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PubMed code 1732526

Compile data set for download or QSAR
Found 101 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 9n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2606
PNG
(3-(5-chloro-1-methyl-1H-indol-3-yl)-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccc(Cl)cc23)c2ccccc12
Show InChI InChI=1S/C22H16ClN3O2/c1-25-10-15(13-5-3-4-6-17(13)25)19-20(22(28)24-21(19)27)16-11-26(2)18-8-7-12(23)9-14(16)18/h3-11H,1-2H3,(H,24,27,28)
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n/an/a 110n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2607
PNG
(3-(1,5-dimethyl-1H-indol-3-yl)-4-(1-methyl-1H-indo...)
Show SMILES Cc1ccc2n(C)cc(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1
Show InChI InChI=1S/C23H19N3O2/c1-13-8-9-19-15(10-13)17(12-26(19)3)21-20(22(27)24-23(21)28)16-11-25(2)18-7-5-4-6-14(16)18/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 170n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2590
PNG
((Arylindolyl)maleimide deriv. 12 | 3-(1H-indol-3-y...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C21H15N3O2/c1-24-11-15(13-7-3-5-9-17(13)24)19-18(20(25)23-21(19)26)14-10-22-16-8-4-2-6-12(14)16/h2-11,22H,1H3,(H,23,25,26)
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n/an/a 220n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2626
PNG
(3-(1,7-dimethyl-1H-indol-3-yl)-4-(1-methyl-1H-indo...)
Show SMILES Cc1cccc2c(cn(C)c12)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C23H19N3O2/c1-13-7-6-9-15-17(12-26(3)21(13)15)20-19(22(27)24-23(20)28)16-11-25(2)18-10-5-4-8-14(16)18/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 280n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2591
PNG
((Arylindolyl)maleimide deriv. 13 | 3,4-bis(1-methy...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H17N3O2/c1-24-11-15(13-7-3-5-9-17(13)24)19-20(22(27)23-21(19)26)16-12-25(2)18-10-6-4-8-14(16)18/h3-12H,1-2H3,(H,23,26,27)
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n/an/a 300n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2620
PNG
(3-(6-amino-1-methyl-1H-indol-3-yl)-4-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(N)ccc23)c2ccccc12
Show InChI InChI=1S/C22H18N4O2/c1-25-10-15(13-5-3-4-6-17(13)25)19-20(22(28)24-21(19)27)16-11-26(2)18-9-12(23)7-8-14(16)18/h3-11H,23H2,1-2H3,(H,24,27,28)
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n/an/a 310n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2594
PNG
((Arylindolyl)maleimide deriv. 16 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(-c3ccccc3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H19N3O2/c1-29-15-20(18-11-5-7-13-22(18)29)24-25(27(32)28-26(24)31)21-16-30(17-9-3-2-4-10-17)23-14-8-6-12-19(21)23/h2-16H,1H3,(H,28,31,32)
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n/an/a 360n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2612
PNG
(3-(1-methyl-1H-indol-3-yl)-4-[1-methyl-5-(methylsu...)
Show SMILES CSc1ccc2n(C)cc(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1
Show InChI InChI=1S/C23H19N3O2S/c1-25-11-16(14-6-4-5-7-18(14)25)20-21(23(28)24-22(20)27)17-12-26(2)19-9-8-13(29-3)10-15(17)19/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 380n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2635
PNG
(3-(1-methyl-1H-indol-3-yl)-4-[1-methyl-2-(methylsu...)
Show SMILES CSc1c(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1C
Show InChI InChI=1S/C23H19N3O2S/c1-25-12-15(13-8-4-6-10-16(13)25)18-20(22(28)24-21(18)27)19-14-9-5-7-11-17(14)26(2)23(19)29-3/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 440n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2634
PNG
(3-(1,2-dimethyl-1H-indol-3-yl)-4-(1-methyl-1H-indo...)
Show SMILES Cc1c(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1C
Show InChI InChI=1S/C23H19N3O2/c1-13-19(15-9-5-7-11-18(15)26(13)3)21-20(22(27)24-23(21)28)16-12-25(2)17-10-6-4-8-14(16)17/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 470n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2580
PNG
(K252a | methyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Show SMILES COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18?,26-,27-/m1/s1
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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2593
PNG
((Arylindolyl)maleimide deriv. 15 | 3-(1-methyl-1H-...)
Show SMILES CCCn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H21N3O2/c1-3-12-27-14-18(16-9-5-7-11-20(16)27)22-21(23(28)25-24(22)29)17-13-26(2)19-10-6-4-8-15(17)19/h4-11,13-14H,3,12H2,1-2H3,(H,25,28,29)
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n/an/a 480n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2608
PNG
(3-(5-amino-1-methyl-1H-indol-3-yl)-4-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccc(N)cc23)c2ccccc12
Show InChI InChI=1S/C22H18N4O2/c1-25-10-15(13-5-3-4-6-17(13)25)19-20(22(28)24-21(19)27)16-11-26(2)18-8-7-12(23)9-14(16)18/h3-11H,23H2,1-2H3,(H,24,27,28)
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n/an/a 490n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2583
PNG
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
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n/an/a 550n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2631
PNG
(3-(1,4-dimethyl-1H-indol-3-yl)-4-(1-methyl-1H-indo...)
Show SMILES Cc1cccc2n(C)cc(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c12
Show InChI InChI=1S/C23H19N3O2/c1-13-7-6-10-18-19(13)16(12-26(18)3)21-20(22(27)24-23(21)28)15-11-25(2)17-9-5-4-8-14(15)17/h4-12H,1-3H3,(H,24,27,28)
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Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2610
PNG
(3-(5-Methoxy-1-methyl-3-indolyl)-4-(1-methyl-3-ind...)
Show SMILES COc1ccc2n(C)cc(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1
Show InChI InChI=1S/C23H19N3O3/c1-25-11-16(14-6-4-5-7-18(14)25)20-21(23(28)24-22(20)27)17-12-26(2)19-9-8-13(29-3)10-15(17)19/h4-12H,1-3H3,(H,24,27,28)
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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2652
PNG
((Phenylindolyl)maleimide deriv. 74 | 3-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)c2ccccc12
Show InChI InChI=1S/C19H13N3O4/c1-21-10-13(11-6-2-4-8-14(11)21)17-16(18(23)20-19(17)24)12-7-3-5-9-15(12)22(25)26/h2-10H,1H3,(H,20,23,24)
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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2597
PNG
((Arylindolyl)maleimide deriv. 19 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H16N2O2/c1-25-13-18(16-10-4-5-12-19(16)25)21-20(22(26)24-23(21)27)17-11-6-8-14-7-2-3-9-15(14)17/h2-13H,1H3,(H,24,26,27)
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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2599
PNG
((Arylindolyl)maleimide deriv. 21 | 3-(1-benzothiop...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2csc3ccccc23)c2ccccc12
Show InChI InChI=1S/C21H14N2O2S/c1-23-10-14(12-6-2-4-8-16(12)23)18-19(21(25)22-20(18)24)15-11-26-17-9-5-3-7-13(15)17/h2-11H,1H3,(H,22,24,25)
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Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2651
PNG
((Phenylindolyl)maleimide deriv. 73 | 3-(2-chloroph...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccccc2Cl)c2ccccc12
Show InChI InChI=1S/C19H13ClN2O2/c1-22-10-13(11-6-3-5-9-15(11)22)17-16(18(23)21-19(17)24)12-7-2-4-8-14(12)20/h2-10H,1H3,(H,21,23,24)
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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2609
PNG
(3-(5-Hydroxy-1-methyl-3-indolyl)-4-(1-methyl-3-ind...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccc(O)cc23)c2ccccc12
Show InChI InChI=1S/C22H17N3O3/c1-24-10-15(13-5-3-4-6-17(13)24)19-20(22(28)23-21(19)27)16-11-25(2)18-8-7-12(26)9-14(16)18/h3-11,26H,1-2H3,(H,23,27,28)
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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2653
PNG
((Phenylindolyl)maleimide deriv. 75 | 3-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccccc2C(F)(F)F)c2ccccc12
Show InChI InChI=1S/C20H13F3N2O2/c1-25-10-13(11-6-3-5-9-15(11)25)17-16(18(26)24-19(17)27)12-7-2-4-8-14(12)20(21,22)23/h2-10H,1H3,(H,24,26,27)
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n/an/a 950n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2627
PNG
(3-(7-Amino-1-methyl-3-indolyl)-4-(1-methyl-3-indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3c(N)cccc23)c2ccccc12
Show InChI InChI=1S/C22H18N4O2/c1-25-10-14(12-6-3-4-9-17(12)25)18-19(22(28)24-21(18)27)15-11-26(2)20-13(15)7-5-8-16(20)23/h3-11H,23H2,1-2H3,(H,24,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2658
PNG
((Phenylindolyl)maleimide deriv. 80 | 3-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c(Cl)ccc(Cl)c2Cl)c2ccccc12
Show InChI InChI=1S/C19H11Cl3N2O2/c1-24-8-10(9-4-2-3-5-13(9)24)14-16(19(26)23-18(14)25)15-11(20)6-7-12(21)17(15)22/h2-8H,1H3,(H,23,25,26)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2628
PNG
(3-(7-methoxy-1-methyl-1H-indol-3-yl)-4-(1-methyl-1...)
Show SMILES COc1cccc2c(cn(C)c12)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C23H19N3O3/c1-25-11-15(13-7-4-5-9-17(13)25)19-20(23(28)24-22(19)27)16-12-26(2)21-14(16)8-6-10-18(21)29-3/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2642
PNG
((Phenylindolyl)maleimide deriv. 64 | 3-(1-methyl-1...)
Show SMILES Cc1cccc(c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C20H16N2O2/c1-12-6-5-7-13(10-12)17-18(20(24)21-19(17)23)15-11-22(2)16-9-4-3-8-14(15)16/h3-11H,1-2H3,(H,21,23,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2636
PNG
(3-(2-methanesulfinyl-1-methyl-1H-indol-3-yl)-4-(1-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c(n(C)c3ccccc23)S(C)=O)c2ccccc12
Show InChI InChI=1S/C23H19N3O3S/c1-25-12-15(13-8-4-6-10-16(13)25)18-20(22(28)24-21(18)27)19-14-9-5-7-11-17(14)26(2)23(19)30(3)29/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2621
PNG
(3-(6-methoxy-1-methyl-1H-indol-3-yl)-4-(1-methyl-1...)
Show SMILES COc1ccc2c(cn(C)c2c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C23H19N3O3/c1-25-11-16(14-6-4-5-7-18(14)25)20-21(23(28)24-22(20)27)17-12-26(2)19-10-13(29-3)8-9-15(17)19/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 1.10E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2622
PNG
(3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(ccc23)[N+]([O-])=O)c2ccccc12
Show InChI InChI=1S/C22H16N4O4/c1-24-10-15(13-5-3-4-6-17(13)24)19-20(22(28)23-21(19)27)16-11-25(2)18-9-12(26(29)30)7-8-14(16)18/h3-11H,1-2H3,(H,23,27,28)
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n/an/a 1.10E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2655
PNG
((Phenylindolyl)maleimide deriv. 77 | 3-(2,5-dimeth...)
Show SMILES Cc1ccc(C)c(c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C21H18N2O2/c1-12-8-9-13(2)15(10-12)18-19(21(25)22-20(18)24)16-11-23(3)17-7-5-4-6-14(16)17/h4-11H,1-3H3,(H,22,24,25)
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n/an/a 1.20E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2592
PNG
((Arylindolyl)maleimide deriv. 14 | 3-(1-benzyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(Cc3ccccc3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C28H21N3O2/c1-30-16-21(19-11-5-7-13-23(19)30)25-26(28(33)29-27(25)32)22-17-31(15-18-9-3-2-4-10-18)24-14-8-6-12-20(22)24/h2-14,16-17H,15H2,1H3,(H,29,32,33)
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n/an/a 1.20E+3n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2615
PNG
(Bisindolylmaleimide deriv. 37 | methyl 1-methyl-3-...)
Show SMILES COC(=O)c1ccc2n(C)cc(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1
Show InChI InChI=1S/C24H19N3O4/c1-26-11-16(14-6-4-5-7-18(14)26)20-21(23(29)25-22(20)28)17-12-27(2)19-9-8-13(10-15(17)19)24(30)31-3/h4-12H,1-3H3,(H,25,28,29)
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n/an/a 1.40E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2629
PNG
(3-(1-Methyl-3-indolyl)-4-(1-methyl-7-nitro-3-indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3c(cccc23)[N+]([O-])=O)c2ccccc12
Show InChI InChI=1S/C22H16N4O4/c1-24-10-14(12-6-3-4-8-16(12)24)18-19(22(28)23-21(18)27)15-11-25(2)20-13(15)7-5-9-17(20)26(29)30/h3-11H,1-2H3,(H,23,27,28)
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n/an/a 1.50E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2619
PNG
(3-(6-chloro-1-methyl-1H-indol-3-yl)-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(Cl)ccc23)c2ccccc12
Show InChI InChI=1S/C22H16ClN3O2/c1-25-10-15(13-5-3-4-6-17(13)25)19-20(22(28)24-21(19)27)16-11-26(2)18-9-12(23)7-8-14(16)18/h3-11H,1-2H3,(H,24,27,28)
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n/an/a 1.60E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2648
PNG
((Phenylindolyl)maleimide deriv. 70 | 3-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc(c2)[N+]([O-])=O)c2ccccc12
Show InChI InChI=1S/C19H13N3O4/c1-21-10-14(13-7-2-3-8-15(13)21)17-16(18(23)20-19(17)24)11-5-4-6-12(9-11)22(25)26/h2-10H,1H3,(H,20,23,24)
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n/an/a 1.90E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2633
PNG
(3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-4-nitro-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cccc([N+]([O-])=O)c23)c2ccccc12
Show InChI InChI=1S/C22H16N4O4/c1-24-10-13(12-6-3-4-7-15(12)24)19-20(22(28)23-21(19)27)14-11-25(2)16-8-5-9-17(18(14)16)26(29)30/h3-11H,1-2H3,(H,23,27,28)
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n/an/a 2.00E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2643
PNG
((Phenylindolyl)maleimide deriv. 65 | 3-(3-chloroph...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc(Cl)c2)c2ccccc12
Show InChI InChI=1S/C19H13ClN2O2/c1-22-10-14(13-7-2-3-8-15(13)22)17-16(18(23)21-19(17)24)11-5-4-6-12(20)9-11/h2-10H,1H3,(H,21,23,24)
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n/an/a 2.00E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2650
PNG
((Phenylindolyl)maleimide deriv. 72 | 3-(1-methyl-1...)
Show SMILES Cc1ccccc1C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C20H16N2O2/c1-12-7-3-4-8-13(12)17-18(20(24)21-19(17)23)15-11-22(2)16-10-6-5-9-14(15)16/h3-11H,1-2H3,(H,21,23,24)
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n/an/a 2.20E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2644
PNG
((Phenylindolyl)maleimide deriv. 66 | 3-(3-bromophe...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc(Br)c2)c2ccccc12
Show InChI InChI=1S/C19H13BrN2O2/c1-22-10-14(13-7-2-3-8-15(13)22)17-16(18(23)21-19(17)24)11-5-4-6-12(20)9-11/h2-10H,1H3,(H,21,23,24)
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n/an/a 2.20E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2630
PNG
(3-(7-(Acetylamino)-1-methyl-3-indolyl)-4-(1-methyl...)
Show SMILES CC(=O)Nc1cccc2c(cn(C)c12)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C24H20N4O3/c1-13(29)25-18-9-6-8-15-17(12-28(3)22(15)18)21-20(23(30)26-24(21)31)16-11-27(2)19-10-5-4-7-14(16)19/h4-12H,1-3H3,(H,25,29)(H,26,30,31)
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n/an/a 2.40E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2656
PNG
((Phenylindolyl)maleimide deriv. 78 | 3-(2,6-dichlo...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c(Cl)cccc2Cl)c2ccccc12
Show InChI InChI=1S/C19H12Cl2N2O2/c1-23-9-11(10-5-2-3-8-14(10)23)15-17(19(25)22-18(15)24)16-12(20)6-4-7-13(16)21/h2-9H,1H3,(H,22,24,25)
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n/an/a 2.40E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2654
PNG
((Phenylindolyl)maleimide deriv. 76 | 3-(2,3-dimeth...)
Show SMILES Cc1cccc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c1C
Show InChI InChI=1S/C21H18N2O2/c1-12-7-6-9-14(13(12)2)18-19(21(25)22-20(18)24)16-11-23(3)17-10-5-4-8-15(16)17/h4-11H,1-3H3,(H,22,24,25)
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n/an/a 2.40E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2614
PNG
(3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-5-nitro-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccc(cc23)[N+]([O-])=O)c2ccccc12
Show InChI InChI=1S/C22H16N4O4/c1-24-10-15(13-5-3-4-6-17(13)24)19-20(22(28)23-21(19)27)16-11-25(2)18-8-7-12(26(29)30)9-14(16)18/h3-11H,1-2H3,(H,23,27,28)
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n/an/a 2.50E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2600
PNG
((Arylindolyl)maleimide deriv. 22 | 3-(1-benzofuran...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2coc3ccccc23)c2ccccc12
Show InChI InChI=1S/C21H14N2O3/c1-23-10-14(12-6-2-4-8-16(12)23)18-19(21(25)22-20(18)24)15-11-26-17-9-5-3-7-13(15)17/h2-11H,1H3,(H,22,24,25)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2598
PNG
((Arylindolyl)maleimide deriv. 20 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccc3ccccc3c2)c2ccccc12
Show InChI InChI=1S/C23H16N2O2/c1-25-13-18(17-8-4-5-9-19(17)25)21-20(22(26)24-23(21)27)16-11-10-14-6-2-3-7-15(14)12-16/h2-13H,1H3,(H,24,26,27)
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n/an/a 2.80E+3n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2605
PNG
((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ncccc23)c2ccccc12
Show InChI InChI=1S/C21H16N4O2/c1-24-10-14(12-6-3-4-8-16(12)24)17-18(21(27)23-20(17)26)15-11-25(2)19-13(15)7-5-9-22-19/h3-11H,1-2H3,(H,23,26,27)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2632
PNG
(3-(4-methoxy-1-methyl-1H-indol-3-yl)-4-(1-methyl-1...)
Show SMILES COc1cccc2n(C)cc(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c12
Show InChI InChI=1S/C23H19N3O3/c1-25-11-14(13-7-4-5-8-16(13)25)20-21(23(28)24-22(20)27)15-12-26(2)17-9-6-10-18(29-3)19(15)17/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2596
PNG
((Arylindolyl)maleimide deriv. 18 | 3-(1H-indol-1-y...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)n2ccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C21H15N3O2/c1-23-12-15(14-7-3-5-9-17(14)23)18-19(21(26)22-20(18)25)24-11-10-13-6-2-4-8-16(13)24/h2-12H,1H3,(H,22,25,26)
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n/an/a 3.00E+3n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2613
PNG
(3-(1-Methyl-3-indolyl)-4-(1-methyl-5-(methylsulfin...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccc(cc23)S(C)=O)c2ccccc12
Show InChI InChI=1S/C23H19N3O3S/c1-25-11-16(14-6-4-5-7-18(14)25)20-21(23(28)24-22(20)27)17-12-26(2)19-9-8-13(30(3)29)10-15(17)19/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2647
PNG
((Phenylindolyl)maleimide deriv. 69 | 3-(3-aminophe...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc(N)c2)c2ccccc12
Show InChI InChI=1S/C19H15N3O2/c1-22-10-14(13-7-2-3-8-15(13)22)17-16(18(23)21-19(17)24)11-5-4-6-12(20)9-11/h2-10H,20H2,1H3,(H,21,23,24)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2602
PNG
((Arylindolyl)maleimide deriv. 24 | 3-(1-Methyl-3-i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cc[nH]c2)c2ccccc12
Show InChI InChI=1S/C17H13N3O2/c1-20-9-12(11-4-2-3-5-13(11)20)15-14(10-6-7-18-8-10)16(21)19-17(15)22/h2-9,18H,1H3,(H,19,21,22)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2625
PNG
(Bisindolylmaleimide deriv. 47 | N-{1-methyl-3-[4-(...)
Show SMILES CC(=O)Nc1ccc2c(cn(C)c2c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C24H20N4O3/c1-13(29)25-14-8-9-16-18(12-28(3)20(16)10-14)22-21(23(30)26-24(22)31)17-11-27(2)19-7-5-4-6-15(17)19/h4-12H,1-3H3,(H,25,29)(H,26,30,31)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2649
PNG
((Phenylindolyl)maleimide deriv. 71 | 3-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc(c2)C(F)(F)F)c2ccccc12
Show InChI InChI=1S/C20H13F3N2O2/c1-25-10-14(13-7-2-3-8-15(13)25)17-16(18(26)24-19(17)27)11-5-4-6-12(9-11)20(21,22)23/h2-10H,1H3,(H,24,26,27)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2604
PNG
((Arylindolyl)maleimide deriv. 26 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccs2)c2ccccc12
Show InChI InChI=1S/C17H12N2O2S/c1-19-9-11(10-5-2-3-6-12(10)19)14-15(13-7-4-8-22-13)17(21)18-16(14)20/h2-9H,1H3,(H,18,20,21)
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n/an/a 5.20E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2611
PNG
(3-[5-(benzyloxy)-1-methyl-1H-indol-3-yl]-4-(1-meth...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccc(OCc4ccccc4)cc23)c2ccccc12
Show InChI InChI=1S/C29H23N3O3/c1-31-15-22(20-10-6-7-11-24(20)31)26-27(29(34)30-28(26)33)23-16-32(2)25-13-12-19(14-21(23)25)35-17-18-8-4-3-5-9-18/h3-16H,17H2,1-2H3,(H,30,33,34)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2641
PNG
((Phenylindolyl)maleimide deriv. 63 | 3-(4-aminophe...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccc(N)cc2)c2ccccc12
Show InChI InChI=1S/C19H15N3O2/c1-22-10-14(13-4-2-3-5-15(13)22)17-16(18(23)21-19(17)24)11-6-8-12(20)9-7-11/h2-10H,20H2,1H3,(H,21,23,24)
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n/an/a 7.50E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2657
PNG
((Phenylindolyl)maleimide deriv. 79 | 3-(3,5-dichlo...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cc(Cl)cc(Cl)c2)c2ccccc12
Show InChI InChI=1S/C19H12Cl2N2O2/c1-23-9-14(13-4-2-3-5-15(13)23)17-16(18(24)22-19(17)25)10-6-11(20)8-12(21)7-10/h2-9H,1H3,(H,22,24,25)
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n/an/a 7.60E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2601
PNG
((Arylindolyl)maleimide deriv. 23 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H14N2O2/c1-21-11-14(13-9-5-6-10-15(13)21)17-16(18(22)20-19(17)23)12-7-3-2-4-8-12/h2-11H,1H3,(H,20,22,23)
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n/an/a 7.70E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2645
PNG
((Phenylindolyl)maleimide deriv. 67 | 3-(3-methoxyp...)
Show SMILES COc1cccc(c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C20H16N2O3/c1-22-11-15(14-8-3-4-9-16(14)22)18-17(19(23)21-20(18)24)12-6-5-7-13(10-12)25-2/h3-11H,1-2H3,(H,21,23,24)
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n/an/a 8.00E+3n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2606
PNG
(3-(5-chloro-1-methyl-1H-indol-3-yl)-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccc(Cl)cc23)c2ccccc12
Show InChI InChI=1S/C22H16ClN3O2/c1-25-10-15(13-5-3-4-6-17(13)25)19-20(22(28)24-21(19)27)16-11-26(2)18-8-7-12(23)9-14(16)18/h3-11H,1-2H3,(H,24,27,28)
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n/an/a 8.40E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2624
PNG
(1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(ccc23)C(N)=O)c2ccccc12
Show InChI InChI=1S/C23H18N4O3/c1-26-10-15(13-5-3-4-6-17(13)26)19-20(23(30)25-22(19)29)16-11-27(2)18-9-12(21(24)28)7-8-14(16)18/h3-11H,1-2H3,(H2,24,28)(H,25,29,30)
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n/an/a 9.50E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2586
PNG
(3,4-Bis(3-indolyl)-3-pyrrolin-2-one | 3,4-bis(1H-i...)
Show SMILES O=C1NCC(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H15N3O/c24-20-19(15-10-22-18-8-4-2-6-13(15)18)16(11-23-20)14-9-21-17-7-3-1-5-12(14)17/h1-10,21-22H,11H2,(H,23,24)
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n/an/a 1.03E+4n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2607
PNG
(3-(1,5-dimethyl-1H-indol-3-yl)-4-(1-methyl-1H-indo...)
Show SMILES Cc1ccc2n(C)cc(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1
Show InChI InChI=1S/C23H19N3O2/c1-13-8-9-19-15(10-13)17(12-26(19)3)21-20(22(27)24-23(21)28)16-11-25(2)18-7-5-4-6-14(16)18/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 1.15E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2583
PNG
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
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n/an/a 1.18E+4n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2631
PNG
(3-(1,4-dimethyl-1H-indol-3-yl)-4-(1-methyl-1H-indo...)
Show SMILES Cc1cccc2n(C)cc(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c12
Show InChI InChI=1S/C23H19N3O2/c1-13-7-6-10-18-19(13)16(12-26(18)3)21-20(22(27)24-23(21)28)15-11-25(2)17-9-5-4-8-14(15)17/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2603
PNG
((Arylindolyl)maleimide deriv. 25 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccsc2)c2ccccc12
Show InChI InChI=1S/C17H12N2O2S/c1-19-8-12(11-4-2-3-5-13(11)19)15-14(10-6-7-22-9-10)16(20)18-17(15)21/h2-9H,1H3,(H,18,20,21)
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n/an/a 1.38E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2610
PNG
(3-(5-Methoxy-1-methyl-3-indolyl)-4-(1-methyl-3-ind...)
Show SMILES COc1ccc2n(C)cc(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1
Show InChI InChI=1S/C23H19N3O3/c1-25-11-16(14-6-4-5-7-18(14)25)20-21(23(28)24-22(20)27)17-12-26(2)19-9-8-13(29-3)10-15(17)19/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2620
PNG
(3-(6-amino-1-methyl-1H-indol-3-yl)-4-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(N)ccc23)c2ccccc12
Show InChI InChI=1S/C22H18N4O2/c1-25-10-15(13-5-3-4-6-17(13)25)19-20(22(28)24-21(19)27)16-11-26(2)18-9-12(23)7-8-14(16)18/h3-11H,23H2,1-2H3,(H,24,27,28)
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n/an/a 1.45E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2618
PNG
(Bisindolylmaleimide deriv. 40 | N-{1-methyl-3-[4-(...)
Show SMILES CC(=O)Nc1ccc2n(C)cc(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1
Show InChI InChI=1S/C24H20N4O3/c1-13(29)25-14-8-9-20-16(10-14)18(12-28(20)3)22-21(23(30)26-24(22)31)17-11-27(2)19-7-5-4-6-15(17)19/h4-12H,1-3H3,(H,25,29)(H,26,30,31)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2617
PNG
(1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccc(cc23)C(N)=O)c2ccccc12
Show InChI InChI=1S/C23H18N4O3/c1-26-10-15(13-5-3-4-6-17(13)26)19-20(23(30)25-22(19)29)16-11-27(2)18-8-7-12(21(24)28)9-14(16)18/h3-11H,1-2H3,(H2,24,28)(H,25,29,30)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2591
PNG
((Arylindolyl)maleimide deriv. 13 | 3,4-bis(1-methy...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H17N3O2/c1-24-11-15(13-7-3-5-9-17(13)24)19-20(22(27)23-21(19)26)16-12-25(2)18-10-6-4-8-14(16)18/h3-12H,1-2H3,(H,23,26,27)
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n/an/a 1.61E+4n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2614
PNG
(3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-5-nitro-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccc(cc23)[N+]([O-])=O)c2ccccc12
Show InChI InChI=1S/C22H16N4O4/c1-24-10-15(13-5-3-4-6-17(13)24)19-20(22(28)23-21(19)27)16-11-25(2)18-8-7-12(26(29)30)9-14(16)18/h3-11H,1-2H3,(H,23,27,28)
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n/an/a 2.13E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2652
PNG
((Phenylindolyl)maleimide deriv. 74 | 3-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)c2ccccc12
Show InChI InChI=1S/C19H13N3O4/c1-21-10-13(11-6-2-4-8-14(11)21)17-16(18(23)20-19(17)24)12-7-3-5-9-15(12)22(25)26/h2-10H,1H3,(H,20,23,24)
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n/an/a 2.15E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2627
PNG
(3-(7-Amino-1-methyl-3-indolyl)-4-(1-methyl-3-indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3c(N)cccc23)c2ccccc12
Show InChI InChI=1S/C22H18N4O2/c1-25-10-14(12-6-3-4-9-17(12)25)18-19(22(28)24-21(18)27)15-11-26(2)20-13(15)7-5-8-16(20)23/h3-11H,23H2,1-2H3,(H,24,27,28)
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n/an/a 2.30E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2623
PNG
(1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(ccc23)C(O)=O)c2ccccc12
Show InChI InChI=1S/C23H17N3O4/c1-25-10-15(13-5-3-4-6-17(13)25)19-20(22(28)24-21(19)27)16-11-26(2)18-9-12(23(29)30)7-8-14(16)18/h3-11H,1-2H3,(H,29,30)(H,24,27,28)
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n/an/a 2.70E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2589
PNG
(1-Hydroxy-3,4-bis(3-indolyl)-2,5-pyrroledione | 1-...)
Show SMILES ON1C(=O)C(=C(C1=O)c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H13N3O3/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23(19)26)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22,26H
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n/an/a 2.89E+4n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2634
PNG
(3-(1,2-dimethyl-1H-indol-3-yl)-4-(1-methyl-1H-indo...)
Show SMILES Cc1c(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1C
Show InChI InChI=1S/C23H19N3O2/c1-13-19(15-9-5-7-11-18(15)26(13)3)21-20(22(27)24-23(21)28)16-12-25(2)17-10-6-4-8-14(16)17/h4-12H,1-3H3,(H,24,27,28)
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n/an/a 3.10E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2638
PNG
((Phenylindolyl)maleimide deriv. 60 | 3-(4-methoxyp...)
Show SMILES COc1ccc(cc1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C20H16N2O3/c1-22-11-15(14-5-3-4-6-16(14)22)18-17(19(23)21-20(18)24)12-7-9-13(25-2)10-8-12/h3-11H,1-2H3,(H,21,23,24)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2639
PNG
((Phenylindolyl)maleimide deriv. 61 | 3-(1-methyl-1...)
Show SMILES CSc1ccc(cc1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C20H16N2O2S/c1-22-11-15(14-5-3-4-6-16(14)22)18-17(19(23)21-20(18)24)12-7-9-13(25-2)10-8-12/h3-11H,1-2H3,(H,21,23,24)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2616
PNG
(1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccc(cc23)C(O)=O)c2ccccc12
Show InChI InChI=1S/C23H17N3O4/c1-25-10-15(13-5-3-4-6-17(13)25)19-20(22(28)24-21(19)27)16-11-26(2)18-8-7-12(23(29)30)9-14(16)18/h3-11H,1-2H3,(H,29,30)(H,24,27,28)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2587
PNG
(5-Hydroxy-3,4-Bis(3-indolyl)-3-pyrrolin-2-one | 5-...)
Show SMILES OC1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H15N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,19,21-22,24H,(H,23,25)
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n/an/a 5.10E+4n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2655
PNG
((Phenylindolyl)maleimide deriv. 77 | 3-(2,5-dimeth...)
Show SMILES Cc1ccc(C)c(c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C21H18N2O2/c1-12-8-9-13(2)15(10-12)18-19(21(25)22-20(18)24)16-11-23(3)17-7-5-4-6-14(16)17/h4-11H,1-3H3,(H,22,24,25)
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n/an/a 8.20E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2584
PNG
((3R,4R)-3,4-bis(1H-indol-3-yl)pyrrolidine-2,5-dion...)
Show SMILES O=C1NC(=O)[C@H]([C@@H]1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H15N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,17-18,21-22H,(H,23,24,25)/t17-,18-/m0/s1
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n/an/a>1.00E+5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2637
PNG
((Phenylindolyl)maleimide deriv. 59 | 3-(4-chloroph...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C19H13ClN2O2/c1-22-10-14(13-4-2-3-5-15(13)22)17-16(18(23)21-19(17)24)11-6-8-12(20)9-7-11/h2-10H,1H3,(H,21,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2646
PNG
((Phenylindolyl)maleimide deriv. 68 | 3-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc(Oc3ccccc3)c2)c2ccccc12
Show InChI InChI=1S/C25H18N2O3/c1-27-15-20(19-12-5-6-13-21(19)27)23-22(24(28)26-25(23)29)16-8-7-11-18(14-16)30-17-9-3-2-4-10-17/h2-15H,1H3,(H,26,28,29)
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n/an/a>1.00E+5n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2582
PNG
(3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyr...)
Show SMILES CN1C(=O)C(=C(C1=O)c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C21H15N3O2/c1-24-20(25)18(14-10-22-16-8-4-2-6-12(14)16)19(21(24)26)15-11-23-17-9-5-3-7-13(15)17/h2-11,22-23H,1H3
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n/an/a>1.00E+5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2601
PNG
((Arylindolyl)maleimide deriv. 23 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H14N2O2/c1-21-11-14(13-9-5-6-10-15(13)21)17-16(18(22)20-19(17)23)12-7-3-2-4-8-12/h2-11H,1H3,(H,20,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



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Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2633
PNG
(3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-4-nitro-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cccc([N+]([O-])=O)c23)c2ccccc12
Show InChI InChI=1S/C22H16N4O4/c1-24-10-13(12-6-3-4-7-15(12)24)19-20(22(28)23-21(19)27)14-11-25(2)16-8-5-9-17(18(14)16)26(29)30/h3-11H,1-2H3,(H,23,27,28)
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n/an/a>1.00E+5n/an/an/an/an/an/a



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Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2642
PNG
((Phenylindolyl)maleimide deriv. 64 | 3-(1-methyl-1...)
Show SMILES Cc1cccc(c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C20H16N2O2/c1-12-6-5-7-13(10-12)17-18(20(24)21-19(17)23)15-11-22(2)16-9-4-3-8-14(15)16/h3-11H,1-2H3,(H,21,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2597
PNG
((Arylindolyl)maleimide deriv. 19 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H16N2O2/c1-25-13-18(16-10-4-5-12-19(16)25)21-20(22(26)24-23(21)27)17-11-6-8-14-7-2-3-9-15(14)17/h2-13H,1H3,(H,24,26,27)
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n/an/a>1.00E+5n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2657
PNG
((Phenylindolyl)maleimide deriv. 79 | 3-(3,5-dichlo...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cc(Cl)cc(Cl)c2)c2ccccc12
Show InChI InChI=1S/C19H12Cl2N2O2/c1-23-9-14(13-4-2-3-5-15(13)23)17-16(18(24)22-19(17)25)10-6-11(20)8-12(21)7-10/h2-9H,1H3,(H,22,24,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2585
PNG
((3R,4S)-3,4-bis(1H-indol-3-yl)pyrrolidine-2,5-dion...)
Show SMILES O=C1NC(=O)[C@@H]([C@@H]1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H15N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,17-18,21-22H,(H,23,24,25)/t17-,18+
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n/an/a>1.00E+5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2592
PNG
((Arylindolyl)maleimide deriv. 14 | 3-(1-benzyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(Cc3ccccc3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C28H21N3O2/c1-30-16-21(19-11-5-7-13-23(19)30)25-26(28(33)29-27(25)32)22-17-31(15-18-9-3-2-4-10-18)24-14-8-6-12-20(22)24/h2-14,16-17H,15H2,1H3,(H,29,32,33)
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n/an/a>1.00E+5n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2640
PNG
((Phenylindolyl)maleimide deriv. 62 | 3-(4-methanes...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccc(cc2)S(C)(=O)=O)c2ccccc12
Show InChI InChI=1S/C20H16N2O4S/c1-22-11-15(14-5-3-4-6-16(14)22)18-17(19(23)21-20(18)24)12-7-9-13(10-8-12)27(2,25)26/h3-11H,1-2H3,(H,21,23,24)
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Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2643
PNG
((Phenylindolyl)maleimide deriv. 65 | 3-(3-chloroph...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc(Cl)c2)c2ccccc12
Show InChI InChI=1S/C19H13ClN2O2/c1-22-10-14(13-7-2-3-8-15(13)22)17-16(18(23)21-19(17)24)11-5-4-6-12(20)9-11/h2-10H,1H3,(H,21,23,24)
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Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2599
PNG
((Arylindolyl)maleimide deriv. 21 | 3-(1-benzothiop...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2csc3ccccc23)c2ccccc12
Show InChI InChI=1S/C21H14N2O2S/c1-23-10-14(12-6-2-4-8-16(12)23)18-19(21(25)22-20(18)24)15-11-26-17-9-5-3-7-13(15)17/h2-11H,1H3,(H,22,24,25)
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Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2595
PNG
((Arylindolyl)maleimide deriv. 17 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cc3ccccc3n2C)c2ccccc12
Show InChI InChI=1S/C22H17N3O2/c1-24-12-15(14-8-4-6-10-17(14)24)19-20(22(27)23-21(19)26)18-11-13-7-3-5-9-16(13)25(18)2/h3-12H,1-2H3,(H,23,26,27)
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n/an/a>1.00E+5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2588
PNG
(3,4-bis(1H-indol-3-yl)-2,5-dihydrofuran-2,5-dione ...)
Show SMILES O=C1OC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H12N2O3/c23-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(24)25-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H
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n/an/a>1.00E+5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2647
PNG
((Phenylindolyl)maleimide deriv. 69 | 3-(3-aminophe...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc(N)c2)c2ccccc12
Show InChI InChI=1S/C19H15N3O2/c1-22-10-14(13-7-2-3-8-15(13)22)17-16(18(23)21-19(17)24)11-5-4-6-12(20)9-11/h2-10H,20H2,1H3,(H,21,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2581
PNG
(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)
Show SMILES O=C1NCc2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
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n/an/an/an/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%