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PubMed code 18308565

Compile data set for download or QSAR
Found 70 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236260
PNG
(7-[(1E)-1-(hydroxyimino)ethyl]-19-methyl-3,13,19,2...)
Show SMILES CC(N=O)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C22H19N5O2/c1-10(26-29)11-3-5-16-13(7-11)19-14-8-23-22(28)20(14)18-12(21(19)24-16)4-6-17-15(18)9-27(2)25-17/h3,5,7,9-10,24H,4,6,8H2,1-2H3,(H,23,28)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236262
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-propyl-...)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OC
Show InChI InChI=1S/C26H27N5O2/c1-5-10-31-21-9-6-15(14(2)29-33-4)11-17(21)23-18-12-27-26(32)24(18)22-16(25(23)31)7-8-20-19(22)13-30(3)28-20/h6,9,11,13H,5,7-8,10,12H2,1-4H3,(H,27,32)/b29-14+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236262
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-propyl-...)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OC
Show InChI InChI=1S/C26H27N5O2/c1-5-10-31-21-9-6-15(14(2)29-33-4)11-17(21)23-18-12-27-26(32)24(18)22-16(25(23)31)7-8-20-19(22)13-30(3)28-20/h6,9,11,13H,5,7-8,10,12H2,1-4H3,(H,27,32)/b29-14+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236266
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3,13,19,2...)
Show SMILES CO\N=C(/C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C23H21N5O2/c1-11(27-30-3)12-4-6-17-14(8-12)20-15-9-24-23(29)21(15)19-13(22(20)25-17)5-7-18-16(19)10-28(2)26-18/h4,6,8,10,25H,5,7,9H2,1-3H3,(H,24,29)/b27-11+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236270
PNG
(1-(4-(4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2c(F)cccc2C(F)(F)F)cc1
Show InChI InChI=1S/C27H19F4N5O3/c1-38-17-11-7-15(8-12-17)23-20(21-24(32)33-13-34-25(21)39-23)14-5-9-16(10-6-14)35-26(37)36-22-18(27(29,30)31)3-2-4-19(22)28/h2-13H,1H3,(H2,32,33,34)(H2,35,36,37)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236246
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3,13,19,20...)
Show SMILES CCO\N=C(/C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C24H23N5O2/c1-4-31-28-12(2)13-5-7-18-15(9-13)21-16-10-25-24(30)22(16)20-14(23(21)26-18)6-8-19-17(20)11-29(3)27-19/h5,7,9,11,26H,4,6,8,10H2,1-3H3,(H,25,30)/b28-12+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236263
PNG
(19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]...)
Show SMILES CC(C)CO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C29H33N5O2/c1-15(2)14-36-32-17(5)18-7-10-24-20(11-18)26-21-12-30-29(35)27(21)25-19(28(26)34(24)16(3)4)8-9-23-22(25)13-33(6)31-23/h7,10-11,13,15-16H,8-9,12,14H2,1-6H3,(H,30,35)/b32-17+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236264
PNG
(19-methyl-7-[(1E)-1-[(propan-2-yloxy)imino]ethyl]-...)
Show SMILES CC(C)O\N=C(/C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C25H25N5O2/c1-12(2)32-29-13(3)14-5-7-19-16(9-14)22-17-10-26-25(31)23(17)21-15(24(22)27-19)6-8-20-18(21)11-30(4)28-20/h5,7,9,11-12,27H,6,8,10H2,1-4H3,(H,26,31)/b29-13+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236270
PNG
(1-(4-(4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2c(F)cccc2C(F)(F)F)cc1
Show InChI InChI=1S/C27H19F4N5O3/c1-38-17-11-7-15(8-12-17)23-20(21-24(32)33-13-34-25(21)39-23)14-5-9-16(10-6-14)35-26(37)36-22-18(27(29,30)31)3-2-4-19(22)28/h2-13H,1H3,(H2,32,33,34)(H2,35,36,37)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236259
PNG
(3-ethyl-19-methyl-7-[(1E)-1-[(2-methylpropoxy)imin...)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OCC(C)C
Show InChI InChI=1S/C28H31N5O2/c1-6-33-23-10-7-17(16(4)31-35-14-15(2)3)11-19(23)25-20-12-29-28(34)26(20)24-18(27(25)33)8-9-22-21(24)13-32(5)30-22/h7,10-11,13,15H,6,8-9,12,14H2,1-5H3,(H,29,34)/b31-16+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236252
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(propan...)
Show SMILES CO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H27N5O2/c1-13(2)31-21-9-6-15(14(3)29-33-5)10-17(21)23-18-11-27-26(32)24(18)22-16(25(23)31)7-8-20-19(22)12-30(4)28-20/h6,9-10,12-13H,7-8,11H2,1-5H3,(H,27,32)/b29-14+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236246
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3,13,19,20...)
Show SMILES CCO\N=C(/C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C24H23N5O2/c1-4-31-28-12(2)13-5-7-18-15(9-13)21-16-10-25-24(30)22(16)20-14(23(21)26-18)6-8-19-17(20)11-29(3)27-19/h5,7,9,11,26H,4,6,8,10H2,1-3H3,(H,25,30)/b28-12+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236258
PNG
(19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]...)
Show SMILES CC(C)CO\N=C(/C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H27N5O2/c1-13(2)12-33-30-14(3)15-5-7-20-17(9-15)23-18-10-27-26(32)24(18)22-16(25(23)28-20)6-8-21-19(22)11-31(4)29-21/h5,7,9,11,13,28H,6,8,10,12H2,1-4H3,(H,27,32)/b30-14+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236248
PNG
(7-[(1E)-(ethoxyimino)methyl]-19-methyl-3,13,19,20-...)
Show SMILES CCO\N=C\c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C23H21N5O2/c1-3-30-25-9-12-4-6-17-14(8-12)20-15-10-24-23(29)21(15)19-13(22(20)26-17)5-7-18-16(19)11-28(2)27-18/h4,6,8-9,11,26H,3,5,7,10H2,1-2H3,(H,24,29)/b25-9+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236254
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Show SMILES CCO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-6-34-30-15(4)16-7-10-22-18(11-16)24-19-12-28-27(33)25(19)23-17(26(24)32(22)14(2)3)8-9-21-20(23)13-31(5)29-21/h7,10-11,13-14H,6,8-9,12H2,1-5H3,(H,28,33)/b30-15+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236268
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(2-methy...)
Show SMILES CCO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H31N5O2/c1-6-35-31-16(4)17-7-10-23-19(11-17)25-20-12-29-28(34)26(20)24-18(27(25)33(23)13-15(2)3)8-9-22-21(24)14-32(5)30-22/h7,10-11,14-15H,6,8-9,12-13H2,1-5H3,(H,29,34)/b31-16+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236264
PNG
(19-methyl-7-[(1E)-1-[(propan-2-yloxy)imino]ethyl]-...)
Show SMILES CC(C)O\N=C(/C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C25H25N5O2/c1-12(2)32-29-13(3)14-5-7-19-16(9-14)22-17-10-26-25(31)23(17)21-15(24(22)27-19)6-8-20-18(21)11-30(4)28-20/h5,7,9,11-12,27H,6,8,10H2,1-4H3,(H,26,31)/b29-13+
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236251
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Show SMILES CO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-14(2)12-32-22-9-6-16(15(3)30-34-5)10-18(22)24-19-11-28-27(33)25(19)23-17(26(24)32)7-8-21-20(23)13-31(4)29-21/h6,9-10,13-14H,7-8,11-12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236267
PNG
(7-[(1E)-1-(methoxyimino)-2-methylpropyl]-19-methyl...)
Show SMILES CO\N=C(/C(C)C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C25H25N5O2/c1-12(2)23(29-32-4)13-5-7-18-15(9-13)21-16-10-26-25(31)22(16)20-14(24(21)27-18)6-8-19-17(20)11-30(3)28-19/h5,7,9,11-12,27H,6,8,10H2,1-4H3,(H,26,31)/b29-23+
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236256
PNG
(3-ethyl-7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3...)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OC
Show InChI InChI=1S/C25H25N5O2/c1-5-30-20-9-6-14(13(2)28-32-4)10-16(20)22-17-11-26-25(31)23(17)21-15(24(22)30)7-8-19-18(21)12-29(3)27-19/h6,9-10,12H,5,7-8,11H2,1-4H3,(H,26,31)/b28-13+
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236269
PNG
(19-methyl-3-(propan-2-yl)-7-[(1E)-1-[(propan-2-ylo...)
Show SMILES CC(C)O\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H31N5O2/c1-14(2)33-23-10-7-17(16(5)31-35-15(3)4)11-19(23)25-20-12-29-28(34)26(20)24-18(27(25)33)8-9-22-21(24)13-32(6)30-22/h7,10-11,13-15H,8-9,12H2,1-6H3,(H,29,34)/b31-16+
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236257
PNG
(19-methyl-3-(2-methylpropyl)-7-[(1E)-1-[(propan-2-...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OC(C)C
Show InChI InChI=1S/C29H33N5O2/c1-15(2)13-34-24-10-7-18(17(5)32-36-16(3)4)11-20(24)26-21-12-30-29(35)27(21)25-19(28(26)34)8-9-23-22(25)14-33(6)31-23/h7,10-11,14-16H,8-9,12-13H2,1-6H3,(H,30,35)/b32-17+
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236254
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Show SMILES CCO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-6-34-30-15(4)16-7-10-22-18(11-16)24-19-12-28-27(33)25(19)23-17(26(24)32(22)14(2)3)8-9-21-20(23)13-31(5)29-21/h7,10-11,13-14H,6,8-9,12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236268
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(2-methy...)
Show SMILES CCO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H31N5O2/c1-6-35-31-16(4)17-7-10-23-19(11-17)25-20-12-29-28(34)26(20)24-18(27(25)33(23)13-15(2)3)8-9-22-21(24)14-32(5)30-22/h7,10-11,14-15H,6,8-9,12-13H2,1-5H3,(H,29,34)/b31-16+
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236253
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-3,19-dimethyl-3,13,...)
Show SMILES CO\N=C(/C)c1ccc2n(C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C24H23N5O2/c1-12(27-31-4)13-5-8-19-15(9-13)21-16-10-25-24(30)22(16)20-14(23(21)29(19)3)6-7-18-17(20)11-28(2)26-18/h5,8-9,11H,6-7,10H2,1-4H3,(H,25,30)/b27-12+
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n/an/a 5n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236251
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Show SMILES CO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-14(2)12-32-22-9-6-16(15(3)30-34-5)10-18(22)24-19-11-28-27(33)25(19)23-17(26(24)32)7-8-21-20(23)13-31(4)29-21/h6,9-10,13-14H,7-8,11-12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50236251
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Show SMILES CO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-14(2)12-32-22-9-6-16(15(3)30-34-5)10-18(22)24-19-11-28-27(33)25(19)23-17(26(24)32)7-8-21-20(23)13-31(4)29-21/h6,9-10,13-14H,7-8,11-12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a 8n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236258
PNG
(19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]...)
Show SMILES CC(C)CO\N=C(/C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H27N5O2/c1-13(2)12-33-30-14(3)15-5-7-20-17(9-15)23-18-10-27-26(32)24(18)22-16(25(23)28-20)6-8-21-19(22)11-31(4)29-21/h5,7,9,11,13,28H,6,8,10,12H2,1-4H3,(H,27,32)/b30-14+
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50236251
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Show SMILES CO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-14(2)12-32-22-9-6-16(15(3)30-34-5)10-18(22)24-19-11-28-27(33)25(19)23-17(26(24)32)7-8-21-20(23)13-31(4)29-21/h6,9-10,13-14H,7-8,11-12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236258
PNG
(19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]...)
Show SMILES CC(C)CO\N=C(/C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H27N5O2/c1-13(2)12-33-30-14(3)15-5-7-20-17(9-15)23-18-10-27-26(32)24(18)22-16(25(23)28-20)6-8-21-19(22)11-31(4)29-21/h5,7,9,11,13,28H,6,8,10,12H2,1-4H3,(H,27,32)/b30-14+
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM25115
PNG
(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Show SMILES NC(=O)c1c(NC(=O)NCCCCN2CCCC2)snc1OCc1c(F)cc(Br)cc1F
Show InChI InChI=1S/C20H24BrF2N5O3S/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30)
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n/an/a 11n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236269
PNG
(19-methyl-3-(propan-2-yl)-7-[(1E)-1-[(propan-2-ylo...)
Show SMILES CC(C)O\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H31N5O2/c1-14(2)33-23-10-7-17(16(5)31-35-15(3)4)11-19(23)25-20-12-29-28(34)26(20)24-18(27(25)33)8-9-22-21(24)13-32(6)30-22/h7,10-11,13-15H,8-9,12H2,1-6H3,(H,29,34)/b31-16+
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n/an/a 11n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236247
PNG
(3-butyl-7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3...)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OC
Show InChI InChI=1S/C27H29N5O2/c1-5-6-11-32-22-10-7-16(15(2)30-34-4)12-18(22)24-19-13-28-27(33)25(19)23-17(26(24)32)8-9-21-20(23)14-31(3)29-21/h7,10,12,14H,5-6,8-9,11,13H2,1-4H3,(H,28,33)/b30-15+
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n/an/a 12n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50236254
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Show SMILES CCO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-6-34-30-15(4)16-7-10-22-18(11-16)24-19-12-28-27(33)25(19)23-17(26(24)32(22)14(2)3)8-9-21-20(23)13-31(5)29-21/h7,10-11,13-14H,6,8-9,12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a 14n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-src


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236249
PNG
(7-[(1E)-(methoxyimino)methyl]-19-methyl-3,13,19,20...)
Show SMILES CO\N=C\c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C22H19N5O2/c1-27-10-15-17(26-27)6-4-12-18(15)20-14(9-23-22(20)28)19-13-7-11(8-24-29-2)3-5-16(13)25-21(12)19/h3,5,7-8,10,25H,4,6,9H2,1-2H3,(H,23,28)/b24-8+
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM25115
PNG
(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Show SMILES NC(=O)c1c(NC(=O)NCCCCN2CCCC2)snc1OCc1c(F)cc(Br)cc1F
Show InChI InChI=1S/C20H24BrF2N5O3S/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30)
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236246
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3,13,19,20...)
Show SMILES CCO\N=C(/C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C24H23N5O2/c1-4-31-28-12(2)13-5-7-18-15(9-13)21-16-10-25-24(30)22(16)20-14(23(21)26-18)6-8-19-17(20)11-29(3)27-19/h5,7,9,11,26H,4,6,8,10H2,1-3H3,(H,25,30)/b28-12+
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n/an/a 23n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236265
PNG
(19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]...)
Show SMILES CC(C)CO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C30H35N5O2/c1-16(2)13-35-25-10-7-19(18(5)33-37-15-17(3)4)11-21(25)27-22-12-31-30(36)28(22)26-20(29(27)35)8-9-24-23(26)14-34(6)32-24/h7,10-11,14,16-17H,8-9,12-13,15H2,1-6H3,(H,31,36)/b33-18+
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n/an/a 23n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236261
PNG
(7-[(1E)-1-(ethoxyimino)-2-methylpropyl]-19-methyl-...)
Show SMILES CCO\N=C(/C(C)C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H27N5O2/c1-5-33-30-24(13(2)3)14-6-8-19-16(10-14)22-17-11-27-26(32)23(17)21-15(25(22)28-19)7-9-20-18(21)12-31(4)29-20/h6,8,10,12-13,28H,5,7,9,11H2,1-4H3,(H,27,32)/b30-24+
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n/an/a 23n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236259
PNG
(3-ethyl-19-methyl-7-[(1E)-1-[(2-methylpropoxy)imin...)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OCC(C)C
Show InChI InChI=1S/C28H31N5O2/c1-6-33-23-10-7-17(16(4)31-35-14-15(2)3)11-19(23)25-20-12-29-28(34)26(20)24-18(27(25)33)8-9-22-21(24)13-32(5)30-22/h7,10-11,13,15H,6,8-9,12,14H2,1-5H3,(H,29,34)/b31-16+
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n/an/a 24n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236268
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(2-methy...)
Show SMILES CCO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H31N5O2/c1-6-35-31-16(4)17-7-10-23-19(11-17)25-20-12-29-28(34)26(20)24-18(27(25)33(23)13-15(2)3)8-9-22-21(24)14-32(5)30-22/h7,10-11,14-15H,6,8-9,12-13H2,1-5H3,(H,29,34)/b31-16+
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n/an/a 25n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236254
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Show SMILES CCO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-6-34-30-15(4)16-7-10-22-18(11-16)24-19-12-28-27(33)25(19)23-17(26(24)32(22)14(2)3)8-9-21-20(23)13-31(5)29-21/h7,10-11,13-14H,6,8-9,12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a 26n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236264
PNG
(19-methyl-7-[(1E)-1-[(propan-2-yloxy)imino]ethyl]-...)
Show SMILES CC(C)O\N=C(/C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C25H25N5O2/c1-12(2)32-29-13(3)14-5-7-19-16(9-14)22-17-10-26-25(31)23(17)21-15(24(22)27-19)6-8-20-18(21)11-30(4)28-20/h5,7,9,11-12,27H,6,8,10H2,1-4H3,(H,26,31)/b29-13+
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n/an/a 28n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236262
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-propyl-...)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OC
Show InChI InChI=1S/C26H27N5O2/c1-5-10-31-21-9-6-15(14(2)29-33-4)11-17(21)23-18-12-27-26(32)24(18)22-16(25(23)31)7-8-20-19(22)13-30(3)28-20/h6,9,11,13H,5,7-8,10,12H2,1-4H3,(H,27,32)/b29-14+
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n/an/a 30n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236251
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Show SMILES CO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-14(2)12-32-22-9-6-16(15(3)30-34-5)10-18(22)24-19-11-28-27(33)25(19)23-17(26(24)32)7-8-21-20(23)13-31(4)29-21/h6,9-10,13-14H,7-8,11-12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a 30n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236250
PNG
(7-[(1E)-1-[(tert-butoxy)imino]ethyl]-19-methyl-3,1...)
Show SMILES C\C(=N/OC(C)(C)C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H27N5O2/c1-13(30-33-26(2,3)4)14-6-8-19-16(10-14)22-17-11-27-25(32)23(17)21-15(24(22)28-19)7-9-20-18(21)12-31(5)29-20/h6,8,10,12,28H,7,9,11H2,1-5H3,(H,27,32)/b30-13+
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n/an/a 31n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236257
PNG
(19-methyl-3-(2-methylpropyl)-7-[(1E)-1-[(propan-2-...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OC(C)C
Show InChI InChI=1S/C29H33N5O2/c1-15(2)13-34-24-10-7-18(17(5)32-36-16(3)4)11-20(24)26-21-12-30-29(35)27(21)25-19(28(26)34)8-9-23-22(25)14-33(6)31-23/h7,10-11,14-16H,8-9,12-13H2,1-6H3,(H,30,35)/b32-17+
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n/an/a 31n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50236251
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Show SMILES CO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-14(2)12-32-22-9-6-16(15(3)30-34-5)10-18(22)24-19-11-28-27(33)25(19)23-17(26(24)32)7-8-21-20(23)13-31(4)29-21/h6,9-10,13-14H,7-8,11-12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a 43n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-src


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236260
PNG
(7-[(1E)-1-(hydroxyimino)ethyl]-19-methyl-3,13,19,2...)
Show SMILES CC(N=O)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C22H19N5O2/c1-10(26-29)11-3-5-16-13(7-11)19-14-8-23-22(28)20(14)18-12(21(19)24-16)4-6-17-15(18)9-27(2)25-17/h3,5,7,9-10,24H,4,6,8H2,1-2H3,(H,23,28)
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n/an/a 44n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236259
PNG
(3-ethyl-19-methyl-7-[(1E)-1-[(2-methylpropoxy)imin...)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OCC(C)C
Show InChI InChI=1S/C28H31N5O2/c1-6-33-23-10-7-17(16(4)31-35-14-15(2)3)11-19(23)25-20-12-29-28(34)26(20)24-18(27(25)33)8-9-22-21(24)13-32(5)30-22/h7,10-11,13,15H,6,8-9,12,14H2,1-5H3,(H,29,34)/b31-16+
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n/an/a 45n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236263
PNG
(19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]...)
Show SMILES CC(C)CO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C29H33N5O2/c1-15(2)14-36-32-17(5)18-7-10-24-20(11-18)26-21-12-30-29(35)27(21)25-19(28(26)34(24)16(3)4)8-9-23-22(25)13-33(6)31-23/h7,10-11,13,15-16H,8-9,12,14H2,1-6H3,(H,30,35)/b32-17+
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n/an/a 46n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236263
PNG
(19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]...)
Show SMILES CC(C)CO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C29H33N5O2/c1-15(2)14-36-32-17(5)18-7-10-24-20(11-18)26-21-12-30-29(35)27(21)25-19(28(26)34(24)16(3)4)8-9-23-22(25)13-33(6)31-23/h7,10-11,13,15-16H,8-9,12,14H2,1-6H3,(H,30,35)/b32-17+
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n/an/a 51n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236257
PNG
(19-methyl-3-(2-methylpropyl)-7-[(1E)-1-[(propan-2-...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OC(C)C
Show InChI InChI=1S/C29H33N5O2/c1-15(2)13-34-24-10-7-18(17(5)32-36-16(3)4)11-20(24)26-21-12-30-29(35)27(21)25-19(28(26)34)8-9-23-22(25)14-33(6)31-23/h7,10-11,14-16H,8-9,12-13H2,1-6H3,(H,30,35)/b32-17+
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n/an/a 52n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236269
PNG
(19-methyl-3-(propan-2-yl)-7-[(1E)-1-[(propan-2-ylo...)
Show SMILES CC(C)O\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H31N5O2/c1-14(2)33-23-10-7-17(16(5)31-35-15(3)4)11-19(23)25-20-12-29-28(34)26(20)24-18(27(25)33)8-9-22-21(24)13-32(6)30-22/h7,10-11,13-15H,8-9,12H2,1-6H3,(H,29,34)/b31-16+
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n/an/a 66n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236266
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3,13,19,2...)
Show SMILES CO\N=C(/C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C23H21N5O2/c1-11(27-30-3)12-4-6-17-14(8-12)20-15-9-24-23(29)21(15)19-13(22(20)25-17)5-7-18-16(19)10-28(2)26-18/h4,6,8,10,25H,5,7,9H2,1-3H3,(H,24,29)/b27-11+
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n/an/a 71n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236261
PNG
(7-[(1E)-1-(ethoxyimino)-2-methylpropyl]-19-methyl-...)
Show SMILES CCO\N=C(/C(C)C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H27N5O2/c1-5-33-30-24(13(2)3)14-6-8-19-16(10-14)22-17-11-27-26(32)23(17)21-15(25(22)28-19)7-9-20-18(21)12-31(4)29-20/h6,8,10,12-13,28H,5,7,9,11H2,1-4H3,(H,27,32)/b30-24+
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n/an/a 92n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236250
PNG
(7-[(1E)-1-[(tert-butoxy)imino]ethyl]-19-methyl-3,1...)
Show SMILES C\C(=N/OC(C)(C)C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H27N5O2/c1-13(30-33-26(2,3)4)14-6-8-19-16(10-14)22-17-11-27-25(32)23(17)21-15(24(22)28-19)7-9-20-18(21)12-31(5)29-20/h6,8,10,12,28H,7,9,11H2,1-5H3,(H,27,32)/b30-13+
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n/an/a 93n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236265
PNG
(19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]...)
Show SMILES CC(C)CO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C30H35N5O2/c1-16(2)13-35-25-10-7-19(18(5)33-37-15-17(3)4)11-21(25)27-22-12-31-30(36)28(22)26-20(29(27)35)8-9-24-23(26)14-34(6)32-24/h7,10-11,14,16-17H,8-9,12-13,15H2,1-6H3,(H,31,36)/b33-18+
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n/an/a 94n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236252
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(propan...)
Show SMILES CO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H27N5O2/c1-13(2)31-21-9-6-15(14(3)29-33-5)10-17(21)23-18-11-27-26(32)24(18)22-16(25(23)31)7-8-20-19(22)12-30(4)28-20/h6,9-10,12-13H,7-8,11H2,1-5H3,(H,27,32)/b29-14+
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n/an/a 97n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236247
PNG
(3-butyl-7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3...)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OC
Show InChI InChI=1S/C27H29N5O2/c1-5-6-11-32-22-10-7-16(15(2)30-34-4)12-18(22)24-19-13-28-27(33)25(19)23-17(26(24)32)8-9-21-20(23)14-31(3)29-21/h7,10,12,14H,5-6,8-9,11,13H2,1-4H3,(H,28,33)/b30-15+
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n/an/a 108n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236249
PNG
(7-[(1E)-(methoxyimino)methyl]-19-methyl-3,13,19,20...)
Show SMILES CO\N=C\c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C22H19N5O2/c1-27-10-15-17(26-27)6-4-12-18(15)20-14(9-23-22(20)28)19-13-7-11(8-24-29-2)3-5-16(13)25-21(12)19/h3,5,7-8,10,25H,4,6,9H2,1-2H3,(H,23,28)/b24-8+
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n/an/a 148n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236267
PNG
(7-[(1E)-1-(methoxyimino)-2-methylpropyl]-19-methyl...)
Show SMILES CO\N=C(/C(C)C)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C25H25N5O2/c1-12(2)23(29-32-4)13-5-7-18-15(9-13)21-16-10-26-25(31)22(16)20-14(24(21)27-18)6-8-19-17(20)11-30(3)28-19/h5,7,9,11-12,27H,6,8,10H2,1-4H3,(H,26,31)/b29-23+
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n/an/a 264n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236248
PNG
(7-[(1E)-(ethoxyimino)methyl]-19-methyl-3,13,19,20-...)
Show SMILES CCO\N=C\c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C23H21N5O2/c1-3-30-25-9-12-4-6-17-14(8-12)20-15-10-24-23(29)21(15)19-13(22(20)26-17)5-7-18-16(19)11-28(2)27-18/h4,6,8-9,11,26H,3,5,7,10H2,1-2H3,(H,24,29)/b25-9+
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n/an/a 264n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236256
PNG
(3-ethyl-7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3...)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(\C)=N\OC
Show InChI InChI=1S/C25H25N5O2/c1-5-30-20-9-6-14(13(2)28-32-4)10-16(20)22-17-11-26-25(31)23(17)21-15(24(22)30)7-8-19-18(21)12-29(3)27-19/h6,9-10,12H,5,7-8,11H2,1-4H3,(H,26,31)/b28-13+
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n/an/a 300n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236253
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-3,19-dimethyl-3,13,...)
Show SMILES CO\N=C(/C)c1ccc2n(C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C24H23N5O2/c1-12(27-31-4)13-5-8-19-15(9-13)21-16-10-25-24(30)22(16)20-14(23(21)29(19)3)6-7-18-17(20)11-28(2)26-18/h5,8-9,11H,6-7,10H2,1-4H3,(H,25,30)/b27-12+
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n/an/a 347n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50236254
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Show SMILES CCO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-6-34-30-15(4)16-7-10-22-18(11-16)24-19-12-28-27(33)25(19)23-17(26(24)32(22)14(2)3)8-9-21-20(23)13-31(5)29-21/h7,10-11,13-14H,6,8-9,12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50236251
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Show SMILES CO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-14(2)12-32-22-9-6-16(15(3)30-34-5)10-18(22)24-19-11-28-27(33)25(19)23-17(26(24)32)7-8-21-20(23)13-31(4)29-21/h6,9-10,13-14H,7-8,11-12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50236251
PNG
(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Show SMILES CO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-14(2)12-32-22-9-6-16(15(3)30-34-5)10-18(22)24-19-11-28-27(33)25(19)23-17(26(24)32)7-8-21-20(23)13-31(4)29-21/h6,9-10,13-14H,7-8,11-12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50236254
PNG
(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Show SMILES CCO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H29N5O2/c1-6-34-30-15(4)16-7-10-22-18(11-16)24-19-12-28-27(33)25(19)23-17(26(24)32(22)14(2)3)8-9-21-20(23)13-31(5)29-21/h7,10-11,13-14H,6,8-9,12H2,1-5H3,(H,28,33)/b30-15+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236255
PNG
(19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4ccccc4[nH]c32)n1
Show InChI InChI=1S/C20H16N4O/c1-24-9-13-15(23-24)7-6-11-16(13)18-12(8-21-20(18)25)17-10-4-2-3-5-14(10)22-19(11)17/h2-5,9,22H,6-8H2,1H3,(H,21,25)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE2 by HTRF assay


Bioorg Med Chem Lett 18: 1916-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.001
BindingDB Entry DOI: 10.7270/Q27M07PV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%