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PubMed code 17343372

Compile data set for download or QSAR
Found 143 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207507
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-p-tolylure...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)cc1
Show InChI InChI=1S/C21H19N5O/c1-13-5-9-15(10-6-13)23-21(27)24-16-11-7-14(8-12-16)17-3-2-4-18-19(17)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207473
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-chlorop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Show InChI InChI=1S/C20H16ClN5O/c21-13-3-1-4-15(11-13)24-20(27)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CSF1R by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207499
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-m-tolylure...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H19N5O/c1-13-4-2-5-16(12-13)24-21(27)23-15-10-8-14(9-11-15)17-6-3-7-18-19(17)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207509
PNG
(1-(4-(3-amino-7-methyl-1H-indazol-4-yl)phenyl)-3-m...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(C)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C22H21N5O/c1-13-4-3-5-17(12-13)25-22(28)24-16-9-7-15(8-10-16)18-11-6-14(2)20-19(18)21(23)27-26-20/h3-12H,1-2H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207484
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-o-tolylure...)
Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C21H19N5O/c1-13-5-2-3-7-17(13)24-21(27)23-15-11-9-14(10-12-15)16-6-4-8-18-19(16)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207474
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluoro-...)
Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)ccc1F
Show InChI InChI=1S/C21H18FN5O/c1-12-11-15(9-10-17(12)22)25-21(28)24-14-7-5-13(6-8-14)16-3-2-4-18-19(16)20(23)27-26-18/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207475
PNG
(1-(4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl)-3-m...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(F)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-3-2-4-15(11-12)25-21(28)24-14-7-5-13(6-8-14)16-9-10-17(22)19-18(16)20(23)27-26-19/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207498
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(thiophen-...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12
Show InChI InChI=1S/C18H15N5OS/c19-17-16-14(2-1-3-15(16)22-23-17)11-4-6-12(7-5-11)20-18(24)21-13-8-9-25-10-13/h1-10H,(H3,19,22,23)(H2,20,21,24)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207475
PNG
(1-(4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl)-3-m...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(F)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-3-2-4-15(11-12)25-21(28)24-14-7-5-13(6-8-14)16-9-10-17(22)19-18(16)20(23)27-26-19/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207491
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-ethylph...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C22H21N5O/c1-2-14-5-3-6-17(13-14)25-22(28)24-16-11-9-15(10-12-16)18-7-4-8-19-20(18)21(23)27-26-19/h3-13H,2H2,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207474
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluoro-...)
Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)ccc1F
Show InChI InChI=1S/C21H18FN5O/c1-12-11-15(9-10-17(12)22)25-21(28)24-14-7-5-13(6-8-14)16-3-2-4-18-19(16)20(23)27-26-18/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207473
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-chlorop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Show InChI InChI=1S/C20H16ClN5O/c21-13-3-1-4-15(11-13)24-20(27)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207501
PNG
(CHEMBL387312 | N-[4-(3-amino-1-methyl-1H-indazol-4...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3n(C)nc(N)c23)c1
Show InChI InChI=1S/C22H21N5O/c1-14-5-3-6-17(13-14)25-22(28)24-16-11-9-15(10-12-16)18-7-4-8-19-20(18)21(23)26-27(19)2/h3-13H,1-2H3,(H2,23,26)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207474
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluoro-...)
Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)ccc1F
Show InChI InChI=1S/C21H18FN5O/c1-12-11-15(9-10-17(12)22)25-21(28)24-14-7-5-13(6-8-14)16-3-2-4-18-19(16)20(23)27-26-18/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207506
PNG
(1-(4-(3-amino-7-bromo-1H-indazol-4-yl)phenyl)-3-m-...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(Br)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18BrN5O/c1-12-3-2-4-15(11-12)25-21(28)24-14-7-5-13(6-8-14)16-9-10-17(22)19-18(16)20(23)27-26-19/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207509
PNG
(1-(4-(3-amino-7-methyl-1H-indazol-4-yl)phenyl)-3-m...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(C)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C22H21N5O/c1-13-4-3-5-17(12-13)25-22(28)24-16-9-7-15(8-10-16)18-11-6-14(2)20-19(18)21(23)27-26-20/h3-12H,1-2H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207474
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluoro-...)
Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)ccc1F
Show InChI InChI=1S/C21H18FN5O/c1-12-11-15(9-10-17(12)22)25-21(28)24-14-7-5-13(6-8-14)16-3-2-4-18-19(16)20(23)27-26-18/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207480
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-(triflu...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H16F3N5O/c22-21(23,24)13-3-1-4-15(11-13)27-20(30)26-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(25)29-28-17/h1-11H,(H3,25,28,29)(H2,26,27,30)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207480
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-(triflu...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H16F3N5O/c22-21(23,24)13-3-1-4-15(11-13)27-20(30)26-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(25)29-28-17/h1-11H,(H3,25,28,29)(H2,26,27,30)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207501
PNG
(CHEMBL387312 | N-[4-(3-amino-1-methyl-1H-indazol-4...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3n(C)nc(N)c23)c1
Show InChI InChI=1S/C22H21N5O/c1-14-5-3-6-17(13-14)25-22(28)24-16-11-9-15(10-12-16)18-7-4-8-19-20(18)21(23)26-27(19)2/h3-13H,1-2H3,(H2,23,26)(H2,24,25,28)
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n/an/a 11n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207507
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-p-tolylure...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)cc1
Show InChI InChI=1S/C21H19N5O/c1-13-5-9-15(10-6-13)23-21(27)24-16-11-7-14(8-12-16)17-3-2-4-18-19(17)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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n/an/a 12n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207488
PNG
(1-(4-(3-amino-7-(2-(dimethylamino)ethoxy)-1H-indaz...)
Show SMILES CN(C)CCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C25H28N6O2/c1-16-5-4-6-19(15-16)28-25(32)27-18-9-7-17(8-10-18)20-11-12-21(33-14-13-31(2)3)23-22(20)24(26)30-29-23/h4-12,15H,13-14H2,1-3H3,(H3,26,29,30)(H2,27,28,32)
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n/an/a 12n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207507
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-p-tolylure...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)cc1
Show InChI InChI=1S/C21H19N5O/c1-13-5-9-15(10-6-13)23-21(27)24-16-11-7-14(8-12-16)17-3-2-4-18-19(17)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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n/an/a 12n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207499
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-m-tolylure...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H19N5O/c1-13-4-2-5-16(12-13)24-21(27)23-15-10-8-14(9-11-15)17-6-3-7-18-19(17)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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n/an/a 12n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207506
PNG
(1-(4-(3-amino-7-bromo-1H-indazol-4-yl)phenyl)-3-m-...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(Br)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18BrN5O/c1-12-3-2-4-15(11-12)25-21(28)24-14-7-5-13(6-8-14)16-9-10-17(22)19-18(16)20(23)27-26-19/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 13n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207473
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-chlorop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Show InChI InChI=1S/C20H16ClN5O/c21-13-3-1-4-15(11-13)24-20(27)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 13n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207483
PNG
(CHEMBL222315 | N-(4-(3-amino-1H-indazol-4-yl)pheny...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4CCCCC4)cc3)c12
Show InChI InChI=1S/C20H22N4O/c21-19-18-16(7-4-8-17(18)23-24-19)13-9-11-15(12-10-13)22-20(25)14-5-2-1-3-6-14/h4,7-12,14H,1-3,5-6H2,(H,22,25)(H3,21,23,24)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207490
PNG
(1-(4-(3-amino-1-(2-methoxyethoxy)-1H-indazol-4-yl)...)
Show SMILES COCCOn1nc(N)c2c(cccc12)-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C23H22ClN5O3/c1-31-12-13-32-29-20-7-3-6-19(21(20)22(25)28-29)15-8-10-17(11-9-15)26-23(30)27-18-5-2-4-16(24)14-18/h2-11,14H,12-13H2,1H3,(H2,25,28)(H2,26,27,30)
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n/an/a 13n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207499
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-m-tolylure...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H19N5O/c1-13-4-2-5-16(12-13)24-21(27)23-15-10-8-14(9-11-15)17-6-3-7-18-19(17)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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n/an/a 13n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207475
PNG
(1-(4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl)-3-m...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(F)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-3-2-4-15(11-12)25-21(28)24-14-7-5-13(6-8-14)16-9-10-17(22)19-18(16)20(23)27-26-19/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 14n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207498
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(thiophen-...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12
Show InChI InChI=1S/C18H15N5OS/c19-17-16-14(2-1-3-15(16)22-23-17)11-4-6-12(7-5-11)20-18(24)21-13-8-9-25-10-13/h1-10H,(H3,19,22,23)(H2,20,21,24)
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n/an/a 15n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207481
PNG
(CHEMBL373798 | N-[4-(3-amino-1H-indazol-4-yl)pheny...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN5O/c21-13-3-1-4-15(11-13)24-20(27)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 15n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207511
PNG
(1-(4-(3-amino-1-(2-(diethylamino)ethoxy)-1H-indazo...)
Show SMILES CCN(CC)CCOn1nc(N)c2c(cccc12)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C27H31FN6O2/c1-4-33(5-2)15-16-36-34-24-8-6-7-21(25(24)26(29)32-34)19-10-12-20(13-11-19)30-27(35)31-23-17-18(3)9-14-22(23)28/h6-14,17H,4-5,15-16H2,1-3H3,(H2,29,32)(H2,30,31,35)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207486
PNG
(1-(4-(3-amino-7-(2-methoxyethoxy)-1H-indazol-4-yl)...)
Show SMILES COCCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C24H25N5O3/c1-15-4-3-5-18(14-15)27-24(30)26-17-8-6-16(7-9-17)19-10-11-20(32-13-12-31-2)22-21(19)23(25)29-28-22/h3-11,14H,12-13H2,1-2H3,(H3,25,28,29)(H2,26,27,30)
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n/an/a 15n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207477
PNG
(1-(4-(3-amino-7-(2-(2-oxopyrrolidin-1-yl)ethoxy)-1...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(OCCN3CCCC3=O)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C27H28N6O3/c1-17-4-2-5-20(16-17)30-27(35)29-19-9-7-18(8-10-19)21-11-12-22(25-24(21)26(28)32-31-25)36-15-14-33-13-3-6-23(33)34/h2,4-5,7-12,16H,3,6,13-15H2,1H3,(H3,28,31,32)(H2,29,30,35)
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n/an/a 15n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207490
PNG
(1-(4-(3-amino-1-(2-methoxyethoxy)-1H-indazol-4-yl)...)
Show SMILES COCCOn1nc(N)c2c(cccc12)-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C23H22ClN5O3/c1-31-12-13-32-29-20-7-3-6-19(21(20)22(25)28-29)15-8-10-17(11-9-15)26-23(30)27-18-5-2-4-16(24)14-18/h2-11,14H,12-13H2,1H3,(H2,25,28)(H2,26,27,30)
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n/an/a 16n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 16n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207507
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-p-tolylure...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)cc1
Show InChI InChI=1S/C21H19N5O/c1-13-5-9-15(10-6-13)23-21(27)24-16-11-7-14(8-12-16)17-3-2-4-18-19(17)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207499
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-m-tolylure...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H19N5O/c1-13-4-2-5-16(12-13)24-21(27)23-15-10-8-14(9-11-15)17-6-3-7-18-19(17)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207512
PNG
(CHEMBL375284 | N-[4-(1H-indazol-4-yl)-phenyl]-N'-(...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]ncc23)c1
Show InChI InChI=1S/C21H18N4O/c1-14-4-2-5-17(12-14)24-21(26)23-16-10-8-15(9-11-16)18-6-3-7-20-19(18)13-22-25-20/h2-13H,1H3,(H,22,25)(H2,23,24,26)
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n/an/a 18n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207494
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluorop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12
Show InChI InChI=1S/C20H16FN5O/c21-13-6-10-15(11-7-13)24-20(27)23-14-8-4-12(5-9-14)16-2-1-3-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207486
PNG
(1-(4-(3-amino-7-(2-methoxyethoxy)-1H-indazol-4-yl)...)
Show SMILES COCCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C24H25N5O3/c1-15-4-3-5-18(14-15)27-24(30)26-17-8-6-16(7-9-17)19-10-11-20(32-13-12-31-2)22-21(19)23(25)29-28-22/h3-11,14H,12-13H2,1-2H3,(H3,25,28,29)(H2,26,27,30)
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n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207471
PNG
(1-(4-(3-amino-1-(2-methoxyethoxy)-1H-indazol-4-yl)...)
Show SMILES COCCOn1nc(N)c2c(cccc12)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C24H24FN5O3/c1-15-6-11-19(25)20(14-15)28-24(31)27-17-9-7-16(8-10-17)18-4-3-5-21-22(18)23(26)29-30(21)33-13-12-32-2/h3-11,14H,12-13H2,1-2H3,(H2,26,29)(H2,27,28,31)
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n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207487
PNG
(1-(4-(3-amino-7-(2-morpholinoethoxy)-1H-indazol-4-...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(OCCN3CCOCC3)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C27H30N6O3/c1-18-3-2-4-21(17-18)30-27(34)29-20-7-5-19(6-8-20)22-9-10-23(25-24(22)26(28)32-31-25)36-16-13-33-11-14-35-15-12-33/h2-10,17H,11-16H2,1H3,(H3,28,31,32)(H2,29,30,34)
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n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207481
PNG
(CHEMBL373798 | N-[4-(3-amino-1H-indazol-4-yl)pheny...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN5O/c21-13-3-1-4-15(11-13)24-20(27)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 23n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207501
PNG
(CHEMBL387312 | N-[4-(3-amino-1-methyl-1H-indazol-4...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3n(C)nc(N)c23)c1
Show InChI InChI=1S/C22H21N5O/c1-14-5-3-6-17(13-14)25-22(28)24-16-11-9-15(10-12-16)18-7-4-8-19-20(18)21(23)26-27(19)2/h3-13H,1-2H3,(H2,23,26)(H2,24,25,28)
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n/an/a 23n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207487
PNG
(1-(4-(3-amino-7-(2-morpholinoethoxy)-1H-indazol-4-...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(OCCN3CCOCC3)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C27H30N6O3/c1-18-3-2-4-21(17-18)30-27(34)29-20-7-5-19(6-8-20)22-9-10-23(25-24(22)26(28)32-31-25)36-16-13-33-11-14-35-15-12-33/h2-10,17H,11-16H2,1H3,(H3,28,31,32)(H2,29,30,34)
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n/an/a 24n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207481
PNG
(CHEMBL373798 | N-[4-(3-amino-1H-indazol-4-yl)pheny...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN5O/c21-13-3-1-4-15(11-13)24-20(27)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 25n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207477
PNG
(1-(4-(3-amino-7-(2-(2-oxopyrrolidin-1-yl)ethoxy)-1...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(OCCN3CCCC3=O)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C27H28N6O3/c1-17-4-2-5-20(16-17)30-27(35)29-19-9-7-18(8-10-19)21-11-12-22(25-24(21)26(28)32-31-25)36-15-14-33-13-3-6-23(33)34/h2,4-5,7-12,16H,3,6,13-15H2,1H3,(H3,28,31,32)(H2,29,30,35)
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n/an/a 25n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207502
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-hydroxy...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(O)c4)cc3)c12
Show InChI InChI=1S/C20H17N5O2/c21-19-18-16(5-2-6-17(18)24-25-19)12-7-9-13(10-8-12)22-20(27)23-14-3-1-4-15(26)11-14/h1-11,26H,(H3,21,24,25)(H2,22,23,27)
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n/an/a 26n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207497
PNG
(1-(4-(3-amino-7-(2-(pyrrolidin-1-yl)ethoxy)-1H-ind...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(OCCN3CCCC3)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C27H30N6O2/c1-18-5-4-6-21(17-18)30-27(34)29-20-9-7-19(8-10-20)22-11-12-23(25-24(22)26(28)32-31-25)35-16-15-33-13-2-3-14-33/h4-12,17H,2-3,13-16H2,1H3,(H3,28,31,32)(H2,29,30,34)
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n/an/a 26n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207494
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluorop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12
Show InChI InChI=1S/C20H16FN5O/c21-13-6-10-15(11-7-13)24-20(27)23-14-8-4-12(5-9-14)16-2-1-3-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 26n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207493
PNG
(1-(4-(3-amino-7-methoxy-1H-indazol-4-yl)phenyl)-3-...)
Show SMILES COc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C22H21N5O2/c1-13-4-3-5-16(12-13)25-22(28)24-15-8-6-14(7-9-15)17-10-11-18(29-2)20-19(17)21(23)27-26-20/h3-12H,1-2H3,(H3,23,26,27)(H2,24,25,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207493
PNG
(1-(4-(3-amino-7-methoxy-1H-indazol-4-yl)phenyl)-3-...)
Show SMILES COc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C22H21N5O2/c1-13-4-3-5-16(12-13)25-22(28)24-15-8-6-14(7-9-15)17-10-11-18(29-2)20-19(17)21(23)27-26-20/h3-12H,1-2H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 28n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207473
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-chlorop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Show InChI InChI=1S/C20H16ClN5O/c21-13-3-1-4-15(11-13)24-20(27)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 28n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207493
PNG
(1-(4-(3-amino-7-methoxy-1H-indazol-4-yl)phenyl)-3-...)
Show SMILES COc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C22H21N5O2/c1-13-4-3-5-16(12-13)25-22(28)24-15-8-6-14(7-9-15)17-10-11-18(29-2)20-19(17)21(23)27-26-20/h3-12H,1-2H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 29n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207497
PNG
(1-(4-(3-amino-7-(2-(pyrrolidin-1-yl)ethoxy)-1H-ind...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(OCCN3CCCC3)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C27H30N6O2/c1-18-5-4-6-21(17-18)30-27(34)29-20-9-7-19(8-10-20)22-11-12-23(25-24(22)26(28)32-31-25)35-16-15-33-13-2-3-14-33/h4-12,17H,2-3,13-16H2,1H3,(H3,28,31,32)(H2,29,30,34)
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n/an/a 31n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207486
PNG
(1-(4-(3-amino-7-(2-methoxyethoxy)-1H-indazol-4-yl)...)
Show SMILES COCCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C24H25N5O3/c1-15-4-3-5-18(14-15)27-24(30)26-17-8-6-16(7-9-17)19-10-11-20(32-13-12-31-2)22-21(19)23(25)29-28-22/h3-11,14H,12-13H2,1-2H3,(H3,25,28,29)(H2,26,27,30)
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n/an/a 32n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207480
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-(triflu...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H16F3N5O/c22-21(23,24)13-3-1-4-15(11-13)27-20(30)26-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(25)29-28-17/h1-11H,(H3,25,28,29)(H2,26,27,30)
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n/an/a 32n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207471
PNG
(1-(4-(3-amino-1-(2-methoxyethoxy)-1H-indazol-4-yl)...)
Show SMILES COCCOn1nc(N)c2c(cccc12)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C24H24FN5O3/c1-15-6-11-19(25)20(14-15)28-24(31)27-17-9-7-16(8-10-17)18-4-3-5-21-22(18)23(26)29-30(21)33-13-12-32-2/h3-11,14H,12-13H2,1-2H3,(H2,26,29)(H2,27,28,31)
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n/an/a 33n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207489
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluorop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12
Show InChI InChI=1S/C20H16FN5O/c21-15-5-1-2-6-16(15)24-20(27)23-13-10-8-12(9-11-13)14-4-3-7-17-18(14)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 34n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207486
PNG
(1-(4-(3-amino-7-(2-methoxyethoxy)-1H-indazol-4-yl)...)
Show SMILES COCCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C24H25N5O3/c1-15-4-3-5-18(14-15)27-24(30)26-17-8-6-16(7-9-17)19-10-11-20(32-13-12-31-2)22-21(19)23(25)29-28-22/h3-11,14H,12-13H2,1-2H3,(H3,25,28,29)(H2,26,27,30)
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n/an/a 34n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207505
PNG
(1-(4-(3-amino-7-(2-(diethylamino)ethoxy)-1H-indazo...)
Show SMILES CCN(CC)CCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C27H32N6O2/c1-4-33(5-2)15-16-35-23-14-13-22(24-25(23)31-32-26(24)28)19-9-11-20(12-10-19)29-27(34)30-21-8-6-7-18(3)17-21/h6-14,17H,4-5,15-16H2,1-3H3,(H3,28,31,32)(H2,29,30,34)
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n/an/a 35n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207503
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-fluoro-...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)cc1F
Show InChI InChI=1S/C21H18FN5O/c1-12-5-8-15(11-17(12)22)25-21(28)24-14-9-6-13(7-10-14)16-3-2-4-18-19(16)20(23)27-26-18/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 36n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207500
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-bromoph...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12
Show InChI InChI=1S/C20H16BrN5O/c21-13-3-1-4-15(11-13)24-20(27)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 36n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207488
PNG
(1-(4-(3-amino-7-(2-(dimethylamino)ethoxy)-1H-indaz...)
Show SMILES CN(C)CCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C25H28N6O2/c1-16-5-4-6-19(15-16)28-25(32)27-18-9-7-17(8-10-18)20-11-12-21(33-14-13-31(2)3)23-22(20)24(26)30-29-23/h4-12,15H,13-14H2,1-3H3,(H3,26,29,30)(H2,27,28,32)
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n/an/a 38n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207506
PNG
(1-(4-(3-amino-7-bromo-1H-indazol-4-yl)phenyl)-3-m-...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(Br)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18BrN5O/c1-12-3-2-4-15(11-12)25-21(28)24-14-7-5-13(6-8-14)16-9-10-17(22)19-18(16)20(23)27-26-19/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 39n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207492
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-cyclopenty...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)NC4CCCC4)cc3)c12
Show InChI InChI=1S/C19H21N5O/c20-18-17-15(6-3-7-16(17)23-24-18)12-8-10-14(11-9-12)22-19(25)21-13-4-1-2-5-13/h3,6-11,13H,1-2,4-5H2,(H3,20,23,24)(H2,21,22,25)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207480
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-(triflu...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H16F3N5O/c22-21(23,24)13-3-1-4-15(11-13)27-20(30)26-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(25)29-28-17/h1-11H,(H3,25,28,29)(H2,26,27,30)
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n/an/a 41n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207498
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(thiophen-...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12
Show InChI InChI=1S/C18H15N5OS/c19-17-16-14(2-1-3-15(16)22-23-17)11-4-6-12(7-5-11)20-18(24)21-13-8-9-25-10-13/h1-10H,(H3,19,22,23)(H2,20,21,24)
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n/an/a 42n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207503
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-fluoro-...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)cc1F
Show InChI InChI=1S/C21H18FN5O/c1-12-5-8-15(11-17(12)22)25-21(28)24-14-9-6-13(7-10-14)16-3-2-4-18-19(16)20(23)27-26-18/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 42n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207491
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-ethylph...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C22H21N5O/c1-2-14-5-3-6-17(13-14)25-22(28)24-16-11-9-15(10-12-16)18-7-4-8-19-20(18)21(23)27-26-19/h3-13H,2H2,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 42n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207472
PNG
(4-(4-aminophenyl)-1H-indazol-3-amine | 4-(4-aminop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(N)cc3)c12
Show InChI InChI=1S/C13H12N4/c14-9-6-4-8(5-7-9)10-2-1-3-11-12(10)13(15)17-16-11/h1-7H,14H2,(H3,15,16,17)
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n/an/a 43n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207514
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-phenylurea...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12
Show InChI InChI=1S/C20H17N5O/c21-19-18-16(7-4-8-17(18)24-25-19)13-9-11-15(12-10-13)23-20(26)22-14-5-2-1-3-6-14/h1-12H,(H3,21,24,25)(H2,22,23,26)
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n/an/a 44n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207503
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-fluoro-...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)cc1F
Show InChI InChI=1S/C21H18FN5O/c1-12-5-8-15(11-17(12)22)25-21(28)24-14-9-6-13(7-10-14)16-3-2-4-18-19(16)20(23)27-26-18/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 47n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207502
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-hydroxy...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(O)c4)cc3)c12
Show InChI InChI=1S/C20H17N5O2/c21-19-18-16(5-2-6-17(18)24-25-19)12-7-9-13(10-8-12)22-20(27)23-14-3-1-4-15(26)11-14/h1-11,26H,(H3,21,24,25)(H2,22,23,27)
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n/an/a 48n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207503
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-fluoro-...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)cc1F
Show InChI InChI=1S/C21H18FN5O/c1-12-5-8-15(11-17(12)22)25-21(28)24-14-9-6-13(7-10-14)16-3-2-4-18-19(16)20(23)27-26-18/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 48n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207487
PNG
(1-(4-(3-amino-7-(2-morpholinoethoxy)-1H-indazol-4-...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(OCCN3CCOCC3)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C27H30N6O3/c1-18-3-2-4-21(17-18)30-27(34)29-20-7-5-19(6-8-20)22-9-10-23(25-24(22)26(28)32-31-25)36-16-13-33-11-14-35-15-12-33/h2-10,17H,11-16H2,1H3,(H3,28,31,32)(H2,29,30,34)
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n/an/a 50n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207477
PNG
(1-(4-(3-amino-7-(2-(2-oxopyrrolidin-1-yl)ethoxy)-1...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(OCCN3CCCC3=O)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C27H28N6O3/c1-17-4-2-5-20(16-17)30-27(35)29-19-9-7-18(8-10-19)21-11-12-22(25-24(21)26(28)32-31-25)36-15-14-33-13-3-6-23(33)34/h2,4-5,7-12,16H,3,6,13-15H2,1H3,(H3,28,31,32)(H2,29,30,35)
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n/an/a 53n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207514
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-phenylurea...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12
Show InChI InChI=1S/C20H17N5O/c21-19-18-16(7-4-8-17(18)24-25-19)13-9-11-15(12-10-13)23-20(26)22-14-5-2-1-3-6-14/h1-12H,(H3,21,24,25)(H2,22,23,26)
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n/an/a 54n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207491
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-ethylph...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C22H21N5O/c1-2-14-5-3-6-17(13-14)25-22(28)24-16-11-9-15(10-12-16)18-7-4-8-19-20(18)21(23)27-26-19/h3-13H,2H2,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 55n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207502
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-hydroxy...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(O)c4)cc3)c12
Show InChI InChI=1S/C20H17N5O2/c21-19-18-16(5-2-6-17(18)24-25-19)12-7-9-13(10-8-12)22-20(27)23-14-3-1-4-15(26)11-14/h1-11,26H,(H3,21,24,25)(H2,22,23,27)
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n/an/a 55n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207487
PNG
(1-(4-(3-amino-7-(2-morpholinoethoxy)-1H-indazol-4-...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(OCCN3CCOCC3)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C27H30N6O3/c1-18-3-2-4-21(17-18)30-27(34)29-20-7-5-19(6-8-20)22-9-10-23(25-24(22)26(28)32-31-25)36-16-13-33-11-14-35-15-12-33/h2-10,17H,11-16H2,1H3,(H3,28,31,32)(H2,29,30,34)
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n/an/a 56n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207505
PNG
(1-(4-(3-amino-7-(2-(diethylamino)ethoxy)-1H-indazo...)
Show SMILES CCN(CC)CCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C27H32N6O2/c1-4-33(5-2)15-16-35-23-14-13-22(24-25(23)31-32-26(24)28)19-9-11-20(12-10-19)29-27(34)30-21-8-6-7-18(3)17-21/h6-14,17H,4-5,15-16H2,1-3H3,(H3,28,31,32)(H2,29,30,34)
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n/an/a 60n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207505
PNG
(1-(4-(3-amino-7-(2-(diethylamino)ethoxy)-1H-indazo...)
Show SMILES CCN(CC)CCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C27H32N6O2/c1-4-33(5-2)15-16-35-23-14-13-22(24-25(23)31-32-26(24)28)19-9-11-20(12-10-19)29-27(34)30-21-8-6-7-18(3)17-21/h6-14,17H,4-5,15-16H2,1-3H3,(H3,28,31,32)(H2,29,30,34)
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n/an/a 61n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207514
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-phenylurea...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12
Show InChI InChI=1S/C20H17N5O/c21-19-18-16(7-4-8-17(18)24-25-19)13-9-11-15(12-10-13)23-20(26)22-14-5-2-1-3-6-14/h1-12H,(H3,21,24,25)(H2,22,23,26)
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n/an/a 64n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207488
PNG
(1-(4-(3-amino-7-(2-(dimethylamino)ethoxy)-1H-indaz...)
Show SMILES CN(C)CCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C25H28N6O2/c1-16-5-4-6-19(15-16)28-25(32)27-18-9-7-17(8-10-18)20-11-12-21(33-14-13-31(2)3)23-22(20)24(26)30-29-23/h4-12,15H,13-14H2,1-3H3,(H3,26,29,30)(H2,27,28,32)
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n/an/a 65n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 66n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207494
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluorop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12
Show InChI InChI=1S/C20H16FN5O/c21-13-6-10-15(11-7-13)24-20(27)23-14-8-4-12(5-9-14)16-2-1-3-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 67n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207500
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-bromoph...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12
Show InChI InChI=1S/C20H16BrN5O/c21-13-3-1-4-15(11-13)24-20(27)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 69n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207488
PNG
(1-(4-(3-amino-7-(2-(dimethylamino)ethoxy)-1H-indaz...)
Show SMILES CN(C)CCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C25H28N6O2/c1-16-5-4-6-19(15-16)28-25(32)27-18-9-7-17(8-10-18)20-11-12-21(33-14-13-31(2)3)23-22(20)24(26)30-29-23/h4-12,15H,13-14H2,1-3H3,(H3,26,29,30)(H2,27,28,32)
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n/an/a 73n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207511
PNG
(1-(4-(3-amino-1-(2-(diethylamino)ethoxy)-1H-indazo...)
Show SMILES CCN(CC)CCOn1nc(N)c2c(cccc12)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C27H31FN6O2/c1-4-33(5-2)15-16-36-34-24-8-6-7-21(25(24)26(29)32-34)19-10-12-20(13-11-19)30-27(35)31-23-17-18(3)9-14-22(23)28/h6-14,17H,4-5,15-16H2,1-3H3,(H2,29,32)(H2,30,31,35)
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n/an/a 74n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207484
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-o-tolylure...)
Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C21H19N5O/c1-13-5-2-3-7-17(13)24-21(27)23-15-11-9-14(10-12-15)16-6-4-8-18-19(16)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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n/an/a 80n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207489
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluorop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12
Show InChI InChI=1S/C20H16FN5O/c21-15-5-1-2-6-16(15)24-20(27)23-13-10-8-12(9-11-13)14-4-3-7-17-18(14)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 82n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207483
PNG
(CHEMBL222315 | N-(4-(3-amino-1H-indazol-4-yl)pheny...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4CCCCC4)cc3)c12
Show InChI InChI=1S/C20H22N4O/c21-19-18-16(7-4-8-17(18)23-24-19)13-9-11-15(12-10-13)22-20(25)14-5-2-1-3-6-14/h4,7-12,14H,1-3,5-6H2,(H,22,25)(H3,21,23,24)
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n/an/a 86n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207484
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-o-tolylure...)
Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C21H19N5O/c1-13-5-2-3-7-17(13)24-21(27)23-15-11-9-14(10-12-15)16-6-4-8-18-19(16)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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n/an/a 86n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207484
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-o-tolylure...)
Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C21H19N5O/c1-13-5-2-3-7-17(13)24-21(27)23-15-11-9-14(10-12-15)16-6-4-8-18-19(16)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
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n/an/a 87n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207513
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H15F4N5O/c22-15-9-6-12(21(23,24)25)10-17(15)28-20(31)27-13-7-4-11(5-8-13)14-2-1-3-16-18(14)19(26)30-29-16/h1-10H,(H3,26,29,30)(H2,27,28,31)
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n/an/a 90n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207500
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-bromoph...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12
Show InChI InChI=1S/C20H16BrN5O/c21-13-3-1-4-15(11-13)24-20(27)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 106n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207497
PNG
(1-(4-(3-amino-7-(2-(pyrrolidin-1-yl)ethoxy)-1H-ind...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(OCCN3CCCC3)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C27H30N6O2/c1-18-5-4-6-21(17-18)30-27(34)29-20-9-7-19(8-10-20)22-11-12-23(25-24(22)26(28)32-31-25)35-16-15-33-13-2-3-14-33/h4-12,17H,2-3,13-16H2,1H3,(H3,28,31,32)(H2,29,30,34)
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n/an/a 120n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207513
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H15F4N5O/c22-15-9-6-12(21(23,24)25)10-17(15)28-20(31)27-13-7-4-11(5-8-13)14-2-1-3-16-18(14)19(26)30-29-16/h1-10H,(H3,26,29,30)(H2,27,28,31)
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n/an/a 150n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207513
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H15F4N5O/c22-15-9-6-12(21(23,24)25)10-17(15)28-20(31)27-13-7-4-11(5-8-13)14-2-1-3-16-18(14)19(26)30-29-16/h1-10H,(H3,26,29,30)(H2,27,28,31)
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n/an/a 151n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207483
PNG
(CHEMBL222315 | N-(4-(3-amino-1H-indazol-4-yl)pheny...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4CCCCC4)cc3)c12
Show InChI InChI=1S/C20H22N4O/c21-19-18-16(7-4-8-17(18)23-24-19)13-9-11-15(12-10-13)22-20(25)14-5-2-1-3-6-14/h4,7-12,14H,1-3,5-6H2,(H,22,25)(H3,21,23,24)
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n/an/a 152n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207492
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-cyclopenty...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)NC4CCCC4)cc3)c12
Show InChI InChI=1S/C19H21N5O/c20-18-17-15(6-3-7-16(17)23-24-18)12-8-10-14(11-9-12)22-19(25)21-13-4-1-2-5-13/h3,6-11,13H,1-2,4-5H2,(H3,20,23,24)(H2,21,22,25)
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n/an/a 153n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207489
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluorop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12
Show InChI InChI=1S/C20H16FN5O/c21-15-5-1-2-6-16(15)24-20(27)23-13-10-8-12(9-11-13)14-4-3-7-17-18(14)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)
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n/an/a 157n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 170n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of TIE2


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 190n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT4


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207476
PNG
(1-(4-(3-amino-7-((4-methylpiperazin-1-yl)methyl)-1...)
Show SMILES CN1CCN(Cc2ccc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)c3c(N)n[nH]c23)CC1
Show InChI InChI=1S/C27H31N7O/c1-18-4-3-5-22(16-18)30-27(35)29-21-9-6-19(7-10-21)23-11-8-20(25-24(23)26(28)32-31-25)17-34-14-12-33(2)13-15-34/h3-11,16H,12-15,17H2,1-2H3,(H3,28,31,32)(H2,29,30,35)
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n/an/a 215n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207513
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H15F4N5O/c22-15-9-6-12(21(23,24)25)10-17(15)28-20(31)27-13-7-4-11(5-8-13)14-2-1-3-16-18(14)19(26)30-29-16/h1-10H,(H3,26,29,30)(H2,27,28,31)
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n/an/a 270n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207508
PNG
(CHEMBL219999 | N-{4-[3-amino-1-(2-hydroxyethyl)-1H...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3n(CCO)nc(N)c23)c1
Show InChI InChI=1S/C23H23N5O2/c1-15-4-2-5-18(14-15)26-23(30)25-17-10-8-16(9-11-17)19-6-3-7-20-21(19)22(24)27-28(20)12-13-29/h2-11,14,29H,12-13H2,1H3,(H2,24,27)(H2,25,26,30)
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n/an/a 270n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207476
PNG
(1-(4-(3-amino-7-((4-methylpiperazin-1-yl)methyl)-1...)
Show SMILES CN1CCN(Cc2ccc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)c3c(N)n[nH]c23)CC1
Show InChI InChI=1S/C27H31N7O/c1-18-4-3-5-22(16-18)30-27(35)29-21-9-6-19(7-10-21)23-11-8-20(25-24(23)26(28)32-31-25)17-34-14-12-33(2)13-15-34/h3-11,16H,12-15,17H2,1-2H3,(H3,28,31,32)(H2,29,30,35)
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n/an/a 290n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207478
PNG
(CHEMBL223572 | N-{4-[3-amino-7-(4-morpholinylmethy...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(CN3CCOCC3)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C26H28N6O2/c1-17-3-2-4-21(15-17)29-26(33)28-20-8-5-18(6-9-20)22-10-7-19(16-32-11-13-34-14-12-32)24-23(22)25(27)31-30-24/h2-10,15H,11-14,16H2,1H3,(H3,27,30,31)(H2,28,29,33)
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n/an/a 390n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207478
PNG
(CHEMBL223572 | N-{4-[3-amino-7-(4-morpholinylmethy...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(CN3CCOCC3)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C26H28N6O2/c1-17-3-2-4-21(15-17)29-26(33)28-20-8-5-18(6-9-20)22-10-7-19(16-32-11-13-34-14-12-32)24-23(22)25(27)31-30-24/h2-10,15H,11-14,16H2,1H3,(H3,27,30,31)(H2,28,29,33)
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n/an/a 400n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207478
PNG
(CHEMBL223572 | N-{4-[3-amino-7-(4-morpholinylmethy...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(CN3CCOCC3)c3[nH]nc(N)c23)c1
Show InChI InChI=1S/C26H28N6O2/c1-17-3-2-4-21(15-17)29-26(33)28-20-8-5-18(6-9-20)22-10-7-19(16-32-11-13-34-14-12-32)24-23(22)25(27)31-30-24/h2-10,15H,11-14,16H2,1H3,(H3,27,30,31)(H2,28,29,33)
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n/an/a 450n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207479
PNG
(CHEMBL222974 | N-[4-(1-methyl-1H-indazol-4-yl)-phe...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3n(C)ncc23)c1
Show InChI InChI=1S/C22H20N4O/c1-15-5-3-6-18(13-15)25-22(27)24-17-11-9-16(10-12-17)19-7-4-8-21-20(19)14-23-26(21)2/h3-14H,1-2H3,(H2,24,25,27)
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n/an/a 465n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207510
PNG
(CHEMBL223236 | N-{4-[3-amino-1-(2-methoxyethyl)-1H...)
Show SMILES COCCn1nc(N)c2c(cccc12)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C24H24FN5O2/c1-15-6-11-19(25)20(14-15)28-24(31)27-17-9-7-16(8-10-17)18-4-3-5-21-22(18)23(26)29-30(21)12-13-32-2/h3-11,14H,12-13H2,1-2H3,(H2,26,29)(H2,27,28,31)
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n/an/a 480n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207508
PNG
(CHEMBL219999 | N-{4-[3-amino-1-(2-hydroxyethyl)-1H...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3n(CCO)nc(N)c23)c1
Show InChI InChI=1S/C23H23N5O2/c1-15-4-2-5-18(14-15)26-23(30)25-17-10-8-16(9-11-17)19-6-3-7-20-21(19)22(24)27-28(20)12-13-29/h2-11,14,29H,12-13H2,1H3,(H2,24,27)(H2,25,26,30)
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n/an/a 600n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207504
PNG
(CHEMBL223185 | N-(4-(3-amino-1H-indazol-4-yl)pheny...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)c4ccccc4)cc3)c12
Show InChI InChI=1S/C20H16N4O/c21-19-18-16(7-4-8-17(18)23-24-19)13-9-11-15(12-10-13)22-20(25)14-5-2-1-3-6-14/h1-12H,(H,22,25)(H3,21,23,24)
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n/an/a 694n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207492
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-cyclopenty...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)NC4CCCC4)cc3)c12
Show InChI InChI=1S/C19H21N5O/c20-18-17-15(6-3-7-16(17)23-24-18)12-8-10-14(11-9-12)22-19(25)21-13-4-1-2-5-13/h3,6-11,13H,1-2,4-5H2,(H3,20,23,24)(H2,21,22,25)
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n/an/a 850n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50207482
PNG
(CHEMBL223237 | N-{4-[3-amino-1-(2-morpholin-4-yl-e...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3n(CCN4CCOCC4)nc(N)c23)c1
Show InChI InChI=1S/C27H30N6O2/c1-19-4-2-5-22(18-19)30-27(34)29-21-10-8-20(9-11-21)23-6-3-7-24-25(23)26(28)31-33(24)13-12-32-14-16-35-17-15-32/h2-11,18H,12-17H2,1H3,(H2,28,31)(H2,29,30,34)
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n/an/a 860n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207476
PNG
(1-(4-(3-amino-7-((4-methylpiperazin-1-yl)methyl)-1...)
Show SMILES CN1CCN(Cc2ccc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)c3c(N)n[nH]c23)CC1
Show InChI InChI=1S/C27H31N7O/c1-18-4-3-5-22(16-18)30-27(35)29-21-9-6-19(7-10-21)23-11-8-20(25-24(23)26(28)32-31-25)17-34-14-12-33(2)13-15-34/h3-11,16H,12-15,17H2,1-2H3,(H3,28,31,32)(H2,29,30,35)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207482
PNG
(CHEMBL223237 | N-{4-[3-amino-1-(2-morpholin-4-yl-e...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3n(CCN4CCOCC4)nc(N)c23)c1
Show InChI InChI=1S/C27H30N6O2/c1-19-4-2-5-22(18-19)30-27(34)29-21-10-8-20(9-11-21)23-6-3-7-24-25(23)26(28)31-33(24)13-12-32-14-16-35-17-15-32/h2-11,18H,12-17H2,1H3,(H2,28,31)(H2,29,30,34)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RET


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207510
PNG
(CHEMBL223236 | N-{4-[3-amino-1-(2-methoxyethyl)-1H...)
Show SMILES COCCn1nc(N)c2c(cccc12)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C24H24FN5O2/c1-15-6-11-19(25)20(14-15)28-24(31)27-17-9-7-16(8-10-17)18-4-3-5-21-22(18)23(26)29-30(21)12-13-32-2/h3-11,14H,12-13H2,1-2H3,(H2,26,29)(H2,27,28,31)
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n/an/a 3.09E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207495
PNG
(CHEMBL222918 | N-[4-(3-dimethylamino-1-methyl-1H-i...)
Show SMILES CN(C)c1nn(C)c2cccc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)c12
Show InChI InChI=1S/C24H25N5O/c1-16-7-5-8-19(15-16)26-24(30)25-18-13-11-17(12-14-18)20-9-6-10-21-22(20)23(28(2)3)27-29(21)4/h5-15H,1-4H3,(H2,25,26,30)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207485
PNG
(CHEMBL220317 | N-(4-(3-amino-1H-indazol-4-yl)pheny...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NS(=O)(=O)c4ccccc4)cc3)c12
Show InChI InChI=1S/C19H16N4O2S/c20-19-18-16(7-4-8-17(18)21-22-19)13-9-11-14(12-10-13)23-26(24,25)15-5-2-1-3-6-15/h1-12,23H,(H3,20,21,22)
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n/an/a 4.62E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207472
PNG
(4-(4-aminophenyl)-1H-indazol-3-amine | 4-(4-aminop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(N)cc3)c12
Show InChI InChI=1S/C13H12N4/c14-9-6-4-8(5-7-9)10-2-1-3-11-12(10)13(15)17-16-11/h1-7H,14H2,(H3,15,16,17)
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n/an/a 4.79E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207472
PNG
(4-(4-aminophenyl)-1H-indazol-3-amine | 4-(4-aminop...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(N)cc3)c12
Show InChI InChI=1S/C13H12N4/c14-9-6-4-8(5-7-9)10-2-1-3-11-12(10)13(15)17-16-11/h1-7H,14H2,(H3,15,16,17)
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n/an/a 7.36E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 9.80E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CDC2 using 5 to 10 ATP umol/L


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207485
PNG
(CHEMBL220317 | N-(4-(3-amino-1H-indazol-4-yl)pheny...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NS(=O)(=O)c4ccccc4)cc3)c12
Show InChI InChI=1S/C19H16N4O2S/c20-19-18-16(7-4-8-17(18)21-22-19)13-9-11-14(12-10-13)23-26(24,25)15-5-2-1-3-6-15/h1-12,23H,(H3,20,21,22)
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n/an/a 1.12E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207496
PNG
(CHEMBL373435 | N-{1-methyl-4-[4-(3-methylphenylure...)
Show SMILES CC(=O)Nc1nn(C)c2cccc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)c12
Show InChI InChI=1S/C24H23N5O2/c1-15-6-4-7-19(14-15)27-24(31)26-18-12-10-17(11-13-18)20-8-5-9-21-22(20)23(25-16(2)30)28-29(21)3/h4-14H,1-3H3,(H,25,28,30)(H2,26,27,31)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50207504
PNG
(CHEMBL223185 | N-(4-(3-amino-1H-indazol-4-yl)pheny...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)c4ccccc4)cc3)c12
Show InChI InChI=1S/C20H16N4O/c21-19-18-16(7-4-8-17(18)23-24-19)13-9-11-15(12-10-13)22-20(25)14-5-2-1-3-6-14/h1-12H,(H,22,25)(H3,21,23,24)
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50207504
PNG
(CHEMBL223185 | N-(4-(3-amino-1H-indazol-4-yl)pheny...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)c4ccccc4)cc3)c12
Show InChI InChI=1S/C20H16N4O/c21-19-18-16(7-4-8-17(18)23-24-19)13-9-11-15(12-10-13)22-20(25)14-5-2-1-3-6-14/h1-12H,(H,22,25)(H3,21,23,24)
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of AKT using 5 to 10 ATP umol/L


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of SRC


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 5.00E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGR


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 5.00E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of LCK


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%