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PubMed code 18313174

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM7533
PNG
((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
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Article
PubMed
n/an/a 700n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin A (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM50266465
PNG
((Z/E)-(2S)-2-amino-5-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C14H16BrN3O3/c15-8-3-4-12-9(6-8)10(13(19)18-12)7-17-5-1-2-11(16)14(20)21/h3-4,6-7,10-11H,1-2,5,16H2,(H,18,19)(H,20,21)/t10?,11-/m0/s1
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n/an/a 6.60E+3n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin A (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50266463
PNG
((Z/E)-(2S)-2-amino-6-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C15H18BrN3O3/c16-9-4-5-13-10(7-9)11(14(20)19-13)8-18-6-2-1-3-12(17)15(21)22/h4-5,7-8,11-12H,1-3,6,17H2,(H,19,20)(H,21,22)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of Src (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266464
PNG
((Z/E)-(2S)-2-amino-6-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C15H19N3O3/c16-12(15(20)21)6-3-4-8-17-9-11-10-5-1-2-7-13(10)18-14(11)19/h1-2,5,7,9,11-12H,3-4,6,8,16H2,(H,18,19)(H,20,21)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50266464
PNG
((Z/E)-(2S)-2-amino-6-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C15H19N3O3/c16-12(15(20)21)6-3-4-8-17-9-11-10-5-1-2-7-13(10)18-14(11)19/h1-2,5,7,9,11-12H,3-4,6,8,16H2,(H,18,19)(H,20,21)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50266466
PNG
((Z/E)-(2S)-2-amino-5-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C14H17N3O3/c15-11(14(19)20)5-3-7-16-8-10-9-4-1-2-6-12(9)17-13(10)18/h1-2,4,6,8,10-11H,3,5,7,15H2,(H,17,18)(H,19,20)/t10?,11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266465
PNG
((Z/E)-(2S)-2-amino-5-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C14H16BrN3O3/c15-8-3-4-12-9(6-8)10(13(19)18-12)7-17-5-1-2-11(16)14(20)21/h3-4,6-7,10-11H,1-2,5,16H2,(H,18,19)(H,20,21)/t10?,11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50266465
PNG
((Z/E)-(2S)-2-amino-5-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C14H16BrN3O3/c15-8-3-4-12-9(6-8)10(13(19)18-12)7-17-5-1-2-11(16)14(20)21/h3-4,6-7,10-11H,1-2,5,16H2,(H,18,19)(H,20,21)/t10?,11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of Ret (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50266463
PNG
((Z/E)-(2S)-2-amino-6-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C15H18BrN3O3/c16-9-4-5-13-10(7-9)11(14(20)19-13)8-18-6-2-1-3-12(17)15(21)22/h4-5,7-8,11-12H,1-3,6,17H2,(H,19,20)(H,21,22)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50266465
PNG
((Z/E)-(2S)-2-amino-5-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C14H16BrN3O3/c15-8-3-4-12-9(6-8)10(13(19)18-12)7-17-5-1-2-11(16)14(20)21/h3-4,6-7,10-11H,1-2,5,16H2,(H,18,19)(H,20,21)/t10?,11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50266466
PNG
((Z/E)-(2S)-2-amino-5-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C14H17N3O3/c15-11(14(19)20)5-3-7-16-8-10-9-4-1-2-6-12(9)17-13(10)18/h1-2,4,6,8,10-11H,3,5,7,15H2,(H,17,18)(H,19,20)/t10?,11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of Src (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50266466
PNG
((Z/E)-(2S)-2-amino-5-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C14H17N3O3/c15-11(14(19)20)5-3-7-16-8-10-9-4-1-2-6-12(9)17-13(10)18/h1-2,4,6,8,10-11H,3,5,7,15H2,(H,17,18)(H,19,20)/t10?,11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50266466
PNG
((Z/E)-(2S)-2-amino-5-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C14H17N3O3/c15-11(14(19)20)5-3-7-16-8-10-9-4-1-2-6-12(9)17-13(10)18/h1-2,4,6,8,10-11H,3,5,7,15H2,(H,17,18)(H,19,20)/t10?,11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of IGF1R (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50266463
PNG
((Z/E)-(2S)-2-amino-6-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C15H18BrN3O3/c16-9-4-5-13-10(7-9)11(14(20)19-13)8-18-6-2-1-3-12(17)15(21)22/h4-5,7-8,11-12H,1-3,6,17H2,(H,19,20)(H,21,22)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of IGF1R (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50266464
PNG
((Z/E)-(2S)-2-amino-6-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C15H19N3O3/c16-12(15(20)21)6-3-4-8-17-9-11-10-5-1-2-7-13(10)18-14(11)19/h1-2,5,7,9,11-12H,3-4,6,8,16H2,(H,18,19)(H,20,21)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of IGF1R (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50266464
PNG
((Z/E)-(2S)-2-amino-6-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C15H19N3O3/c16-12(15(20)21)6-3-4-8-17-9-11-10-5-1-2-7-13(10)18-14(11)19/h1-2,5,7,9,11-12H,3-4,6,8,16H2,(H,18,19)(H,20,21)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of Src (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266463
PNG
((Z/E)-(2S)-2-amino-6-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C15H18BrN3O3/c16-9-4-5-13-10(7-9)11(14(20)19-13)8-18-6-2-1-3-12(17)15(21)22/h4-5,7-8,11-12H,1-3,6,17H2,(H,19,20)(H,21,22)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50266464
PNG
((Z/E)-(2S)-2-amino-6-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C15H19N3O3/c16-12(15(20)21)6-3-4-8-17-9-11-10-5-1-2-7-13(10)18-14(11)19/h1-2,5,7,9,11-12H,3-4,6,8,16H2,(H,18,19)(H,20,21)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of Ret (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266466
PNG
((Z/E)-(2S)-2-amino-5-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C14H17N3O3/c15-11(14(19)20)5-3-7-16-8-10-9-4-1-2-6-12(9)17-13(10)18/h1-2,4,6,8,10-11H,3,5,7,15H2,(H,17,18)(H,19,20)/t10?,11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50266465
PNG
((Z/E)-(2S)-2-amino-5-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C14H16BrN3O3/c15-8-3-4-12-9(6-8)10(13(19)18-12)7-17-5-1-2-11(16)14(20)21/h3-4,6-7,10-11H,1-2,5,16H2,(H,18,19)(H,20,21)/t10?,11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of Src (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50266464
PNG
((Z/E)-(2S)-2-amino-6-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C15H19N3O3/c16-12(15(20)21)6-3-4-8-17-9-11-10-5-1-2-7-13(10)18-14(11)19/h1-2,5,7,9,11-12H,3-4,6,8,16H2,(H,18,19)(H,20,21)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50266465
PNG
((Z/E)-(2S)-2-amino-5-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C14H16BrN3O3/c15-8-3-4-12-9(6-8)10(13(19)18-12)7-17-5-1-2-11(16)14(20)21/h3-4,6-7,10-11H,1-2,5,16H2,(H,18,19)(H,20,21)/t10?,11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50266463
PNG
((Z/E)-(2S)-2-amino-6-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C15H18BrN3O3/c16-9-4-5-13-10(7-9)11(14(20)19-13)8-18-6-2-1-3-12(17)15(21)22/h4-5,7-8,11-12H,1-3,6,17H2,(H,19,20)(H,21,22)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50266465
PNG
((Z/E)-(2S)-2-amino-5-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C14H16BrN3O3/c15-8-3-4-12-9(6-8)10(13(19)18-12)7-17-5-1-2-11(16)14(20)21/h3-4,6-7,10-11H,1-2,5,16H2,(H,18,19)(H,20,21)/t10?,11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of IGF1R (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50266463
PNG
((Z/E)-(2S)-2-amino-6-([(5-bromo-2-oxo-indolin-3-yl...)
Show SMILES N[C@@H](CCCCN=CC1C(=O)Nc2ccc(Br)cc12)C(O)=O
Show InChI InChI=1S/C15H18BrN3O3/c16-9-4-5-13-10(7-9)11(14(20)19-13)8-18-6-2-1-3-12(17)15(21)22/h4-5,7-8,11-12H,1-3,6,17H2,(H,19,20)(H,21,22)/t11?,12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of Ret (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50266466
PNG
((Z/E)-(2S)-2-amino-5-([(2-oxo-indolin-3-ylidene)me...)
Show SMILES N[C@@H](CCCN=CC1C(=O)Nc2ccccc12)C(O)=O
Show InChI InChI=1S/C14H17N3O3/c15-11(14(19)20)5-3-7-16-8-10-9-4-1-2-6-12(9)17-13(10)18/h1-2,4,6,8,10-11H,3,5,7,15H2,(H,17,18)(H,19,20)/t10?,11-/m0/s1
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PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of Ret (unknown origin)


Eur J Med Chem 43: 2316-22 (2008)


Article DOI: 10.1016/j.ejmech.2008.01.010
BindingDB Entry DOI: 10.7270/Q2S75G36
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%