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PubMed code 17329100

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206658
PNG
((S)-N-(1-(2-amino-3-(4-hydroxy-2,6-dimethylphenyl)...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)c1ccccc1
Show InChI InChI=1S/C25H33N3O3/c1-4-24(30)28(19-8-6-5-7-9-19)20-10-12-27(13-11-20)25(31)23(26)16-22-17(2)14-21(29)15-18(22)3/h5-9,14-15,20,23,29H,4,10-13,16,26H2,1-3H3/t23-/m0/s1
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47n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206658
PNG
((S)-N-(1-(2-amino-3-(4-hydroxy-2,6-dimethylphenyl)...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)c1ccccc1
Show InChI InChI=1S/C25H33N3O3/c1-4-24(30)28(19-8-6-5-7-9-19)20-10-12-27(13-11-20)25(31)23(26)16-22-17(2)14-21(29)15-18(22)3/h5-9,14-15,20,23,29H,4,10-13,16,26H2,1-3H3/t23-/m0/s1
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50n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206643
PNG
(CHEMBL390480 | N-(1-((2S,3R)-2-amino-3-(4-hydroxy-...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)[C@H](C)c1c(C)cc(O)cc1C)c1ccccc1
Show InChI InChI=1S/C26H35N3O3/c1-5-23(31)29(20-9-7-6-8-10-20)21-11-13-28(14-12-21)26(32)25(27)19(4)24-17(2)15-22(30)16-18(24)3/h6-10,15-16,19,21,25,30H,5,11-14,27H2,1-4H3/t19-,25+/m1/s1
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260n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206643
PNG
(CHEMBL390480 | N-(1-((2S,3R)-2-amino-3-(4-hydroxy-...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)[C@H](C)c1c(C)cc(O)cc1C)c1ccccc1
Show InChI InChI=1S/C26H35N3O3/c1-5-23(31)29(20-9-7-6-8-10-20)21-11-13-28(14-12-21)26(32)25(27)19(4)24-17(2)15-22(30)16-18(24)3/h6-10,15-16,19,21,25,30H,5,11-14,27H2,1-4H3/t19-,25+/m1/s1
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300n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206659
PNG
((S)-N-(1-(2-amino-3,3-diphenylpropanoyl)piperidin-...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H33N3O2/c1-2-26(33)32(24-16-10-5-11-17-24)25-18-20-31(21-19-25)29(34)28(30)27(22-12-6-3-7-13-22)23-14-8-4-9-15-23/h3-17,25,27-28H,2,18-21,30H2,1H3/t28-/m0/s1
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400n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206648
PNG
(CHEMBL388899 | N-(1-((2S,3S)-2-amino-3-(4-hydroxy-...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)[C@@H](C)c1c(C)cc(O)cc1C)c1ccccc1
Show InChI InChI=1S/C26H35N3O3/c1-5-23(31)29(20-9-7-6-8-10-20)21-11-13-28(14-12-21)26(32)25(27)19(4)24-17(2)15-22(30)16-18(24)3/h6-10,15-16,19,21,25,30H,5,11-14,27H2,1-4H3/t19-,25-/m0/s1
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500n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206644
PNG
(CHEMBL395545 | N-(1-(3-amino-3-(4-chlorophenyl)pro...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)CC(N)c1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1S/C23H28ClN3O2/c1-2-22(28)27(19-6-4-3-5-7-19)20-12-14-26(15-13-20)23(29)16-21(25)17-8-10-18(24)11-9-17/h3-11,20-21H,2,12-16,25H2,1H3
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990n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206651
PNG
((S)-N-(1-(2-amino-3-(naphthalen-2-yl)propanoyl)pip...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C27H31N3O2/c1-2-26(31)30(23-10-4-3-5-11-23)24-14-16-29(17-15-24)27(32)25(28)19-20-12-13-21-8-6-7-9-22(21)18-20/h3-13,18,24-25H,2,14-17,19,28H2,1H3/t25-/m0/s1
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1.10E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206648
PNG
(CHEMBL388899 | N-(1-((2S,3S)-2-amino-3-(4-hydroxy-...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)[C@@H](C)c1c(C)cc(O)cc1C)c1ccccc1
Show InChI InChI=1S/C26H35N3O3/c1-5-23(31)29(20-9-7-6-8-10-20)21-11-13-28(14-12-21)26(32)25(27)19(4)24-17(2)15-22(30)16-18(24)3/h6-10,15-16,19,21,25,30H,5,11-14,27H2,1-4H3/t19-,25-/m0/s1
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1.70E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206653
PNG
(CHEMBL389109 | N-(1-(3-(3-bromophenyl)propanoyl)pi...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)CCc1cccc(Br)c1)c1ccccc1
Show InChI InChI=1S/C23H27BrN2O2/c1-2-22(27)26(20-9-4-3-5-10-20)21-13-15-25(16-14-21)23(28)12-11-18-7-6-8-19(24)17-18/h3-10,17,21H,2,11-16H2,1H3
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1.90E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206644
PNG
(CHEMBL395545 | N-(1-(3-amino-3-(4-chlorophenyl)pro...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)CC(N)c1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1S/C23H28ClN3O2/c1-2-22(28)27(19-6-4-3-5-7-19)20-12-14-26(15-13-20)23(29)16-21(25)17-8-10-18(24)11-9-17/h3-11,20-21H,2,12-16,25H2,1H3
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2.40E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206646
PNG
((S)-N-(1-(2-amino-2-(2,3-dihydro-1H-inden-2-yl)ace...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)C1Cc2ccccc2C1)c1ccccc1
Show InChI InChI=1S/C25H31N3O2/c1-2-23(29)28(21-10-4-3-5-11-21)22-12-14-27(15-13-22)25(30)24(26)20-16-18-8-6-7-9-19(18)17-20/h3-11,20,22,24H,2,12-17,26H2,1H3/t24-/m0/s1
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2.60E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206645
PNG
((S)-N-(1-(2-amino-3-(benzo[b]thiophen-3-yl)propano...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1csc2ccccc12)c1ccccc1
Show InChI InChI=1S/C25H29N3O2S/c1-2-24(29)28(19-8-4-3-5-9-19)20-12-14-27(15-13-20)25(30)22(26)16-18-17-31-23-11-7-6-10-21(18)23/h3-11,17,20,22H,2,12-16,26H2,1H3/t22-/m0/s1
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2.60E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206660
PNG
(CHEMBL231049 | N-(1-(3-amino-3-p-tolylpropanoyl)pi...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)CC(N)c1ccc(C)cc1)c1ccccc1
Show InChI InChI=1S/C24H31N3O2/c1-3-23(28)27(20-7-5-4-6-8-20)21-13-15-26(16-14-21)24(29)17-22(25)19-11-9-18(2)10-12-19/h4-12,21-22H,3,13-17,25H2,1-2H3
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2.90E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206660
PNG
(CHEMBL231049 | N-(1-(3-amino-3-p-tolylpropanoyl)pi...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)CC(N)c1ccc(C)cc1)c1ccccc1
Show InChI InChI=1S/C24H31N3O2/c1-3-23(28)27(20-7-5-4-6-8-20)21-13-15-26(16-14-21)24(29)17-22(25)19-11-9-18(2)10-12-19/h4-12,21-22H,3,13-17,25H2,1-2H3
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3.00E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206651
PNG
((S)-N-(1-(2-amino-3-(naphthalen-2-yl)propanoyl)pip...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C27H31N3O2/c1-2-26(31)30(23-10-4-3-5-11-23)24-14-16-29(17-15-24)27(32)25(28)19-20-12-13-21-8-6-7-9-22(21)18-20/h3-13,18,24-25H,2,14-17,19,28H2,1H3/t25-/m0/s1
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3.30E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206649
PNG
(CHEMBL230311 | N-(1-(3-(3-chloro-4-methoxyphenyl)p...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)CCc1ccc(OC)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C24H29ClN2O3/c1-3-23(28)27(19-7-5-4-6-8-19)20-13-15-26(16-14-20)24(29)12-10-18-9-11-22(30-2)21(25)17-18/h4-9,11,17,20H,3,10,12-16H2,1-2H3
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3.80E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206655
PNG
((S)-N-(1-(2-amino-3-phenylpropanoyl)piperidin-4-yl...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H29N3O2/c1-2-22(27)26(19-11-7-4-8-12-19)20-13-15-25(16-14-20)23(28)21(24)17-18-9-5-3-6-10-18/h3-12,20-21H,2,13-17,24H2,1H3/t21-/m0/s1
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3.90E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206656
PNG
((R)-N-(1-(2-amino-2-phenylacetyl)piperidin-4-yl)-N...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@H](N)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H27N3O2/c1-2-20(26)25(18-11-7-4-8-12-18)19-13-15-24(16-14-19)22(27)21(23)17-9-5-3-6-10-17/h3-12,19,21H,2,13-16,23H2,1H3/t21-/m1/s1
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5.10E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206649
PNG
(CHEMBL230311 | N-(1-(3-(3-chloro-4-methoxyphenyl)p...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)CCc1ccc(OC)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C24H29ClN2O3/c1-3-23(28)27(19-7-5-4-6-8-19)20-13-15-26(16-14-20)24(29)12-10-18-9-11-22(30-2)21(25)17-18/h4-9,11,17,20H,3,10,12-16H2,1-2H3
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6.30E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206654
PNG
((S)-N-(1-(2-amino-2-phenylacetyl)piperidin-4-yl)-N...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H27N3O2/c1-2-20(26)25(18-11-7-4-8-12-18)19-13-15-24(16-14-19)22(27)21(23)17-9-5-3-6-10-17/h3-12,19,21H,2,13-16,23H2,1H3/t21-/m0/s1
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6.40E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206659
PNG
((S)-N-(1-(2-amino-3,3-diphenylpropanoyl)piperidin-...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H33N3O2/c1-2-26(33)32(24-16-10-5-11-17-24)25-18-20-31(21-19-25)29(34)28(30)27(22-12-6-3-7-13-22)23-14-8-4-9-15-23/h3-17,25,27-28H,2,18-21,30H2,1H3/t28-/m0/s1
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6.50E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206652
PNG
((R)-N-(1-(2-amino-3-(4-chlorophenyl)propanoyl)pipe...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@H](N)Cc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1S/C23H28ClN3O2/c1-2-22(28)27(19-6-4-3-5-7-19)20-12-14-26(15-13-20)23(29)21(25)16-17-8-10-18(24)11-9-17/h3-11,20-21H,2,12-16,25H2,1H3/t21-/m1/s1
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6.90E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206655
PNG
((S)-N-(1-(2-amino-3-phenylpropanoyl)piperidin-4-yl...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H29N3O2/c1-2-22(27)26(19-11-7-4-8-12-19)20-13-15-25(16-14-20)23(28)21(24)17-18-9-5-3-6-10-18/h3-12,20-21H,2,13-17,24H2,1H3/t21-/m0/s1
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6.90E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206647
PNG
((S)-N-(1-(2-amino-3-(4-hydroxyphenyl)propanoyl)pip...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1ccc(O)cc1)c1ccccc1
Show InChI InChI=1S/C23H29N3O3/c1-2-22(28)26(18-6-4-3-5-7-18)19-12-14-25(15-13-19)23(29)21(24)16-17-8-10-20(27)11-9-17/h3-11,19,21,27H,2,12-16,24H2,1H3/t21-/m0/s1
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7.90E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206657
PNG
(CHEMBL230310 | N-(1-(3-amino-3-(4-methoxyphenyl)pr...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)CC(N)c1ccc(OC)cc1)c1ccccc1
Show InChI InChI=1S/C24H31N3O3/c1-3-23(28)27(19-7-5-4-6-8-19)20-13-15-26(16-14-20)24(29)17-22(25)18-9-11-21(30-2)12-10-18/h4-12,20,22H,3,13-17,25H2,1-2H3
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9.00E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206650
PNG
((S)-N-(1-(2-amino-3-(thiazol-4-yl)propanoyl)piperi...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1cscn1)c1ccccc1
Show InChI InChI=1S/C20H26N4O2S/c1-2-19(25)24(16-6-4-3-5-7-16)17-8-10-23(11-9-17)20(26)18(21)12-15-13-27-14-22-15/h3-7,13-14,17-18H,2,8-12,21H2,1H3/t18-/m0/s1
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9.70E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50206657
PNG
(CHEMBL230310 | N-(1-(3-amino-3-(4-methoxyphenyl)pr...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)CC(N)c1ccc(OC)cc1)c1ccccc1
Show InChI InChI=1S/C24H31N3O3/c1-3-23(28)27(19-7-5-4-6-8-19)20-13-15-26(16-14-20)24(29)17-22(25)18-9-11-21(30-2)12-10-18/h4-12,20,22H,3,13-17,25H2,1-2H3
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9.70E+3n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H] DAMGO from rat mu opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206653
PNG
(CHEMBL389109 | N-(1-(3-(3-bromophenyl)propanoyl)pi...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)CCc1cccc(Br)c1)c1ccccc1
Show InChI InChI=1S/C23H27BrN2O2/c1-2-22(27)26(20-9-4-3-5-10-20)21-13-15-25(16-14-21)23(28)12-11-18-7-6-8-19(24)17-18/h3-10,17,21H,2,11-16H2,1H3
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1.20E+4n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206646
PNG
((S)-N-(1-(2-amino-2-(2,3-dihydro-1H-inden-2-yl)ace...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)C1Cc2ccccc2C1)c1ccccc1
Show InChI InChI=1S/C25H31N3O2/c1-2-23(29)28(21-10-4-3-5-11-21)22-12-14-27(15-13-22)25(30)24(26)20-16-18-8-6-7-9-19(18)17-20/h3-11,20,22,24H,2,12-17,26H2,1H3/t24-/m0/s1
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1.50E+4n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206645
PNG
((S)-N-(1-(2-amino-3-(benzo[b]thiophen-3-yl)propano...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1csc2ccccc12)c1ccccc1
Show InChI InChI=1S/C25H29N3O2S/c1-2-24(29)28(19-8-4-3-5-9-19)20-12-14-27(15-13-20)25(30)22(26)16-18-17-31-23-11-7-6-10-21(18)23/h3-11,17,20,22H,2,12-16,26H2,1H3/t22-/m0/s1
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1.50E+4n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206647
PNG
((S)-N-(1-(2-amino-3-(4-hydroxyphenyl)propanoyl)pip...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1ccc(O)cc1)c1ccccc1
Show InChI InChI=1S/C23H29N3O3/c1-2-22(28)26(18-6-4-3-5-7-18)19-12-14-25(15-13-19)23(29)21(24)16-17-8-10-20(27)11-9-17/h3-11,19,21,27H,2,12-16,24H2,1H3/t21-/m0/s1
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1.60E+4n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50206650
PNG
((S)-N-(1-(2-amino-3-(thiazol-4-yl)propanoyl)piperi...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)Cc1cscn1)c1ccccc1
Show InChI InChI=1S/C20H26N4O2S/c1-2-19(25)24(16-6-4-3-5-7-16)17-8-10-23(11-9-17)20(26)18(21)12-15-13-27-14-22-15/h3-7,13-14,17-18H,2,8-12,21H2,1H3/t18-/m0/s1
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7.60E+4n/an/an/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from human delta opioid receptor transfected in HN9.10 cells


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50206643
PNG
(CHEMBL390480 | N-(1-((2S,3R)-2-amino-3-(4-hydroxy-...)
Show SMILES CCC(=O)N(C1CCN(CC1)C(=O)[C@@H](N)[C@H](C)c1c(C)cc(O)cc1C)c1ccccc1
Show InChI InChI=1S/C26H35N3O3/c1-5-23(31)29(20-9-7-6-8-10-20)21-11-13-28(14-12-21)26(32)25(27)19(4)24-17(2)15-22(30)16-18(24)3/h6-10,15-16,19,21,25,30H,5,11-14,27H2,1-4H3/t19-,25+/m1/s1
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Antagonist activity at mu opioid receptor as inhibition of electrically stimulated guinea pig ileum contraction


Bioorg Med Chem Lett 17: 2161-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.114
BindingDB Entry DOI: 10.7270/Q270813K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%