-dihydro-imidazo[4,5-...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2c(ccc3[nH]cnc23)[nH]1
Show InChI InChI=1S/C22H22N4O/c27-22(20-13-17-18(25-20)6-7-19-21(17)24-14-23-19)26-10-8-16(9-11-26)12-15-4-2-1-3-5-15/h1-7,13-14,16,25H,8-12H2,(H,23,24)
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n/an/a 50n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204886
PNG
((4-benzylpiperidin-1-yl)-(1,6-dihydro-pirrolo[2,3-...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2c(ccc3cn[nH]c23)[nH]1
Show InChI InChI=1S/C22H22N4O/c27-22(20-13-18-19(24-20)7-6-17-14-23-25-21(17)18)26-10-8-16(9-11-26)12-15-4-2-1-3-5-15/h1-7,13-14,16,24H,8-12H2,(H,23,25)
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n/an/a 58n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204874
PNG
((6-hydroxy-1H-indole-2-yl)-[4-(hydroxy-phenyl-meth...)
Show SMILES OC(C1CCN(CC1)C(=O)c1cc2ccc(O)cc2[nH]1)c1ccccc1
Show InChI InChI=1S/C21H22N2O3/c24-17-7-6-16-12-19(22-18(16)13-17)21(26)23-10-8-15(9-11-23)20(25)14-4-2-1-3-5-14/h1-7,12-13,15,20,22,24-25H,8-11H2
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n/an/a 60n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204886
PNG
((4-benzylpiperidin-1-yl)-(1,6-dihydro-pirrolo[2,3-...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2c(ccc3cn[nH]c23)[nH]1
Show InChI InChI=1S/C22H22N4O/c27-22(20-13-18-19(24-20)7-6-17-14-23-25-21(17)18)26-10-8-16(9-11-26)12-15-4-2-1-3-5-15/h1-7,13-14,16,24H,8-12H2,(H,23,25)
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n/an/a 64n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204871
PNG
((6-hydroxy-1H-indole-2-yl)-[4-(4-methoxy-benzyl)-p...)
Show SMILES COc1ccc(CC2CCN(CC2)C(=O)c2cc3ccc(O)cc3[nH]2)cc1
Show InChI InChI=1S/C22H24N2O3/c1-27-19-6-2-15(3-7-19)12-16-8-10-24(11-9-16)22(26)21-13-17-4-5-18(25)14-20(17)23-21/h2-7,13-14,16,23,25H,8-12H2,1H3
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n/an/a 80n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204898
PNG
((6-hydroxy-1H-indole-2-yl)-(4-phenoxypiperidine)-m...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CC1)Oc1ccccc1
Show InChI InChI=1S/C20H20N2O3/c23-15-7-6-14-12-19(21-18(14)13-15)20(24)22-10-8-17(9-11-22)25-16-4-2-1-3-5-16/h1-7,12-13,17,21,23H,8-11H2
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n/an/a 89n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204877
PNG
(CHEMBL373891 | [4-(4-fluorobenzyl)piperidine-1-yl]...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C21H21FN2O2/c22-17-4-1-14(2-5-17)11-15-7-9-24(10-8-15)21(26)20-12-16-3-6-18(25)13-19(16)23-20/h1-6,12-13,15,23,25H,7-11H2
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n/an/a 90n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134654
PNG
((4-Benzyl-piperidin-1-yl)-(5,7-dihydroxy-1H-indol-...)
Show SMILES Oc1cc(O)c2[nH]c(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O3/c24-17-11-16-12-18(22-20(16)19(25)13-17)21(26)23-8-6-15(7-9-23)10-14-4-2-1-3-5-14/h1-5,11-13,15,22,24-25H,6-10H2
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n/an/a 106n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204898
PNG
((6-hydroxy-1H-indole-2-yl)-(4-phenoxypiperidine)-m...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CC1)Oc1ccccc1
Show InChI InChI=1S/C20H20N2O3/c23-15-7-6-14-12-19(21-18(14)13-15)20(24)22-10-8-17(9-11-22)25-16-4-2-1-3-5-16/h1-7,12-13,17,21,23H,8-11H2
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n/an/a 107n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204874
PNG
((6-hydroxy-1H-indole-2-yl)-[4-(hydroxy-phenyl-meth...)
Show SMILES OC(C1CCN(CC1)C(=O)c1cc2ccc(O)cc2[nH]1)c1ccccc1
Show InChI InChI=1S/C21H22N2O3/c24-17-7-6-16-12-19(22-18(16)13-17)21(26)23-10-8-15(9-11-23)20(25)14-4-2-1-3-5-14/h1-7,12-13,15,20,22,24-25H,8-11H2
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n/an/a 111n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204893
PNG
(CHEMBL220441 | N-[2-(4-benzyl-piperidine-1-carbony...)
Show SMILES CS(=O)(=O)Nc1cccc2[nH]c(cc12)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H25N3O3S/c1-29(27,28)24-20-9-5-8-19-18(20)15-21(23-19)22(26)25-12-10-17(11-13-25)14-16-6-3-2-4-7-16/h2-9,15,17,23-24H,10-14H2,1H3
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n/an/a 119n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50080016
PNG
((E)-1-(4-Benzyl-piperidin-1-yl)-3-(4-hydroxy-pheny...)
Show SMILES Oc1ccc(\C=C\C(=O)N2CCC(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C21H23NO2/c23-20-9-6-17(7-10-20)8-11-21(24)22-14-12-19(13-15-22)16-18-4-2-1-3-5-18/h1-11,19,23H,12-16H2/b11-8+
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n/an/a 131n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204875
PNG
(CHEMBL374012 | [5(6)-amino-1H-benzimidazol-2-yl]-(...)
Show SMILES Nc1cc2nc([nH]c2cc1N)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23N5O/c21-15-11-17-18(12-16(15)22)24-19(23-17)20(26)25-8-6-14(7-9-25)10-13-4-2-1-3-5-13/h1-5,11-12,14H,6-10,21-22H2,(H,23,24)
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n/an/a 143n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50080029
PNG
(4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...)
Show SMILES C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1
Show InChI InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1
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n/an/a 159n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134650
PNG
((4-Benzyl-piperidin-1-yl)-(7-hydroxy-1H-indol-2-yl...)
Show SMILES Oc1cccc2cc([nH]c12)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O2/c24-19-8-4-7-17-14-18(22-20(17)19)21(25)23-11-9-16(10-12-23)13-15-5-2-1-3-6-15/h1-8,14,16,22,24H,9-13H2
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n/an/a 165n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204878
PNG
((4-benzylamino-1H-indol-2-yl)-(4-benzyl-piperidin-...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2c(NCc3ccccc3)cccc2[nH]1
Show InChI InChI=1S/C28H29N3O/c32-28(31-16-14-22(15-17-31)18-21-8-3-1-4-9-21)27-19-24-25(12-7-13-26(24)30-27)29-20-23-10-5-2-6-11-23/h1-13,19,22,29-30H,14-18,20H2
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n/an/a 191n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204902
PNG
(6-(4-benzylpiperidin-1-carbonyl)-3,5-dihydro-imida...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1nc2cc3oc(=O)[nH]c3cc2[nH]1
Show InChI InChI=1S/C21H20N4O3/c26-20(25-8-6-14(7-9-25)10-13-4-2-1-3-5-13)19-22-15-11-17-18(12-16(15)23-19)28-21(27)24-17/h1-5,11-12,14H,6-10H2,(H,22,23)(H,24,27)
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n/an/a 193n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50080016
PNG
((E)-1-(4-Benzyl-piperidin-1-yl)-3-(4-hydroxy-pheny...)
Show SMILES Oc1ccc(\C=C\C(=O)N2CCC(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C21H23NO2/c23-20-9-6-17(7-10-20)8-11-21(24)22-14-12-19(13-15-22)16-18-4-2-1-3-5-18/h1-11,19,23H,12-16H2/b11-8+
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n/an/a 196n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204879
PNG
((6-hydroxy-1H-indole-2-yl)-[4-(4-methylbenzyl)-pip...)
Show SMILES Cc1ccc(CC2CCN(CC2)C(=O)c2cc3ccc(O)cc3[nH]2)cc1
Show InChI InChI=1S/C22H24N2O2/c1-15-2-4-16(5-3-15)12-17-8-10-24(11-9-17)22(26)21-13-18-6-7-19(25)14-20(18)23-21/h2-7,13-14,17,23,25H,8-12H2,1H3
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n/an/a 208n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204893
PNG
(CHEMBL220441 | N-[2-(4-benzyl-piperidine-1-carbony...)
Show SMILES CS(=O)(=O)Nc1cccc2[nH]c(cc12)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H25N3O3S/c1-29(27,28)24-20-9-5-8-19-18(20)15-21(23-19)22(26)25-12-10-17(11-13-25)14-16-6-3-2-4-7-16/h2-9,15,17,23-24H,10-14H2,1H3
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n/an/a 215n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204904
PNG
((6-hydroxy-1H-indole-2-yl)-[4-(2-methoxy-benzyl)-p...)
Show SMILES COc1ccccc1CC1CCN(CC1)C(=O)c1cc2ccc(O)cc2[nH]1
Show InChI InChI=1S/C22H24N2O3/c1-27-21-5-3-2-4-17(21)12-15-8-10-24(11-9-15)22(26)20-13-16-6-7-18(25)14-19(16)23-20/h2-7,13-15,23,25H,8-12H2,1H3
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n/an/a 249n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204892
PNG
(7-(4-benzylpiperidin-1-carbonyl)-1,6-dihydro-3-oxa...)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1nc2c([nH]1)c1oc(=O)[nH]c1c1oc(=O)[nH]c21
Show InChI InChI=1S/C22H19N5O5/c28-20(27-8-6-12(7-9-27)10-11-4-2-1-3-5-11)19-23-13-14(24-19)17-16(26-22(30)31-17)18-15(13)25-21(29)32-18/h1-5,12H,6-10H2,(H,23,24)(H,25,29)(H,26,30)
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n/an/a 328n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204897
PNG
((6-hydroxy-1H-indole-2-yl)-(4-phenylamino-piperidi...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CC1)Nc1ccccc1
Show InChI InChI=1S/C20H21N3O2/c24-17-7-6-14-12-19(22-18(14)13-17)20(25)23-10-8-16(9-11-23)21-15-4-2-1-3-5-15/h1-7,12-13,16,21-22,24H,8-11H2
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n/an/a 348n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134649
PNG
((6-Hydroxy-1H-indol-2-yl)-(4-phenethyl-piperidin-1...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CCc2ccccc2)CC1
Show InChI InChI=1S/C22H24N2O2/c25-19-9-8-18-14-21(23-20(18)15-19)22(26)24-12-10-17(11-13-24)7-6-16-4-2-1-3-5-16/h1-5,8-9,14-15,17,23,25H,6-7,10-13H2
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n/an/a 359n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134650
PNG
((4-Benzyl-piperidin-1-yl)-(7-hydroxy-1H-indol-2-yl...)
Show SMILES Oc1cccc2cc([nH]c12)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H22N2O2/c24-19-8-4-7-17-14-18(22-20(17)19)21(25)23-11-9-16(10-12-23)13-15-5-2-1-3-6-15/h1-8,14,16,22,24H,9-13H2
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n/an/a 380n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204876
PNG
((5-amino-1H-indol-2-yl)-(4-benzyl-piperidin-1-yl)-...)
Show SMILES Nc1ccc2[nH]c(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23N3O/c22-18-6-7-19-17(13-18)14-20(23-19)21(25)24-10-8-16(9-11-24)12-15-4-2-1-3-5-15/h1-7,13-14,16,23H,8-12,22H2
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n/an/a 596n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204894
PNG
((6-amino-1H-indol-2-yl)-(4-benzyl-piperidin-1-yl)-...)
Show SMILES Nc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23N3O/c22-18-7-6-17-13-20(23-19(17)14-18)21(25)24-10-8-16(9-11-24)12-15-4-2-1-3-5-15/h1-7,13-14,16,23H,8-12,22H2
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n/an/a 627n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204889
PNG
(CHEMBL222457 | N-[2-(4-benzyl-piperidine-1-carbony...)
Show SMILES CS(=O)(=O)Nc1ccc2[nH]c(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H25N3O3S/c1-29(27,28)24-19-7-8-20-18(14-19)15-21(23-20)22(26)25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14-15,17,23-24H,9-13H2,1H3
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n/an/a 631n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204881
PNG
((4-benzoylpiperidine-1-yl)-(6-hydroxy-1H-indole-2-...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C21H20N2O3/c24-17-7-6-16-12-19(22-18(16)13-17)21(26)23-10-8-15(9-11-23)20(25)14-4-2-1-3-5-14/h1-7,12-13,15,22,24H,8-11H2
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n/an/a 744n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134649
PNG
((6-Hydroxy-1H-indol-2-yl)-(4-phenethyl-piperidin-1...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CCc2ccccc2)CC1
Show InChI InChI=1S/C22H24N2O2/c25-19-9-8-18-14-21(23-20(18)15-19)22(26)24-12-10-17(11-13-24)7-6-16-4-2-1-3-5-16/h1-5,8-9,14-15,17,23,25H,6-7,10-13H2
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n/an/a 875n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204897
PNG
((6-hydroxy-1H-indole-2-yl)-(4-phenylamino-piperidi...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CC1)Nc1ccccc1
Show InChI InChI=1S/C20H21N3O2/c24-17-7-6-14-12-19(22-18(14)13-17)20(25)23-10-8-16(9-11-23)21-15-4-2-1-3-5-15/h1-7,12-13,16,21-22,24H,8-11H2
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n/an/a 1.08E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204867
PNG
(2-(4-benzyl-piperidin-1-ylmethyl)-1H-indol-6-ol | ...)
Show SMILES Oc1ccc2cc(CN3CCC(Cc4ccccc4)CC3)[nH]c2c1
Show InChI InChI=1S/C21H24N2O/c24-20-7-6-18-13-19(22-21(18)14-20)15-23-10-8-17(9-11-23)12-16-4-2-1-3-5-16/h1-7,13-14,17,22,24H,8-12,15H2
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n/an/a 1.16E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204889
PNG
(CHEMBL222457 | N-[2-(4-benzyl-piperidine-1-carbony...)
Show SMILES CS(=O)(=O)Nc1ccc2[nH]c(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H25N3O3S/c1-29(27,28)24-19-7-8-20-18(14-19)15-21(23-20)22(26)25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14-15,17,23-24H,9-13H2,1H3
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n/an/a 1.55E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204880
PNG
((4-benzylpiperidin-1-yl)-(5-hydroxybenzofuran-2-yl...)
Show SMILES Oc1ccc2oc(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H21NO3/c23-18-6-7-19-17(13-18)14-20(25-19)21(24)22-10-8-16(9-11-22)12-15-4-2-1-3-5-15/h1-7,13-14,16,23H,8-12H2
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n/an/a 1.90E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204890
PNG
((6-hydroxy-1H-indole-2-yl)-[3-(4-methoxybenzyl)pip...)
Show SMILES COc1ccc(CC2CCCN(C2)C(=O)c2cc3ccc(O)cc3[nH]2)cc1
Show InChI InChI=1S/C22H24N2O3/c1-27-19-8-4-15(5-9-19)11-16-3-2-10-24(14-16)22(26)21-12-17-6-7-18(25)13-20(17)23-21/h4-9,12-13,16,23,25H,2-3,10-11,14H2,1H3
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n/an/a 2.21E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204872
PNG
((4-benzylpiperidin-1-yl)-(6-hydroxybenzothiazol-2-...)
Show SMILES Oc1ccc2nc(sc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H20N2O2S/c23-16-6-7-17-18(13-16)25-19(21-17)20(24)22-10-8-15(9-11-22)12-14-4-2-1-3-5-14/h1-7,13,15,23H,8-12H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204900
PNG
((4-benzylpiperidin-1-yl)-(5-hydroxybenzothiophen-2...)
Show SMILES Oc1ccc2sc(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H21NO2S/c23-18-6-7-19-17(13-18)14-20(25-19)21(24)22-10-8-16(9-11-22)12-15-4-2-1-3-5-15/h1-7,13-14,16,23H,8-12H2
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n/an/a 5.61E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204869
PNG
((4-benzylpiperidin-1-yl)-(6-hydroxy-1-methyl-1H-in...)
Show SMILES Cn1c(cc2ccc(O)cc12)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H24N2O2/c1-23-20-15-19(25)8-7-18(20)14-21(23)22(26)24-11-9-17(10-12-24)13-16-5-3-2-4-6-16/h2-8,14-15,17,25H,9-13H2,1H3
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n/an/a 5.77E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204866
PNG
((4-benzylpiperidin-1-yl)-(6-hydroxybenzofuran-2-yl...)
Show SMILES Oc1ccc2cc(oc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H21NO3/c23-18-7-6-17-13-20(25-19(17)14-18)21(24)22-10-8-16(9-11-22)12-15-4-2-1-3-5-15/h1-7,13-14,16,23H,8-12H2
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n/an/a 6.92E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204903
PNG
(2-(4-benzyl-piperidin-1-sulfonyl)-1H-indol-6-ol | ...)
Show SMILES Oc1ccc2cc([nH]c2c1)S(=O)(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H22N2O3S/c23-18-7-6-17-13-20(21-19(17)14-18)26(24,25)22-10-8-16(9-11-22)12-15-4-2-1-3-5-15/h1-7,13-14,16,21,23H,8-12H2
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n/an/a>8.00E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204896
PNG
((6-hydroxy-1H-indole-2-yl)-[2-(4-methoxybenzyl)-pi...)
Show SMILES COc1ccc(CC2CCCCN2C(=O)c2cc3ccc(O)cc3[nH]2)cc1
Show InChI InChI=1S/C22H24N2O3/c1-27-19-9-5-15(6-10-19)12-17-4-2-3-11-24(17)22(26)21-13-16-7-8-18(25)14-20(16)23-21/h5-10,13-14,17,23,25H,2-4,11-12H2,1H3
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n/an/a>8.00E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50134655
PNG
((6-Hydroxy-1H-indol-2-yl)-(4-phenyl-piperidin-1-yl...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C20H20N2O2/c23-17-7-6-16-12-19(21-18(16)13-17)20(24)22-10-8-15(9-11-22)14-4-2-1-3-5-14/h1-7,12-13,15,21,23H,8-11H2
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Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204880
PNG
((4-benzylpiperidin-1-yl)-(5-hydroxybenzofuran-2-yl...)
Show SMILES Oc1ccc2oc(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H21NO3/c23-18-6-7-19-17(13-18)14-20(25-19)21(24)22-10-8-16(9-11-22)12-15-4-2-1-3-5-15/h1-7,13-14,16,23H,8-12H2
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UniProtKB/SwissProt

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UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204900
PNG
((4-benzylpiperidin-1-yl)-(5-hydroxybenzothiophen-2...)
Show SMILES Oc1ccc2sc(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H21NO2S/c23-18-6-7-19-17(13-18)14-20(25-19)21(24)22-10-8-16(9-11-22)12-15-4-2-1-3-5-15/h1-7,13-14,16,23H,8-12H2
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UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
N-methyl D-aspartate receptor subtype 2B (NMDA)(NR2B)


(Rattus norvegicus (Rat))
BDBM50204866
PNG
((4-benzylpiperidin-1-yl)-(6-hydroxybenzofuran-2-yl...)
Show SMILES Oc1ccc2cc(oc2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H21NO3/c23-18-7-6-17-13-20(25-19(17)14-18)21(24)22-10-8-16(9-11-22)12-15-4-2-1-3-5-15/h1-7,13-14,16,23H,8-12H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%