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PubMed code 17720494

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219939
PNG
(CHEMBL240693 | N-((1r,4r)-4-(2-(4-(2,3-dichlorophe...)
Show SMILES Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3cccnc3)CC2)c1Cl
Show InChI InChI=1S/C23H30Cl2N4O2S/c24-21-4-1-5-22(23(21)25)29-15-13-28(14-16-29)12-10-18-6-8-19(9-7-18)27-32(30,31)20-3-2-11-26-17-20/h1-5,11,17-19,27H,6-10,12-16H2/t18-,19-
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n/an/a 0.200n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219946
PNG
(CHEMBL391700 | N-((1r,4r)-4-(2-(4-(3-(trifluoromet...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2cccnc2)CC1
Show InChI InChI=1S/C24H31F3N4O2S/c25-24(26,27)20-3-1-4-22(17-20)31-15-13-30(14-16-31)12-10-19-6-8-21(9-7-19)29-34(32,33)23-5-2-11-28-18-23/h1-5,11,17-19,21,29H,6-10,12-16H2/t19-,21-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219943
PNG
(CHEMBL428910 | N-((1r,4r)-4-(2-(4-(3-cyano-5-(trif...)
Show SMILES FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2cccnc2)CC1)C#N
Show InChI InChI=1S/C25H30F3N5O2S/c26-25(27,28)21-14-20(17-29)15-23(16-21)33-12-10-32(11-13-33)9-7-19-3-5-22(6-4-19)31-36(34,35)24-2-1-8-30-18-24/h1-2,8,14-16,18-19,22,31H,3-7,9-13H2/t19-,22-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219944
PNG
(CHEMBL239847 | N-((1r,4r)-4-(2-(4-(4-bromo-2-metho...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccc(Br)cc2OC)CC1
Show InChI InChI=1S/C26H36BrN3O4S/c1-33-23-8-10-24(11-9-23)35(31,32)28-22-6-3-20(4-7-22)13-14-29-15-17-30(18-16-29)25-12-5-21(27)19-26(25)34-2/h5,8-12,19-20,22,28H,3-4,6-7,13-18H2,1-2H3/t20-,22-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219940
PNG
(CHEMBL240271 | N-((1r,4r)-4-(2-(4-(3-(trifluoromet...)
Show SMILES FC(F)(F)c1cccc(CC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc(cc3)-n3cccn3)CC2)c1
Show InChI InChI=1S/C30H37F3N4O2S/c31-30(32,33)26-4-1-3-25(22-26)21-24-14-19-36(20-15-24)18-13-23-5-7-27(8-6-23)35-40(38,39)29-11-9-28(10-12-29)37-17-2-16-34-37/h1-4,9-12,16-17,22-24,27,35H,5-8,13-15,18-21H2/t23-,27-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219947
PNG
(CHEMBL429093 | N-((1r,4r)-4-(2-(4-(3-cyanophenyl)p...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(c2)C#N)CC1
Show InChI InChI=1S/C27H36N4O4S/c1-34-26-11-10-25(19-27(26)35-2)36(32,33)29-23-8-6-21(7-9-23)12-13-30-14-16-31(17-15-30)24-5-3-4-22(18-24)20-28/h3-5,10-11,18-19,21,23,29H,6-9,12-17H2,1-2H3/t21-,23-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219945
PNG
(CHEMBL240273 | N-((1r,4r)-4-(2-(4-(3-cyano-5-(trif...)
Show SMILES FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2ccc3NC(=O)CCc3c2)CC1)C#N
Show InChI InChI=1S/C29H34F3N5O3S/c30-29(31,32)23-15-21(19-33)16-25(18-23)37-13-11-36(12-14-37)10-9-20-1-4-24(5-2-20)35-41(39,40)26-6-7-27-22(17-26)3-8-28(38)34-27/h6-7,15-18,20,24,35H,1-5,8-14H2,(H,34,38)/t20-,24-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219935
PNG
(CHEMBL392528 | N-[4-(4-{2-[4-(3-cyano-5-trifluorom...)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cc(cc(c2)C(F)(F)F)C#N)CC1
Show InChI InChI=1S/C28H34F3N5O3S/c1-20(37)33-24-6-8-27(9-7-24)40(38,39)34-25-4-2-21(3-5-25)10-11-35-12-14-36(15-13-35)26-17-22(19-32)16-23(18-26)28(29,30)31/h6-9,16-18,21,25,34H,2-5,10-15H2,1H3,(H,33,37)/t21-,25-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219949
PNG
(3-oxo-N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)pheno...)
Show SMILES FC(F)(F)c1cccc(OC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc4OCC(=O)Nc4c3)CC2)c1
Show InChI InChI=1S/C28H34F3N3O5S/c29-28(30,31)20-2-1-3-23(16-20)39-22-11-14-34(15-12-22)13-10-19-4-6-21(7-5-19)33-40(36,37)24-8-9-26-25(17-24)32-27(35)18-38-26/h1-3,8-9,16-17,19,21-22,33H,4-7,10-15,18H2,(H,32,35)/t19-,21-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219942
PNG
(CHEMBL240051 | N-((1r,4r)-4-(2-(4-(2,5-dichlorophe...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCC(CC2)Nc2cc(Cl)ccc2Cl)CC1
Show InChI InChI=1S/C25H32Cl2FN3O2S/c26-19-3-10-24(27)25(17-19)29-21-12-15-31(16-13-21)14-11-18-1-6-22(7-2-18)30-34(32,33)23-8-4-20(28)5-9-23/h3-5,8-10,17-18,21-22,29-30H,1-2,6-7,11-16H2/t18-,22-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219948
PNG
(CHEMBL236407 | N-((1r,4r)-4-(2-(4-(3-(trifluoromet...)
Show SMILES FC(F)(F)c1cccc(CC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3cc4ccccc4s3)CC2)c1
Show InChI InChI=1S/C29H35F3N2O2S2/c30-29(31,32)25-6-3-4-23(19-25)18-22-13-16-34(17-14-22)15-12-21-8-10-26(11-9-21)33-38(35,36)28-20-24-5-1-2-7-27(24)37-28/h1-7,19-22,26,33H,8-18H2/t21-,26-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219938
PNG
(CHEMBL391699 | N-((1r,4r)-4-(2-(4-(3-(trifluoromet...)
Show SMILES FC(F)(F)c1cccc(OC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3cccnc3)CC2)c1
Show InChI InChI=1S/C25H32F3N3O3S/c26-25(27,28)20-3-1-4-23(17-20)34-22-11-15-31(16-12-22)14-10-19-6-8-21(9-7-19)30-35(32,33)24-5-2-13-29-18-24/h1-5,13,17-19,21-22,30H,6-12,14-16H2/t19-,21-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219937
PNG
(4-chloro-N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)ph...)
Show SMILES FC(F)(F)c1cccc(NC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc(Cl)cc3)CC2)c1
Show InChI InChI=1S/C26H33ClF3N3O2S/c27-21-6-10-25(11-7-21)36(34,35)32-23-8-4-19(5-9-23)12-15-33-16-13-22(14-17-33)31-24-3-1-2-20(18-24)26(28,29)30/h1-3,6-7,10-11,18-19,22-23,31-32H,4-5,8-9,12-17H2/t19-,23-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219936
PNG
(4-bromo-N-((1r,4r)-4-(2-(4-(3-cyano-5-(trifluorome...)
Show SMILES FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2ccc(Br)cc2)CC1)C#N
Show InChI InChI=1S/C26H30BrF3N4O2S/c27-22-3-7-25(8-4-22)37(35,36)32-23-5-1-19(2-6-23)9-10-33-11-13-34(14-12-33)24-16-20(18-31)15-21(17-24)26(28,29)30/h3-4,7-8,15-17,19,23,32H,1-2,5-6,9-14H2/t19-,23-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219934
PNG
(CHEMBL399833 | N-((1r,4r)-4-(2-(4-(3-(trifluoromet...)
Show SMILES FC(F)(F)c1cccc(CC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc(Cl)cc3)CC2)c1
Show InChI InChI=1S/C27H34ClF3N2O2S/c28-24-6-10-26(11-7-24)36(34,35)32-25-8-4-20(5-9-25)12-15-33-16-13-21(14-17-33)18-22-2-1-3-23(19-22)27(29,30)31/h1-3,6-7,10-11,19-21,25,32H,4-5,8-9,12-18H2/t20-,25-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219939
PNG
(CHEMBL240693 | N-((1r,4r)-4-(2-(4-(2,3-dichlorophe...)
Show SMILES Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3cccnc3)CC2)c1Cl
Show InChI InChI=1S/C23H30Cl2N4O2S/c24-21-4-1-5-22(23(21)25)29-15-13-28(14-16-29)12-10-18-6-8-19(9-7-18)27-32(30,31)20-3-2-11-26-17-20/h1-5,11,17-19,27H,6-10,12-16H2/t18-,19-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219941
PNG
(CHEMBL240909 | N-((1r,4r)-4-(2-(4-(3-cyano-5-(trif...)
Show SMILES Cc1ccc(cn1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cc(cc(c2)C(F)(F)F)C#N)CC1
Show InChI InChI=1S/C26H32F3N5O2S/c1-19-2-7-25(18-31-19)37(35,36)32-23-5-3-20(4-6-23)8-9-33-10-12-34(13-11-33)24-15-21(17-30)14-22(16-24)26(27,28)29/h2,7,14-16,18,20,23,32H,3-6,8-13H2,1H3/t20-,23-
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Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219940
PNG
(CHEMBL240271 | N-((1r,4r)-4-(2-(4-(3-(trifluoromet...)
Show SMILES FC(F)(F)c1cccc(CC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc(cc3)-n3cccn3)CC2)c1
Show InChI InChI=1S/C30H37F3N4O2S/c31-30(32,33)26-4-1-3-25(22-26)21-24-14-19-36(20-15-24)18-13-23-5-7-27(8-6-23)35-40(38,39)29-11-9-28(10-12-29)37-17-2-16-34-37/h1-4,9-12,16-17,22-24,27,35H,5-8,13-15,18-21H2/t23-,27-
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n/an/a 4.30n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219949
PNG
(3-oxo-N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)pheno...)
Show SMILES FC(F)(F)c1cccc(OC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc4OCC(=O)Nc4c3)CC2)c1
Show InChI InChI=1S/C28H34F3N3O5S/c29-28(30,31)20-2-1-3-23(16-20)39-22-11-14-34(15-12-22)13-10-19-4-6-21(7-5-19)33-40(36,37)24-8-9-26-25(17-24)32-27(35)18-38-26/h1-3,8-9,16-17,19,21-22,33H,4-7,10-15,18H2,(H,32,35)/t19-,21-
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n/an/a 5.30n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50219950
PNG
(3-cyano-N-((1r,4r)-4-(2-(4-(3-cyano-5-(trifluorome...)
Show SMILES FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2cccc(c2)C#N)CC1)C#N
Show InChI InChI=1S/C27H30F3N5O2S/c28-27(29,30)23-14-22(19-32)15-25(17-23)35-12-10-34(11-13-35)9-8-20-4-6-24(7-5-20)33-38(36,37)26-3-1-2-21(16-26)18-31/h1-3,14-17,20,24,33H,4-13H2/t20-,24-
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n/an/a 5.80n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219942
PNG
(CHEMBL240051 | N-((1r,4r)-4-(2-(4-(2,5-dichlorophe...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCC(CC2)Nc2cc(Cl)ccc2Cl)CC1
Show InChI InChI=1S/C25H32Cl2FN3O2S/c26-19-3-10-24(27)25(17-19)29-21-12-15-31(16-13-21)14-11-18-1-6-22(7-2-18)30-34(32,33)23-8-4-20(28)5-9-23/h3-5,8-10,17-18,21-22,29-30H,1-2,6-7,11-16H2/t18-,22-
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n/an/a 9n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219937
PNG
(4-chloro-N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)ph...)
Show SMILES FC(F)(F)c1cccc(NC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc(Cl)cc3)CC2)c1
Show InChI InChI=1S/C26H33ClF3N3O2S/c27-21-6-10-25(11-7-21)36(34,35)32-23-8-4-19(5-9-23)12-15-33-16-13-22(14-17-33)31-24-3-1-2-20(18-24)26(28,29)30/h1-3,6-7,10-11,18-19,22-23,31-32H,4-5,8-9,12-17H2/t19-,23-
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n/an/a 16n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219950
PNG
(3-cyano-N-((1r,4r)-4-(2-(4-(3-cyano-5-(trifluorome...)
Show SMILES FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2cccc(c2)C#N)CC1)C#N
Show InChI InChI=1S/C27H30F3N5O2S/c28-27(29,30)23-14-22(19-32)15-25(17-23)35-12-10-34(11-13-35)9-8-20-4-6-24(7-5-20)33-38(36,37)26-3-1-2-21(16-26)18-31/h1-3,14-17,20,24,33H,4-13H2/t20-,24-
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n/an/a 23n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219943
PNG
(CHEMBL428910 | N-((1r,4r)-4-(2-(4-(3-cyano-5-(trif...)
Show SMILES FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2cccnc2)CC1)C#N
Show InChI InChI=1S/C25H30F3N5O2S/c26-25(27,28)21-14-20(17-29)15-23(16-21)33-12-10-32(11-13-33)9-7-19-3-5-22(6-4-19)31-36(34,35)24-2-1-8-30-18-24/h1-2,8,14-16,18-19,22,31H,3-7,9-13H2/t19-,22-
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n/an/a 24n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219936
PNG
(4-bromo-N-((1r,4r)-4-(2-(4-(3-cyano-5-(trifluorome...)
Show SMILES FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2ccc(Br)cc2)CC1)C#N
Show InChI InChI=1S/C26H30BrF3N4O2S/c27-22-3-7-25(8-4-22)37(35,36)32-23-5-1-19(2-6-23)9-10-33-11-13-34(14-12-33)24-16-20(18-31)15-21(17-24)26(28,29)30/h3-4,7-8,15-17,19,23,32H,1-2,5-6,9-14H2/t19-,23-
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n/an/a 26n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219944
PNG
(CHEMBL239847 | N-((1r,4r)-4-(2-(4-(4-bromo-2-metho...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccc(Br)cc2OC)CC1
Show InChI InChI=1S/C26H36BrN3O4S/c1-33-23-8-10-24(11-9-23)35(31,32)28-22-6-3-20(4-7-22)13-14-29-15-17-30(18-16-29)25-12-5-21(27)19-26(25)34-2/h5,8-12,19-20,22,28H,3-4,6-7,13-18H2,1-2H3/t20-,22-
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n/an/a 28n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219946
PNG
(CHEMBL391700 | N-((1r,4r)-4-(2-(4-(3-(trifluoromet...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2cccnc2)CC1
Show InChI InChI=1S/C24H31F3N4O2S/c25-24(26,27)20-3-1-4-22(17-20)31-15-13-30(14-16-31)12-10-19-6-8-21(9-7-19)29-34(32,33)23-5-2-11-28-18-23/h1-5,11,17-19,21,29H,6-10,12-16H2/t19-,21-
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n/an/a 29n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219945
PNG
(CHEMBL240273 | N-((1r,4r)-4-(2-(4-(3-cyano-5-(trif...)
Show SMILES FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2ccc3NC(=O)CCc3c2)CC1)C#N
Show InChI InChI=1S/C29H34F3N5O3S/c30-29(31,32)23-15-21(19-33)16-25(18-23)37-13-11-36(12-14-37)10-9-20-1-4-24(5-2-20)35-41(39,40)26-6-7-27-22(17-26)3-8-28(38)34-27/h6-7,15-18,20,24,35H,1-5,8-14H2,(H,34,38)/t20-,24-
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n/an/a 30n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219935
PNG
(CHEMBL392528 | N-[4-(4-{2-[4-(3-cyano-5-trifluorom...)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cc(cc(c2)C(F)(F)F)C#N)CC1
Show InChI InChI=1S/C28H34F3N5O3S/c1-20(37)33-24-6-8-27(9-7-24)40(38,39)34-25-4-2-21(3-5-25)10-11-35-12-14-36(15-13-35)26-17-22(19-32)16-23(18-26)28(29,30)31/h6-9,16-18,21,25,34H,2-5,10-15H2,1H3,(H,33,37)/t21-,25-
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n/an/a 39n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219941
PNG
(CHEMBL240909 | N-((1r,4r)-4-(2-(4-(3-cyano-5-(trif...)
Show SMILES Cc1ccc(cn1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cc(cc(c2)C(F)(F)F)C#N)CC1
Show InChI InChI=1S/C26H32F3N5O2S/c1-19-2-7-25(18-31-19)37(35,36)32-23-5-3-20(4-6-23)8-9-33-10-12-34(13-11-33)24-15-21(17-30)14-22(16-24)26(27,28)29/h2,7,14-16,18,20,23,32H,3-6,8-13H2,1H3/t20-,23-
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n/an/a 39n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219934
PNG
(CHEMBL399833 | N-((1r,4r)-4-(2-(4-(3-(trifluoromet...)
Show SMILES FC(F)(F)c1cccc(CC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc(Cl)cc3)CC2)c1
Show InChI InChI=1S/C27H34ClF3N2O2S/c28-24-6-10-26(11-7-24)36(34,35)32-25-8-4-20(5-9-25)12-15-33-16-13-21(14-17-33)18-22-2-1-3-23(19-22)27(29,30)31/h1-3,6-7,10-11,19-21,25,32H,4-5,8-9,12-18H2/t20-,25-
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n/an/a 41n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219947
PNG
(CHEMBL429093 | N-((1r,4r)-4-(2-(4-(3-cyanophenyl)p...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(c2)C#N)CC1
Show InChI InChI=1S/C27H36N4O4S/c1-34-26-11-10-25(19-27(26)35-2)36(32,33)29-23-8-6-21(7-9-23)12-13-30-14-16-31(17-15-30)24-5-3-4-22(18-24)20-28/h3-5,10-11,18-19,21,23,29H,6-9,12-17H2,1-2H3/t21-,23-
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n/an/a 57n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219938
PNG
(CHEMBL391699 | N-((1r,4r)-4-(2-(4-(3-(trifluoromet...)
Show SMILES FC(F)(F)c1cccc(OC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3cccnc3)CC2)c1
Show InChI InChI=1S/C25H32F3N3O3S/c26-25(27,28)20-3-1-4-23(17-20)34-22-11-15-31(16-12-22)14-10-19-6-8-21(9-7-19)30-35(32,33)24-5-2-13-29-18-24/h1-5,13,17-19,21-22,30H,6-12,14-16H2/t19-,21-
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n/an/a 66n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50219948
PNG
(CHEMBL236407 | N-((1r,4r)-4-(2-(4-(3-(trifluoromet...)
Show SMILES FC(F)(F)c1cccc(CC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3cc4ccccc4s3)CC2)c1
Show InChI InChI=1S/C29H35F3N2O2S2/c30-29(31,32)25-6-3-4-23(19-25)18-22-13-16-34(17-14-22)15-12-21-8-10-26(11-9-21)33-38(35,36)28-20-24-5-1-2-7-27(24)37-28/h1-7,19-22,26,33H,8-18H2/t21-,26-
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n/an/a 91n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranes


Bioorg Med Chem Lett 17: 5340-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.015
BindingDB Entry DOI: 10.7270/Q22F7N5G
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%