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Found 51 Enz. Inhib. hit(s) with all data for entry = 50020669
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216250((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216250((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216249((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216245((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216251((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216252((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216252((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216250((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216248((6R,10bR)-9-(3-morpholinopropoxy)-6-(pyridin-3-yl)...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216256((6S,10bR)-6-(H-imidazo[1,2-a]pyridin-3-yl)-9-(3-mo...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216242((6R,10bR)-9-(3-morpholinopropoxy)-6-(thiophen-3-yl...)
Affinity DataKi:  2nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216245((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  2nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216255((6S,10bR)-9-(3-morpholinopropoxy)-6-(pyridin-2-yl)...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216252((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216247((6S,10bR)-9-(3-morpholinopropoxy)-6-(thiophen-2-yl...)
Affinity DataKi:  3nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216247((6S,10bR)-9-(3-morpholinopropoxy)-6-(thiophen-2-yl...)
Affinity DataKi:  3nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216242((6R,10bR)-9-(3-morpholinopropoxy)-6-(thiophen-3-yl...)
Affinity DataKi:  3nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216253((6S,10bR)-9-(3-morpholinopropoxy)-6-(thiazol-2-yl)...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216249((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216244((6S,10bR)-9-(3-morpholinopropoxy)-6-(thiazol-5-yl)...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216243((6S,10bR)-9-(3-morpholinopropoxy)-6-(pyrazin-2-yl)...)
Affinity DataKi:  4nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216246((6S,10bR)-9-(3-morpholinopropoxy)-6-(1H-pyrazol-5-...)
Affinity DataKi:  4nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216248((6R,10bR)-9-(3-morpholinopropoxy)-6-(pyridin-3-yl)...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216242((6R,10bR)-9-(3-morpholinopropoxy)-6-(thiophen-3-yl...)
Affinity DataKi:  5nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216254((6S,10bR)-6-(4-(1H-pyrazol-1-yl)phenyl)-9-(3-morph...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216241((6S,10bR)-6-(4-(1H-imidazol-1-yl)phenyl)-9-(3-morp...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216254((6S,10bR)-6-(4-(1H-pyrazol-1-yl)phenyl)-9-(3-morph...)
Affinity DataKi:  6nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216247((6S,10bR)-9-(3-morpholinopropoxy)-6-(thiophen-2-yl...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216244((6S,10bR)-9-(3-morpholinopropoxy)-6-(thiazol-5-yl)...)
Affinity DataKi:  6nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216241((6S,10bR)-6-(4-(1H-imidazol-1-yl)phenyl)-9-(3-morp...)
Affinity DataKi:  6.70nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216245((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  8.30nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216255((6S,10bR)-9-(3-morpholinopropoxy)-6-(pyridin-2-yl)...)
Affinity DataKi:  8.30nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216248((6R,10bR)-9-(3-morpholinopropoxy)-6-(pyridin-3-yl)...)
Affinity DataKi:  12.3nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216254((6S,10bR)-6-(4-(1H-pyrazol-1-yl)phenyl)-9-(3-morph...)
Affinity DataKi:  12.3nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216241((6S,10bR)-6-(4-(1H-imidazol-1-yl)phenyl)-9-(3-morp...)
Affinity DataKi:  16.7nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216249((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  18.7nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216244((6S,10bR)-9-(3-morpholinopropoxy)-6-(thiazol-5-yl)...)
Affinity DataKi:  19.7nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216251((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  20nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216243((6S,10bR)-9-(3-morpholinopropoxy)-6-(pyrazin-2-yl)...)
Affinity DataKi:  22.7nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216246((6S,10bR)-9-(3-morpholinopropoxy)-6-(1H-pyrazol-5-...)
Affinity DataKi:  24.3nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216255((6S,10bR)-9-(3-morpholinopropoxy)-6-(pyridin-2-yl)...)
Affinity DataKi:  31.3nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216256((6S,10bR)-6-(H-imidazo[1,2-a]pyridin-3-yl)-9-(3-mo...)
Affinity DataKi:  39nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216253((6S,10bR)-9-(3-morpholinopropoxy)-6-(thiazol-2-yl)...)
Affinity DataKi:  53.3nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216251((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  66nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216245((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  74nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216243((6S,10bR)-9-(3-morpholinopropoxy)-6-(pyrazin-2-yl)...)
Affinity DataKi:  88nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216245((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  107nMAssay Description:Binding affinity to DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216256((6S,10bR)-6-(H-imidazo[1,2-a]pyridin-3-yl)-9-(3-mo...)
Affinity DataKi:  119nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216246((6S,10bR)-9-(3-morpholinopropoxy)-6-(1H-pyrazol-5-...)
Affinity DataKi:  121nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216253((6S,10bR)-9-(3-morpholinopropoxy)-6-(thiazol-2-yl)...)
Affinity DataKi:  291nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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