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PubMed code 1825116

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228862
PNG
(CHEMBL171141)
Show SMILES O=C(NCc1ccccc1)c1cccnc1OC1CC2CCC1C2
Show InChI InChI=1S/C20H22N2O2/c23-19(22-13-14-5-2-1-3-6-14)17-7-4-10-21-20(17)24-18-12-15-8-9-16(18)11-15/h1-7,10,15-16,18H,8-9,11-13H2,(H,22,23)
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n/an/a 220n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228865
PNG
(CHEMBL354430)
Show SMILES Cc1ccc(CNC(=O)c2cccnc2Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H17FN2O2/c1-14-4-6-15(7-5-14)13-23-19(24)18-3-2-12-22-20(18)25-17-10-8-16(21)9-11-17/h2-12H,13H2,1H3,(H,23,24)
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n/an/a 540n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228867
PNG
(CHEMBL170122)
Show SMILES COc1ccc(CNC(=O)c2cccnc2Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H17FN2O3/c1-25-16-8-4-14(5-9-16)13-23-19(24)18-3-2-12-22-20(18)26-17-10-6-15(21)7-11-17/h2-12H,13H2,1H3,(H,23,24)
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n/an/a 730n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228850
PNG
(CHEMBL168005)
Show SMILES COC(=O)c1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C21H18N2O4/c1-26-21(25)16-9-5-10-17(13-16)27-20-18(11-6-12-22-20)19(24)23-14-15-7-3-2-4-8-15/h2-13H,14H2,1H3,(H,23,24)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50008705
PNG
(CHEMBL168418 | N-Benzyl-2-phenoxy-nicotinamide)
Show SMILES O=C(NCc1ccccc1)c1cccnc1Oc1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-18(21-14-15-8-3-1-4-9-15)17-12-7-13-20-19(17)23-16-10-5-2-6-11-16/h1-13H,14H2,(H,21,22)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228849
PNG
(CHEMBL171394)
Show SMILES Fc1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C19H15FN2O2/c20-15-8-4-9-16(12-15)24-19-17(10-5-11-21-19)18(23)22-13-14-6-2-1-3-7-14/h1-12H,13H2,(H,22,23)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50218545
PNG
(NITRAQUAZONE | Nitraquazone)
Show SMILES CCn1c(=O)n(-c2cccc(c2)[N+]([O-])=O)c2ccccc2c1=O
Show InChI InChI=1S/C16H13N3O4/c1-2-17-15(20)13-8-3-4-9-14(13)18(16(17)21)11-6-5-7-12(10-11)19(22)23/h3-10H,2H2,1H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228859
PNG
(CHEMBL352655)
Show SMILES Clc1ccc(Oc2ncccc2C(=O)NCc2ccccc2)cc1Cl
Show InChI InChI=1S/C19H14Cl2N2O2/c20-16-9-8-14(11-17(16)21)25-19-15(7-4-10-22-19)18(24)23-12-13-5-2-1-3-6-13/h1-11H,12H2,(H,23,24)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228864
PNG
(CHEMBL352351)
Show SMILES Fc1ccc(Oc2ncccc2C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C18H13FN2O2/c19-13-8-10-15(11-9-13)23-18-16(7-4-12-20-18)17(22)21-14-5-2-1-3-6-14/h1-12H,(H,21,22)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228866
PNG
(CHEMBL423073)
Show SMILES COc1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C20H18N2O3/c1-24-16-9-5-10-17(13-16)25-20-18(11-6-12-21-20)19(23)22-14-15-7-3-2-4-8-15/h2-13H,14H2,1H3,(H,22,23)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228858
PNG
(CHEMBL169003)
Show SMILES Fc1ccc(Oc2ncccc2C(=O)NCc2ccccc2)cc1
Show InChI InChI=1S/C19H15FN2O2/c20-15-8-10-16(11-9-15)24-19-17(7-4-12-21-19)18(23)22-13-14-5-2-1-3-6-14/h1-12H,13H2,(H,22,23)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228860
PNG
(CHEMBL169474)
Show SMILES CC(C)NC(=O)c1cccnc1Oc1ccc(F)cc1
Show InChI InChI=1S/C15H15FN2O2/c1-10(2)18-14(19)13-4-3-9-17-15(13)20-12-7-5-11(16)6-8-12/h3-10H,1-2H3,(H,18,19)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228854
PNG
(CHEMBL353878)
Show SMILES COc1ccc(Oc2ncccc2C(=O)NCc2ccccc2)cc1
Show InChI InChI=1S/C20H18N2O3/c1-24-16-9-11-17(12-10-16)25-20-18(8-5-13-21-20)19(23)22-14-15-6-3-2-4-7-15/h2-13H,14H2,1H3,(H,22,23)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228851
PNG
(CHEMBL169911)
Show SMILES Fc1ccc(CNC(=O)c2cccnc2Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H14F2N2O2/c20-14-5-3-13(4-6-14)12-23-18(24)17-2-1-11-22-19(17)25-16-9-7-15(21)8-10-16/h1-11H,12H2,(H,23,24)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228868
PNG
(CHEMBL168121)
Show SMILES FC(F)(F)c1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C20H15F3N2O2/c21-20(22,23)15-8-4-9-16(12-15)27-19-17(10-5-11-24-19)18(26)25-13-14-6-2-1-3-7-14/h1-12H,13H2,(H,25,26)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228850
PNG
(CHEMBL168005)
Show SMILES COC(=O)c1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C21H18N2O4/c1-26-21(25)16-9-5-10-17(13-16)27-20-18(11-6-12-22-20)19(24)23-14-15-7-3-2-4-8-15/h2-13H,14H2,1H3,(H,23,24)
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n/an/a 6.60E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228861
PNG
(CHEMBL169269)
Show SMILES O=C(NCc1ccccc1)c1cccnc1Oc1cccc(c1)C#N
Show InChI InChI=1S/C20H15N3O2/c21-13-16-8-4-9-17(12-16)25-20-18(10-5-11-22-20)19(24)23-14-15-6-2-1-3-7-15/h1-12H,14H2,(H,23,24)
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n/an/a 9.80E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228848
PNG
(CHEMBL169676)
Show SMILES Fc1ccccc1Oc1ncccc1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H15FN2O2/c20-16-10-4-5-11-17(16)24-19-15(9-6-12-21-19)18(23)22-13-14-7-2-1-3-8-14/h1-12H,13H2,(H,22,23)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228852
PNG
(CHEMBL353471)
Show SMILES COc1ccccc1Oc1ncccc1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H18N2O3/c1-24-17-11-5-6-12-18(17)25-20-16(10-7-13-21-20)19(23)22-14-15-8-3-2-4-9-15/h2-13H,14H2,1H3,(H,22,23)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50218545
PNG
(NITRAQUAZONE | Nitraquazone)
Show SMILES CCn1c(=O)n(-c2cccc(c2)[N+]([O-])=O)c2ccccc2c1=O
Show InChI InChI=1S/C16H13N3O4/c1-2-17-15(20)13-8-3-4-9-14(13)18(16(17)21)11-6-5-7-12(10-11)19(22)23/h3-10H,2H2,1H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228859
PNG
(CHEMBL352655)
Show SMILES Clc1ccc(Oc2ncccc2C(=O)NCc2ccccc2)cc1Cl
Show InChI InChI=1S/C19H14Cl2N2O2/c20-16-9-8-14(11-17(16)21)25-19-15(7-4-10-22-19)18(24)23-12-13-5-2-1-3-6-13/h1-11H,12H2,(H,23,24)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228861
PNG
(CHEMBL169269)
Show SMILES O=C(NCc1ccccc1)c1cccnc1Oc1cccc(c1)C#N
Show InChI InChI=1S/C20H15N3O2/c21-13-16-8-4-9-17(12-16)25-20-18(10-5-11-22-20)19(24)23-14-15-6-2-1-3-7-15/h1-12H,14H2,(H,23,24)
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n/an/a 2.20E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228866
PNG
(CHEMBL423073)
Show SMILES COc1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C20H18N2O3/c1-24-16-9-5-10-17(13-16)25-20-18(11-6-12-21-20)19(23)22-14-15-7-3-2-4-8-15/h2-13H,14H2,1H3,(H,22,23)
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n/an/a 2.30E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228865
PNG
(CHEMBL354430)
Show SMILES Cc1ccc(CNC(=O)c2cccnc2Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H17FN2O2/c1-14-4-6-15(7-5-14)13-23-19(24)18-3-2-12-22-20(18)25-17-10-8-16(21)9-11-17/h2-12H,13H2,1H3,(H,23,24)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228860
PNG
(CHEMBL169474)
Show SMILES CC(C)NC(=O)c1cccnc1Oc1ccc(F)cc1
Show InChI InChI=1S/C15H15FN2O2/c1-10(2)18-14(19)13-4-3-9-17-15(13)20-12-7-5-11(16)6-8-12/h3-10H,1-2H3,(H,18,19)
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n/an/a 2.60E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228867
PNG
(CHEMBL170122)
Show SMILES COc1ccc(CNC(=O)c2cccnc2Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H17FN2O3/c1-25-16-8-4-14(5-9-16)13-23-19(24)18-3-2-12-22-20(18)26-17-10-6-15(21)7-11-17/h2-12H,13H2,1H3,(H,23,24)
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n/an/a 2.60E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228862
PNG
(CHEMBL171141)
Show SMILES O=C(NCc1ccccc1)c1cccnc1OC1CC2CCC1C2
Show InChI InChI=1S/C20H22N2O2/c23-19(22-13-14-5-2-1-3-6-14)17-7-4-10-21-20(17)24-18-12-15-8-9-16(18)11-15/h1-7,10,15-16,18H,8-9,11-13H2,(H,22,23)
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n/an/a 2.70E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228849
PNG
(CHEMBL171394)
Show SMILES Fc1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C19H15FN2O2/c20-15-8-4-9-16(12-15)24-19-17(10-5-11-21-19)18(23)22-13-14-6-2-1-3-7-14/h1-12H,13H2,(H,22,23)
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n/an/a 2.90E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228858
PNG
(CHEMBL169003)
Show SMILES Fc1ccc(Oc2ncccc2C(=O)NCc2ccccc2)cc1
Show InChI InChI=1S/C19H15FN2O2/c20-15-8-10-16(11-9-15)24-19-17(7-4-12-21-19)18(23)22-13-14-5-2-1-3-6-14/h1-12H,13H2,(H,22,23)
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n/an/a 3.70E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228864
PNG
(CHEMBL352351)
Show SMILES Fc1ccc(Oc2ncccc2C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C18H13FN2O2/c19-13-8-10-15(11-9-13)23-18-16(7-4-12-20-18)17(22)21-14-5-2-1-3-6-14/h1-12H,(H,21,22)
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n/an/a 4.30E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50008705
PNG
(CHEMBL168418 | N-Benzyl-2-phenoxy-nicotinamide)
Show SMILES O=C(NCc1ccccc1)c1cccnc1Oc1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-18(21-14-15-8-3-1-4-9-15)17-12-7-13-20-19(17)23-16-10-5-2-6-11-16/h1-13H,14H2,(H,21,22)
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n/an/a 4.90E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228851
PNG
(CHEMBL169911)
Show SMILES Fc1ccc(CNC(=O)c2cccnc2Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H14F2N2O2/c20-14-5-3-13(4-6-14)12-23-18(24)17-2-1-11-22-19(17)25-16-9-7-15(21)8-10-16/h1-11H,12H2,(H,23,24)
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n/an/a 5.10E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228868
PNG
(CHEMBL168121)
Show SMILES FC(F)(F)c1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C20H15F3N2O2/c21-20(22,23)15-8-4-9-16(12-15)27-19-17(10-5-11-24-19)18(26)25-13-14-6-2-1-3-7-14/h1-12H,13H2,(H,25,26)
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n/an/a 5.40E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228854
PNG
(CHEMBL353878)
Show SMILES COc1ccc(Oc2ncccc2C(=O)NCc2ccccc2)cc1
Show InChI InChI=1S/C20H18N2O3/c1-24-16-9-11-17(12-10-16)25-20-18(8-5-13-21-20)19(23)22-14-15-6-3-2-4-7-15/h2-13H,14H2,1H3,(H,22,23)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228852
PNG
(CHEMBL353471)
Show SMILES COc1ccccc1Oc1ncccc1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H18N2O3/c1-24-17-11-5-6-12-18(17)25-20-16(10-7-13-21-20)19(23)22-14-15-8-3-2-4-9-15/h2-13H,14H2,1H3,(H,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228848
PNG
(CHEMBL169676)
Show SMILES Fc1ccccc1Oc1ncccc1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H15FN2O2/c20-16-10-4-5-11-17(16)24-19-15(9-6-12-21-19)18(23)22-13-14-7-2-1-3-8-14/h1-12H,13H2,(H,22,23)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%