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Found 23 Enz. Inhib. hit(s) with all data for entry = 50038042
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50222001((4R,6S,E)-4-hydroxy-6-(2-(6,7,8-trifluoro-4-(4-iso...)
Affinity DataIC50:  3.21E+3nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50221989((4R,6S,E)-6-(2-(6-fluoro-4,7-bis(3-methoxyphenylth...)
Affinity DataIC50:  3.64E+3nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50221999((4R,6S,E)-6-(2-(4,6,7,8-tetrakis(4-isopropylphenyl...)
Affinity DataIC50:  4.35E+3nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50222000((4R,6S,E)-6-(2-(6-fluoro-4,7-bis(phenylthio)quinol...)
Affinity DataIC50:  4.41E+3nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50221992((4R,6S,E)-4-hydroxy-6-(2-(6,7,8-trifluoro-4-(4-flu...)
Affinity DataIC50:  7.93E+3nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50371228(Crestor | ROSUVASTATIN CALCIUM | Rosuvastatin | US...)
Affinity DataIC50:  9.03E+3nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50222007((4R,6S,E)-6-(2-(7-chloro-6-fluoro-4-(3-methoxyphen...)
Affinity DataIC50:  9.24E+3nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50371229(Livalo | PITAVASTATIN CALCIUM | cid_24848419)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50221998((4R,6S,E)-6-(2-(6-fluoro-4,7-bis(4-isopropylphenyl...)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50222008((4R,6S,E)-4-hydroxy-6-(2-(6,7,8-trifluoro-4-(pheny...)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50222005((4R,6S,E)-6-(2-(6-fluoro-4,7,8-tris(4-fluorophenyl...)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50221996((4R,6S,E)-4-hydroxy-6-(2-(4-(4-isopropylphenylthio...)
Affinity DataIC50:  1.27E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50221993(CHEMBL393220 | Calcium (betaR,deltaR)-2-(p-fluorop...)
Affinity DataIC50:  1.32E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50222003((4R,6S,E)-6-(2-(4,6,7-tris(4-isopropylphenylthio)q...)
Affinity DataIC50:  1.42E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50221987((4R,6S,E)-6-(2-(4,6,7-tris(3-methoxyphenylthio)qui...)
Affinity DataIC50:  1.54E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50221990((4R,6S,E)-6-(2-(4,7-bis(4-isopropylphenylthio)quin...)
Affinity DataIC50:  1.58E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50222006((4R,6S,E)-6-(2-(4-(4-fluorophenylthio)quinolin-3-y...)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50007276(Sodium; 7-[3-(4-fluoro-phenyl)-1-isopropyl-1H-indo...)
Affinity DataIC50:  2.12E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50221994((4R,6S,E)-6-(2-(7-chloro-6-fluoro-4-(4-isopropylph...)
Affinity DataIC50:  2.21E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50222009((4R,6S,E)-6-(2-(4,6,7-tris(phenylthio)quinolin-3-y...)
Affinity DataIC50:  3.26E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50222004((4R,6S,E)-6-(2-(6-fluoro-4,7-bis(4-fluorophenylthi...)
Affinity DataIC50:  3.89E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50222002((4R,6S,E)-6-(2-(6,8-difluoro-4,7-bis(3-methoxyphen...)
Affinity DataIC50:  4.97E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50221995((4R,6S,E)-6-(2-(6-fluoro-4,7,8-tris(3-methoxypheny...)
Affinity DataIC50:  7.46E+4nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed