Compile Data Set for Download or QSAR
maximum 50k data
Found 14 Enz. Inhib. hit(s) with all data for entry = 2845
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25198(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25194(3-{[7-(pyridin-2-yl)quinolin-4-yl]amino}phenol | 7...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataIC50:  25nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25192(4-chloro-2-fluoro-5-({7-[2-(hydroxymethyl)-1,3-thi...)
Affinity DataIC50:  25nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25200(3-({6-methanesulfonyl-7-[2-(morpholin-4-ylmethyl)-...)
Affinity DataIC50:  34nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25190(2-chloro-4-fluoro-5-({7-[3-({[2-(morpholin-4-yl)et...)
Affinity DataIC50:  75nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25193(4-methyl-3-{[7-(pyridin-2-yl)quinolin-4-yl]amino}p...)
Affinity DataIC50:  75nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25195(4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...)
Affinity DataIC50:  80nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25199(5-{[7-(1-benzofuran-2-yl)quinolin-4-yl]amino}-2-br...)
Affinity DataIC50:  85nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25197(6-substituted 4-anilinoquinoline, 37 | N-(cyclopro...)
Affinity DataIC50:  90nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25196(4-[(5-hydroxy-2-methylphenyl)amino]-N-(propan-2-yl...)
Affinity DataIC50:  95nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25188(3-{[3-chloro-7-(1,3-thiazol-5-yl)quinolin-4-yl]ami...)
Affinity DataIC50:  100nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25201(4-Anilino-6,7-disubstituted quinoline, 41 | 4-chlo...)
Affinity DataIC50: >1.00E+3nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25189(4-methyl-3-{[6-(pyridin-4-yl)-2-(trifluoromethyl)q...)
Affinity DataIC50: >1.00E+3nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed