BindingDB logo
myBDB logout

PubMed code 17500511

Compile data set for download or QSAR
Found 19 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22492
PNG
(3-(4-butoxyphenyl)-3-(thiophen-2-yl)propanoic acid...)
Show SMILES CCCCOc1ccc(cc1)C(CC(O)=O)c1cccs1
Show InChI InChI=1S/C17H20O3S/c1-2-3-10-20-14-8-6-13(7-9-14)15(12-17(18)19)16-5-4-11-21-16/h4-9,11,15H,2-3,10,12H2,1H3,(H,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 1.29E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22484
PNG
(3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 17...)
Show SMILES COCCCOc1ccc(cc1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C19H22O4/c1-22-12-5-13-23-17-10-8-16(9-11-17)18(14-19(20)21)15-6-3-2-4-7-15/h2-4,6-11,18H,5,12-14H2,1H3,(H,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 7.58E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22494
PNG
(3,3-diphenylpropanoic acid derivative, 57 | 3-[3-(...)
Show SMILES CCCCCOc1cccc(c1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C20H24O3/c1-2-3-7-13-23-18-12-8-11-17(14-18)19(15-20(21)22)16-9-5-4-6-10-16/h4-6,8-12,14,19H,2-3,7,13,15H2,1H3,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22495
PNG
(5,5-diphenylpentanoic acid derivative, 61 | 5-(4-b...)
Show SMILES CCCCOc1ccc(cc1)C(CCCC(O)=O)c1ccccc1
Show InChI InChI=1S/C21H26O3/c1-2-3-16-24-19-14-12-18(13-15-19)20(10-7-11-21(22)23)17-8-5-4-6-9-17/h4-6,8-9,12-15,20H,2-3,7,10-11,16H2,1H3,(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22477
PNG
(3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 3 ...)
Show SMILES CCCOc1ccc(cc1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C18H20O3/c1-2-12-21-16-10-8-15(9-11-16)17(13-18(19)20)14-6-4-3-5-7-14/h3-11,17H,2,12-13H2,1H3,(H,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 4.80E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22487
PNG
(3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 22...)
Show SMILES CCC(C)COc1ccc(cc1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C20H24O3/c1-3-15(2)14-23-18-11-9-17(10-12-18)19(13-20(21)22)16-7-5-4-6-8-16/h4-12,15,19H,3,13-14H2,1-2H3,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 300n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22491
PNG
(3-(4-butoxyphenyl)-3-[4-(trifluoromethyl)phenyl]pr...)
Show SMILES CCCCOc1ccc(cc1)C(CC(O)=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H21F3O3/c1-2-3-12-26-17-10-6-15(7-11-17)18(13-19(24)25)14-4-8-16(9-5-14)20(21,22)23/h4-11,18H,2-3,12-13H2,1H3,(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22493
PNG
(3-(4-butoxyphenyl)-3-(2-hydroxyphenyl)propanoic ac...)
Show SMILES CCCCOc1ccc(cc1)C(CC(O)=O)c1ccccc1O
Show InChI InChI=1S/C19H22O4/c1-2-3-12-23-15-10-8-14(9-11-15)17(13-19(21)22)16-6-4-5-7-18(16)20/h4-11,17,20H,2-3,12-13H2,1H3,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 4.80E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22481
PNG
(3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 11...)
Show SMILES CCCCCCCOc1ccc(cc1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C22H28O3/c1-2-3-4-5-9-16-25-20-14-12-19(13-15-20)21(17-22(23)24)18-10-7-6-8-11-18/h6-8,10-15,21H,2-5,9,16-17H2,1H3,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 4.26E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22486
PNG
(3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 20...)
Show SMILES CC(C)CCOc1ccc(cc1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C20H24O3/c1-15(2)12-13-23-18-10-8-17(9-11-18)19(14-20(21)22)16-6-4-3-5-7-16/h3-11,15,19H,12-14H2,1-2H3,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.86E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22478
PNG
(3-(4-butoxyphenyl)-3-phenylpropanoic acid | 3-Aryl...)
Show SMILES CCCCOc1ccc(cc1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C19H22O3/c1-2-3-13-22-17-11-9-16(10-12-17)18(14-19(20)21)15-7-5-4-6-8-15/h4-12,18H,2-3,13-14H2,1H3,(H,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.20E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22480
PNG
(3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 9 ...)
Show SMILES CCCCCCOc1ccc(cc1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C21H26O3/c1-2-3-4-8-15-24-19-13-11-18(12-14-19)20(16-21(22)23)17-9-6-5-7-10-17/h5-7,9-14,20H,2-4,8,15-16H2,1H3,(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.88E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22488
PNG
(3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 24...)
Show SMILES CCC(CC)COc1ccc(cc1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C21H26O3/c1-3-16(4-2)15-24-19-12-10-18(11-13-19)20(14-21(22)23)17-8-6-5-7-9-17/h5-13,16,20H,3-4,14-15H2,1-2H3,(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 640n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22490
PNG
(3-(4-butoxyphenyl)-3-[3-(trifluoromethyl)phenyl]pr...)
Show SMILES CCCCOc1ccc(cc1)C(CC(O)=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H21F3O3/c1-2-3-11-26-17-9-7-14(8-10-17)18(13-19(24)25)15-5-4-6-16(12-15)20(21,22)23/h4-10,12,18H,2-3,11,13H2,1H3,(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.84E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22479
PNG
(3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 7 ...)
Show SMILES CCCCCOc1ccc(cc1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C20H24O3/c1-2-3-7-14-23-18-12-10-17(11-13-18)19(15-20(21)22)16-8-5-4-6-9-16/h4-6,8-13,19H,2-3,7,14-15H2,1H3,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.97E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22485
PNG
(3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 19...)
Show SMILES CC(=C)CCOc1ccc(cc1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C20H22O3/c1-15(2)12-13-23-18-10-8-17(9-11-18)19(14-20(21)22)16-6-4-3-5-7-16/h3-11,19H,1,12-14H2,2H3,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.71E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22482
PNG
(3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 13...)
Show SMILES OC(=O)CC(c1ccccc1)c1ccc(OCCCC(F)(F)F)cc1
Show InChI InChI=1S/C19H19F3O3/c20-19(21,22)11-4-12-25-16-9-7-15(8-10-16)17(13-18(23)24)14-5-2-1-3-6-14/h1-3,5-10,17H,4,11-13H2,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 3.16E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22483
PNG
(3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 15...)
Show SMILES C\C=C\COc1ccc(cc1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C19H20O3/c1-2-3-13-22-17-11-9-16(10-12-17)18(14-19(20)21)15-7-5-4-6-8-15/h2-12,18H,13-14H2,1H3,(H,20,21)/b3-2+
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.71E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22489
PNG
(3-(4-butoxyphenyl)-3-(3-fluorophenyl)propanoic aci...)
Show SMILES CCCCOc1ccc(cc1)C(CC(O)=O)c1cccc(F)c1
Show InChI InChI=1S/C19H21FO3/c1-2-3-11-23-17-9-7-14(8-10-17)18(13-19(21)22)15-5-4-6-16(20)12-15/h4-10,12,18H,2-3,11,13H2,1H3,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.44E+3n/an/an/a37



Johnson & Johnson Pharmaceutical



Assay Description
Human embryonic kidney (HEK293) cells expressing human GPR40 receptors were grown in Dulbecco modified Eagles medium (DMEM)/F12 media supplemented w...


J Med Chem 50: 2807-17 (2007)


Article DOI: 10.1021/jm070130j
BindingDB Entry DOI: 10.7270/Q2CV4G1D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%