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PubMed code 1738153

Compile data set for download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008612
PNG
(CHEMBL154588 | Sodium; 3-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)c1cccc(NC(=O)C(CS)Cc2ccccc2)c1
Show InChI InChI=1S/C16H17NO4S2/c18-16(13(11-22)9-12-5-2-1-3-6-12)17-14-7-4-8-15(10-14)23(19,20)21/h1-8,10,13,22H,9,11H2,(H,17,18)(H,19,20,21)/p-1
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n/an/a 0.270n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008616
PNG
(CHEMBL157625 | Sodium; 2-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)CCNC(=O)[C@@H](CS)Cc1ccccc1
Show InChI InChI=1S/C12H17NO4S2/c14-12(13-6-7-19(15,16)17)11(9-18)8-10-4-2-1-3-5-10/h1-5,11,18H,6-9H2,(H,13,14)(H,15,16,17)/p-1/t11-/m1/s1
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n/an/a 0.820n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008595
PNG
(CHEMBL351330 | Sodium; 4-(2-mercaptomethyl-4-methy...)
Show SMILES CC(C)CC(CS)C(=O)Nc1ccc(cc1)S([O-])(=O)=O
Show InChI InChI=1S/C13H19NO4S2/c1-9(2)7-10(8-19)13(15)14-11-3-5-12(6-4-11)20(16,17)18/h3-6,9-10,19H,7-8H2,1-2H3,(H,14,15)(H,16,17,18)/p-1
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n/an/a 0.900n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008602
PNG
(CHEMBL435444 | Sodium; 4-(2-mercaptomethyl-3-p-tol...)
Show SMILES Cc1ccc(CC(CS)C(=O)Nc2ccc(cc2)S([O-])(=O)=O)cc1
Show InChI InChI=1S/C17H19NO4S2/c1-12-2-4-13(5-3-12)10-14(11-23)17(19)18-15-6-8-16(9-7-15)24(20,21)22/h2-9,14,23H,10-11H2,1H3,(H,18,19)(H,20,21,22)/p-1
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n/an/a 1.10n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008605
PNG
(CHEMBL157663 | Sodium; 2-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)CCNC(=O)C(CS)Cc1ccccc1
Show InChI InChI=1S/C12H17NO4S2/c14-12(13-6-7-19(15,16)17)11(9-18)8-10-4-2-1-3-5-10/h1-5,11,18H,6-9H2,(H,13,14)(H,15,16,17)/p-1
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n/an/a 1.5n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008590
PNG
(CHEMBL154774 | Sodium; 4-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)c1ccc(NC(=O)C(CS)Cc2ccccc2)cc1
Show InChI InChI=1S/C16H17NO4S2/c18-16(13(11-22)10-12-4-2-1-3-5-12)17-14-6-8-15(9-7-14)23(19,20)21/h1-9,13,22H,10-11H2,(H,17,18)(H,19,20,21)/p-1
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n/an/a 1.70n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008603
PNG
((2-Mercaptomethyl-3-phenyl-propionylamino)-methane...)
Show SMILES OS(=O)(=O)CNC(=O)C(CS)Cc1ccccc1
Show InChI InChI=1S/C11H15NO4S2/c13-11(12-8-18(14,15)16)10(7-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,12,13)(H,14,15,16)
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n/an/a 2.20n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008591
PNG
(CHEMBL346587 | Sodium; 3-(2-mercaptomethyl-4-methy...)
Show SMILES CC(C)CC(CS)C(=O)Nc1cccc(c1)S([O-])(=O)=O
Show InChI InChI=1S/C13H19NO4S2/c1-9(2)6-10(8-19)13(15)14-11-4-3-5-12(7-11)20(16,17)18/h3-5,7,9-10,19H,6,8H2,1-2H3,(H,14,15)(H,16,17,18)/p-1
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n/an/a 2.40n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008599
PNG
(CHEMBL155953 | Sodium; 3-(2-mercaptomethyl-3-p-tol...)
Show SMILES Cc1ccc(CC(CS)C(=O)Nc2cccc(c2)S([O-])(=O)=O)cc1
Show InChI InChI=1S/C17H19NO4S2/c1-12-5-7-13(8-6-12)9-14(11-23)17(19)18-15-3-2-4-16(10-15)24(20,21)22/h2-8,10,14,23H,9,11H2,1H3,(H,18,19)(H,20,21,22)/p-1
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n/an/a 2.5n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM21641
PNG
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Show SMILES OC(=O)CNC(=O)C(CS)Cc1ccccc1
Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)
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n/an/a 2.60n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against Enkephalinase enzyme


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008618
PNG
(CHEMBL155417 | Sodium; 2-(2-mercaptomethyl-3-p-tol...)
Show SMILES Cc1ccc(CC(CS)C(=O)NCCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C13H19NO4S2/c1-10-2-4-11(5-3-10)8-12(9-19)13(15)14-6-7-20(16,17)18/h2-5,12,19H,6-9H2,1H3,(H,14,15)(H,16,17,18)/p-1
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n/an/a 3.10n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008589
PNG
(CHEMBL155783 | Sodium; 4-[2-mercaptomethyl-3-(4-me...)
Show SMILES COc1ccc(CC(CS)C(=O)Nc2ccc(cc2)S([O-])(=O)=O)cc1
Show InChI InChI=1S/C17H19NO5S2/c1-23-15-6-2-12(3-7-15)10-13(11-24)17(19)18-14-4-8-16(9-5-14)25(20,21)22/h2-9,13,24H,10-11H2,1H3,(H,18,19)(H,20,21,22)/p-1
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n/an/a 3.20n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008623
PNG
(CHEMBL440183 | Sodium; 2-[3-(4-fluoro-phenyl)-2-me...)
Show SMILES [O-]S(=O)(=O)CCNC(=O)C(CS)Cc1ccc(F)cc1
Show InChI InChI=1S/C12H16FNO4S2/c13-11-3-1-9(2-4-11)7-10(8-19)12(15)14-5-6-20(16,17)18/h1-4,10,19H,5-8H2,(H,14,15)(H,16,17,18)/p-1
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n/an/a 3.5n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008600
PNG
(CHEMBL156374 | Sodium; 2-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)CCNC(=O)[C@H](CS)Cc1ccccc1
Show InChI InChI=1S/C12H17NO4S2/c14-12(13-6-7-19(15,16)17)11(9-18)8-10-4-2-1-3-5-10/h1-5,11,18H,6-9H2,(H,13,14)(H,15,16,17)/p-1/t11-/m0/s1
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n/an/a 4.40n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008609
PNG
(CHEMBL347390 | Sodium; 2-[2-mercaptomethyl-3-(4-me...)
Show SMILES COc1ccc(CC(CS)C(=O)NCCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C13H19NO5S2/c1-19-12-4-2-10(3-5-12)8-11(9-20)13(15)14-6-7-21(16,17)18/h2-5,11,20H,6-9H2,1H3,(H,14,15)(H,16,17,18)/p-1
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n/an/a 4.40n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008622
PNG
(CHEMBL158345 | Sodium; 4-[3-(4-fluoro-phenyl)-2-me...)
Show SMILES [O-]S(=O)(=O)c1ccc(NC(=O)C(CS)Cc2ccc(F)cc2)cc1
Show InChI InChI=1S/C16H16FNO4S2/c17-13-3-1-11(2-4-13)9-12(10-23)16(19)18-14-5-7-15(8-6-14)24(20,21)22/h1-8,12,23H,9-10H2,(H,18,19)(H,20,21,22)/p-1
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n/an/a 5n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008607
PNG
(CHEMBL154766 | Sodium; 2-(2-mercaptomethyl-4-methy...)
Show SMILES CC(C)CC(CS)C(=O)NCCS([O-])(=O)=O
Show InChI InChI=1S/C9H19NO4S2/c1-7(2)5-8(6-15)9(11)10-3-4-16(12,13)14/h7-8,15H,3-6H2,1-2H3,(H,10,11)(H,12,13,14)/p-1
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n/an/a 5.20n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against Enkephalinase enzyme


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008620
PNG
(CHEMBL156012 | Sodium; 3-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)CCCNC(=O)C(CS)Cc1ccccc1
Show InChI InChI=1S/C13H19NO4S2/c15-13(14-7-4-8-20(16,17)18)12(10-19)9-11-5-2-1-3-6-11/h1-3,5-6,12,19H,4,7-10H2,(H,14,15)(H,16,17,18)/p-1
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n/an/a 5.40n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008610
PNG
(CHEMBL156013 | Sodium; 4-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)c1ccc(NC(=O)C(CS)Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C20H19NO4S2/c22-20(15(13-26)12-14-6-2-1-3-7-14)21-18-10-11-19(27(23,24)25)17-9-5-4-8-16(17)18/h1-11,15,26H,12-13H2,(H,21,22)(H,23,24,25)/p-1
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n/an/a 7.40n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against Enkephalinase enzyme


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008597
PNG
(CHEMBL156099 | Sodium; 2-(2-mercaptomethyl-3-napht...)
Show SMILES [O-]S(=O)(=O)CCNC(=O)C(CS)Cc1cccc2ccccc12
Show InChI InChI=1S/C16H19NO4S2/c18-16(17-8-9-23(19,20)21)14(11-22)10-13-6-3-5-12-4-1-2-7-15(12)13/h1-7,14,22H,8-11H2,(H,17,18)(H,19,20,21)/p-1
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n/an/a 8.40n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008613
PNG
(CHEMBL157079 | Sodium; 4-[(2-mercaptomethyl-3-phen...)
Show SMILES [O-]S(=O)(=O)c1ccc(CNC(=O)C(CS)Cc2ccccc2)cc1
Show InChI InChI=1S/C17H19NO4S2/c19-17(15(12-23)10-13-4-2-1-3-5-13)18-11-14-6-8-16(9-7-14)24(20,21)22/h1-9,15,23H,10-12H2,(H,18,19)(H,20,21,22)/p-1
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n/an/a 11n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008615
PNG
(2-(2-Mercaptomethyl-5-phenyl-pentanoylamino)-ethan...)
Show SMILES OS(=O)(=O)CCNC(=O)C(CS)CCCc1ccccc1
Show InChI InChI=1S/C14H21NO4S2/c16-14(15-9-10-21(17,18)19)13(11-20)8-4-7-12-5-2-1-3-6-12/h1-3,5-6,13,20H,4,7-11H2,(H,15,16)(H,17,18,19)
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n/an/a 11n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008617
PNG
(CHEMBL156757 | Sodium; 4-(3-benzo[d]isoxazol-3-yl-...)
Show SMILES [O-]S(=O)(=O)c1ccc(NC(=O)C(CS)Cc2noc3ccccc23)cc1
Show InChI InChI=1S/C17H16N2O5S2/c20-17(18-12-5-7-13(8-6-12)26(21,22)23)11(10-25)9-15-14-3-1-2-4-16(14)24-19-15/h1-8,11,25H,9-10H2,(H,18,20)(H,21,22,23)/p-1
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n/an/a 12n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008606
PNG
(CHEMBL155779 | Sodium; 4-[3-(4-dimethylamino-pheny...)
Show SMILES CN(C)c1ccc(CC(CS)C(=O)Nc2ccc(cc2)S([O-])(=O)=O)cc1
Show InChI InChI=1S/C18H22N2O4S2/c1-20(2)16-7-3-13(4-8-16)11-14(12-25)18(21)19-15-5-9-17(10-6-15)26(22,23)24/h3-10,14,25H,11-12H2,1-2H3,(H,19,21)(H,22,23,24)/p-1
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n/an/a 14n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008596
PNG
(CHEMBL154368 | Sodium; 4-[2-mercaptomethyl-3-(4-ni...)
Show SMILES [O-][N+](=O)c1ccc(CC(CS)C(=O)Nc2ccc(cc2)S([O-])(=O)=O)cc1
Show InChI InChI=1S/C16H16N2O6S2/c19-16(17-13-3-7-15(8-4-13)26(22,23)24)12(10-25)9-11-1-5-14(6-2-11)18(20)21/h1-8,12,25H,9-10H2,(H,17,19)(H,22,23,24)/p-1
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n/an/a 14n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against Enkephalinase enzyme


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008621
PNG
(CHEMBL422339 | Sodium; 2-[2-mercaptomethyl-3-(4-ni...)
Show SMILES [O-][N+](=O)c1ccc(CC(CS)C(=O)NCCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C12H16N2O6S2/c15-12(13-5-6-22(18,19)20)10(8-21)7-9-1-3-11(4-2-9)14(16)17/h1-4,10,21H,5-8H2,(H,13,15)(H,18,19,20)/p-1
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n/an/a 17n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against Enkephalinase enzyme


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008592
PNG
(CHEMBL347040 | Sodium; 1-(2-mercaptomethyl-3-pheny...)
Show SMILES CC(NC(=O)C(CS)Cc1ccccc1)S([O-])(=O)=O
Show InChI InChI=1S/C12H17NO4S2/c1-9(19(15,16)17)13-12(14)11(8-18)7-10-5-3-2-4-6-10/h2-6,9,11,18H,7-8H2,1H3,(H,13,14)(H,15,16,17)/p-1
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n/an/a 31n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008614
PNG
(4-(2-Mercaptomethyl-3-pyridin-3-yl-propionylamino)...)
Show SMILES OS(=O)(=O)c1ccc(NC(=O)C(CS)Cc2cccnc2)cc1
Show InChI InChI=1S/C15H16N2O4S2/c18-15(12(10-22)8-11-2-1-7-16-9-11)17-13-3-5-14(6-4-13)23(19,20)21/h1-7,9,12,22H,8,10H2,(H,17,18)(H,19,20,21)
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n/an/a 33n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008604
PNG
(CHEMBL155070 | Sodium; 4-(2-mercaptomethyl-3-napht...)
Show SMILES [O-]S(=O)(=O)c1ccc(NC(=O)C(CS)Cc2cccc3ccccc23)cc1
Show InChI InChI=1S/C20H19NO4S2/c22-20(21-17-8-10-18(11-9-17)27(23,24)25)16(13-26)12-15-6-3-5-14-4-1-2-7-19(14)15/h1-11,16,26H,12-13H2,(H,21,22)(H,23,24,25)/p-1
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n/an/a 34n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008611
PNG
(CHEMBL422165 | Sodium; 2-[3-(4-dimethylamino-pheny...)
Show SMILES CN(C)c1ccc(CC(CS)C(=O)NCCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C14H22N2O4S2/c1-16(2)13-5-3-11(4-6-13)9-12(10-21)14(17)15-7-8-22(18,19)20/h3-6,12,21H,7-10H2,1-2H3,(H,15,17)(H,18,19,20)/p-1
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n/an/a 37n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008598
PNG
(CHEMBL422526 | Sodium; 4-(3-biphenyl-4-yl-2-mercap...)
Show SMILES [O-]S(=O)(=O)c1ccc(NC(=O)C(CS)Cc2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C22H21NO4S2/c24-22(23-20-10-12-21(13-11-20)29(25,26)27)19(15-28)14-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-13,19,28H,14-15H2,(H,23,24)(H,25,26,27)/p-1
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n/an/a 52n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008624
PNG
(4-(2-Mercaptomethyl-5-phenyl-pentanoylamino)-benze...)
Show SMILES OS(=O)(=O)c1ccc(NC(=O)C(CS)CCCc2ccccc2)cc1
Show InChI InChI=1S/C18H21NO4S2/c20-18(19-16-9-11-17(12-10-16)25(21,22)23)15(13-24)8-4-7-14-5-2-1-3-6-14/h1-3,5-6,9-12,15,24H,4,7-8,13H2,(H,19,20)(H,21,22,23)
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n/an/a 110n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008594
PNG
(CHEMBL156361 | Sodium; 2-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)c1ccccc1NC(=O)C(CS)Cc1ccccc1
Show InChI InChI=1S/C16H17NO4S2/c18-16(13(11-22)10-12-6-2-1-3-7-12)17-14-8-4-5-9-15(14)23(19,20)21/h1-9,13,22H,10-11H2,(H,17,18)(H,19,20,21)/p-1
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n/an/a 140n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008608
PNG
(CHEMBL154790 | Sodium; 4-[2-mercaptomethyl-3-(4-tr...)
Show SMILES [O-]S(=O)(=O)c1ccc(NC(=O)C(CS)Cc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C17H16F3NO4S2/c18-17(19,20)13-3-1-11(2-4-13)9-12(10-26)16(22)21-14-5-7-15(8-6-14)27(23,24)25/h1-8,12,26H,9-10H2,(H,21,22)(H,23,24,25)/p-1
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n/an/a 150n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008593
PNG
(CHEMBL346060 | Sodium; 1-(2-mercaptomethyl-3-pheny...)
Show SMILES CC(C)CC(NC(=O)C(CS)Cc1ccccc1)S([O-])(=O)=O
Show InChI InChI=1S/C15H23NO4S2/c1-11(2)8-14(22(18,19)20)16-15(17)13(10-21)9-12-6-4-3-5-7-12/h3-7,11,13-14,21H,8-10H2,1-2H3,(H,16,17)(H,18,19,20)/p-1
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n/an/a 250n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM21641
PNG
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Show SMILES OC(=O)CNC(=O)C(CS)Cc1ccccc1
Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)
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n/an/a 420n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme (ACE) from rabbit lung


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008619
PNG
(CHEMBL158290 | Sodium; 2-[(2-mercaptomethyl-3-phen...)
Show SMILES CN(CCS([O-])(=O)=O)C(=O)C(CS)Cc1ccccc1
Show InChI InChI=1S/C13H19NO4S2/c1-14(7-8-20(16,17)18)13(15)12(10-19)9-11-5-3-2-4-6-11/h2-6,12,19H,7-10H2,1H3,(H,16,17,18)/p-1
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n/an/a 490n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50008601
PNG
(CHEMBL155288 | Sodium; 2-[cyclopropyl-(2-mercaptom...)
Show SMILES [O-]S(=O)(=O)CCN(C1CC1)C(=O)C(CS)Cc1ccccc1
Show InChI InChI=1S/C15H21NO4S2/c17-15(13(11-21)10-12-4-2-1-3-5-12)16(14-6-7-14)8-9-22(18,19)20/h1-5,13-14,21H,6-11H2,(H,18,19,20)/p-1
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n/an/a 4.20E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against enkephalinase enzyme from rat.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50008603
PNG
((2-Mercaptomethyl-3-phenyl-propionylamino)-methane...)
Show SMILES OS(=O)(=O)CNC(=O)C(CS)Cc1ccccc1
Show InChI InChI=1S/C11H15NO4S2/c13-11(12-8-18(14,15)16)10(7-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,12,13)(H,14,15,16)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin I converting enzyme from rabbit lung


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50008610
PNG
(CHEMBL156013 | Sodium; 4-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)c1ccc(NC(=O)C(CS)Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C20H19NO4S2/c22-20(15(13-26)12-14-6-2-1-3-7-14)21-18-10-11-19(27(23,24)25)17-9-5-4-8-16(17)18/h1-11,15,26H,12-13H2,(H,21,22)(H,23,24,25)/p-1
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n/an/a 3.70E+4n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme (ACE) from rabbit lung


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50008590
PNG
(CHEMBL154774 | Sodium; 4-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)c1ccc(NC(=O)C(CS)Cc2ccccc2)cc1
Show InChI InChI=1S/C16H17NO4S2/c18-16(13(11-22)10-12-4-2-1-3-5-12)17-14-6-8-15(9-7-14)23(19,20)21/h1-9,13,22H,10-11H2,(H,17,18)(H,19,20,21)/p-1
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n/an/a 1.20E+5n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin I converting enzyme from rabbit lung


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50008612
PNG
(CHEMBL154588 | Sodium; 3-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)c1cccc(NC(=O)C(CS)Cc2ccccc2)c1
Show InChI InChI=1S/C16H17NO4S2/c18-16(13(11-22)9-12-5-2-1-3-6-12)17-14-7-4-8-15(10-14)23(19,20)21/h1-8,10,13,22H,9,11H2,(H,17,18)(H,19,20,21)/p-1
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n/an/a 2.90E+5n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin I converting enzyme from rabbit lung


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50008616
PNG
(CHEMBL157625 | Sodium; 2-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)CCNC(=O)[C@@H](CS)Cc1ccccc1
Show InChI InChI=1S/C12H17NO4S2/c14-12(13-6-7-19(15,16)17)11(9-18)8-10-4-2-1-3-5-10/h1-5,11,18H,6-9H2,(H,13,14)(H,15,16,17)/p-1/t11-/m1/s1
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n/an/a 4.30E+5n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin I converting enzyme from rabbit lung


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50008605
PNG
(CHEMBL157663 | Sodium; 2-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)CCNC(=O)C(CS)Cc1ccccc1
Show InChI InChI=1S/C12H17NO4S2/c14-12(13-6-7-19(15,16)17)11(9-18)8-10-4-2-1-3-5-10/h1-5,11,18H,6-9H2,(H,13,14)(H,15,16,17)/p-1
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n/an/a 7.20E+5n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin I converting enzyme from rabbit lung


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50008600
PNG
(CHEMBL156374 | Sodium; 2-(2-mercaptomethyl-3-pheny...)
Show SMILES [O-]S(=O)(=O)CCNC(=O)[C@H](CS)Cc1ccccc1
Show InChI InChI=1S/C12H17NO4S2/c14-12(13-6-7-19(15,16)17)11(9-18)8-10-4-2-1-3-5-10/h1-5,11,18H,6-9H2,(H,13,14)(H,15,16,17)/p-1/t11-/m0/s1
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PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 7.40E+5n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin I converting enzyme from rabbit lung


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%