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PubMed code 17725339

Compile data set for download or QSAR
Found 61 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kinesin-like protein 1


(Homo sapiens)
BDBM50220180
PNG
(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1F)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10F4N2O2S/c14-11-7-9(3-6-12(11)19-22(18,20)21)8-1-4-10(5-2-8)13(15,16)17/h1-7,19H,(H2,18,20,21)
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3.5n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220182
PNG
(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O2S/c14-13(15,16)11-5-1-9(2-6-11)10-3-7-12(8-4-10)18-21(17,19)20/h1-8,18H,(H2,17,19,20)
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6.20n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220169
PNG
(CHEMBL244933 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H12F3NO2S/c1-21(19,20)18-13-8-4-11(5-9-13)10-2-6-12(7-3-10)14(15,16)17/h2-9,18H,1H3
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120n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220180
PNG
(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1F)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10F4N2O2S/c14-11-7-9(3-6-12(11)19-22(18,20)21)8-1-4-10(5-2-8)13(15,16)17/h1-7,19H,(H2,18,20,21)
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n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220195
PNG
(CHEMBL243885 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES NC(=S)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2S/c15-14(16,17)11-5-1-9(2-6-11)10-3-7-12(8-4-10)19-13(18)20/h1-8H,(H3,18,19,20)
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n/an/a 11n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220159
PNG
(CHEMBL389589 | N-[3'-fluoro-4'-(trifluoromethyl)-1...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C13H10F4N2O2S/c14-12-7-9(3-6-11(12)13(15,16)17)8-1-4-10(5-2-8)19-22(18,20)21/h1-7,19H,(H2,18,20,21)
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n/an/a 15n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220185
PNG
(1-(3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)urea...)
Show SMILES NC(=O)Nc1ccc(cc1F)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H10F4N2O/c15-11-7-9(3-6-12(11)20-13(19)21)8-1-4-10(5-2-8)14(16,17)18/h1-7H,(H3,19,20,21)
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n/an/a 15n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220182
PNG
(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O2S/c14-13(15,16)11-5-1-9(2-6-11)10-3-7-12(8-4-10)18-21(17,19)20/h1-8,18H,(H2,17,19,20)
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n/an/a 18n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220201
PNG
(CHEMBL243431 | N-[3-amino-4'-(trifluoromethyl)-4-b...)
Show SMILES Nc1cc(ccc1NS(N)(=O)=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H12F3N3O2S/c14-13(15,16)10-4-1-8(2-5-10)9-3-6-12(11(17)7-9)19-22(18,20)21/h1-7,19H,17H2,(H2,18,20,21)
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n/an/a 24n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220155
PNG
(CHEMBL244697 | N-[3'-nitro-4'-(trifluoromethyl)-4-...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc(c(c1)[N+]([O-])=O)C(F)(F)F
Show InChI InChI=1S/C13H10F3N3O4S/c14-13(15,16)11-6-3-9(7-12(11)19(20)21)8-1-4-10(5-2-8)18-24(17,22)23/h1-7,18H,(H2,17,22,23)
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n/an/a 28n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220176
PNG
(CHEMBL242181 | N-[4-(2,2-difluoro-1,3-benzodioxol-...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc2OC(F)(F)Oc2c1
Show InChI InChI=1S/C13H10F2N2O4S/c14-13(15)20-11-6-3-9(7-12(11)21-13)8-1-4-10(5-2-8)17-22(16,18)19/h1-7,17H,(H2,16,18,19)
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n/an/a 31n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220162
PNG
(CHEMBL243883 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES NC(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O/c15-14(16,17)11-5-1-9(2-6-11)10-3-7-12(8-4-10)19-13(18)20/h1-8H,(H3,18,19,20)
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n/an/a 39n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220188
PNG
(CHEMBL244126 | N-(4'-t-butyl-4-biphenylyl)urea)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccc(NC(N)=O)cc1
Show InChI InChI=1S/C17H20N2O/c1-17(2,3)14-8-4-12(5-9-14)13-6-10-15(11-7-13)19-16(18)20/h4-11H,1-3H3,(H3,18,19,20)
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n/an/a 54n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220192
PNG
(CHEMBL397249 | N-(4'-isopropyl-4-biphenylyl)urea)
Show SMILES CC(C)c1ccc(cc1)-c1ccc(NC(N)=O)cc1
Show InChI InChI=1S/C16H18N2O/c1-11(2)12-3-5-13(6-4-12)14-7-9-15(10-8-14)18-16(17)19/h3-11H,1-2H3,(H3,17,18,19)
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n/an/a 57n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220177
PNG
(CHEMBL389588 | N-{4'-[(trifluoromethyl)sulfonyl]-4...)
Show SMILES NC(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O3S/c15-14(16,17)23(21,22)12-7-3-10(4-8-12)9-1-5-11(6-2-9)19-13(18)20/h1-8H,(H3,18,19,20)
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n/an/a 58n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220172
PNG
(4'-(trifluoromethyl)-4-biphenylyl sulfamate | CHEM...)
Show SMILES NS(=O)(=O)Oc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10F3NO3S/c14-13(15,16)11-5-1-9(2-6-11)10-3-7-12(8-4-10)20-21(17,18)19/h1-8H,(H2,17,18,19)
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n/an/a 64n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220209
PNG
(CHEMBL242780 | N-[3-(methoxy)-4'-(trifluoromethyl)...)
Show SMILES COc1cc(ccc1NS(N)(=O)=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H13F3N2O3S/c1-22-13-8-10(4-7-12(13)19-23(18,20)21)9-2-5-11(6-3-9)14(15,16)17/h2-8,19H,1H3,(H2,18,20,21)
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n/an/a 66n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220170
PNG
(CHEMBL243649 | N-[3-Chloro-4'-(trifluoromethyl)-4-...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1Cl)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10ClF3N2O2S/c14-11-7-9(3-6-12(11)19-22(18,20)21)8-1-4-10(5-2-8)13(15,16)17/h1-7,19H,(H2,18,20,21)
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n/an/a 67n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220181
PNG
(CHEMBL397673 | N-[4-(2,2,3,3-tetrafluoro-2,3-dihyd...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc2OC(F)(F)C(F)(F)Oc2c1
Show InChI InChI=1S/C14H10F4N2O4S/c15-13(16)14(17,18)24-12-7-9(3-6-11(12)23-13)8-1-4-10(5-2-8)20-25(19,21)22/h1-7,20H,(H2,19,21,22)
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n/an/a 67n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220174
PNG
(1-[4'-(trifluoromethyl)-4-biphenylyl]methanesulfon...)
Show SMILES NS(=O)(=O)Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H12F3NO2S/c15-14(16,17)13-7-5-12(6-8-13)11-3-1-10(2-4-11)9-21(18,19)20/h1-8H,9H2,(H2,18,19,20)
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n/an/a 118n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220197
PNG
(CHEMBL242357 | N-[3-methyl-4'-(trifluoromethyl)-4-...)
Show SMILES Cc1cc(ccc1NS(N)(=O)=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H13F3N2O2S/c1-9-8-11(4-7-13(9)19-22(18,20)21)10-2-5-12(6-3-10)14(15,16)17/h2-8,19H,1H3,(H2,18,20,21)
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n/an/a 141n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220169
PNG
(CHEMBL244933 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H12F3NO2S/c1-21(19,20)18-13-8-4-11(5-9-13)10-2-6-12(7-3-10)14(15,16)17/h2-9,18H,1H3
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n/an/a 161n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220157
PNG
(CHEMBL395487 | N-[3'-amino-4'-(trifluoromethyl)-4-...)
Show SMILES Nc1cc(ccc1C(F)(F)F)-c1ccc(NS(N)(=O)=O)cc1
Show InChI InChI=1S/C13H12F3N3O2S/c14-13(15,16)11-6-3-9(7-12(11)17)8-1-4-10(5-2-8)19-22(18,20)21/h1-7,19H,17H2,(H2,18,20,21)
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n/an/a 167n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220179
PNG
(CHEMBL243906 | N-{4'-[(trifluoromethyl)sulfonyl]-4...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C14H12F3NO4S2/c1-23(19,20)18-12-6-2-10(3-7-12)11-4-8-13(9-5-11)24(21,22)14(15,16)17/h2-9,18H,1H3
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n/an/a 176n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220189
PNG
(CHEMBL243681 | N-[3-cyano-4'-(trifluoromethyl)-4-b...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1C#N)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H10F3N3O2S/c15-14(16,17)12-4-1-9(2-5-12)10-3-6-13(11(7-10)8-18)20-23(19,21)22/h1-7,20H,(H2,19,21,22)
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n/an/a 196n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220203
PNG
(CHEMBL244511 | N-{4'-[(trifluoromethyl)thio]-4-bip...)
Show SMILES NC(=O)Nc1ccc(cc1)-c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C14H11F3N2OS/c15-14(16,17)21-12-7-3-10(4-8-12)9-1-5-11(6-2-9)19-13(18)20/h1-8H,(H3,18,19,20)
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n/an/a 240n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220178
PNG
(CHEMBL244510 | N-(4'-bromo-3,3'-difluoro-4-bipheny...)
Show SMILES NC(=O)Nc1ccc(cc1F)-c1ccc(Br)c(F)c1
Show InChI InChI=1S/C13H9BrF2N2O/c14-9-3-1-7(5-10(9)15)8-2-4-12(11(16)6-8)18-13(17)19/h1-6H,(H3,17,18,19)
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n/an/a 262n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220166
PNG
(CHEMBL244329 | N-[4-(2,2,4,4-tetrafluoro-4H-1,3-be...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc2OC(F)(F)OC(F)(F)c2c1
Show InChI InChI=1S/C14H10F4N2O4S/c15-13(16)11-7-9(3-6-12(11)23-14(17,18)24-13)8-1-4-10(5-2-8)20-25(19,21)22/h1-7,20H,(H2,19,21,22)
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n/an/a 319n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220193
PNG
(4'-(trifluoromethyl)-4-biphenylsulfonamide | CHEMB...)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10F3NO2S/c14-13(15,16)11-5-1-9(2-6-11)10-3-7-12(8-4-10)20(17,18)19/h1-8H,(H2,17,18,19)
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n/an/a 345n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220196
PNG
(CHEMBL243215 | N-[3-hydroxy-4'-(trifluoromethyl)-4...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O3S/c14-13(15,16)10-4-1-8(2-5-10)9-3-6-11(12(19)7-9)18-22(17,20)21/h1-7,18-19H,(H2,17,20,21)
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n/an/a 349n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220202
PNG
(CHEMBL242182 | N-[4-(2,2-dimethyl-1,3-benzodioxol-...)
Show SMILES CC1(C)Oc2ccc(cc2O1)-c1ccc(NS(N)(=O)=O)cc1
Show InChI InChI=1S/C15H16N2O4S/c1-15(2)20-13-8-5-11(9-14(13)21-15)10-3-6-12(7-4-10)17-22(16,18)19/h3-9,17H,1-2H3,(H2,16,18,19)
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n/an/a 482n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220210
PNG
(CHEMBL241936 | N-[3,5-difluoro-4'-(trifluoromethyl...)
Show SMILES NS(=O)(=O)Nc1c(F)cc(cc1F)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H9F5N2O2S/c14-10-5-8(6-11(15)12(10)20-23(19,21)22)7-1-3-9(4-2-7)13(16,17)18/h1-6,20H,(H2,19,21,22)
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n/an/a 502n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220171
PNG
(CHEMBL398232 | N-[2-fluoro-4'-(trifluoromethyl)-4-...)
Show SMILES NS(=O)(=O)Nc1ccc(c(F)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10F4N2O2S/c14-12-7-10(19-22(18,20)21)5-6-11(12)8-1-3-9(4-2-8)13(15,16)17/h1-7,19H,(H2,18,20,21)
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n/an/a 685n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220207
PNG
(4'-(trifluoromethyl)-4-biphenylol | CHEMBL244264)
Show SMILES Oc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H9F3O/c14-13(15,16)11-5-1-9(2-6-11)10-3-7-12(17)8-4-10/h1-8,17H
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n/an/a 700n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220194
PNG
(4'-(trifluoromethyl)-4-biphenylyl carbamate | CHEM...)
Show SMILES NC(=O)Oc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H10F3NO2/c15-14(16,17)11-5-1-9(2-6-11)10-3-7-12(8-4-10)20-13(18)19/h1-8H,(H2,18,19)
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n/an/a 716n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220200
PNG
(CHEMBL430383 | N-[4'-(trifluoromethoxy)-4-biphenyl...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C14H12F3NO3S/c1-22(19,20)18-12-6-2-10(3-7-12)11-4-8-13(9-5-11)21-14(15,16)17/h2-9,18H,1H3
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n/an/a 792n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220206
PNG
(CHEMBL244075 | N-cyano-N'-[4'-(trifluoromethyl)-4-...)
Show SMILES NC(NC#N)=Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4/c16-15(17,18)12-5-1-10(2-6-12)11-3-7-13(8-4-11)22-14(20)21-9-19/h1-8H,(H3,20,21,22)
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n/an/a 840n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220173
PNG
(CHEMBL244125 | N-(4'-methyl-4-biphenylyl)urea)
Show SMILES Cc1ccc(cc1)-c1ccc(NC(N)=O)cc1
Show InChI InChI=1S/C14H14N2O/c1-10-2-4-11(5-3-10)12-6-8-13(9-7-12)16-14(15)17/h2-9H,1H3,(H3,15,16,17)
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n/an/a 1.38E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220163
PNG
(CHEMBL244078 | N-methyl-N-[4'-(trifluoromethyl)-4-...)
Show SMILES CN(c1ccc(cc1)-c1ccc(cc1)C(F)(F)F)S(N)(=O)=O
Show InChI InChI=1S/C14H13F3N2O2S/c1-19(22(18,20)21)13-8-4-11(5-9-13)10-2-6-12(7-3-10)14(15,16)17/h2-9H,1H3,(H2,18,20,21)
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n/an/a 1.42E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220204
PNG
(CHEMBL396772 | N-[3-(methylamino)-4'-(trifluoromet...)
Show SMILES CNc1cc(ccc1NS(N)(=O)=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H14F3N3O2S/c1-19-13-8-10(4-7-12(13)20-23(18,21)22)9-2-5-11(6-3-9)14(15,16)17/h2-8,19-20H,1H3,(H2,18,21,22)
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n/an/a 1.45E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220175
PNG
(4'-trifluoromethyl-biphenyl-4-ylamine | CHEMBL2421...)
Show SMILES Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10F3N/c14-13(15,16)11-5-1-9(2-6-11)10-3-7-12(17)8-4-10/h1-8H,17H2
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n/an/a 1.65E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220190
PNG
(CHEMBL244077 | N,N-dimethyl-N'-[4'-(trifluoromethy...)
Show SMILES CN(C)S(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H15F3N2O2S/c1-20(2)23(21,22)19-14-9-5-12(6-10-14)11-3-7-13(8-4-11)15(16,17)18/h3-10,19H,1-2H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220160
PNG
(CHEMBL242150 | N-(4'-chloro-4-biphenylyl)methanesu...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C13H12ClNO2S/c1-18(16,17)15-13-8-4-11(5-9-13)10-2-6-12(14)7-3-10/h2-9,15H,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220208
PNG
(CHEMBL242141 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES CCS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H14F3NO2S/c1-2-22(20,21)19-14-9-5-12(6-10-14)11-3-7-13(8-4-11)15(16,17)18/h3-10,19H,2H2,1H3
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n/an/a 2.52E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220158
PNG
(CHEMBL243640 | methyl[4'-(trifluoromethyl)-4-biphe...)
Show SMILES CNc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H12F3N/c1-18-13-8-4-11(5-9-13)10-2-6-12(7-3-10)14(15,16)17/h2-9,18H,1H3
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n/an/a 3.73E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220191
PNG
(4-(trifluoromethyl)biphenyl | CHEMBL242993)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C13H9F3/c14-13(15,16)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H
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n/an/a 5.32E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220186
PNG
(CHEMBL429816 | N-[4'-(trifluoromethyl)-3-biphenyly...)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H12F3NO2S/c1-21(19,20)18-13-4-2-3-11(9-13)10-5-7-12(8-6-10)14(15,16)17/h2-9,18H,1H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220199
PNG
(CHEMBL244690 | N-[3'-(trifluoromethyl)-4-biphenyly...)
Show SMILES NC(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O/c15-14(16,17)11-3-1-2-10(8-11)9-4-6-12(7-5-9)19-13(18)20/h1-8H,(H3,18,19,20)
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n/an/a 7.20E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220205
PNG
(CHEMBL242180 | N-[4-(1,3-benzodioxol-5-yl)phenyl]s...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C13H12N2O4S/c14-20(16,17)15-11-4-1-9(2-5-11)10-3-6-12-13(7-10)19-8-18-12/h1-7,15H,8H2,(H2,14,16,17)
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n/an/a 7.68E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220161
PNG
(CHEMBL244512 | N-[4'-(ethylsulfonyl)-3-fluoro-4-bi...)
Show SMILES CCS(=O)(=O)c1ccc(cc1)-c1ccc(NC(N)=O)c(F)c1
Show InChI InChI=1S/C15H15FN2O3S/c1-2-22(20,21)12-6-3-10(4-7-12)11-5-8-14(13(16)9-11)18-15(17)19/h3-9H,2H2,1H3,(H3,17,18,19)
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n/an/a 1.09E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220212
PNG
(CHEMBL242183 | N-[4-(2,3-dihydro-1,4-benzodioxin-6...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc2OCCOc2c1
Show InChI InChI=1S/C14H14N2O4S/c15-21(17,18)16-12-4-1-10(2-5-12)11-3-6-13-14(9-11)20-8-7-19-13/h1-6,9,16H,7-8H2,(H2,15,17,18)
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220198
PNG
(CHEMBL242140 | N-methyl-N-[4'-(trifluoromethyl)-4-...)
Show SMILES CN(c1ccc(cc1)-c1ccc(cc1)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C15H14F3NO2S/c1-19(22(2,20)21)14-9-5-12(6-10-14)11-3-7-13(8-4-11)15(16,17)18/h3-10H,1-2H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50060996
PNG
(4'-(trifluoromethyl)-4-biphenylcarboxylic acid | 4...)
Show SMILES OC(=O)c1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H9F3O2/c15-14(16,17)12-7-5-10(6-8-12)9-1-3-11(4-2-9)13(18)19/h1-8H,(H,18,19)
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220165
PNG
(CHEMBL437175 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES NC(N)=Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H12F3N3/c15-14(16,17)11-5-1-9(2-6-11)10-3-7-12(8-4-10)20-13(18)19/h1-8H,(H4,18,19,20)
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220167
PNG
(CHEMBL243889 | N-[4'-(2,2,2-trifluoroethyl)-4-biph...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(CC(F)(F)F)cc1
Show InChI InChI=1S/C15H14F3NO2S/c1-22(20,21)19-14-8-6-13(7-9-14)12-4-2-11(3-5-12)10-15(16,17)18/h2-9,19H,10H2,1H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220183
PNG
(CHEMBL429467 | N-[4'-(trifluoroacetyl)-4-biphenyly...)
Show SMILES NC(=O)Nc1ccc(cc1)-c1ccc(cc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C15H11F3N2O2/c16-15(17,18)13(21)11-3-1-9(2-4-11)10-5-7-12(8-6-10)20-14(19)22/h1-8H,(H3,19,20,22)
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220168
PNG
(CHEMBL388269 | N-methyl-1-[4'-(trifluoromethyl)-4-...)
Show SMILES CNS(=O)(=O)Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H14F3NO2S/c1-19-22(20,21)10-11-2-4-12(5-3-11)13-6-8-14(9-7-13)15(16,17)18/h2-9,19H,10H2,1H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220211
PNG
(CHEMBL244094 | N-4-biphenylylurea)
Show SMILES NC(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C13H12N2O/c14-13(16)15-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,(H3,14,15,16)
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220187
PNG
(CHEMBL390646 | N-Methyl-N'-[4'-(trifluoromethyl)-4...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H13F3N2O/c1-19-14(21)20-13-8-4-11(5-9-13)10-2-6-12(7-3-10)15(16,17)18/h2-9H,1H3,(H2,19,20,21)
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220164
PNG
(CHEMBL243887 | N,N-dimethyl-N'-[4'-(trifluoromethy...)
Show SMILES CN(C)C(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H15F3N2O/c1-21(2)15(22)20-14-9-5-12(6-10-14)11-3-7-13(8-4-11)16(17,18)19/h3-10H,1-2H3,(H,20,22)
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220184
PNG
(4'-(trifluoromethyl)-4-biphenylcarboxamide | CHEMB...)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H10F3NO/c15-14(16,17)12-7-5-10(6-8-12)9-1-3-11(4-2-9)13(18)19/h1-8H,(H2,18,19)
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%