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PubMed code 17391959

Compile data set for download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209158
PNG
(2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1
Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)
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n/an/a 6n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209158
PNG
(2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1
Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)
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n/an/a 10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209148
PNG
(CHEMBL246166 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H19N3O4S/c1-32-26(31)25(30)27-22-11-5-10-19-20(22)14-21-23(28-29-24(19)21)16-13-18(34-15-16)9-6-12-33-17-7-3-2-4-8-17/h2-5,7-8,10-11,13,15H,12,14H2,1H3,(H,27,30)(H,28,29)
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n/an/a 20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50209158
PNG
(2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1
Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)
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n/an/a 22n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt3 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209143
PNG
(2-methoxy-N-(3-thiophen-3-yl-2,4-dihydro-indeno[1,...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H15N3O2S/c1-22-8-15(21)18-14-4-2-3-11-12(14)7-13-16(19-20-17(11)13)10-5-6-23-9-10/h2-6,9H,7-8H2,1H3,(H,18,21)(H,19,20)
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n/an/a 30n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209148
PNG
(CHEMBL246166 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H19N3O4S/c1-32-26(31)25(30)27-22-11-5-10-19-20(22)14-21-23(28-29-24(19)21)16-13-18(34-15-16)9-6-12-33-17-7-3-2-4-8-17/h2-5,7-8,10-11,13,15H,12,14H2,1H3,(H,27,30)(H,28,29)
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n/an/a 36n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50209158
PNG
(2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1
Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)
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n/an/a 45n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CSF1R by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209158
PNG
(2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1
Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)
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n/an/a 49n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209151
PNG
(CHEMBL247388 | N-(3-thiophen-3-yl-2,4-dihydro-inde...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H13N3O3S/c1-23-17(22)16(21)18-13-4-2-3-10-11(13)7-12-14(19-20-15(10)12)9-5-6-24-8-9/h2-6,8H,7H2,1H3,(H,18,21)(H,19,20)
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n/an/a 50n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209146
PNG
(CHEMBL247585 | N-(3-thiophen-3-yl-2,4-dihydro-inde...)
Show SMILES O=C(Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1)c1ccccc1
Show InChI InChI=1S/C21H15N3OS/c25-21(13-5-2-1-3-6-13)22-18-8-4-7-15-16(18)11-17-19(23-24-20(15)17)14-9-10-26-12-14/h1-10,12H,11H2,(H,22,25)(H,23,24)
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n/an/a 50n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209150
PNG
(2-methoxy-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H21N3O3S/c1-31-15-24(30)27-23-11-5-10-20-21(23)14-22-25(28-29-26(20)22)17-13-19(33-16-17)9-6-12-32-18-7-3-2-4-8-18/h2-5,7-8,10-11,13,16H,12,14-15H2,1H3,(H,27,30)(H,28,29)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209154
PNG
(5-methyl-isoxazole-3-carboxylic acid (3-thiophen-3...)
Show SMILES Cc1cc(no1)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C19H14N4O2S/c1-10-7-16(23-25-10)19(24)20-15-4-2-3-12-13(15)8-14-17(21-22-18(12)14)11-5-6-26-9-11/h2-7,9H,8H2,1H3,(H,20,24)(H,21,22)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50209148
PNG
(CHEMBL246166 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H19N3O4S/c1-32-26(31)25(30)27-22-11-5-10-19-20(22)14-21-23(28-29-24(19)21)16-13-18(34-15-16)9-6-12-33-17-7-3-2-4-8-17/h2-5,7-8,10-11,13,15H,12,14H2,1H3,(H,27,30)(H,28,29)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt3 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209143
PNG
(2-methoxy-N-(3-thiophen-3-yl-2,4-dihydro-indeno[1,...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H15N3O2S/c1-22-8-15(21)18-14-4-2-3-11-12(14)7-13-16(19-20-17(11)13)10-5-6-23-9-10/h2-6,9H,7-8H2,1H3,(H,18,21)(H,19,20)
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n/an/a 70n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209154
PNG
(5-methyl-isoxazole-3-carboxylic acid (3-thiophen-3...)
Show SMILES Cc1cc(no1)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C19H14N4O2S/c1-10-7-16(23-25-10)19(24)20-15-4-2-3-12-13(15)8-14-17(21-22-18(12)14)11-5-6-26-9-11/h2-7,9H,8H2,1H3,(H,20,24)(H,21,22)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209151
PNG
(CHEMBL247388 | N-(3-thiophen-3-yl-2,4-dihydro-inde...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H13N3O3S/c1-23-17(22)16(21)18-13-4-2-3-10-11(13)7-12-14(19-20-15(10)12)9-5-6-24-8-9/h2-6,8H,7H2,1H3,(H,18,21)(H,19,20)
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n/an/a 80n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209153
PNG
(CHEMBL247389 | furan-2-carboxylic acid (3-thiophen...)
Show SMILES O=C(Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1)c1ccco1
Show InChI InChI=1S/C19H13N3O2S/c23-19(16-5-2-7-24-16)20-15-4-1-3-12-13(15)9-14-17(21-22-18(12)14)11-6-8-25-10-11/h1-8,10H,9H2,(H,20,23)(H,21,22)
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n/an/a 90n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209146
PNG
(CHEMBL247585 | N-(3-thiophen-3-yl-2,4-dihydro-inde...)
Show SMILES O=C(Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1)c1ccccc1
Show InChI InChI=1S/C21H15N3OS/c25-21(13-5-2-1-3-6-13)22-18-8-4-7-15-16(18)11-17-19(23-24-20(15)17)14-9-10-26-12-14/h1-10,12H,11H2,(H,22,25)(H,23,24)
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n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209153
PNG
(CHEMBL247389 | furan-2-carboxylic acid (3-thiophen...)
Show SMILES O=C(Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1)c1ccco1
Show InChI InChI=1S/C19H13N3O2S/c23-19(16-5-2-7-24-16)20-15-4-1-3-12-13(15)9-14-17(21-22-18(12)14)11-6-8-25-10-11/h1-8,10H,9H2,(H,20,23)(H,21,22)
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n/an/a 110n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50209150
PNG
(2-methoxy-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H21N3O3S/c1-31-15-24(30)27-23-11-5-10-20-21(23)14-22-25(28-29-26(20)22)17-13-19(33-16-17)9-6-12-32-18-7-3-2-4-8-18/h2-5,7-8,10-11,13,16H,12,14-15H2,1H3,(H,27,30)(H,28,29)
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n/an/a 113n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CSF1R by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209148
PNG
(CHEMBL246166 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H19N3O4S/c1-32-26(31)25(30)27-22-11-5-10-19-20(22)14-21-23(28-29-24(19)21)16-13-18(34-15-16)9-6-12-33-17-7-3-2-4-8-17/h2-5,7-8,10-11,13,15H,12,14H2,1H3,(H,27,30)(H,28,29)
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n/an/a 127n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209144
PNG
(2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-yny...)
Show SMILES COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H25N3O4S/c1-33-13-14-34-17-26(32)29-25-11-5-10-22-23(25)16-24-27(30-31-28(22)24)19-15-21(36-18-19)9-6-12-35-20-7-3-2-4-8-20/h2-5,7-8,10-11,15,18H,12-14,16-17H2,1H3,(H,29,32)(H,30,31)
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n/an/a 136n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50209150
PNG
(2-methoxy-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H21N3O3S/c1-31-15-24(30)27-23-11-5-10-20-21(23)14-22-25(28-29-26(20)22)17-13-19(33-16-17)9-6-12-32-18-7-3-2-4-8-18/h2-5,7-8,10-11,13,16H,12,14-15H2,1H3,(H,27,30)(H,28,29)
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n/an/a 153n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt3 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209156
PNG
(CHEMBL395427 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES CCOC(=O)CC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-2-34-26(33)16-25(32)29-24-12-6-11-21-22(24)15-23-27(30-31-28(21)23)18-14-20(36-17-18)10-7-13-35-19-8-4-3-5-9-19/h3-6,8-9,11-12,14,17H,2,13,15-16H2,1H3,(H,29,32)(H,30,31)
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n/an/a 153n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209150
PNG
(2-methoxy-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H21N3O3S/c1-31-15-24(30)27-23-11-5-10-20-21(23)14-22-25(28-29-26(20)22)17-13-19(33-16-17)9-6-12-32-18-7-3-2-4-8-18/h2-5,7-8,10-11,13,16H,12,14-15H2,1H3,(H,27,30)(H,28,29)
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n/an/a 175n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209146
PNG
(CHEMBL247585 | N-(3-thiophen-3-yl-2,4-dihydro-inde...)
Show SMILES O=C(Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1)c1ccccc1
Show InChI InChI=1S/C21H15N3OS/c25-21(13-5-2-1-3-6-13)22-18-8-4-7-15-16(18)11-17-19(23-24-20(15)17)14-9-10-26-12-14/h1-10,12H,11H2,(H,22,25)(H,23,24)
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n/an/a 180n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50209148
PNG
(CHEMBL246166 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H19N3O4S/c1-32-26(31)25(30)27-22-11-5-10-19-20(22)14-21-23(28-29-24(19)21)16-13-18(34-15-16)9-6-12-33-17-7-3-2-4-8-17/h2-5,7-8,10-11,13,15H,12,14H2,1H3,(H,27,30)(H,28,29)
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n/an/a 190n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CSF1R by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209159
PNG
(CHEMBL246343 | [(3-thiophen-3-yl-2,4-dihydro-inden...)
Show SMILES OC(=O)CNC(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H13N3O3S/c21-14(22)7-18-17(23)11-3-1-2-10-12(11)6-13-15(19-20-16(10)13)9-4-5-24-8-9/h1-5,8H,6-7H2,(H,18,23)(H,19,20)(H,21,22)
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n/an/a 240n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209156
PNG
(CHEMBL395427 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES CCOC(=O)CC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-2-34-26(33)16-25(32)29-24-12-6-11-21-22(24)15-23-27(30-31-28(21)23)18-14-20(36-17-18)10-7-13-35-19-8-4-3-5-9-19/h3-6,8-9,11-12,14,17H,2,13,15-16H2,1H3,(H,29,32)(H,30,31)
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n/an/a 263n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209144
PNG
(2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-yny...)
Show SMILES COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H25N3O4S/c1-33-13-14-34-17-26(32)29-25-11-5-10-22-23(25)16-24-27(30-31-28(22)24)19-15-21(36-18-19)9-6-12-35-20-7-3-2-4-8-20/h2-5,7-8,10-11,15,18H,12-14,16-17H2,1H3,(H,29,32)(H,30,31)
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n/an/a 270n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209160
PNG
(2-[(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyraz...)
Show SMILES OCCNCc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H17N3OS/c21-6-5-18-9-11-2-1-3-13-14(11)8-15-16(19-20-17(13)15)12-4-7-22-10-12/h1-4,7,10,18,21H,5-6,8-9H2,(H,19,20)
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n/an/a 270n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209145
PNG
(CHEMBL245362 | N-(3-thiophen-3-yl-2,4-dihydro-inde...)
Show SMILES CCCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C18H17N3OS/c1-2-4-16(22)19-15-6-3-5-12-13(15)9-14-17(20-21-18(12)14)11-7-8-23-10-11/h3,5-8,10H,2,4,9H2,1H3,(H,19,22)(H,20,21)
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n/an/a 290n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209161
PNG
(CHEMBL395694 | ethanesulfonic acid (3-thiophen-3-y...)
Show SMILES CCS(=O)(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C16H15N3O2S2/c1-2-23(20,21)19-14-5-3-4-11-12(14)8-13-15(17-18-16(11)13)10-6-7-22-9-10/h3-7,9,19H,2,8H2,1H3,(H,17,18)
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n/an/a 290n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209161
PNG
(CHEMBL395694 | ethanesulfonic acid (3-thiophen-3-y...)
Show SMILES CCS(=O)(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C16H15N3O2S2/c1-2-23(20,21)19-14-5-3-4-11-12(14)8-13-15(17-18-16(11)13)10-6-7-22-9-10/h3-7,9,19H,2,8H2,1H3,(H,17,18)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209147
PNG
(3-[(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyraz...)
Show SMILES OC(=O)CCNC(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C18H15N3O3S/c22-15(23)4-6-19-18(24)12-3-1-2-11-13(12)8-14-16(20-21-17(11)14)10-5-7-25-9-10/h1-3,5,7,9H,4,6,8H2,(H,19,24)(H,20,21)(H,22,23)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209159
PNG
(CHEMBL246343 | [(3-thiophen-3-yl-2,4-dihydro-inden...)
Show SMILES OC(=O)CNC(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H13N3O3S/c21-14(22)7-18-17(23)11-3-1-2-10-12(11)6-13-15(19-20-16(10)13)9-4-5-24-8-9/h1-5,8H,6-7H2,(H,18,23)(H,19,20)(H,21,22)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209160
PNG
(2-[(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyraz...)
Show SMILES OCCNCc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H17N3OS/c21-6-5-18-9-11-2-1-3-13-14(11)8-15-16(19-20-17(13)15)12-4-7-22-10-12/h1-4,7,10,18,21H,5-6,8-9H2,(H,19,20)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209157
PNG
((3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazol-...)
Show SMILES CCOC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H15N3O2S/c1-2-22-17(21)18-14-5-3-4-11-12(14)8-13-15(19-20-16(11)13)10-6-7-23-9-10/h3-7,9H,2,8H2,1H3,(H,18,21)(H,19,20)
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n/an/a 450n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209145
PNG
(CHEMBL245362 | N-(3-thiophen-3-yl-2,4-dihydro-inde...)
Show SMILES CCCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C18H17N3OS/c1-2-4-16(22)19-15-6-3-5-12-13(15)9-14-17(20-21-18(12)14)11-7-8-23-10-11/h3,5-8,10H,2,4,9H2,1H3,(H,19,22)(H,20,21)
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n/an/a 560n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209147
PNG
(3-[(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyraz...)
Show SMILES OC(=O)CCNC(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C18H15N3O3S/c22-15(23)4-6-19-18(24)12-3-1-2-11-13(12)8-14-16(20-21-17(11)14)10-5-7-25-9-10/h1-3,5,7,9H,4,6,8H2,(H,19,24)(H,20,21)(H,22,23)
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n/an/a 580n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209156
PNG
(CHEMBL395427 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES CCOC(=O)CC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-2-34-26(33)16-25(32)29-24-12-6-11-21-22(24)15-23-27(30-31-28(21)23)18-14-20(36-17-18)10-7-13-35-19-8-4-3-5-9-19/h3-6,8-9,11-12,14,17H,2,13,15-16H2,1H3,(H,29,32)(H,30,31)
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n/an/a 619n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50209144
PNG
(2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-yny...)
Show SMILES COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H25N3O4S/c1-33-13-14-34-17-26(32)29-25-11-5-10-22-23(25)16-24-27(30-31-28(22)24)19-15-21(36-18-19)9-6-12-35-20-7-3-2-4-8-20/h2-5,7-8,10-11,15,18H,12-14,16-17H2,1H3,(H,29,32)(H,30,31)
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n/an/a 624n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt3 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209157
PNG
((3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazol-...)
Show SMILES CCOC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H15N3O2S/c1-2-22-17(21)18-14-5-3-4-11-12(14)8-13-15(19-20-16(11)13)10-6-7-23-9-10/h3-7,9H,2,8H2,1H3,(H,18,21)(H,19,20)
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n/an/a 650n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209150
PNG
(2-methoxy-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H21N3O3S/c1-31-15-24(30)27-23-11-5-10-20-21(23)14-22-25(28-29-26(20)22)17-13-19(33-16-17)9-6-12-32-18-7-3-2-4-8-18/h2-5,7-8,10-11,13,16H,12,14-15H2,1H3,(H,27,30)(H,28,29)
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n/an/a 710n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209162
PNG
(2-(4-methyl-piperazin-1-yl)-N-(3-thiophen-3-yl-2,4...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2ccsc2)CC1
Show InChI InChI=1S/C21H23N5OS/c1-25-6-8-26(9-7-25)12-19(27)22-18-4-2-3-15-16(18)11-17-20(23-24-21(15)17)14-5-10-28-13-14/h2-5,10,13H,6-9,11-12H2,1H3,(H,22,27)(H,23,24)
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n/an/a 710n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209154
PNG
(5-methyl-isoxazole-3-carboxylic acid (3-thiophen-3...)
Show SMILES Cc1cc(no1)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C19H14N4O2S/c1-10-7-16(23-25-10)19(24)20-15-4-2-3-12-13(15)8-14-17(21-22-18(12)14)11-5-6-26-9-11/h2-7,9H,8H2,1H3,(H,20,24)(H,21,22)
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n/an/a 900n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209162
PNG
(2-(4-methyl-piperazin-1-yl)-N-(3-thiophen-3-yl-2,4...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2ccsc2)CC1
Show InChI InChI=1S/C21H23N5OS/c1-25-6-8-26(9-7-25)12-19(27)22-18-4-2-3-15-16(18)11-17-20(23-24-21(15)17)14-5-10-28-13-14/h2-5,10,13H,6-9,11-12H2,1H3,(H,22,27)(H,23,24)
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n/an/a 920n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209153
PNG
(CHEMBL247389 | furan-2-carboxylic acid (3-thiophen...)
Show SMILES O=C(Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1)c1ccco1
Show InChI InChI=1S/C19H13N3O2S/c23-19(16-5-2-7-24-16)20-15-4-1-3-12-13(15)9-14-17(21-22-18(12)14)11-6-8-25-10-11/h1-8,10H,9H2,(H,20,23)(H,21,22)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50209156
PNG
(CHEMBL395427 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES CCOC(=O)CC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-2-34-26(33)16-25(32)29-24-12-6-11-21-22(24)15-23-27(30-31-28(21)23)18-14-20(36-17-18)10-7-13-35-19-8-4-3-5-9-19/h3-6,8-9,11-12,14,17H,2,13,15-16H2,1H3,(H,29,32)(H,30,31)
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n/an/a 1.11E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt3 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209151
PNG
(CHEMBL247388 | N-(3-thiophen-3-yl-2,4-dihydro-inde...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H13N3O3S/c1-23-17(22)16(21)18-13-4-2-3-10-11(13)7-12-14(19-20-15(10)12)9-5-6-24-8-9/h2-6,8H,7H2,1H3,(H,18,21)(H,19,20)
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n/an/a 1.12E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50209144
PNG
(2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-yny...)
Show SMILES COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H25N3O4S/c1-33-13-14-34-17-26(32)29-25-11-5-10-22-23(25)16-24-27(30-31-28(22)24)19-15-21(36-18-19)9-6-12-35-20-7-3-2-4-8-20/h2-5,7-8,10-11,15,18H,12-14,16-17H2,1H3,(H,29,32)(H,30,31)
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n/an/a 1.27E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CSF1R by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209143
PNG
(2-methoxy-N-(3-thiophen-3-yl-2,4-dihydro-indeno[1,...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H15N3O2S/c1-22-8-15(21)18-14-4-2-3-11-12(14)7-13-16(19-20-17(11)13)10-5-6-23-9-10/h2-6,9H,7-8H2,1H3,(H,18,21)(H,19,20)
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n/an/a 1.58E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209160
PNG
(2-[(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyraz...)
Show SMILES OCCNCc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H17N3OS/c21-6-5-18-9-11-2-1-3-13-14(11)8-15-16(19-20-17(13)15)12-4-7-22-10-12/h1-4,7,10,18,21H,5-6,8-9H2,(H,19,20)
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n/an/a 1.67E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209157
PNG
((3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazol-...)
Show SMILES CCOC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H15N3O2S/c1-2-22-17(21)18-14-5-3-4-11-12(14)8-13-15(19-20-16(11)13)10-6-7-23-9-10/h3-7,9H,2,8H2,1H3,(H,18,21)(H,19,20)
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n/an/a 2.55E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50209156
PNG
(CHEMBL395427 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES CCOC(=O)CC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-2-34-26(33)16-25(32)29-24-12-6-11-21-22(24)15-23-27(30-31-28(21)23)18-14-20(36-17-18)10-7-13-35-19-8-4-3-5-9-19/h3-6,8-9,11-12,14,17H,2,13,15-16H2,1H3,(H,29,32)(H,30,31)
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n/an/a 2.98E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CSF1R by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209149
PNG
(1-(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazo...)
Show SMILES OC(=O)C1CCCN(C1)C(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C21H19N3O3S/c25-20(24-7-2-3-12(10-24)21(26)27)15-5-1-4-14-16(15)9-17-18(22-23-19(14)17)13-6-8-28-11-13/h1,4-6,8,11-12H,2-3,7,9-10H2,(H,22,23)(H,26,27)
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n/an/a 3.08E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209155
PNG
(1-(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazo...)
Show SMILES OC(=O)C1CCN(CC1)C(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C21H19N3O3S/c25-20(24-7-4-12(5-8-24)21(26)27)15-3-1-2-14-16(15)10-17-18(22-23-19(14)17)13-6-9-28-11-13/h1-3,6,9,11-12H,4-5,7-8,10H2,(H,22,23)(H,26,27)
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n/an/a 3.47E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209162
PNG
(2-(4-methyl-piperazin-1-yl)-N-(3-thiophen-3-yl-2,4...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2ccsc2)CC1
Show InChI InChI=1S/C21H23N5OS/c1-25-6-8-26(9-7-25)12-19(27)22-18-4-2-3-15-16(18)11-17-20(23-24-21(15)17)14-5-10-28-13-14/h2-5,10,13H,6-9,11-12H2,1H3,(H,22,27)(H,23,24)
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n/an/a 4.33E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209144
PNG
(2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-yny...)
Show SMILES COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H25N3O4S/c1-33-13-14-34-17-26(32)29-25-11-5-10-22-23(25)16-24-27(30-31-28(22)24)19-15-21(36-18-19)9-6-12-35-20-7-3-2-4-8-20/h2-5,7-8,10-11,15,18H,12-14,16-17H2,1H3,(H,29,32)(H,30,31)
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n/an/a 4.33E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209161
PNG
(CHEMBL395694 | ethanesulfonic acid (3-thiophen-3-y...)
Show SMILES CCS(=O)(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C16H15N3O2S2/c1-2-23(20,21)19-14-5-3-4-11-12(14)8-13-15(17-18-16(11)13)10-6-7-22-9-10/h3-7,9,19H,2,8H2,1H3,(H,17,18)
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n/an/a 4.39E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209149
PNG
(1-(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazo...)
Show SMILES OC(=O)C1CCCN(C1)C(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C21H19N3O3S/c25-20(24-7-2-3-12(10-24)21(26)27)15-5-1-4-14-16(15)9-17-18(22-23-19(14)17)13-6-8-28-11-13/h1,4-6,8,11-12H,2-3,7,9-10H2,(H,22,23)(H,26,27)
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n/an/a 4.84E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50209158
PNG
(2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1
Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)
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n/an/a 4.88E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Tie2 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209159
PNG
(CHEMBL246343 | [(3-thiophen-3-yl-2,4-dihydro-inden...)
Show SMILES OC(=O)CNC(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C17H13N3O3S/c21-14(22)7-18-17(23)11-3-1-2-10-12(11)6-13-15(19-20-16(10)13)9-4-5-24-8-9/h1-5,8H,6-7H2,(H,18,23)(H,19,20)(H,21,22)
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n/an/a 5.15E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209147
PNG
(3-[(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyraz...)
Show SMILES OC(=O)CCNC(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C18H15N3O3S/c22-15(23)4-6-19-18(24)12-3-1-2-11-13(12)8-14-16(20-21-17(11)14)10-5-7-25-9-10/h1-3,5,7,9H,4,6,8H2,(H,19,24)(H,20,21)(H,22,23)
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n/an/a 5.61E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209155
PNG
(1-(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazo...)
Show SMILES OC(=O)C1CCN(CC1)C(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C21H19N3O3S/c25-20(24-7-4-12(5-8-24)21(26)27)15-3-1-2-14-16(15)10-17-18(22-23-19(14)17)13-6-9-28-11-13/h1-3,6,9,11-12H,4-5,7-8,10H2,(H,22,23)(H,26,27)
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n/an/a 7.04E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209152
PNG
(CHEMBL245934 | [1-(3-thiophen-3-yl-2,4-dihydro-ind...)
Show SMILES OCC1CCN(Cc2cccc-3c2Cc2c-3n[nH]c2-c2ccsc2)CC1
Show InChI InChI=1S/C21H23N3OS/c25-12-14-4-7-24(8-5-14)11-15-2-1-3-17-18(15)10-19-20(22-23-21(17)19)16-6-9-26-13-16/h1-3,6,9,13-14,25H,4-5,7-8,10-12H2,(H,22,23)
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n/an/a 7.18E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209145
PNG
(CHEMBL245362 | N-(3-thiophen-3-yl-2,4-dihydro-inde...)
Show SMILES CCCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C18H17N3OS/c1-2-4-16(22)19-15-6-3-5-12-13(15)9-14-17(20-21-18(12)14)11-7-8-23-10-11/h3,5-8,10H,2,4,9H2,1H3,(H,19,22)(H,20,21)
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n/an/a 9.54E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50209144
PNG
(2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-yny...)
Show SMILES COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H25N3O4S/c1-33-13-14-34-17-26(32)29-25-11-5-10-22-23(25)16-24-27(30-31-28(22)24)19-15-21(36-18-19)9-6-12-35-20-7-3-2-4-8-20/h2-5,7-8,10-11,15,18H,12-14,16-17H2,1H3,(H,29,32)(H,30,31)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Tie2 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50209150
PNG
(2-methoxy-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H21N3O3S/c1-31-15-24(30)27-23-11-5-10-20-21(23)14-22-25(28-29-26(20)22)17-13-19(33-16-17)9-6-12-32-18-7-3-2-4-8-18/h2-5,7-8,10-11,13,16H,12,14-15H2,1H3,(H,27,30)(H,28,29)
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n/an/a 1.37E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Fyn by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50209150
PNG
(2-methoxy-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H21N3O3S/c1-31-15-24(30)27-23-11-5-10-20-21(23)14-22-25(28-29-26(20)22)17-13-19(33-16-17)9-6-12-32-18-7-3-2-4-8-18/h2-5,7-8,10-11,13,16H,12,14-15H2,1H3,(H,27,30)(H,28,29)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50209152
PNG
(CHEMBL245934 | [1-(3-thiophen-3-yl-2,4-dihydro-ind...)
Show SMILES OCC1CCN(Cc2cccc-3c2Cc2c-3n[nH]c2-c2ccsc2)CC1
Show InChI InChI=1S/C21H23N3OS/c25-12-14-4-7-24(8-5-14)11-15-2-1-3-17-18(15)10-19-20(22-23-21(17)19)16-6-9-26-13-16/h1-3,6,9,13-14,25H,4-5,7-8,10-12H2,(H,22,23)
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n/an/a 1.76E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50209150
PNG
(2-methoxy-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H21N3O3S/c1-31-15-24(30)27-23-11-5-10-20-21(23)14-22-25(28-29-26(20)22)17-13-19(33-16-17)9-6-12-32-18-7-3-2-4-8-18/h2-5,7-8,10-11,13,16H,12,14-15H2,1H3,(H,27,30)(H,28,29)
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n/an/a 2.08E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lyn by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50209148
PNG
(CHEMBL246166 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H19N3O4S/c1-32-26(31)25(30)27-22-11-5-10-19-20(22)14-21-23(28-29-24(19)21)16-13-18(34-15-16)9-6-12-33-17-7-3-2-4-8-17/h2-5,7-8,10-11,13,15H,12,14H2,1H3,(H,27,30)(H,28,29)
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n/an/a 2.14E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50209148
PNG
(CHEMBL246166 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H19N3O4S/c1-32-26(31)25(30)27-22-11-5-10-19-20(22)14-21-23(28-29-24(19)21)16-13-18(34-15-16)9-6-12-33-17-7-3-2-4-8-17/h2-5,7-8,10-11,13,15H,12,14H2,1H3,(H,27,30)(H,28,29)
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n/an/a 2.30E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Fyn by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50209148
PNG
(CHEMBL246166 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H19N3O4S/c1-32-26(31)25(30)27-22-11-5-10-19-20(22)14-21-23(28-29-24(19)21)16-13-18(34-15-16)9-6-12-33-17-7-3-2-4-8-17/h2-5,7-8,10-11,13,15H,12,14H2,1H3,(H,27,30)(H,28,29)
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n/an/a 2.47E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Tie2 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50209156
PNG
(CHEMBL395427 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES CCOC(=O)CC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-2-34-26(33)16-25(32)29-24-12-6-11-21-22(24)15-23-27(30-31-28(21)23)18-14-20(36-17-18)10-7-13-35-19-8-4-3-5-9-19/h3-6,8-9,11-12,14,17H,2,13,15-16H2,1H3,(H,29,32)(H,30,31)
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n/an/a 2.65E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50209152
PNG
(CHEMBL245934 | [1-(3-thiophen-3-yl-2,4-dihydro-ind...)
Show SMILES OCC1CCN(Cc2cccc-3c2Cc2c-3n[nH]c2-c2ccsc2)CC1
Show InChI InChI=1S/C21H23N3OS/c25-12-14-4-7-24(8-5-14)11-15-2-1-3-17-18(15)10-19-20(22-23-21(17)19)16-6-9-26-13-16/h1-3,6,9,13-14,25H,4-5,7-8,10-12H2,(H,22,23)
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n/an/a 2.79E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50209150
PNG
(2-methoxy-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H21N3O3S/c1-31-15-24(30)27-23-11-5-10-20-21(23)14-22-25(28-29-26(20)22)17-13-19(33-16-17)9-6-12-32-18-7-3-2-4-8-18/h2-5,7-8,10-11,13,16H,12,14-15H2,1H3,(H,27,30)(H,28,29)
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n/an/a 3.03E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Hck by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50209148
PNG
(CHEMBL246166 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H19N3O4S/c1-32-26(31)25(30)27-22-11-5-10-19-20(22)14-21-23(28-29-24(19)21)16-13-18(34-15-16)9-6-12-33-17-7-3-2-4-8-17/h2-5,7-8,10-11,13,15H,12,14H2,1H3,(H,27,30)(H,28,29)
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n/an/a 3.06E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lyn by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50209158
PNG
(2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1
Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)
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n/an/a 3.10E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50209150
PNG
(2-methoxy-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H21N3O3S/c1-31-15-24(30)27-23-11-5-10-20-21(23)14-22-25(28-29-26(20)22)17-13-19(33-16-17)9-6-12-32-18-7-3-2-4-8-18/h2-5,7-8,10-11,13,16H,12,14-15H2,1H3,(H,27,30)(H,28,29)
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n/an/a 4.06E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Tie2 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50209150
PNG
(2-methoxy-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen...)
Show SMILES COCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H21N3O3S/c1-31-15-24(30)27-23-11-5-10-20-21(23)14-22-25(28-29-26(20)22)17-13-19(33-16-17)9-6-12-32-18-7-3-2-4-8-18/h2-5,7-8,10-11,13,16H,12,14-15H2,1H3,(H,27,30)(H,28,29)
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n/an/a 4.33E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Src by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50209148
PNG
(CHEMBL246166 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H19N3O4S/c1-32-26(31)25(30)27-22-11-5-10-19-20(22)14-21-23(28-29-24(19)21)16-13-18(34-15-16)9-6-12-33-17-7-3-2-4-8-17/h2-5,7-8,10-11,13,15H,12,14H2,1H3,(H,27,30)(H,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Src by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50209144
PNG
(2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-yny...)
Show SMILES COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H25N3O4S/c1-33-13-14-34-17-26(32)29-25-11-5-10-22-23(25)16-24-27(30-31-28(22)24)19-15-21(36-18-19)9-6-12-35-20-7-3-2-4-8-20/h2-5,7-8,10-11,15,18H,12-14,16-17H2,1H3,(H,29,32)(H,30,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Src by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50209156
PNG
(CHEMBL395427 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES CCOC(=O)CC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-2-34-26(33)16-25(32)29-24-12-6-11-21-22(24)15-23-27(30-31-28(21)23)18-14-20(36-17-18)10-7-13-35-19-8-4-3-5-9-19/h3-6,8-9,11-12,14,17H,2,13,15-16H2,1H3,(H,29,32)(H,30,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lyn by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209149
PNG
(1-(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazo...)
Show SMILES OC(=O)C1CCCN(C1)C(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C21H19N3O3S/c25-20(24-7-2-3-12(10-24)21(26)27)15-5-1-4-14-16(15)9-17-18(22-23-19(14)17)13-6-8-28-11-13/h1,4-6,8,11-12H,2-3,7,9-10H2,(H,22,23)(H,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50209144
PNG
(2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-yny...)
Show SMILES COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H25N3O4S/c1-33-13-14-34-17-26(32)29-25-11-5-10-22-23(25)16-24-27(30-31-28(22)24)19-15-21(36-18-19)9-6-12-35-20-7-3-2-4-8-20/h2-5,7-8,10-11,15,18H,12-14,16-17H2,1H3,(H,29,32)(H,30,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50209156
PNG
(CHEMBL395427 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES CCOC(=O)CC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-2-34-26(33)16-25(32)29-24-12-6-11-21-22(24)15-23-27(30-31-28(21)23)18-14-20(36-17-18)10-7-13-35-19-8-4-3-5-9-19/h3-6,8-9,11-12,14,17H,2,13,15-16H2,1H3,(H,29,32)(H,30,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Hck by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50209148
PNG
(CHEMBL246166 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES COC(=O)C(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C26H19N3O4S/c1-32-26(31)25(30)27-22-11-5-10-19-20(22)14-21-23(28-29-24(19)21)16-13-18(34-15-16)9-6-12-33-17-7-3-2-4-8-17/h2-5,7-8,10-11,13,15H,12,14H2,1H3,(H,27,30)(H,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Hck by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50209144
PNG
(2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-yny...)
Show SMILES COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H25N3O4S/c1-33-13-14-34-17-26(32)29-25-11-5-10-22-23(25)16-24-27(30-31-28(22)24)19-15-21(36-18-19)9-6-12-35-20-7-3-2-4-8-20/h2-5,7-8,10-11,15,18H,12-14,16-17H2,1H3,(H,29,32)(H,30,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Fyn by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50209158
PNG
(2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1
Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lyn by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50209156
PNG
(CHEMBL395427 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES CCOC(=O)CC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-2-34-26(33)16-25(32)29-24-12-6-11-21-22(24)15-23-27(30-31-28(21)23)18-14-20(36-17-18)10-7-13-35-19-8-4-3-5-9-19/h3-6,8-9,11-12,14,17H,2,13,15-16H2,1H3,(H,29,32)(H,30,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Tie2 by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50209156
PNG
(CHEMBL395427 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES CCOC(=O)CC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-2-34-26(33)16-25(32)29-24-12-6-11-21-22(24)15-23-27(30-31-28(21)23)18-14-20(36-17-18)10-7-13-35-19-8-4-3-5-9-19/h3-6,8-9,11-12,14,17H,2,13,15-16H2,1H3,(H,29,32)(H,30,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Fyn by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50209158
PNG
(2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1
Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Fyn by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50209155
PNG
(1-(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazo...)
Show SMILES OC(=O)C1CCN(CC1)C(=O)c1cccc-2c1Cc1c-2n[nH]c1-c1ccsc1
Show InChI InChI=1S/C21H19N3O3S/c25-20(24-7-4-12(5-8-24)21(26)27)15-3-1-2-14-16(15)10-17-18(22-23-19(14)17)13-6-9-28-11-13/h1-3,6,9,11-12H,4-5,7-8,10H2,(H,22,23)(H,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50209156
PNG
(CHEMBL395427 | N-{3-[5-(3-phenoxy-prop-1-ynyl)-thi...)
Show SMILES CCOC(=O)CC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-2-34-26(33)16-25(32)29-24-12-6-11-21-22(24)15-23-27(30-31-28(21)23)18-14-20(36-17-18)10-7-13-35-19-8-4-3-5-9-19/h3-6,8-9,11-12,14,17H,2,13,15-16H2,1H3,(H,29,32)(H,30,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Src by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50209158
PNG
(2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1
Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Hck by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50209158
PNG
(2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...)
Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1
Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Src by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM50209144
PNG
(2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-yny...)
Show SMILES COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H25N3O4S/c1-33-13-14-34-17-26(32)29-25-11-5-10-22-23(25)16-24-27(30-31-28(22)24)19-15-21(36-18-19)9-6-12-35-20-7-3-2-4-8-20/h2-5,7-8,10-11,15,18H,12-14,16-17H2,1H3,(H,29,32)(H,30,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Hck by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50209144
PNG
(2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-yny...)
Show SMILES COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1
Show InChI InChI=1S/C28H25N3O4S/c1-33-13-14-34-17-26(32)29-25-11-5-10-22-23(25)16-24-27(30-31-28(22)24)19-15-21(36-18-19)9-6-12-35-20-7-3-2-4-8-20/h2-5,7-8,10-11,15,18H,12-14,16-17H2,1H3,(H,29,32)(H,30,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Lyn by HTRF assay


Bioorg Med Chem Lett 17: 3136-40 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.031
BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%